Backgrounds. The production of free radicals has a role in the regulation of biological function, cellular damage, and the pathogenesis of central nervous system conditions. Epilepsy is a highly prevalent serious brain disorder, and oxidative stress is regarded as a possible mechanism involved in epileptogenesis. Experimental studies suggest that oxidative stress is a contributing factor to the onset and evolution of epilepsy.Objective. A review was conducted to investigate the link between oxidative stress and seizures, and oxidative stress and age as risk factors for epilepsy. The role of oxidative stress in seizure induction and propagation is also discussed.Results/Conclusions. Oxidative stress and mitochondrial dysfunction are involved in neuronal death and seizures. There is evidence that suggests that antioxidant therapy may reduce lesions induced by oxidative free radicals in some animal seizure models. Studies have demonstrated that mitochondrial dysfunction is associated with chronic oxidative stress and may have an essential role in the epileptogenesis process; however, few studies have shown an established link between oxidative stress, seizures, and age.

Objectives: to describe the process of construction and validation of an educational booklet on care for children with gastrostomy, directed to caregivers. Methods: a methodological study developed in five stages: bibliographic survey; situational diagnosis; illustration, layout, design and text construction; expert validation and Flesch-Kincaid Readability calculation; validation with the target audience. Content Validity Index and Suitability Assessment of Materials were applied for expert analysis. Results: the Content Validity Index obtained overall score of 0.93. In the Suitability Assessment of Materials score, the booklet scored 85.2%. It presented a satisfactory readability percentage, with an overall score of 72%, and was consistent with caregivers’ assessment in the validation with the target audience, considering the explanatory technology, important and adequate. Conclusions: the developed educational booklet was considered valid for use by caregivers, thus contributing to the maintenance of best practices in care for children with gastrostomy.

Objective: to describe the process of validating a multimedia application on a mobile platform to promote foot care for people with diabetes. Method: a technological production and methodological type study. Content and appearance were validated by 39 judges (29 nursing judges and ten information and communication technology judges and 15 people from the target audience). Results: nursing judges made it possible to validate the material with a total Content Validity Index of 0.95, a non-significant binomial test for most items and Cronbach’s alpha of 0.92, information and communication technology judges with Suitability Assessment of Materials of 99.2% and the target audience with an agreement index of 98%. Conclusion: the application proved to be valid and reliable for use in clinical practice as an educational technology to promote foot care for people with diabetes.

O presente estudo foi realizado na Área de Proteção Ambiental da Serra da Ibiapaba no município de Cocal, Piauí. Objetivou-se realizar o levantamento das plantas utilizadas pela comunidade, das partes usadas, das indicações, das formas de uso e de administração dessas plantas. Foram realizadas 80 entrevistas com 100% dos moradores de notório saber, residentes no município que utilizavam e/ou comercializavam plantas de uso medicinal. Para definição da amostra utilizou-se o método de bola de neve. Em incursões guiadas por membros da comunidade, foram coletadas as etnoespécies citadas. Após essa etapa, as espécies foram identificadas em laboratório e calculado o Fator de Consenso dos Informantes (FCI) para cada categoria de doença. O material foi incorporado ao acervo do Herbário Graziela Barroso (TEPB/UFPI). Foram identificadas 76 espécies, distribuídas em 61 gêneros e 36 famílias. Sobresairam-se Leguminosae com 22 espécies (28,9%), seguida por Euphorbiaceae com 6 (7,8%), e Solanaceae 4 (5,2%). Os gêneros Croton L. e Hymenaea L. obtiveram o maior destaque, somando 8 (10,5%) do total de espécies. As espécies mais presentes nas indicações de uso foram Ximenia americana com 14 (5,9%), Tabebuia impetiginosa com 9 (3,9%) e Anacardium occidentale com 7 (2,9%). Observou-se que 80,5% dos entrevistados tinham mais de 50 anos e residiam no município a mais de 20 anos, sendo que 70% possuíam apenas ensino fundamental incompleto e 20 % eram analfabetos. Houve maior consenso entre os informantes para tratamento das doenças do sistema respiratório (0,66) e do aparelho digestório (0,65). A maioria das indicações de usos 81 (34,17%) relatados para 28 (36,8%) das espécies visavam curar males do sistema respiratório, tais como asma, bronquite, gripe, inflamação na garganta, pneumonia e sinusite. Para o preparo dos remédios, as partes mais utilizadas foram as cascas (30,5%), as folhas (29,4%) e as raízes (12,6%). As preparações mais comuns foram os chás, garrafadas e lambedores, administrados por via oral. Os resultados sinalizaram para a importância do potencial bioativo da vegetação do carrasco.

Objectives: to describe the process of construction and validation of an educational booklet to promote bonding between mothers and newborns in a Neonatal Intensive Care Unit. Methods: methodological study developed through data collection in the literature and with the target audience; construction of the booklet; qualification of the material through validation by judges (health and communication experts/designer) and assessment by the target audience (mothers of at-risk newborns). Data were analyzed descriptively. Results: booklet content was validated, obtaining an overall Content Validity Index of 0.92. Appearance was rated “Superior” with 80% percentage. Mothers performed an assessment with 100% agreement between the items. Conclusions: the booklet was validated in all domains assessed and can be used by mothers with children hospitalized in the Neonatal Unit.