The Amaryllidaceae family is widely distributed in the tropics, presenting biological activity attributed mostly to alkaloids, such as an important inhibitory activity of acetylcholinesterase (AChE), antifungal, antibacterial, and cytotoxic activities. The present study aims to review the spectrum of action of the main biological activities and toxicity of secondary metabolites found in Amaryllidaceae through a literature review, using Prisma and the descriptors “Pharmacological effects of Amaryllidaceae” and “Amaryllidaceae family” and “Pharmacological actions of Amaryllidaceae”, used in English and Portuguese. The literature search was done in March and May 2023. Original works published from 2012 to 2023, available in full, and presenting experimental and clinical studies were included. After the selection considering the inclusion and exclusion criteria, 60 articles fulfilled the defined criteria. From a pharmacological point of view, the highlight is due to the alkaloid galantamine, which has the potential- and is already used - for treating Alzheimer's. The toxicological aspect must be considered and evaluated carefully, as alkaloids have been associated with adverse effects such as nausea, vomiting, diarrhea, abdominal pain, and cardiovascular, neurological, and respiratory changes. Furthermore, some studies indicate that consuming these plants in significant quantities can lead to hepatic and renal toxicity. Therefore, the therapeutical use of this family's plant drugs and derivatives requires further studies to elucidate its effects and point out metabolites with therapeutic potential.

Amaryllidaceae alkaloids have attracted significant attention in cancer research for their potential antitumor properties. To date, numerous studies have investigated the effects of these alkaloids on cancer cell lines, but a comprehensive synthesis of the existing evidence through a literature review is warranted. This article presents a comprehensive literature review aimed at evaluating the antitumor effects of amaryllidaceae alkaloids on various cancer cell lines and elucidating the underlying mechanisms of action. A search was conducted in major scientific databases, including Google Scholar, PubMed, Scopus, and Web of Science, to identify relevant studies published between 2013 and 2023. Studies that examined the antitumor effects of amaryllidaceae alkaloids on cancer cell lines were included in the review. Data were extracted, analyzed, and synthesized to provide an in-depth overview of the findings. The alkaloids exhibited potent cytotoxicity and suppressed cell proliferation in a concentration-dependent manner. Mechanistic investigations unveiled that amaryllidaceae alkaloids induced apoptosis, cell cycle arrest, and hindered angiogenesis in cancer cells. Moreover, they demonstrated favorable selectivity towards cancer cells, sparing normal cells, suggesting potential as targeted therapies. This literature review consolidates and critically appraises the available evidence on the antitumor effects of amaryllidaceae alkaloids on cancer cell lines. The findings underscore their potential as promising candidates for further exploration in cancer therapeutics. Future preclinical and clinical studies are vital to advance their development and translation into effective anticancer drugs.

Foodborne diseases are common illnesses caused by the consumption of food contaminated with microorganisms, such as viruses, fungi, bacteria, and protozoa. Every year, 600 million people become ill and 420,000 people die as a result of consuming contaminated food. Therefore, food safety is an important issue. In this study, samples of homemade spiced mayonnaise and self-serve acai sold in the city of Araguaína, Tocantins, Brazil were analyzed for microbiological contaminants. Acai was collected from 10 stores, one sample from each store, and tested for mold, yeast, and coliforms, as well as coliform identification and total and thermotolerant coliform counts. Mayonnaise was collected from 20 snack bars, one sample from each. These samples were inoculated on MacConkey and Salmonella Shigella agar plates, and the plates were analyzed for growth. Salmonella spp. were detected in some Mayonnaise samples, and coliforms were detected in all acai samples; 60% of samples had thermotolerant coliforms, and only 40% were within the limits established by ANVISA. The collected samples of mayonnaise and acai were contaminated with molds and yeasts above the established limit of 10³ CFU/g. Thus, the analyzed mayonnaise and acai samples were contaminated and unfit for consumption, demonstrating the importance of hygienic-sanitary measures in food handling.

A talidomida foi amplamente prescrita no passado por seus efeitos contra enjôos matinais de gravidas, no entanto, muitas crianças foram afetadas por seus efeitos teratogênicos até então desconhecidos, alguns anos depois o fármaco vem sendo utilizado no tratamento do Eritema Nodoso Hansêmico (ENH). O presente estudo visa analisar a dispensação da talidomida no tratamento da hanseníase por meio da Assistência farmacêutica (AF), que utiliza o método de consultório no município de Araguaína-TO. Objetivando averiguar a dispensação e analisar o método empregado, além de revisar o tratamento da hanseníase com a talidomida. Trata-se de um estudo retrospectivo de prontuários referentes às dispensações de talidomida no tratamento da hanseníase, obtidos pela Assistência Farmacêutica nos anos de 2013 a 2018. Através disto, foi desenvolvida uma planilha como instrumento de trabalho, onde foram obtidos os dados de cada usuário referente ao gênero, número de pacientes, idade e reações frequentes, e assim traçar o perfil do usuário em tratamento de hanseníase atendido pela AF e ressaltar o atendimento realizado no consultório farmacêutico, uma iniciativa pioneira no Brasil.

Crohn's disease is an inflammatory disease of the gastrointestinal tract with a multifactorial etiology. Based on the severity of Crohn's Disease and the effect it causes on patients' quality of life, this paper aims to discuss its main clinical aspects, involving diagnosis and better professional management. A literature review was carried out with data collection through a bibliographic review for secondary surveys in the PUBMED, SCIELO and LILACS online databases. The incidence of Crohn's Disease (CD) between females and males is similar, ranging from 15 to 40 years old. It has the highest number of cases in Europe, North America and South America. There are several classifications for Crohn's Disease, and therefore it is the health professional's responsibility to know them, in order to know how to distinguish and carry out the correct drug prescription and treatment. Therefore, it is imperative that you are aware of the main characteristics, such as symptoms, etiology and preventive methods.

Chronic urticaria (CU) is a mast cell-driven inflammatory skin disorder characterized by recurrent wheals, angioedema, or both lasting more than six weeks, often resulting in significant impairment of quality of life. Although CU has traditionally been regarded as a predominantly histamine-mediated condition, evidence accumulated over the past decade has redefined chronic spontaneous urticaria (CSU) as a complex immune-mediated disease with marked biological heterogeneity. Distinct pathogenic mechanisms involving autoimmune pathways, dysregulated mast cell activation, and chronic inflammatory networks have been identified, providing a mechanistic basis for disease persistence, variable severity, and therapeutic refractoriness. This review synthesizes current concepts in CSU pathophysiology, with emphasis on mast cell biology, autoimmune endotypes, and inflammatory amplification mechanisms. We further discuss emerging biomarkers with potential relevance for disease stratification and treatment prediction, as well as established and novel therapeutic strategies targeting key pathogenic pathways. By integrating mechanistic insights with clinical implications, this review highlights the transition toward endotype-driven and biomarker-guided management of chronic urticaria.