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Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency greatly hinders Plasmodium vivax malaria radical cure and further elimination due to 8-aminoquinolines-associated hemolysis. Although the deleterious health effects of primaquine in G6PD deficient individuals have been known for over 50 years, G6PD testing is not routinely performed before primaquine treatment in most P. vivax endemic areas. Method/Principal findings The qualitative CareStart G6PD screening test was implemented in 12 malaria treatment units (MTUs) in the municipality of Rio Preto da Eva, Western Brazilian Amazon, a malaria endemic area, between February 2019 and early January 2020. Training materials were developed and validated; evaluations were conducted on the effectiveness of training health care professionals (HCPs) to perform the test, the interpretation and reliability of routine testing performed by HCPs, and perceptions of HCPs and patients. Most HCPs were unaware of G6PD deficiency and primaquine-related adverse effects. Most of 110 HCPs trained (86/110, 78%) were able to correctly perform the G6PD test after a single 4-hour training session. The test performed by HCPs during implementation showed 100.0% (4/4) sensitivity and 68.1% (62/91) specificity in identifying G6PD deficient patients as compared to a point-of-care quantitative test (Standard G6PD). Conclusions/Significance G6PD screening using the qualitative CareStart G6PD test performed by HCPs in MTUs of an endemic area showed high sensitivity and concerning low specificity. The amount of false G6PD deficiency detected led to substantial loss of opportunities for radical cure.
Jose Diego Brito-Sousa; Felipe Murta; Sheila Vitor-Silva; Vanderson S. Sampaio; Maxwell O. Mendes; Marcelo A. M. Brito; Talita S. B. Batista; Alicia P. C. Santos; Leonardo L. G. Marques; Laila R. A. Barbosa; Marly M. Melo; Djane C. Baia-Da-Silva; Alexandre V. Silva-Neto; Thalie C. Santos; Brenda K. A. Souza; Erick F. G. Figueiredo; Emanuelle L. Silva; Sheila Rodovalho; Theresa H. Nakagawa; Ana Ruth Arcanjo; André M. Siqueira; Gisely C. Melo; Judith Recht; Gonzalo J. Domingo; Quique Bassat; Germana Bancone; Wuelton M. Monteiro; Marcus V. G. Lacerda. Real-life implementation of a G6PD deficiency screening qualitative test into routine vivax malaria diagnostic units in the Brazilian Amazon (SAFEPRIM study). PLOS Neglected Tropical Diseases 2021, 15, e0009415 .
AMA StyleJose Diego Brito-Sousa, Felipe Murta, Sheila Vitor-Silva, Vanderson S. Sampaio, Maxwell O. Mendes, Marcelo A. M. Brito, Talita S. B. Batista, Alicia P. C. Santos, Leonardo L. G. Marques, Laila R. A. Barbosa, Marly M. Melo, Djane C. Baia-Da-Silva, Alexandre V. Silva-Neto, Thalie C. Santos, Brenda K. A. Souza, Erick F. G. Figueiredo, Emanuelle L. Silva, Sheila Rodovalho, Theresa H. Nakagawa, Ana Ruth Arcanjo, André M. Siqueira, Gisely C. Melo, Judith Recht, Gonzalo J. Domingo, Quique Bassat, Germana Bancone, Wuelton M. Monteiro, Marcus V. G. Lacerda. Real-life implementation of a G6PD deficiency screening qualitative test into routine vivax malaria diagnostic units in the Brazilian Amazon (SAFEPRIM study). PLOS Neglected Tropical Diseases. 2021; 15 (5):e0009415.
Chicago/Turabian StyleJose Diego Brito-Sousa; Felipe Murta; Sheila Vitor-Silva; Vanderson S. Sampaio; Maxwell O. Mendes; Marcelo A. M. Brito; Talita S. B. Batista; Alicia P. C. Santos; Leonardo L. G. Marques; Laila R. A. Barbosa; Marly M. Melo; Djane C. Baia-Da-Silva; Alexandre V. Silva-Neto; Thalie C. Santos; Brenda K. A. Souza; Erick F. G. Figueiredo; Emanuelle L. Silva; Sheila Rodovalho; Theresa H. Nakagawa; Ana Ruth Arcanjo; André M. Siqueira; Gisely C. Melo; Judith Recht; Gonzalo J. Domingo; Quique Bassat; Germana Bancone; Wuelton M. Monteiro; Marcus V. G. Lacerda. 2021. "Real-life implementation of a G6PD deficiency screening qualitative test into routine vivax malaria diagnostic units in the Brazilian Amazon (SAFEPRIM study)." PLOS Neglected Tropical Diseases 15, no. 5: e0009415.
Paula Bonates; Guilherme Augusto Pivoto João; Kátia Santana Cruz; Marcelo De Souza Ferreira; Djane Clarys Baía-Da-Silva; Maria Eduarda Leão de Farias; José Diego Brito-Sousa; Monique Freire Santana; Luciana Aires de Oliveira; Ana Cláudia Alves Cortez; João Vicente Braga Souza; Marcus Vinicius Guimarães Lacerda. Fatal rhino-orbito-cerebral mucormycosis infection associated with diabetic ketoacidosis post-COVID-19. Revista da Sociedade Brasileira de Medicina Tropical 2021, 54, e03582021 .
AMA StylePaula Bonates, Guilherme Augusto Pivoto João, Kátia Santana Cruz, Marcelo De Souza Ferreira, Djane Clarys Baía-Da-Silva, Maria Eduarda Leão de Farias, José Diego Brito-Sousa, Monique Freire Santana, Luciana Aires de Oliveira, Ana Cláudia Alves Cortez, João Vicente Braga Souza, Marcus Vinicius Guimarães Lacerda. Fatal rhino-orbito-cerebral mucormycosis infection associated with diabetic ketoacidosis post-COVID-19. Revista da Sociedade Brasileira de Medicina Tropical. 2021; 54 ():e03582021.
Chicago/Turabian StylePaula Bonates; Guilherme Augusto Pivoto João; Kátia Santana Cruz; Marcelo De Souza Ferreira; Djane Clarys Baía-Da-Silva; Maria Eduarda Leão de Farias; José Diego Brito-Sousa; Monique Freire Santana; Luciana Aires de Oliveira; Ana Cláudia Alves Cortez; João Vicente Braga Souza; Marcus Vinicius Guimarães Lacerda. 2021. "Fatal rhino-orbito-cerebral mucormycosis infection associated with diabetic ketoacidosis post-COVID-19." Revista da Sociedade Brasileira de Medicina Tropical 54, no. : e03582021.
