The detection of biomolecules using various biosensors with excellent sensitivity, selectivity, stability, and reproducibility, is of great significance in the analytical and biomedical fields toward achieving their practical applications. Noble metal nanoparticles are favorable candidates due to their unique optical, surface electrical effect, and catalytic properties. Among these noble metal nanoparticles, platinum nanoparticles (Pt NPs) have been widely employed for the detection of bioactive substances such as glucose, glutamic acid, and hormones. However, there is still a long way to go before the potential challenges in the practical applications of biomolecules are fully overcome. Bearing this in mind, combined with our research experience, we summarized the recent progress of the Pt NP-based biosensors and highlighted the current problems that exist in their practical applications. The current review would provide fundamental guidance for future applications using the Pt NP-based biosensors in food, agricultural, and medical fields.

HPB@COF nanoparticles were synthesized in situ using a one-pot method, and exhibited excellent pH-responsive release properties and photothermal tumor treatment effects.