Background This case–control study was conducted to investigate the relationship between serum nesfatin-1 levels and nutritional status and blood parameters in patients diagnosed with metabolic syndrome. Methods Thirty patients (case) diagnosed with metabolic syndrome according to National Cholesterol Education Program-Adult Treatment Panel III criteria were included. Thirty healthy subjects (control) matched with patients with metabolic syndrome in terms of age, gender and body mass index were included. Three-day food consumption records were obtained. Anthropometric indices were measured and body composition was determined by bioelectrical impedance method. Biochemical parameters and serum nesfatin-1 levels were measured after 8 hours of fasting. Results Serum nesfatin-1 levels were 0.245±0.272 ng/mL in the case group and 0.528±0.987 ng/mL in the control group (p>0.05). There was a positive significant correlation between serum nesfatin-1 levels and body weight, waist and hip circumferences in the case group (p<0.05). Each unit increase in hip circumference measurement affects the levels of nesfatin by 0.014 times. In the control group, there was a positive significant correlation between body weight and serum nesfatin-1 levels (p<0.05). A significant correlation was detected between HbA1c and serum nesfatin-1 levels in the case group (p<0.05). A significant relationship was detected between dietary fibre intake and the serum nesfatin-1 levels in the case group (p<0.05). Conclusions Anthropometric indices and blood parameters were correlated with serum nesfatin-1 levels in patients with metabolic syndrome. More clinical trials may be performed to establish the relationship between serum nesfatin-1 levels and nutritional status.

BACKGROUND: The risk of developing an eating disorder can increase with obesity and body weight gain in adolescents. Eating disorders can cause serious physical and psychological problems. OBJECTIVE: This study was conducted to determine the frequency of eating disorders in adolescents and examine the relationship between obesity and weight gain. METHODS: The sample was selected from a population of high school students between the ages of 14–19. The Eating Disorder Examination Questionnaire (EDE-Q) was used to determine the frequency of eating disorders. The relationship between anthropometric measurements and the EDE-Q was evaluated. RESULTS: A total of 387 students, 67.4% of the sample female, were included in the study. When the students are evaluated according to BMI classification, 74.67% of the students are in the normal category, 16.53% are overweight, and 5.42% are obese. While female students received a total score of 1.36±1.45 on the scale, male students received a score of 0.85±0.97 (p < 0.05). There was a positive correlation between body weight and BMI, EDE-Q’s total score, and sub-dimension scores (p < 0.05). Additionally, the regression analysis revealed that the total score on the scale was significantly associated with body weight and BMI. EDE-Q’s total score increased by 1 unit, there was an increase of approximately 3.01 kg in body weight and 1.19 kg/m2 in BMI. CONCLUSION: In adolescents, the risk of developing an eating disorder can increase with obesity and body weight gain. Early diagnosis and treatment of eating disorders can help prevent long-term health problems.

Dirençli nişasta, sağlıklı insanların ince bağırsaklarında sindirilmeyen ve emilmeyen, ancak kolondaki yerleşik mikroflora ile kolonda fermente edilen nişasta veya nişastalı gıda ürünlerinin toplamıdır. Dirençli nişastanın kolonda fermente olması sonucu doymuş alifatik organik asitler ailesine ait olan asetat, propiyonat ve bütirat gibi kısa zincirli yağ asitleri üretilmektedir. Dirençli nişasta, yararlı bakterilerin büyümesini ve aktivitesini uyarma, kısa zincirli yağ asitleri üretme gibi fonksiyonel özellikleri nedeni ile prebiyotik olarak kabul edilmektedir. Dirençli nişastanın vücut ağırlığı regülasyonunu sağladığı, insülin duyarlılığı ve glukoz yanıtını iyileştirdiği, kan lipid düzeyleri üzerinde düşürücü etki gösterdiği bilinmektedir. İnflamatuar bağırsak hastalıkları, gastrointestinal sistem içerisinde kronik veya tekrarlayan immün aktivasyon ve inflamasyon ile karakterizedir. Dirençli nişastanın, kolonda sağlığa yararlı bakterilerin büyümesini uyarması, patolojik etkileri baskılaması ve inflamatuar yanıtı düzenlemesi nedeni ile inflamatuar bağırsak hastalıkları üzerinde yararlı etkilerinin olabileceği düşünülmektedir. Gastrointestinal kanalda kolonize olan bakteri, virüs, mantar, protozoa gibi mikroorganizmalardan oluşan ve organ gibi işlev gören ekosistem, bağırsak mikrobiyotası olarak adlandırılmaktadır. Dirençli nişastanın kolonda fermentasyonuyla; safra asidi dönüşümünü ve bütirat konsantrasyonlarını artırdığı, bütiratın ise normal epitel hücre büyümesi ve kolonik hastalıkların önlenmesi için önemli olduğu kanıtlanmıştır. Ayrıca dirençli nişasta, sağlığa yararlı bakterilerin büyümesini sağlayarak mikrobiyota üzerinde olumlu etki göstermektedir. Mikrobiyotayı düzenlemesi nedeni ile dirençli nişastanın hem inflamatuar bağırsak hastalıkları hem de diğer kronik hastalıklar üzerinde yararlı etkilerinin olabileceği düşünülmektedir.