Although high mortality has been reported in many COVID-19 studies, very limited postmortem information from complete autopsies is available. We report the findings in the adrenal glands in 28 autopsies with confirmed SARS-CoV-2 infection. Microscopic lesions were identified in the adrenal glands in 12/28 patients (46%). Seven cases showed necrosis, generally ischemic; four showed cortical lipid degeneration; two showed hemorrhage; and one unspecific focal adrenalitis. Vascular thrombosis in one patient and focal inflammation in association with other findings in three patients were observed. No case presented adrenal insufficiency. In conclusion, adrenal lesions are frequent in patients with severe COVID-19. The lesions are mild but could contribute to the lethal outcome.
Monique Freire Santana; Mayla Gabriela Silva Borba; Djane Clarys Baía-Da-Silva; Fernando Val; Márcia Almeida Araújo Alexandre; Jose Diego Brito-Sousa; Gisely Cardoso Melo; Marcos Vinícius Oliveira Queiroga; Maria Eduarda Leão Farias; Cecília Cunha Camilo; Felipe Gomes Naveca; Mariana Simão Xavier; Wuelton Marcelo Monteiro; Guilherme Augusto Pivoto João; Ludhmila Abrahão Hajjar; Jaume Ordi; Marcus Vinícius Guimarães Lacerda; Luiz Carlos Lima Ferreira. Case Report: Adrenal Pathology Findings in Severe COVID-19: An Autopsy Study. The American Journal of Tropical Medicine and Hygiene 2020, 103, 1604 -1607.
AMA StyleMonique Freire Santana, Mayla Gabriela Silva Borba, Djane Clarys Baía-Da-Silva, Fernando Val, Márcia Almeida Araújo Alexandre, Jose Diego Brito-Sousa, Gisely Cardoso Melo, Marcos Vinícius Oliveira Queiroga, Maria Eduarda Leão Farias, Cecília Cunha Camilo, Felipe Gomes Naveca, Mariana Simão Xavier, Wuelton Marcelo Monteiro, Guilherme Augusto Pivoto João, Ludhmila Abrahão Hajjar, Jaume Ordi, Marcus Vinícius Guimarães Lacerda, Luiz Carlos Lima Ferreira. Case Report: Adrenal Pathology Findings in Severe COVID-19: An Autopsy Study. The American Journal of Tropical Medicine and Hygiene. 2020; 103 (4):1604-1607.
Chicago/Turabian StyleMonique Freire Santana; Mayla Gabriela Silva Borba; Djane Clarys Baía-Da-Silva; Fernando Val; Márcia Almeida Araújo Alexandre; Jose Diego Brito-Sousa; Gisely Cardoso Melo; Marcos Vinícius Oliveira Queiroga; Maria Eduarda Leão Farias; Cecília Cunha Camilo; Felipe Gomes Naveca; Mariana Simão Xavier; Wuelton Marcelo Monteiro; Guilherme Augusto Pivoto João; Ludhmila Abrahão Hajjar; Jaume Ordi; Marcus Vinícius Guimarães Lacerda; Luiz Carlos Lima Ferreira. 2020. "Case Report: Adrenal Pathology Findings in Severe COVID-19: An Autopsy Study." The American Journal of Tropical Medicine and Hygiene 103, no. 4: 1604-1607.
The first cases of the new coronavirus 2019 disease (COVID-19) were reported in December 2019 when a group of patients was admitted to hospitals in Wuhan, the capital of Hubei province in central China, with an initial diagnosis of pneumonia of unknown etiology.1 Initially, the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was confined to Hubei province, but it rapidly spread to many other countries,2,3 compelling the World Health Organization to officially declare a global pandemic on March 11, 2020. SARS-CoV-2 infection appears to cause a wide range of symptoms.4,5 Most deaths involve older adults, many of whom had underlying chronic diseases.6,7
Mayla Gabriela Silva Borba; Fernando Fonseca Almeida Val; Vanderson Souza Sampaio; Marcia Almeida Araújo Alexandre; Gisely Cardoso Melo; Marcelo Brito; Maria Paula Gomes Mourão; José Diego Brito-Sousa; Djane Baía-Da-Silva; Marcus Vinitius Farias Guerra; Ludhmila Abrahão Hajjar; Rosemary Costa Pinto; Antonio Alcirley Silva Balieiro; Antônio Guilherme Fonseca Pacheco; James Dean Oliveira Santos; Felipe Gomes Naveca; Mariana Simão Xavier; André Machado Siqueira; Alexandre Schwarzbold; Júlio Croda; Maurício Lacerda Nogueira; Gustavo Adolfo Sierra Romero; Quique Bassat; Cor Jesus Fontes; Bernardino Cláudio Albuquerque; Cláudio-Tadeu Daniel-Ribeiro; Wuelton Marcelo Monteiro; Marcus Vinícius Guimarães Lacerda. Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. JAMA Network Open 2020, 3, e208857 -e208857.
AMA StyleMayla Gabriela Silva Borba, Fernando Fonseca Almeida Val, Vanderson Souza Sampaio, Marcia Almeida Araújo Alexandre, Gisely Cardoso Melo, Marcelo Brito, Maria Paula Gomes Mourão, José Diego Brito-Sousa, Djane Baía-Da-Silva, Marcus Vinitius Farias Guerra, Ludhmila Abrahão Hajjar, Rosemary Costa Pinto, Antonio Alcirley Silva Balieiro, Antônio Guilherme Fonseca Pacheco, James Dean Oliveira Santos, Felipe Gomes Naveca, Mariana Simão Xavier, André Machado Siqueira, Alexandre Schwarzbold, Júlio Croda, Maurício Lacerda Nogueira, Gustavo Adolfo Sierra Romero, Quique Bassat, Cor Jesus Fontes, Bernardino Cláudio Albuquerque, Cláudio-Tadeu Daniel-Ribeiro, Wuelton Marcelo Monteiro, Marcus Vinícius Guimarães Lacerda. Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. JAMA Network Open. 2020; 3 (4):e208857-e208857.
