Long-term renal outcomes following snake envenomation may vary across regions, yet remain poorly characterized in South Korea. We investigated the long-term risk of chronic kidney disease (CKD) following snake envenomation and snakebite-related acute kidney injury (AKI). This nationwide population-based cohort study used data from the Korean National Health Information Database (2012–2023). We matched 729 adults hospitalized for snake envenomation who received antivenom to 2916 individuals without snake envenomation (1:4). Using a 1-year landmark design, we assessed incident CKD with Cox proportional hazards models and Kaplan–Meier analysis. CKD occurred in 48 patients with snake envenomation and in 156 controls, with incidence rates of 7.16 and 5.59 per 1000 person-years, respectively. Snake envenomation was not significantly associated with incident CKD (adjusted hazard ratio [aHR], 1.15; 95% confidence interval [CI], 0.85–1.55). Among patients with snake envenomation, 73 patients (10.0%) had coded AKI during the index hospitalization. Snakebite-related AKI was associated with incident CKD (aHR, 4.25; 95% CI, 2.15–8.40), whereas the association with severe envenomation did not reach statistical significance. CKD developed in 17 of the 73 patients with AKI (23.3%). Thus, no statistically significant association was detected between snake envenomation and incident CKD overall, whereas coded AKI was associated with subsequent CKD among envenomated patients. New CKD events continued to occur throughout follow-up.

Background/Objectives: Out-of-hospital cardiac arrest (OHCA) is associated with high mortality, and outcomes may be influenced by underlying conditions such as cancer, hypertension (HTN), and diabetes mellitus (DM). This study aimed to evaluate whether HTN and DM modify the effects of post-resuscitation treatments—specifically targeted temperature management (TTM) and percutaneous coronary intervention (PCI)—on survival and neurological recovery in OHCA patients with a history of cancer. Methods: This retrospective cohort study analyzed data from the Korean national OHCA registry between January 2018 and December 2021. Adults aged ≥18 years with presumed cardiac-origin OHCA and a documented history of cancer—defined as any prior cancer diagnosis recorded in medical records regardless of remission status—were included. Multivariable logistic regression was used to examine associations between treatment and outcomes, and interaction effects were assessed using adjusted p-values to account for multiple testing. Results: Among the 124,916 EMS-assessed OHCA cases, 4115 patients met the inclusion criteria. TTM and PCI were both statistically associated with good neurological recovery (TTM: adjusted odds ratio [aOR], 1.69; 95% confidence interval [CI], 1.12–2.55; p < 0.05; PCI: aOR, 11.35; 95% CI, 7.98–16.14; p < 0.05). In interaction analyses, the benefit of TTM and PCI for achieving good neurological recovery was attenuated in patients with diabetes mellitus (DM; TTM: aOR, 0.59; 95% CI, 0.23–1.49; PCI: aOR, 4.94; 95% CI, 2.69–9.06) and hypertension (HTN; TTM: aOR, 0.94; 95% CI, 0.49–1.82; PCI: aOR, 7.47; 95% CI, 4.48–12.44), with adjusted p-values < 0.05 for all interactions. Conclusions: In OHCA patients with a history of cancer, TTM and PCI are associated with improved survival and neurological outcomes. However, the presence of comorbidities such as HTN and DM may attenuate these benefits. These findings support the need for individualized post-resuscitation care strategies that account for comorbid conditions.