Renal involvement in Systemic Lupus Erythematous (SLE) patients is one of the leading causes of morbidity and a significant contributor to mortality. It’s estimated that nearly 50% of SLE individuals develop kidney disease in the first year of the diagnosis. Class IV lupus nephritis (LN-IV) is the class of lupus nephritis most common in Colombian patients with SLE. Altered miRNAs expression levels have been reported in human autoimmune diseases including lupus. Variations in the expression pattern of peripheral blood circulating miRNAs specific for this class of lupus nephritis could be correlated with the pathophysiological status of this group of individuals. The aim of this study was to evaluate the relative abundance of circulating microRNAs in peripheral blood from Colombian patients with LN-IV. Circulating miRNAs in plasma of patients with diagnosis of LN-IV were compared with individuals without renal involvement (LNN group) and healthy individuals (CTL group). Total RNA was extracted from 10 ml of venous blood and subsequently sequenced using Illumina. The sequences were processed and these were analyzed using miRBase and Ensembl databases. Differential gene expression analysis was carried out with edgeR and functional analysis were done with DIANA-miRPath. Analysis was carried out using as variables of selection fold change (≥2 o ≤-2) and false discovery rate (0.05). We identified 24 circulating microRNAs with differential abundance between LN-IV and CTL groups, fourteen of these microRNAs are described for the first time to lupus nephritis (hsa-miR-589-3p, hsa-miR-1260b, hsa-miR-4511, hsa-miR-485-5p, hsa-miR-584-5p, hsa-miR-543, hsa-miR-153-3p, hsa-miR-6087, hsa-miR-3942-5p, hsa-miR-7977, hsa-miR-323b-3p, hsa-miR-4732-3p and hsa-miR-6741-3p). These changes in the abundance of miRNAs could be interpreted as alterations in the miRNAs-mRNA regulatory network in the pathogenesis of LN, preceding the clinical onset of the disease. The findings thus contribute to understanding the disease process and are likely to pave the way towards identifying disease biomarkers for early diagnosis of LN.

Introducción: Adolescentes y adultos jóvenes participan frecuentemente en comportamientos sexuales riesgosos (relaciones sexuales sin protección, sexo con parejas casuales, promiscuidad, iniciación sexual temprana, etc.), trayendo consigo embarazos no planeados, Infecciones de Transmisión Sexual, suicidios, abortos, afectaciones académicas y laborales. El objetivo del estudio, fue identificar los comportamientos sexuales riesgosos y factores asociados en estudiantes de una universidad en Barranquilla, 2019. Materiales y métodos: Estudio de tipo descriptivo-correlacional de corte transversal, se utilizó la Encuesta de Riesgo Sexual, que evaluó comportamientos sexuales riesgosos en universitarios de Barranquilla, en los últimos seis meses, se generaron los coeficientes de correlación Chi cuadrado de Pearson (nivel de confianza 95%; p≤0.05) para medir la asociación entre los puntajes de riesgo sexual y factores sociodemográficos y académicos. Resultados: El 63% de los participantes inició actividad sexual antes de los 18 años. 87% han participado una o más veces en comportamientos sexuales de riesgo: sexo vaginal sin condón (73%), fellatio sin condón (60.3%), número de parejas con quién tienen comportamientos sexuales (66.2%) y experiencias sexuales inesperadas (54.4%). Los hombres y estudiantes de Derecho tenían puntajes de riesgo sexual más altos que las mujeres y los estudiantes de Enfermería. Conclusión: Los universitarios están en riesgo y participando en comportamientos sexuales riesgosos, que podrían afectar su salud y proyecto de vida. Los factores de mayor riesgo fueron; sexo temprano, género, edad >20 años, prácticas sexuales arriesgadas como el sexo vaginal, oral y anal sin protección y conductas sexuales impulsivas y no planificadas. Introduction: Adolescents and young adults are frequently involved in risky sexual behavior (unprotected sex, sex with casual partners, promiscuity, early sexual initiation, etc.) bringing with them, unplanned pregnancies, sexually transmitted infections, suicides, abortions, academic and labor affectations. The objective of the study was to identify risky sexual behaviors and associated factors in students at a university in Barranquilla, 2019.Materials and methods: Study descriptive-correlational cross-sectional, the sexual risk survey was used, which evaluated risky sexual behavior in university students of Barranquilla in the last six months, were generated correlation coefficients Chi-square Pearson (95% confidence level; p≤0.05) to measure the association between sexual risk scores and sociodemographic and academic factors.Results: 63% of participants initiated sexual activity before the age of 18. The 87% have participated one or more times in risky sexual behaviors: vaginal sex without a condom (73%), fellatio without a condom (60.3%), number of partners with whom they have sexual behaviors (66.2%) and unexpected sexual experiences (54.4%). Men and law students had higher sexual risk scores than women and nursing students.Conclusion: The university students are at risk and participating in risky sexual behavior, which could affect their health and life Project. The major risk factors were; early sex, gender, age >20 years, risky sexual practices such as vaginal, oral, and anal unprotected sex and impulsive and unplanned sexual behaviors.