Chicago/Turabian StyleMayla Gabriela Silva Borba; Fernando Fonseca Almeida Val; Vanderson Souza Sampaio; Marcia Almeida Araújo Alexandre; Gisely Cardoso Melo; Marcelo Brito; Maria Paula Gomes Mourão; José Diego Brito-Sousa; Djane Baía-Da-Silva; Marcus Vinitius Farias Guerra; Ludhmila Abrahão Hajjar; Rosemary Costa Pinto; Antonio Alcirley Silva Balieiro; Antônio Guilherme Fonseca Pacheco; James Dean Oliveira Santos; Felipe Gomes Naveca; Mariana Simão Xavier; André Machado Siqueira; Alexandre Schwarzbold; Júlio Croda; Maurício Lacerda Nogueira; Gustavo Adolfo Sierra Romero; Quique Bassat; Cor Jesus Fontes; Bernardino Cláudio Albuquerque; Cláudio-Tadeu Daniel-Ribeiro; Wuelton Marcelo Monteiro; Marcus Vinícius Guimarães Lacerda. 2020. "Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection." JAMA Network Open 3, no. 4: e208857-e208857.
The first cases of the new coronavirus (COVID-19) were reported in December, 2019, when a group of patients was admitted to hospitals with an initial diagnosis of pneumonia of unknown etiology1. Initially, the outbreak of the new SARSCoV-2 coronavirus (coronavirus disease 2019; formerly 2019-nCoV) was centralized in the province of Hubei, Republic of China, and later spread to many other countries2. SARS-CoV-2 infection appears to cause a wide range of symptoms, encompassing asymptomatic infection, mild infections of the upper respiratory tract, severe viral pneumonia, respiratory failure, multiple organ failure and death3. Some studies have shown detailed clinical features of some patients with SARS-CoV-24. Of the 44,672 laboratory confirmed patients in China, almost 5% had critical illnesses and almost 50% of the critical patients died, with the overall rate of fatal cases (2.3%) being higher than that observed for seasonal influenza5. Most deaths involved older adults, many of whom had underlying chronic diseases4,6, while children are less likely to develop severe infections7. Despite there being no available data so far, anecdotal data from Italy showed a huge number of deaths in the elderly, paving the way for drastic control measures worldwide and compassionate use of drugs in severe cases.
Wuelton Marcelo Monteiro; Jose Diego Brito-Sousa; Djane Baía-Da-Silva; Gisely Cardoso De Melo; André Machado Siqueira; Fernando Val; Cláudio Tadeu Daniel-Ribeiro; Marcus Vinicius Guimarães Lacerda. Driving forces for COVID-19 clinical trials using chloroquine: the need to choose the right research questions and outcomes. Revista da Sociedade Brasileira de Medicina Tropical 2020, 53, e20200155 .
AMA StyleWuelton Marcelo Monteiro, Jose Diego Brito-Sousa, Djane Baía-Da-Silva, Gisely Cardoso De Melo, André Machado Siqueira, Fernando Val, Cláudio Tadeu Daniel-Ribeiro, Marcus Vinicius Guimarães Lacerda. Driving forces for COVID-19 clinical trials using chloroquine: the need to choose the right research questions and outcomes. Revista da Sociedade Brasileira de Medicina Tropical. 2020; 53 ():e20200155.
Chicago/Turabian StyleWuelton Marcelo Monteiro; Jose Diego Brito-Sousa; Djane Baía-Da-Silva; Gisely Cardoso De Melo; André Machado Siqueira; Fernando Val; Cláudio Tadeu Daniel-Ribeiro; Marcus Vinicius Guimarães Lacerda. 2020. "Driving forces for COVID-19 clinical trials using chloroquine: the need to choose the right research questions and outcomes." Revista da Sociedade Brasileira de Medicina Tropical 53, no. : e20200155.
We present postmortem evidence of invasive pulmonary aspergillosis (IPA) in a patient with severe COVID-19. Autopsies of COVID-19 confirmed cases were performed. The patient died despite antimicrobials, mechanical ventilation, and vasopressor support. Histopathology and peripheral blood galactomannan antigen testing confirmed IPA. Aspergillus penicillioides infection was confirmed by nucleotide sequencing and BLAST analysis. Further reports are needed to assess the occurrence and frequency of IPA in SARS-CoV-2 infections, and how they interact clinically.
Monique Freire Santana; Guilherme Pivoto; Márcia A. Araujo Alexandre; Djane Clarys Baía-Da-Silva; Mayla Gabriela Da Silva Borba; Fernando Almeida Val; Jose Diego Brito-Sousa; Gisely Cardoso Melo; Wuelton Marcelo Monteiro; João Vicente Braga Souza; Silviane Bezerra Pinheiro; Luiz Carlos Lima Ferreira; Felipe Gomes Naveca; Valdinete Nascimento; André Lima Guerra Corado; Ludhmila Abrahão Hajjar; João Ricardo Silva Neto; George Alan Villarouco Siva; Alessandro C. Pasqualotto; Marcus Vinícius Guimarães Lacerda. Confirmed Invasive Pulmonary Aspergillosis and COVID-19: the value of postmortem findings to support antemortem management. Revista da Sociedade Brasileira de Medicina Tropical 2020, 53, e20200401 .
AMA StyleMonique Freire Santana, Guilherme Pivoto, Márcia A. Araujo Alexandre, Djane Clarys Baía-Da-Silva, Mayla Gabriela Da Silva Borba, Fernando Almeida Val, Jose Diego Brito-Sousa, Gisely Cardoso Melo, Wuelton Marcelo Monteiro, João Vicente Braga Souza, Silviane Bezerra Pinheiro, Luiz Carlos Lima Ferreira, Felipe Gomes Naveca, Valdinete Nascimento, André Lima Guerra Corado, Ludhmila Abrahão Hajjar, João Ricardo Silva Neto, George Alan Villarouco Siva, Alessandro C. Pasqualotto, Marcus Vinícius Guimarães Lacerda. Confirmed Invasive Pulmonary Aspergillosis and COVID-19: the value of postmortem findings to support antemortem management. Revista da Sociedade Brasileira de Medicina Tropical. 2020; 53 ():e20200401.
