International migration presents significant challenges for social protection systems, particularly in contexts characterized by vulnerability and limited resources. In this setting, interventions aimed at promoting safe migration and preventing exploitation have gained increasing relevance. The aim of this study was to examine satisfaction, experiences, and perceived outcomes from the perspective of participants in a safe migration and human trafficking prevention program implemented in Chile between 2024 and 2025, while identifying barriers and facilitators associated with program implementation. A mixed-methods study with a convergent parallel design was conducted. The quantitative component included a survey administered to program beneficiaries (N = 131). The qualitative component comprised focus groups with beneficiaries (N = 47) and professionals (N = 29), as well as in-depth interviews with five key informants representing public institutions, academia, scientific societies, and civil society organizations. In addition, a review of program documents and monitoring records was undertaken. Qualitative data were analyzed using reflexive thematic analysis and subsequently interpreted through a multilevel analytical framework. Results showed high levels of satisfaction with the program (M = 4.50/5 (SD = 0.74). Participants highlighted migration guidance, training, and psychosocial support as valuable resources, while irregular migration status, labor market barriers, and discrimination were identified as key challenges. Access to information, institutional support, and social networks emerged as important facilitators of social integration experiences.