Introducción: El uso racional de los medicamentos tiene implicaciones sanitarias de gran importancia, una vez que si se practica la automedicación se generan importantes efectos negativos sobre la salud. Objetivo: Describir las creencias en torno a la práctica de la automedicación entre los habitantes con edades de 20 a 59 años de la localidad 2 de la ciudad de Cartagena, Colombia. Materiales y Métodos: Estudio descriptivo de corte trasversal. La población de estudio fue de 428 personas, a quienes se les aplicó un instrumento, cuya información se analizó mediante estadística descriptiva. Resultados y Discusión: Los encuestados fueron de sexo femenino (58,6%), de 20-29 años de edad (35%), con formación secundaria completa (29,7%), de procedencia urbana (78%), jefes de hogar (50,2%), en unión libre (44,2%). La prevalencia de la automedicación estuvo en 89,7%. La falta de tiempo (28,3%) y la demora en la atención médica (22,7%) fueron las principales razones para hacerlo. La principal influencia proviene de la familia (49,3%). Los encuestados creen que algunos medicamentos son milagrosos y de efecto rápido; es común el uso de hierbas y plantas medicinales. Los medicamentos de mayor consumo fueron los destinados al tratamiento del dolor (95,1%), junto con los antipiréticos (72,4%) y las vitaminas/minerales (53,7%). Conclusiones: La automedicación fue una práctica muy usada y difundida en la población estudiada.Cómo citar este artículo: Del Toro M, Díaz A, Barrios Z, Castillo IY. Automedicación y creencias en torno a su práctica en Cartagena, Colombia. Rev Cuid. 2017; 8(1): 1509-18. http://dx.doi.org/10.15649/cuidarte.v8i1.367

INTRODUCTION: The obstetirc or noenatal risk factors, are in many cases the major evidence to define and forecast of an early neonatal sepsis, considering that a newborn that has lived less tan 72 hours presents unspecified clinical manifestations and the diagnostic exams utilize infectious and inflammatory markers, with there being very litttle scientific evidence to support and establish an early diagnosis. Objective: Associate the obstetric and neonatal risk factors with the presence of early sepsis in Cartagena. MATERIALS & METHODS: A retrospective study of cases and controls was conducted. The sample consisted of 183 cases and 366 controls, including pacients who met simultaneously inclusion and exclusion criteria. A bivariated analysis and a multivariated model of regression logistics were used. RESULTS: Among the associtated variables and early sepsis in which it was able to define the risk that is found when there is a premature membrane rupture > 18 hours (OR 9,57 IC 95% 4,12-22,26), premature newborn (OR 8,19 IC 95% 3,66-18,3), the presence of maternal fever (OR 6,49 IC 95% 3,43-12,3), marital status (OR 5,89 IC 95% 3,42-10,15) and level of education (OR 4,80 IC 95% 2,63-8,77). CONCLUSIONS: The mechanisms of fetal evaluation and maternal prophylaxis should be prioritized in the cases of pregnant women that present a premature membrane rupture >18 hours, and have kids who were born premature and living in couple with a low level of education.

Background: Informed consent is an important factor in a child’s moral structure from which different types of doctor–patient relationships arise. Children’s autonomy is currently under discussion in terms of their decent treatment, beyond what doctors and researchers perceive. To describe the influential practices that exist among clinicians and researchers toward children with chronic diseases during the process of obtaining informed consent.Methods: This was a cross-sectional, qualitative study via a subjective and interpretivist approach. The study was performed by conducting semi-structured interviews of 21 clinicians and researchers. Data analysis was performed using the SPSS version 21® and Atlas Ti version 7.0® programs.Results: The deliberative and paternalistic models were influential practices in the physician–patient relationship. In the deliberative model, the child is expected to have a moral awareness of their care. The paternalistic model determined that submission was a way of structuring the child because he or she is considered to be a subject of extreme care.Conclusions: The differentiated objectification [educational] process recognizes the internal and external elements of the child. Informed consent proved to be an appropriate means for strengthening moral and structuring the child.

Objetivo. Determinar la prevalencia de la infección por Ehrlichia canis y Anaplasma sp. y su correlación con aspectos epidemiológicos y de laboratorio, en caninos atendidos en clínicas veterinarias de Barranquilla, Colombia. Materiales y Métodos. Estudio de tipo descriptivo, retrospectivo de corte transversal. Los datos se obtuvieron en los meses de enero a agosto de 2015. Se analizaron 184 caninos compatibles clínicamente con infección por Ehrlichia canis y Anaplasma sp., se utilizaron los criterios de positividad de un kit comercial de inmunocromatografía y el extendido de sangre periférica, además se recolectaron datos epidemiológicos y de laboratorio. Resultados. 63 caninos (34%) fue la prevalencia global de Ehrlichia canis y Anaplasma sp., 52/184 (28%) caninos con E. canis y 11/184 (6%) con Anaplasma sp. El hemograma de los pacientes caninos positivos con E. canis y Anaplasma sp., presentaron disminución del hematocrito, leucopenia y trombocitopenia. Conclusiones. Los hallazgos encontrados a partir de este estudio muestran una alta prevalencia y endemicidad de E. canis y Anaplasma sp. en Barranquilla en contraste con otras regiones de Colombia. Los datos del hemograma demostraron ser relevantes en el diagnóstico y pronóstico de estas enfermedades.