Chicago/Turabian StyleMonique Freire Santana; Guilherme Pivoto; Márcia A. Araujo Alexandre; Djane Clarys Baía-Da-Silva; Mayla Gabriela Da Silva Borba; Fernando Almeida Val; Jose Diego Brito-Sousa; Gisely Cardoso Melo; Wuelton Marcelo Monteiro; João Vicente Braga Souza; Silviane Bezerra Pinheiro; Luiz Carlos Lima Ferreira; Felipe Gomes Naveca; Valdinete Nascimento; André Lima Guerra Corado; Ludhmila Abrahão Hajjar; João Ricardo Silva Neto; George Alan Villarouco Siva; Alessandro C. Pasqualotto; Marcus Vinícius Guimarães Lacerda. 2020. "Confirmed Invasive Pulmonary Aspergillosis and COVID-19: the value of postmortem findings to support antemortem management." Revista da Sociedade Brasileira de Medicina Tropical 53, no. : e20200401.
The outbreak of new coronavirus disease 2019 (COVID-19) reported for the first time in Wuhan, China in late December 2019 have rapidly spread to other countries and it was declared on January 30, 2020 as a public health emergency of international concern (PHEIC) by the World Health Organization. Before the first COVID-19 cases were reported in Brazil, several measures have been implemented including the adjustment of legal framework to carry out isolation and quarantine. As the cases increased significantly, new measures, mainly to reduce mortality and severe cases, have also been implemented. Rapid and robust preparedness actions have been undertaken in Brazil while first cases have not yet been identified in Latin-American. The outcome of this early preparation should be analyzed in future studies.
Julio Croda; Wanderson Kleber de Oliveira; Rodrigo Lins Frutuoso; Luiz Henrique Mandetta; Djane Clarys Baia-Da-Silva; José Diego Brito-Sousa; Wuelton Marcelo Monteiro; Marcus Vinícius Guimarães Lacerda. COVID-19 in Brazil: advantages of a socialized unified health system and preparation to contain cases. Revista da Sociedade Brasileira de Medicina Tropical 2020, 53, e20200167 .
AMA StyleJulio Croda, Wanderson Kleber de Oliveira, Rodrigo Lins Frutuoso, Luiz Henrique Mandetta, Djane Clarys Baia-Da-Silva, José Diego Brito-Sousa, Wuelton Marcelo Monteiro, Marcus Vinícius Guimarães Lacerda. COVID-19 in Brazil: advantages of a socialized unified health system and preparation to contain cases. Revista da Sociedade Brasileira de Medicina Tropical. 2020; 53 ():e20200167.
Chicago/Turabian StyleJulio Croda; Wanderson Kleber de Oliveira; Rodrigo Lins Frutuoso; Luiz Henrique Mandetta; Djane Clarys Baia-Da-Silva; José Diego Brito-Sousa; Wuelton Marcelo Monteiro; Marcus Vinícius Guimarães Lacerda. 2020. "COVID-19 in Brazil: advantages of a socialized unified health system and preparation to contain cases." Revista da Sociedade Brasileira de Medicina Tropical 53, no. : e20200167.
Background Acute kidney injury (AKI) is a common complication of Plasmodium falciparum malaria and can also occur secondary to P. malariae infections. Its association with P. vivax malaria is not well estimated neither understood.Methods Retrospective assessment of medical records was conducted among P. vivax malaria hospitalized patients in a reference hospital of Manaus, Brazilian Amazon, from 2009 to 2017. AKI was classified according to Acute Kidney Injury Network (AKIN) criteria and through the World Health Organization (WHO) criteria for severe malaria. Patients diagnosed with primaquine-induced hemolysis due to confirmed glucose 6-phosphate dehydrogenase deficiency (G6PDd) and chronic renal failure were excluded. Prevalence of AKI and factors associated to this complication were assessed.Results Out of 28,095 P. vivax malaria diagnoses during the study period in the reference center, 638 cases (2.3%) required hospitalization; with 433 (67.8%) of those patients having at least one creatinine measure. Twenty-two patients (5.1%) were diagnosed with AKI as per WHO criteria; 241 patients presented more than two creatinine measures, of which 117 (49.2%) patients had AKI per AKIN criteria. These were stratified in stage I (n=88; 75.2%), stage II (n=6; 5.1%), and stage III (n=23; 19.6%). Major risk factor for AKI was older age. Renal replacement therapy (dialysis) was necessary in 6 cases (1.4%).Conclusions AKI secondary to vivax malaria was not unfrequent amongst hospitalized patients and may be a potentially severe complication. WHO diagnostic criteria for malaria AKI was shown to underestimate the real burden of AKI. Renal impairment should be closely monitored especially in older patients.
Thalie Santos; Jose Diego Brito-Sousa; Fernando Val; Jacqueline Sachett; Miguel Md Mo; Nadia Cubas-Vega; Paola López-Tejo; Izabella Safe; Rebeca Bessa; Maria Graças Alecrim; Karla Israel; Flor Martinez-Espinosa; Camila Bôtto-Menezes; Gisely Melo; Quique Bassat; Marcus Lacerda; Wuelton Monteiro. Acute kidney injury in Plasmodium vivax malaria hospitalized patients in Manaus, Brazilian Amazon: are we underestimating the real burden? 2019, 1 .
AMA StyleThalie Santos, Jose Diego Brito-Sousa, Fernando Val, Jacqueline Sachett, Miguel Md Mo, Nadia Cubas-Vega, Paola López-Tejo, Izabella Safe, Rebeca Bessa, Maria Graças Alecrim, Karla Israel, Flor Martinez-Espinosa, Camila Bôtto-Menezes, Gisely Melo, Quique Bassat, Marcus Lacerda, Wuelton Monteiro. Acute kidney injury in Plasmodium vivax malaria hospitalized patients in Manaus, Brazilian Amazon: are we underestimating the real burden? . 2019; ():1.
Chicago/Turabian StyleThalie Santos; Jose Diego Brito-Sousa; Fernando Val; Jacqueline Sachett; Miguel Md Mo; Nadia Cubas-Vega; Paola López-Tejo; Izabella Safe; Rebeca Bessa; Maria Graças Alecrim; Karla Israel; Flor Martinez-Espinosa; Camila Bôtto-Menezes; Gisely Melo; Quique Bassat; Marcus Lacerda; Wuelton Monteiro. 2019. "Acute kidney injury in Plasmodium vivax malaria hospitalized patients in Manaus, Brazilian Amazon: are we underestimating the real burden?" , no. : 1.
