Sinusitis not properly treated can generate multiple complications. Among these complications, oculo-orbital manifestations can be difficult to treat and can lead to vision loss, despite modern antibiotic therapy. In this paper, we aimed to discuss the orbital complications of rhinosinusitis, especially orbital cellulitis, and the method of treatment, highlighted by the presentation of a clinical case diagnosed and treated medically and surgically in the ENT and Ophthalmology Departments, within the Braila County Emergency Clinical Hospital.

Inverted papilloma is a benign tumor that can become malignant. It most commonly develops on the lateral rhinosinusal wall and has a maximum incidence in the ethmoid cells. In most cases, it occurs unilaterally, the main symptom being nasal obstruction. Treatment can generally be performed through endoscopic sinus surgery, involving total resection due to its malignancy potential and risk of recurrence. Given the increased interest in this pathology, we present the most important aspects of sinonasal inverted papilloma, from etiology to therapeutic management, exemplifying with a case from our own experience.

Background/Objectives: Vascular patches used in cardiovascular reconstruction remain limited by thrombosis, calcification, restricted remodeling, and inability to accommodate somatic growth. This proof-of-concept study aimed to fabricate and characterize porous vascular patches by fused deposition modeling (FDM) using polylactic acid (PLA) and thermoplastic polyurethane (TPU) in single-material and multilayer configurations. Methods: PLA/TPU patches with different polymer compositions, layer sequences, interfilament spacing, and staggered layer arrangements were fabricated by FDM. Mass and dimensional changes during in vitro immersion were assessed for the constituent polymers (n = 3 per polymer) and selected patch configurations (n = 1 per configuration). Patch microstructure and the in-plane dimensions of surface-visible pore openings were evaluated by top-view optical microscopy and ImageJ analysis, while time to first visually detectable fluid passage was assessed using a 22% (w/w) aqueous glycerol test solution under low hydrostatic pressure. Results: PLA and TPU exhibited distinct mass and dimensional profiles during 140 days of immersion, with mean mass increases of 1.37% and 3.68%, respectively. Selected patch specimens showed different temporal mass-change profiles during 42 days of immersion in phosphate-buffered saline (PBS). Descriptive pore measurements varied among the investigated configurations; V7b showed mean dimensions of 96.5 × 93.2 µm. In the exploratory test, fluid passage was first visually detected at 18 min (V5-TPU), 59 min (V6b) and 135 min (V7b). Conclusions: FDM enabled the fabrication of porous PLA/TPU vascular patch prototypes with different material composition and multilayer architectures. These findings establish a preliminary basis for further physicochemical, mechanical, biological, and hemodynamic evaluations of FDM-fabricated PLA/TPU vascular patches.

Background: Liver cirrhosis is associated with portal hypertension and its gastrointestinal complications, but non-variceal gastroduodenal mucosal injury and its relationship to Helicobacter pylori (H. pylori) infection and hepatic disease severity remain incompletely characterized. Methods: This retrospective, cross-sectional study included 162 patients undergoing first upper gastrointestinal endoscopy (61 with cirrhosis, 101 controls), assessed using a composite gastroduodenal mucosal injury score (range 0–16) across the antrum, gastric corpus, duodenal bulb, and second duodenal portion. Results: Cirrhosis was independently associated with a higher injury burden after adjusting for H. pylori status, nonsteroidal anti-inflammatory drug (NSAID), antiplatelet, anticoagulant, and proton pump inhibitor (PPI) use (adjusted count ratio [aCR] = 1.33, 95% CI: 1.09–1.63, p = 0.006); and H. pylori infection was independently and separately associated with higher injury burden (aCR = 1.25, 95% CI: 1.01–1.54, p = 0.037), while none of the four medication classes showed an independent association. This excess injury was concentrated almost exclusively in the gastric corpus (adjusted aCR = 3.04, p < 0.0001), with no significant differences at other sites. Injury severity did not correlate with Child–Pugh class or tests of the liver’s biosynthetic capacity (all p > 0.05). Only patients with concurrent cirrhosis and H. pylori infection showed significantly elevated injury relative to unexposed controls (adjusted aCR = 1.87, 95% CI: 1.38–2.53, p < 0.0001), with a significant, exploratory cirrhosis × H. pylori interaction (aCR = 1.56, p = 0.037). Conclusions: Cirrhosis is therefore associated with a corpus-predominant pattern of gastroduodenal injury, compatible with, though not proof of, a portal hypertension-related mechanism, and shows a significant positive multiplicative interaction with concurrent H. pylori infection; given the exploratory nature of this analysis, these findings are hypothesis-generating and warrant prospective confirmation before informing endoscopic screening or infection-screening practice.