The increased consumption of fruits, vegetables, and whole grains contributes to the reduced risk of many diseases related to metabolic syndrome, including neurodegenerative diseases, cardiovascular disease (CVD), diabetes, and cancer. Citrus, the genus Citrus L., is one of the most important fruit crops, rich in carotenoids, flavonoids, terpenes, limonoids, and many other bioactive compounds of nutritional and nutraceutical value. Moreover, polymethoxylated flavones (PMFs), a unique class of bioactive flavonoids, abundantly occur in citrus fruits. In addition, citrus essential oil, rich in limonoids and terpenes, is an economically important product due to its potent antioxidant, antimicrobial, and flavoring properties. Mechanistic, observational, and intervention studies have demonstrated the health benefits of citrus bioactives in minimizing the risk of metabolic syndrome. This review provides a comprehensive view of the composition of carotenoids, flavonoids, terpenes, and limonoids of citrus fruits and their associated health benefits.

Citrus contains a range of highly beneficial bioactive compounds, such as polyphenols, carotenoids, and vitamins that show antimicrobial and antioxidant properties and help in building the body’s immune system. On consumption or processing, approximately 50% of the fruit remains as inedible waste, which includes peels, seeds, pulp, and segment residues. This waste still consists of substantial quantities of bioactive compounds that cause environmental pollution and are harmful to the ecosystem because of their high biological oxygen demand. In recent years, citrus cultivation and the production of processed foods have become a major agricultural industry. In addition to being a substantial source of economy, it is an ideal and sustainable and renewable resource for obtaining bioactive compounds and co-products for food and pharmaceutical industries. In the present article, the various methods of extraction, conventional and modern, as well as separation and isolation of individual bioactive compounds from the extraction mixture and their determination have been reviewed. This article presents both aspects of extraction methods, i.e., on a small laboratory scale and on an industrial mass scale. These methods and techniques have been extensively and critically reviewed with anticipated future perspectives towards the maximum utilization of the citrus waste.

Citrus is one of the largest and most popular fruit crops commercially grown across the globe. It is not only important in terms of economy but is also popular for its nutritional benefits to human and farm animals. Citrus is available in several varieties, all with attractive colors. It is consumed either fresh or in processed form. After processing, approximately 50% of the fruit remains unconsumed and discarded as waste. The latter includes fruit pith residue, peels and seeds. Direct disposal of these wastes to the environment causes serious problems as these contain bioactive compounds. Release of these bioactive compounds to the open landfills cause bad odor and spread of diseases, and disposal to water bodies or seepage to the underground water table deteriorates water quality and harms aquatic life. In this regard, a number of research are being focused on the development of better reuse methods to obtain value-added phytochemicals as well as for safe disposal. The important phytochemicals obtained from citrus include essential oils, flavonoids, citric acid, pectin, etc., which have now become popular topics in industrial research, food and synthetic chemistry. The present article reviews recent advances in exploring the effects of flavonoids obtained from citrus wastes, the extraction procedure and their usage in view of various health benefits.

Citrus is the largest grown fruit crop on the globe with an annual production of ~110–124 million tons. Approximately, 45–55% of the whole fruit post-processing is generally discarded as waste by the food processing industries. The waste is a huge problem to the environment in terms of land and water pollution along with displeasure from aesthetic viewpoint and spread of diseases owing to its huge content of fermentable sugars. The waste can be utilized as a raw material feedstock for producing a number of valuable chemicals and products, such as bioethanol, biogas, bio-oil, organic acids, enzymes, and so on. The production of these chemicals from waste biomass gives an inexpensive alternative to the harsh chemicals used during industrial synthesis processes as well as the possibility of controlling pollution from the waste discarded to the environment. The derived chemicals can be further utilized in the production of industrially important chemicals, as solvents and building blocks of newer chemicals. Furthermore, organic acids, pectin, enzymes, prebiotics, etc., derived from citrus wastes have an edge over their synthetic counterparts in practical applications in the food processing and pharmaceutical industries.

Diverse medicinal plants such as those from the genus Artemisia have been employed globally for centuries by individuals belonging to different cultures. Universally, Artemisia species have been used to remedy various maladies that range from simple fevers to malaria. A survey conducted by the World Health Organization (WHO) demonstrated that 80% of the global population is highly reliant on herbal medicine for their primary healthcare. WHO recommends artemisinin-based combination therapies (ACT) for the treatment of global diseases such as malaria. Artemisinin is a bioactive compound derived from Artemisia annua leaves. It is a sesquiterpene endoperoxide with potent antimalarial properties. This review strives to instill natural products to chemists and others in diverse fields with a heterogeneous set of knowledge compiled from multifaceted researchers and organizations in literature. In particular, the various Artemisia species and effective extraction, isolation, and characterization methodologies are discussed in detail. An in-depth investigation into the literature reveals that divergent species of Artemisia exhibit a vast array of biological activities such as antimalarial, antitumor, and anti-inflammatory activities. There is substantial potential for bioactive compounds from Artemisia to provide significant relief from differing human ailments, but more meticulous research in this field is needed.