Despite glucose-6-phosphate dehydrogenase (G6PD) deficiency prevalence of 5% in the Amazon, primaquine is administered without G6PD screening. This is an important cause of hospitalization among Plasmodium vivax–infected individuals, leading to life-threatening anemia and acute renal failure across endemic areas. In Manaus, the frequency of primaquine-induced hemolysis was 85.2 cases per 100 000 primaquine users.
Jose Diego Brito-Sousa; Thalie C Santos; Sara Avalos; Gustavo Fontecha; Gisely C Melo; Fernando Val; André M Siqueira; Graça C Alecrim; Quique Bassat; Marcus V G Lacerda; Wuelton M Monteiro. Clinical Spectrum of Primaquine-induced Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficiency: A 9-Year Hospitalization-based Study From the Brazilian Amazon. Clinical Infectious Diseases 2019, 69, 1440 -1442.
AMA StyleJose Diego Brito-Sousa, Thalie C Santos, Sara Avalos, Gustavo Fontecha, Gisely C Melo, Fernando Val, André M Siqueira, Graça C Alecrim, Quique Bassat, Marcus V G Lacerda, Wuelton M Monteiro. Clinical Spectrum of Primaquine-induced Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficiency: A 9-Year Hospitalization-based Study From the Brazilian Amazon. Clinical Infectious Diseases. 2019; 69 (8):1440-1442.
Chicago/Turabian StyleJose Diego Brito-Sousa; Thalie C Santos; Sara Avalos; Gustavo Fontecha; Gisely C Melo; Fernando Val; André M Siqueira; Graça C Alecrim; Quique Bassat; Marcus V G Lacerda; Wuelton M Monteiro. 2019. "Clinical Spectrum of Primaquine-induced Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficiency: A 9-Year Hospitalization-based Study From the Brazilian Amazon." Clinical Infectious Diseases 69, no. 8: 1440-1442.
Introduction: The common lancehead snakes (Bothrops atrox) are responsible for up to 90% of snakebites in the Amazon, especially in remote areas. The prevalence of microhematuria is similar to that of coagulopathy in B. atrox envenomation in the Amazon. Thus, this study aimed to assess the reliability of microhematuria as an inexpensive and simple alternative to detect snake-induced consumption coagulopathy. Methods: We analyzed samples from patients with confirmed B. atrox envenomation in terms of plasma fibrinogen and microhematuria (>3 red blood cells per high power field) in order to access the reliability of microhematuria to detect snakebite-induced coagulopathy, within 12 hours from admission. Results: A total of 186 patients were recruited. From the total, 85.5% of patients had hypofibrinogenemia and only about 50% (n = 94) had a microscopic examination of urine within 12 hours where microhematuria was present in 39 (41.5%). Diagnostic performance showed 38.6% sensitivity and 36.4% specificity (cutpoint 200 mg/dL). No clear association was seen between microhematuria and hypofibrinogenemia (r: -0.10; p: .34). Conclusion: In this study, microhematuria presented poor diagnostic performance to detect coagulopathy. Further studies are necessary to screen inexpensive and simple alternative diagnostic tools.
Jose Diego De Brito Sousa; Sâmella Silva De Oliveira; Jacqueline Sachett; Hui Wen Fan; Wuelton Marcelo Monteiro. Low accuracy of microscopic hematuria in detecting coagulopathy from Bothrops pit viper bites, Brazilian Amazon. Clinical Toxicology 2019, 57, 816 -818.
AMA StyleJose Diego De Brito Sousa, Sâmella Silva De Oliveira, Jacqueline Sachett, Hui Wen Fan, Wuelton Marcelo Monteiro. Low accuracy of microscopic hematuria in detecting coagulopathy from Bothrops pit viper bites, Brazilian Amazon. Clinical Toxicology. 2019; 57 (9):816-818.
Chicago/Turabian StyleJose Diego De Brito Sousa; Sâmella Silva De Oliveira; Jacqueline Sachett; Hui Wen Fan; Wuelton Marcelo Monteiro. 2019. "Low accuracy of microscopic hematuria in detecting coagulopathy from Bothrops pit viper bites, Brazilian Amazon." Clinical Toxicology 57, no. 9: 816-818.
Bothrops snakebites usually present systemic bleeding, and the clinical–epidemiological and laboratorial factors associated with the development of this manifestation are not well established. In this study, we assessed the prevalence of Bothrops snakebites with systemic bleeding reported at the Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, in Manaus, Amazonas State, Brazil, and the clinical–epidemiological and laboratorial factors associated with systemic bleeding. This is an observational, cross-sectional study carried out between August, 2013 and July, 2016. Patients who developed systemic bleeding on admission or during hospitalization were considered cases, and those with non-systemic bleeding were included in the control group. Systemic bleeding was observed in 63 (15.3%) of the 442 Bothrops snakebites evaluated. Bothrops snakebites mostly occurred in males (78.2%), in rural areas (89.0%) and in the age group of 11 to 30 years old (40.4%). It took most of the patients (59.8%) less than 3 h to receive medical assistance. Unclottable blood (AOR = 3.11 (95% CI = 1.53 to 6.31; p = 0.002)) and thrombocytopenia (AOR = 4.52 (95% CI = 2.03 to 10.09; p < 0.001)) on admission were independently associated with systemic bleeding during hospitalization. These hemostatic disorders on admission increase the chances of systemic bleeding during hospitalization. Prospective studies are needed to clarify the pathophysiology of systemic bleeding in Bothrops snakebites in the Amazon region.
Sâmella S. Oliveira; Eliane C. Alves; Alessandra S. Santos; João Pedro T. Pereira; Lybia Kássia S. Sarraff; Elizandra F. Nascimento; José Diego De-Brito-Sousa; Vanderson S. Sampaio; Marcus V.G. Lacerda; Jacqueline A.G. Sachett; Ida S. Sano-Martins; Wuelton M. Monteiro. Factors Associated with Systemic Bleeding in Bothrops Envenomation in a Tertiary Hospital in the Brazilian Amazon. Toxins 2019, 11, 22 .
