Recent earthquakes show that masonry infill walls should be taken into account during the design and assessment process of structures, since this type of non-structural elements increase the in-plane stiffness of the structure and consequently the natural period. An overview of the past researches conducted on the modelling of masonry infilled frame issues has been done, with discussion of past analytical investigations and different modelling approaches that many authors have proposed, including micro- and macro-modelling strategies. After this, the present work presents an improved numerical model, based on the Rodrigues et al. (J Earthq Eng 14:390–416, 2010) approach, for simulating the masonry infill walls behaviour in the computer program OpenSees. The main results of the in-plane calibration analyses obtained with one experimental test are presented and discussed. For last, two reinforced concrete regular buildings were studied and subjected to several ground motions, with and without infills’ walls.