Postoperative recovery can be impaired by many conditions, some of which are difficult to diagnose clinically. These include type 2 neurological complications such as hypoactive subtype of postoperative delirium (PD) and early postoperative cognitive dysfunction (ePOCD). Hope for their timely detection may lie with novel biomarkers. Plasma concentrations of microRNA-1-3p, microRNA-21-5p, glial fibrillary acidic protein (GFAP), neuroserpin (NSP), phosphorylated axonal neurofilament subunit H (pNfH) and visinin-like protein 1 (VILIP-1) were investigated in 30 patients undergoing elective off-pump coronary artery bypass grafting. Blood samples were collected at the start and end of a surgery as well as 24 h postoperatively. Associations between the studied biomarkers’ perioperative expression and type 2 neurological complications were analyzed. PD was associated with postoperative expression of GFAP; ePOCD was associated with postoperative expression of microRNA-21-5p and GFAP as well as intraoperative expression of NSP. The predictive accuracy of these molecules was found acceptable, with all their areas under the curve (AUC) values above 0.7. Multivariable regression indicated that microRNA-21-5p, GFAP and NSP were the only significant predictors of ePOCD. Evaluation of a multi-marker model including these three molecules revealed its outstanding predictive accuracy for ePOCD (AUC = 0.95). The use of microRNA-21-5p, GFAP and NSP for monitoring postoperative recovery warrants further research considering their potential to predict PD and ePOCD.

Increasing understanding of human genome variability allows for better use of the predictive potential of DNA. An obvious direct application is the prediction of the physical phenotypes. Significant success has been achieved, especially in predicting pigmentation characteristics, but the inference of some phenotypes is still challenging. In search of further improvements in predicting human eye colour, we conducted whole-exome (enriched in regulome) sequencing of 150 Polish samples to discover new markers. For this, we adopted quantitative characterization of eye colour phenotypes using high-resolution photographic images of the iris in combination with DIAT software analysis. An independent set of 849 samples was used for subsequent predictive modelling. Newly identified candidates and 114 additional literature-based selected SNPs, previously associated with pigmentation, and advanced machine learning algorithms were used. Whole-exome sequencing analysis found 27 previously unreported candidate SNP markers for eye colour. The highest overall prediction accuracies were achieved with LASSO-regularized and BIC-based selected regression models. A new candidate variant, rs2253104, located in theARFIP2gene and identified with the HyperLasso method, revealed predictive potential and was included in the best-performing regression models. Advanced machine learning approaches showed a significant increase in sensitivity of intermediate eye colour prediction (up to 39%) compared to 0% obtained for the original IrisPlex model. We identified a new potential predictor of eye colour and evaluated several widely used advanced machine learning algorithms in predictive analysis of this trait. Our results provide useful hints for developing future predictive models for eye colour in forensic and anthropological studies.

The paper presents the possibility of using data mining tools — artificial neural networks — in prediction of hydrometer reading after 24 h in order to limit the duration of the test to 4 h. The authors analysed a database of 693 granulometric composition analysis results of genetically different soils with the use of radial basis function network (RBF) and multilayer perceptron (MLP). The calculations performed showed that it is possible to use MLP to shorten the test time without affecting the quality of the results. The presented accuracy of the model, in the range of 0.55–0.72, allows one to determine the content of silt and clay fractions with an accuracy of 0.49% for equivalent diameter (dT) and 1.50% for percentage of all particles with a diameter smaller than dT (ZT). The results were better than that achieved using linear re-gression models with all predictors (REG), stepwise regression models (SREG), and classification and regression trees (CRT). Taking into account the uncertainty of hydrometric determinations, the obtained forecast values is lower than this uncertainty, therefore neural networks can be used to predict the results of this type of research.

Statistical analysis methods have been widely used in all industries. In well logs analyses, they have been used from the very beginning to predict petrophysical parameters such as permeability and porosity or to generate synthetic curves such as density or sonic logs. Initially, logs were generated as simple functions of other measurements. Then, as a result of the popularisation of algorithms such as the k-nearest neighbours (k-NN) or artificial neural networks (ANN), logs were created based on other logs. In this study, various industry and general scientific programmes were used for statistical data analysis, treating the well logs data as individual data sets, obtaining very convergent results. The methods developed for processing well logs data, such as Multi-Resolution Graph-Based Clustering (MRGBC), as well as algorithms commonly used in statistical analysis such as Kohonen self-organising maps (SOM), k-NN, and ANN were applied. The use of the aforementioned statis-tical methods allows for the electrofacies determination and prediction of an Rt log based on the other recorded well logs. Correct determination of Rt in resistivity measurements made with the Dual Laterolog tool in the conditions of the Groningen effect is often problematic. The applied calculation methods allow for the correct estimation of Rt in the tested well.