AMA StyleSâmella S. Oliveira, Eliane C. Alves, Alessandra S. Santos, João Pedro T. Pereira, Lybia Kássia S. Sarraff, Elizandra F. Nascimento, José Diego De-Brito-Sousa, Vanderson S. Sampaio, Marcus V.G. Lacerda, Jacqueline A.G. Sachett, Ida S. Sano-Martins, Wuelton M. Monteiro. Factors Associated with Systemic Bleeding in Bothrops Envenomation in a Tertiary Hospital in the Brazilian Amazon. Toxins. 2019; 11 (1):22.
Chicago/Turabian StyleSâmella S. Oliveira; Eliane C. Alves; Alessandra S. Santos; João Pedro T. Pereira; Lybia Kássia S. Sarraff; Elizandra F. Nascimento; José Diego De-Brito-Sousa; Vanderson S. Sampaio; Marcus V.G. Lacerda; Jacqueline A.G. Sachett; Ida S. Sano-Martins; Wuelton M. Monteiro. 2019. "Factors Associated with Systemic Bleeding in Bothrops Envenomation in a Tertiary Hospital in the Brazilian Amazon." Toxins 11, no. 1: 22.
Keywords: Rapid diagnostic test; Plasmodium vivax; Plasmodium falciparum; Sensitivity; Specificity
Monica Regina Farias Costa; Ana Luísa Rubert Barcelos; Maria Angélica De Camargo; Gisely Cardoso De Melo; Anne Cristine Almeida; Allyson Costa; Jose Diego De Brito Sousa; Marly Marques De Melo; Maria Das Graças Costa Alecrim; Marcus Vinicius Guimarães De Lacerda; Wuelton Marcelo Monteiro. Performance of an immuno-rapid malaria Pf/Pv rapid diagnostic test for malaria diagnosis in the Western Brazilian Amazon. Revista da Sociedade Brasileira de Medicina Tropical 2019, 52, e20170450 .
AMA StyleMonica Regina Farias Costa, Ana Luísa Rubert Barcelos, Maria Angélica De Camargo, Gisely Cardoso De Melo, Anne Cristine Almeida, Allyson Costa, Jose Diego De Brito Sousa, Marly Marques De Melo, Maria Das Graças Costa Alecrim, Marcus Vinicius Guimarães De Lacerda, Wuelton Marcelo Monteiro. Performance of an immuno-rapid malaria Pf/Pv rapid diagnostic test for malaria diagnosis in the Western Brazilian Amazon. Revista da Sociedade Brasileira de Medicina Tropical. 2019; 52 ():e20170450.
Chicago/Turabian StyleMonica Regina Farias Costa; Ana Luísa Rubert Barcelos; Maria Angélica De Camargo; Gisely Cardoso De Melo; Anne Cristine Almeida; Allyson Costa; Jose Diego De Brito Sousa; Marly Marques De Melo; Maria Das Graças Costa Alecrim; Marcus Vinicius Guimarães De Lacerda; Wuelton Marcelo Monteiro. 2019. "Performance of an immuno-rapid malaria Pf/Pv rapid diagnostic test for malaria diagnosis in the Western Brazilian Amazon." Revista da Sociedade Brasileira de Medicina Tropical 52, no. : e20170450.
In Brazil, malaria is an important public health problem first reported in 1560. Historically, fluctuations in malaria cases in Brazil are attributed to waves of economic development; construction of railroads, highways, and hydroelectric dams; and population displacement and land occupation policies. Vector control measures have been widely used with an important role in reducing malaria cases. In this review article, we reviewed the vector control measures established in the Brazilian territory and aspects associated with such measures for malaria. Although some vector control measures are routinely used in Brazil, many entomological and effectiveness information still need better evidence in endemic areas where Plasmodium vivax predominates. Herein, we outlined some of the needs and priorities for future research: a) update of the cartography of malaria vectors in Brazil, adding molecular techniques for the correct identification of species and complexes of species; b) evaluation of vector competence of anophelines in Brazil; c) strengthening of local entomology teams to perform vector control measures and interpret results; d) evaluation of vector control measures, especially use of insecticide-treated nets and long-lasting insecticidal nets, estimating their effectiveness, cost-benefit, and population acceptance; e) establishment of colonies of malaria vectors in Brazil, i.e., Anopheles darlingi, to understand parasite-vector interactions better; f) study of new vector control strategies with impacts on non-endophilic vectors; g) estimation of the impact of insecticide resistance in different geographical areas; and h) identification of the relative contribution of natural and artificial breeding sites in different epidemiological contexts for transmission.
Djane Clarys Baia-Da-Silva; José Diego Brito-Sousa; Sheila Rodrigues Rodovalho; Cassio Peterka; Gilberto Moresco; Oscar Martín Mesones Lapouble; Gisely Cardoso De Melo; Vanderson De Souza Sampaio; Maria Das Graças Costa Alecrim; Paulo Pimenta; José Bento Pereira Lima; Marcus Vinícius Guimarães De Lacerda; Wuelton Marcelo Monteiro. Current vector control challenges in the fight against malaria in Brazil. Revista da Sociedade Brasileira de Medicina Tropical 2019, 52, e20180542 .
AMA StyleDjane Clarys Baia-Da-Silva, José Diego Brito-Sousa, Sheila Rodrigues Rodovalho, Cassio Peterka, Gilberto Moresco, Oscar Martín Mesones Lapouble, Gisely Cardoso De Melo, Vanderson De Souza Sampaio, Maria Das Graças Costa Alecrim, Paulo Pimenta, José Bento Pereira Lima, Marcus Vinícius Guimarães De Lacerda, Wuelton Marcelo Monteiro. Current vector control challenges in the fight against malaria in Brazil. Revista da Sociedade Brasileira de Medicina Tropical. 2019; 52 ():e20180542.
Chicago/Turabian StyleDjane Clarys Baia-Da-Silva; José Diego Brito-Sousa; Sheila Rodrigues Rodovalho; Cassio Peterka; Gilberto Moresco; Oscar Martín Mesones Lapouble; Gisely Cardoso De Melo; Vanderson De Souza Sampaio; Maria Das Graças Costa Alecrim; Paulo Pimenta; José Bento Pereira Lima; Marcus Vinícius Guimarães De Lacerda; Wuelton Marcelo Monteiro. 2019. "Current vector control challenges in the fight against malaria in Brazil." Revista da Sociedade Brasileira de Medicina Tropical 52, no. : e20180542.
