Background/Objectives: The aim of this study was to investigate the effect of different auditory conditions on pattern-reversal visual evoked potential (PVEP) responses among healthy adults. Methods: This repeated-measure design with a fixed baseline and randomized order of the two auditory conditions was conducted at the Retina Clinic, Ophthalmology Department, Tertiary Hospital in Riyadh, Saudi Arabia. Healthy adults with no systemic or ocular diseases aged 20–60 years were included. All participants underwent comprehensive visual and ocular assessment, including best-corrected visual acuity (BCVA), slit-lamp examination, optical coherence tomography (OCT), screening audiometry, and a PVEP test conducted under three auditory conditions: silence, Quran recitation, and music exposure. P100 latency and amplitude were recorded using 1° and 0.25° stimulation sizes. Statistical analysis was performed using non-parametric statistics. A p-value of less than 0.05 was considered statistically significant. Results: Significant differences in PVEP amplitude responses were observed across auditory conditions, particularly at the 1° stimulation size. The Friedman test demonstrated significant amplitude differences at the 1° stimulation size (χ² = 16.379, p < 0.001), with silence producing adjusted significantly higher amplitudes compared with Quran recitation and music exposure (p = 0.001 and p = 0.003), respectively. Significant positive correlations were identified between BCVA and P100 amplitude at Quran exposure (r = 0.178, p < 0.05) only at the 0.25° stimulation size. Conclusions: The stimulus size can be sensitive in revealing auditory-related changes in different retinal areas of functional visual pathway alterations. In comparison to baseline (silence), which generally produces the highest amplitudes, both auditory conditions (Quran recitation and music) were associated with lower P100 amplitude, while no significant difference was observed between Quran recitation and music.

Background/Objectives: To investigate the effect of different sound types on pattern visual evoked potential (VEP) responses among healthy adults. Methods: This prospective cross-sectional trial was conducted at the Retina Clinic, Ophthalmology Department, tertiary Hospital in Riyadh, Saudi Arabia. Healthy adults with no systemic or ocular diseases aged 20-60 years were included. All participants underwent comprehensive visual and ocular assessment including best-corrected visual acuity (BCVA), slit-lamp examination, optical coherence tomography (OCT), screening audiometry, and pattern-reversal visual evoked potential (VEP) test conducted under three auditory conditions: silence, Quran recitation, and music exposure. P100 latency and amplitude were recorded using 1° and 0.25° stimulation sizes. Statistical analysis was performed using non-parametric statistical tests including the Friedman test and Bonferroni-corrected post-hoc comparisons. Results: Significant differences in VEP amplitude responses were observed across auditory conditions, particularly at the 1° stimulation size indicated 95% confidence intervals and exact P value for effects. The Friedman test demonstrated significant amplitude differences at the 1° stimulation size (χ²(2)=16.379, p<0.001), with silence producing significantly higher amplitudes compared with Quran recitation and music exposure (p=0.001). Significant positive correlations were identified between BCVA and P100 amplitude at music exposure (r=0.218, p<0.001) only at the 0.25° stimulation size. Conclusion: Different auditory stimulation significantly influenced VEP responses. Stimulation size could be sensitive in detecting the functional visual pathway in healthy adults, but it could be great sensitive for detecting abnormalities in ocular conditions. Further studies are required to assess the potential value of VEP as a non-invasive test for early neural dysfunction.