2,4-Di-tert-butylphenol or 2,4-bis(1,1-dimethylethyl)-phenol (2,4-DTBP) is a common toxic secondary metabolite produced by various groups of organisms. The biosources and bioactivities of 2,4-DTBP have been well investigated, but the phenol has not been systematically reviewed. This article provides a comprehensive review of 2,4-DTBP and its analogs with emphasis on natural sources and bioactivities. 2,4-DTBP has been found in at least 169 species of bacteria (16 species, 10 families), fungi (11 species, eight families), diatom (one species, one family), liverwort (one species, one family), pteridiphyta (two species, two families), gymnosperms (four species, one family), dicots (107 species, 58 families), monocots (22 species, eight families), and animals (five species, five families). 2,4-DTBP is often a major component of violate or essential oils and it exhibits potent toxicity against almost all testing organisms, including the producers; however, it is not clear why organisms produce autotoxic 2,4-DTBP and its analogs. The accumulating evidence indicates that the endocidal regulation seems to be the primary function of the phenols in the producing organisms.

International food trade plays an important role in food security, but little research has been devoted to studying crop dynamics in importing countries caused by trade. We studied the spatiotemporal patterns of soybean planting area in China (the largest soybean importing country) in response to soybean imports. The results show how the soybean planting area from 1980 to 2012 in China is dominated by two temporal patterns, both of which first increased, then decreased, with an 8-year time lag. The first increasing-decreasing pattern is affected by increasing soybean imports, and the second increasing-decreasing pattern is driven by decreasing domestic soybean profits. The results also show spatially distinct spatial patterns: soybean planting area decreased in southeastern China while it increased in northwestern China. Our analysis of soybean planting area helps China and other food-importing countries understand spatiotemporal responses of domestic agricultural cultivations caused by international food trade and agricultural pollution management.