Crotalus bites are considered a public health problem especially in Latin America. This study was performed to describe the epidemiology, spatial distribution and environmental determinants of Crotalus durissus bites in the Brazilian Amazon. Crotalus durissus envenomings official database included cases reported from 2010 to 2015. A total of 70,816 snakebites were recorded in the Amazon Region, 3,058 (4.3%) cases being classified as crotalid, with a mean incidence rate of 11.1/100,000 inhabitants/year. The highest mean incidence rates were reported in Roraima, Tocantins and Maranhão. Area covered by water bodies, precipitation and soil humidity were negatively associated to rattlesnake encountering. Rattlesnake bites incidence was positively associated to tree canopy loss and altitude. In the Amazon, severe manifestations at admission, delayed medical assistance, lack of antivenom administration and ages ≥61 and 0-15 years were predictors of death in C. durissus snakebites. Spatial distribution of rattlesnake bites across the Brazilian Amazon showed higher incidence in areas of transition from the equatorial forest to the savanna, and in the savanna itself. Such results may aid focused policy-making in order to mitigate the burden, clinical complications and death as well as to manage Crotalus rattlesnake populations in the Brazilian Amazon.
Hildegard Loren Rebouças Santos; José Diego De Brito Sousa; João Arthur Alcântara; Jacqueline De Almeida Gonçalves Sachett; Thiago Soares Villas Boas; Ivan Saraiva; Paulo Sergio Bernarde; Samara Freire Valente Magalhães; Gisely Cardoso de Melo; Henry Maia Peixoto; Maria Regina Oliveira; Vanderson Sampaio; Wuelton Marcelo Monteiro. Rattlesnakes bites in the Brazilian Amazon: Clinical epidemiology, spatial distribution and ecological determinants. Acta Tropica 2018, 191, 69 -76.
AMA StyleHildegard Loren Rebouças Santos, José Diego De Brito Sousa, João Arthur Alcântara, Jacqueline De Almeida Gonçalves Sachett, Thiago Soares Villas Boas, Ivan Saraiva, Paulo Sergio Bernarde, Samara Freire Valente Magalhães, Gisely Cardoso de Melo, Henry Maia Peixoto, Maria Regina Oliveira, Vanderson Sampaio, Wuelton Marcelo Monteiro. Rattlesnakes bites in the Brazilian Amazon: Clinical epidemiology, spatial distribution and ecological determinants. Acta Tropica. 2018; 191 ():69-76.
Chicago/Turabian StyleHildegard Loren Rebouças Santos; José Diego De Brito Sousa; João Arthur Alcântara; Jacqueline De Almeida Gonçalves Sachett; Thiago Soares Villas Boas; Ivan Saraiva; Paulo Sergio Bernarde; Samara Freire Valente Magalhães; Gisely Cardoso de Melo; Henry Maia Peixoto; Maria Regina Oliveira; Vanderson Sampaio; Wuelton Marcelo Monteiro. 2018. "Rattlesnakes bites in the Brazilian Amazon: Clinical epidemiology, spatial distribution and ecological determinants." Acta Tropica 191, no. : 69-76.
Objective To analyze the temporal and spatial distribution as well as the environmental and socioeconomic factors associated with cutaneous leishmaniasis incidence in the state of Amazonas, Brazil from 2007 to 2015. Methods Spatial and temporal distribution was evaluated from sequential thematic maps of the mean incidence rates of the disease. A negative binomial regression analysis was performed to evaluate the association of the factors studied with the mean incidence rate of ACL. Results The average proportion of deforestation was negatively associated with the average incidence rate of cutaneous leishmaniasis in municipalities (β=‐2.178; p=0.019; 95%CI ‐3.996, ‐0.361), and the health system performance index (effectiveness) (β=‐0.852; p=0.008; 95%CI ‐1.481, ‐0.225). Conversely, the municipal human development index (MHDI) was a factor positively related to the average incidence among the municipalities (β=7.728; p=0.003; 95%CI 2.716, 12.738). Conclusion Our study shows the important impact of socioeconomic and environmental factors on ACL incidence in the Amazonas State. This article is protected by copyright. All rights reserved.
Maria Gabriela De Almeida Rodrigues; Jose Diego Brito-Sousa; Ádila Liliane Barros Dias; Wuelton Marcelo Monteiro; Vanderson De Souza Sampaio. The role of deforestation on American cutaneous leishmaniasis incidence: spatial‐temporal distribution, environmental and socioeconomic factors associated in the Brazilian Amazon. Tropical Medicine & International Health 2018, 24, 348 -355.
AMA StyleMaria Gabriela De Almeida Rodrigues, Jose Diego Brito-Sousa, Ádila Liliane Barros Dias, Wuelton Marcelo Monteiro, Vanderson De Souza Sampaio. The role of deforestation on American cutaneous leishmaniasis incidence: spatial‐temporal distribution, environmental and socioeconomic factors associated in the Brazilian Amazon. Tropical Medicine & International Health. 2018; 24 (3):348-355.
Chicago/Turabian StyleMaria Gabriela De Almeida Rodrigues; Jose Diego Brito-Sousa; Ádila Liliane Barros Dias; Wuelton Marcelo Monteiro; Vanderson De Souza Sampaio. 2018. "The role of deforestation on American cutaneous leishmaniasis incidence: spatial‐temporal distribution, environmental and socioeconomic factors associated in the Brazilian Amazon." Tropical Medicine & International Health 24, no. 3: 348-355.
