Rutin (RTN) is a natural flavonoid with well-documented anti-angiogenic, antioxidant, anti-inflammatory, and anti-cancer properties. However, its therapeutic potential is limited by its extremely low water solubility, which results in poor and unpredictable bioavailability. To address these limitations, we developed a new formulation that complexes RTN with a soluble polymeric β-cyclodextrin (βCPCD). βCPCD is synthesized by cross-linking polyethylene glycol (PEG) and β-cyclodextrin (βCD). The high complexing capacity of βCPCD was demonstrated by a ∼ 50-fold increase in RTN solubility and complete dissolution within 60 min. These results suggest a dual encapsulation mechanism involving (i) the inclusion of RTN within the βCD cavity and (ii) the allocation of RTN within the free volume of the three-dimensional (3D) polymeric structure. The host-guest interaction was confirmed via UV-Vis titration, NMR, µ-Raman and FTIR-ATR spectroscopy analyses. The thermal stability of the lyophilized complex was assessed by TGA, and the morphology was investigated by SEM. Preliminary docking and molecular dynamics simulations were carried out considering a local scenario consisting of a single RTN and a βCD-PEG unit. The excellent biocompatibility of βCPCD in Danio rerio zebrafish embryos (survivability > 95%) and the notable enhancement of the antiangiogenic effect of the RTN complex compared to the free drug highlight the potential of βCPCD as an effective delivery system to improve RTN performance.

Cesium-based fluoride thin films are attracting growing interest in photovoltaic and optoelectronic applications due to their optical properties, which make them suitable as hosts for lanthanide-based energy conversion layers. Here, we report a one-pot synthesis of a novel heterobimetallic single-source adduct with formula [Cs(tetraglyme)₂]⁺[Y(hfa)₄]⁻ (hfa = hexafluoroacetylacetonate; tetraglyme = 2,5,8,11,14-pentaoxapentadecane). The compound has been fully characterized by FT-IR spectroscopy, energy-dispersive X-ray analysis (EDX), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). A partial structure of Cs-Y has been obtained by single-crystal X-ray diffraction, thus confirming the ionic nature of the Cs-Y complex and a well-defined coordination environment for both metal centers. Using a sol–gel/spin-coating approach, the complex has been used as a single-source precursor for the fabrication of pure CsY₂F₇ phase as thin films on silicon and quartz substrates. The films exhibit homogeneous morphology and stoichiometry, making CsY₂F₇ a promising host material for energy conversion layers for application in solar cells. As a proof-of-concept, a luminescent Eu-doped CsY₂F₇ film has been fabricated. This study represents the first work on the deposition of Cs-Y fluoride layers.