Hsin-Chun Chen

Dr. Hsin-Chun Chen

Department of Cosmeceutics, China Medical University, Taichung 406, Taiwan
orcid

Research Focus & Metrics

Academic Career Length

20Years (2007-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
7 September 2019 in Foods
Verified
Journal Article
Open access
PDF file
LLLi Yun Lin
Li Yun Lin
CCCheng-Hung Chuang
Cheng-Hung Chuang
Hsin-Chun ChenHsin-Chun Chen
Hsin-Chun Chen
KYKai-Min Yang
Kai-Min Yang
Lime peels are mainly obtained from the byproducts of the juice manufacturing industry, which we obtained and used to extract essential oil (2.3%) in order to examine the antioxidant and hypolipidaemic effects. We identified 60 volatile compounds of lime essential oil (LEO) with GC/MS, of which the predominant constituents were limonene, γ-terpinene, and β-pinene. Lime essential oil was measured according to the DPPH assay and ABTS assay, with IC50 values of 2.36 mg/mL and 0.26 mg/mL, respectively. This study also explored the protective effects of LEO against lipid-induced hyperlipidemia in a rat model. Two groups of rats received oral LEO in doses of 0.74 g/100 g and 2.23 g/100 g with their diets. Eight weeks later, we found that the administration of LEO improved the serum total cholesterol, triglyceride, low-density lipoprotein cholesterol, alanine aminotransferase, and aspartate transaminase levels in the hyperlipidemic rats (p < 0.05). Simultaneously, the LEO improved the health of the rats in terms of obesity, atherogenic index, and fatty liver.

1 January 2013 in Evidence-Based Complementary and Alternative Medicine
Verified
Journal Article
Open access
PDF file
Hsiu-Mei ChiangHsiu-Mei Chiang
Hsiu-Mei Chiang
Hsin-Chun ChenHsin-Chun Chen
Hsin-Chun Chen
HCHua-Hsien Chiu
Hua-Hsien Chiu
CCChien-Wen Chen
Chien-Wen Chen
SWSsu-Meng Wang
Ssu-Meng Wang
KWKuo-Ching Wen
Kuo-Ching Wen
In this study, we investigated whether the protective effects ofNeonauclea reticulatawater extract against ultraviolet B (UVB) irradiation in human skin fibroblast cell cultures (Hs68) are governed by its ability to protect against oxidative stress and expression of matrix metalloproteinases (MMPs). We found thatNeonauclea reticulataextract exhibited DPPH scavenging activity and inhibited AAPH-induced haemolysis of erythrocytes in a dose- and time-dependent manner. We also found that pretreatment of fibroblasts withNeonauclea reticulatawater extract resulted in markedly lower levels of MMP-1, -3, and -9 expressions. Furthermore, our results indicate thatNeonauclea reticulataextract inhibits the expression of MMPs by inhibiting ERK, JNK, and p38 phosphorylation. Our results also demonstrate that treatment withNeonauclea reticulataextract protects against UVB-induced depletion of collagen. In addition,Neonauclea reticulataextract did not have a cytotoxic effect. These findings indicate that the antioxidant activity ofNeonauclea reticulataextract resulted in inhibition of MMP-1, -3, and -9 expressions and in increased levels of collagen activity. Our results suggest thatNeonauclea reticulataextract can protect against photoaging.

1 January 2013 in Food Chemistry
Verified
Journal Article
Closed access
LPLi-Wen Peng
Li-Wen Peng
MSMing-Jen Sheu
Ming-Jen Sheu
LLLi-Yun Lin
Li-Yun Lin
CWChun-Ta Wu
Chun-Ta Wu
HCHsiu-Mei Chiang
Hsiu-Mei Chiang
Hsin-Chun ChenHsin-Chun Chen
Hsin-Chun Chen

26 April 2020 in New Phytologist
Verified
Journal Article
Closed access
PDF file
HJHong Jiang
Hong Jiang
JKJi‐Jun Kong
Ji‐Jun Kong
Hsin-Chun ChenHsin-Chun Chen
Hsin-Chun Chen
ZXZhen‐Yong Xiang
Zhen‐Yong Xiang
WZWei‐Ping Zhang
Wei‐Ping Zhang
YLYung-I Lee
Yung-I Lee

31 May 2021 in Molecules
Verified
Journal Article
Open access
PDF file
KYKai-Min Yang
Kai-Min Yang
LCLouis Chao
Louis Chao
CWChin-Sheng Wu
Chin-Sheng Wu
ZYZih-Sian Ye
Zih-Sian Ye
Hsin-Chun ChenHsin-Chun Chen
Hsin-Chun Chen
Peanut oil is favored by consumers due to its rich nutritional value and unique flavor. This study used headspace solid-phase microextraction (HS-SPME) combined with gas chromatography (GC) and gas chromatography–mass spectrometry (GC-MS) to examine the differences in the peanut oil aroma on the basis of variety, roasting temperatures, and pressing components. The results revealed that the optimal conditions for extracting peanut oil were achieved through the use of 50/30 μm DVB/CAR/PDMS fibers at 60 °C for 50 min. The primary compounds present in peanut oil were pyrazines. When peanuts were roasted, the temperature raised from 120 °C to 140 °C and the content of aldehydes in peanut oil increased; however, the content of aldehydes in No. 9 oil at 160 °C decreased. The components of peanut shell oil varied depending on the peanut variety. The most marked difference was observed in terms of the main compound at the two roasting temperatures. This compound was a pyrazine, and the content increased with the roasting temperature in hekei oils. When the roasting temperature was lower, No. 9 oil contained more fatty acid oxidation products such as hexanal, heptanal, and nonanal. When the roasting temperature increased, No. 9 oil contained more furfural and 5-methylfurfural. Heren oil was easier to oxidize and produced nonanal that possessed a fatty aroma.

8 June 2016 in Molecules
Verified
Journal Article
Open access
PDF file
CLCHIA-LIN Lee
CHIA-LIN Lee
SLShou-Lun Lee
Shou-Lun Lee
CCChao-Jung Chen
Chao-Jung Chen
Hsin-Chun ChenHsin-Chun Chen
Hsin-Chun Chen
MKMing-Ching Kao
Ming-Ching Kao
Yang-Chang WuYang-Chang Wu
Yang-Chang Wu
Ipomoea batatas has long been used in folk medicine for the treatment of hyperglycemia or as a food additive for the prevention of type 2 diabetes. However, neither the plant extract nor its active components have been evaluated systematically. In this work four crude extracts, including n-hexane- (IBH), 95% MeOH- (IBM), n-BuOH- (IBB), and H2O-soluble (IBW) fractions, were prepared by fractionation of a methanolic extract of purple I. batatas leaves. Twenty-four pure compounds 1–24 were then isolated by various chromatographic techniques and their structures identified from NMR and MS data. Glucose uptake assays in differentiated 3T3-L1 adipocytes and rat primary hepatocytes, as well as western blot analysis, were carried out to evaluate the antidiabetic activity of this species. The IBH crude fraction, with methyl decanoate (22) as a major and active compound, showed the greatest effect on glucose uptake, most likely via activation of Glut4 and regulation of the PI3K/AKT pathway. Quercetin 3-O-β-d-sophoroside (1), quercetin (3), benzyl β-d-glucoside (10), 4-hydroxy-3-methoxybenzaldehyde (12), and methyl decanoate (22) could be important components contributing to the antidiabetic effects. We conclude that purple I. batatas leaves have potential as an antidiabetic plant source and the active constituents 1, 3, 10, 12, and 22 are promising lead candidates for future investigation.