Acute Kidney Injury (AKI) is the main systemic complication and cause of death in viperid envenomation. Although there are hypotheses for the development of AKI, the mechanisms involved are still not established. The aim of this study was to evaluate the clinical-laboratorial-epidemiological factors associated with AKI in victims of Bothrops sp envenomation. This is an observational study carried out at the Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. AKI was defined according to the guidelines of the Acute Kidney Injury Network (AKIN). Among the 186 patients evaluated, AKI was observed in 24 (12.9%) after 48 hours of admission. Stage I was present in 17 (70.8%) patients, II in 3 (12.5%) and III in 4 (16.7%). Epidemiological characterization showed predominance of men, occurrence in rural areas, aged between 16–60 years, feet as the most affected anatomical region, and time to medical assistance less than 3 hours. Hypertension and diabetes were the comorbidities identified. Most of the accidents were classified as moderate, and clinical manifestations included severe pain, mild edema, local bleeding and headache. Laboratory results showed blood uncoagulability, hypofibrinogenemia, leukocytosis, increase of creatine kinase, and high lactate dehydrogenase levels. Multivariate analysis showed an association with high LDH levels [AOR = 1.01 (95% CI = 1.01–1.01, p<0.002)], local bleeding [AOR = 0.13 (95%CI = 0.027–0.59, p<0.009)], and the presence of comorbidities [AOR = 60.96 (95%CI = 9.69–383.30; p<0.000)]. Herein, laboratory markers such as high LDH levels along with local bleeding and comorbidities may aid in the diagnosis of AKI.
Eliane Campos Alves; Jacqueline De Almeida Gonçalves Sachett; Vanderson Sampaio; Jose Diego Brito-Sousa; Sâmella Silva De Oliveira; Elizandra Freitas Do Nascimento; Alessandra Dos Santos Santos; Iran Mendonça Da Silva; Ana Maria Moura-Da-Silva; Fan Hui Wen; Mônica Colombini; Marcus Vinicius Guimarães De Lacerda; Wuelton Marcelo Monteiro; Luiz Carlos De Lima Ferreira. Predicting acute renal failure in Bothrops snakebite patients in a tertiary reference center, Western Brazilian Amazon. PLoS ONE 2018, 13, e0202361 .
AMA StyleEliane Campos Alves, Jacqueline De Almeida Gonçalves Sachett, Vanderson Sampaio, Jose Diego Brito-Sousa, Sâmella Silva De Oliveira, Elizandra Freitas Do Nascimento, Alessandra Dos Santos Santos, Iran Mendonça Da Silva, Ana Maria Moura-Da-Silva, Fan Hui Wen, Mônica Colombini, Marcus Vinicius Guimarães De Lacerda, Wuelton Marcelo Monteiro, Luiz Carlos De Lima Ferreira. Predicting acute renal failure in Bothrops snakebite patients in a tertiary reference center, Western Brazilian Amazon. PLoS ONE. 2018; 13 (8):e0202361.
Chicago/Turabian StyleEliane Campos Alves; Jacqueline De Almeida Gonçalves Sachett; Vanderson Sampaio; Jose Diego Brito-Sousa; Sâmella Silva De Oliveira; Elizandra Freitas Do Nascimento; Alessandra Dos Santos Santos; Iran Mendonça Da Silva; Ana Maria Moura-Da-Silva; Fan Hui Wen; Mônica Colombini; Marcus Vinicius Guimarães De Lacerda; Wuelton Marcelo Monteiro; Luiz Carlos De Lima Ferreira. 2018. "Predicting acute renal failure in Bothrops snakebite patients in a tertiary reference center, Western Brazilian Amazon." PLoS ONE 13, no. 8: e0202361.
Snake envenomation is a major public health problem in Brazil. Systemic complications that may arise from snakebites are mainly related to coagulopathy. The Lee–White clotting time (LWCT) is a simple and inexpensive test and available even in remote health facilities. However, the diagnostic value of such test needs to be evaluated to accurately diagnose coagulopathy in the clinical practice. This study aimed to assess the reliability of the LWCT performed in hospital routine to diagnose venom-induced coagulopathy. We studied 186 patients admitted at the Tropical Medicine Foundation Dr. Heitor Vieira Dourado in Manaus, Amazonas, Brazil, with Bothrops envenomation diagnosis. At admission, blood samples were collected for performing LWCT and the concentration of fibrinogen. Sensitivity, specificity, positive predictive value, negative predictive value, likelihood ratios, diagnostic odds ratio, and accuracy were calculated with 95% confidence intervals. From the total, 85.5% had hypofibrinogenemia. The sensitivity of the LWCT to the diagnosis of hypofibrinogenemia was 78.0% and the specificity 40.7%. The accuracy of the test was 72.6%, and patients with a prolonged LWCT had 2.4 higher odds of developing hypofibrinogenemia. In addition, the LWCT was also compared with venom antigen levels and systemic hemorrhage. The LWCT showed moderate sensitivity to detect consumption coagulopathy and constitutes a valuable tool for the diagnosis of Bothrops snake envenomation and indication of antivenom therapy.
Jose Diego De Brito Sousa; Jacqueline Almeida Gonçalves Sachett; Sâmella Silva De Oliveira; Iran Mendonça-Da-Silva; Hedylamar Oliveira Marques; Marcus Vinicius Guimarães De Lacerda; Hui Wen Fan; Wuelton Marcelo Monteiro. Accuracy of the Lee–White Clotting Time Performed in the Hospital Routine to Detect Coagulopathy in Bothrops atrox Envenomation. The American Journal of Tropical Medicine and Hygiene 2018, 98, 1547 -1551.
AMA StyleJose Diego De Brito Sousa, Jacqueline Almeida Gonçalves Sachett, Sâmella Silva De Oliveira, Iran Mendonça-Da-Silva, Hedylamar Oliveira Marques, Marcus Vinicius Guimarães De Lacerda, Hui Wen Fan, Wuelton Marcelo Monteiro. Accuracy of the Lee–White Clotting Time Performed in the Hospital Routine to Detect Coagulopathy in Bothrops atrox Envenomation. The American Journal of Tropical Medicine and Hygiene. 2018; 98 (5):1547-1551.
Chicago/Turabian StyleJose Diego De Brito Sousa; Jacqueline Almeida Gonçalves Sachett; Sâmella Silva De Oliveira; Iran Mendonça-Da-Silva; Hedylamar Oliveira Marques; Marcus Vinicius Guimarães De Lacerda; Hui Wen Fan; Wuelton Marcelo Monteiro. 2018. "Accuracy of the Lee–White Clotting Time Performed in the Hospital Routine to Detect Coagulopathy in Bothrops atrox Envenomation." The American Journal of Tropical Medicine and Hygiene 98, no. 5: 1547-1551.