Gallium (Ga)-based liquid metals (LMs), as an emerging functional material, stand out among many candidates due to their combination of fluidic and metallic attributes, and they have extensively attracted the attention of academic researchers. When fabricated into droplet form, these metals are imbued with many fantastic characteristics, such as a high specific surface area and self-healing properties. Additionally, Ga-based liquid metal droplets (LMDs) achieve higher response accuracy to external stimuli, satisfying the demands of many applications requiring micro-size and precise stimulus-responsivity. Herein, we focus on reviewing the properties of Ga-based LMs and their droplets, the fabrication strategies of metal droplets, their stimulus-response motion under different external fields, and their applications in microfluidic systems, biomedical applications, and micromachines. To further advance the development of responsive Ga-based LMDs, the future outlooks with key challenges related to their further applications are also presented here.