To investigate the neonatal effect and placental transfer of dexmedetomidine during caesarean section under epidural anaesthesia. Forty parturients with a single newborn who were scheduled for caesarean section were enrolled. Patients received 0.5 µg/kg dexmedetomidine 10 min after epidural anaesthesia, followed by 0.5 µg/kg/h until abdominal closure (Dex group) or infusion of normal saline (NS group). Systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were monitored before infusion (T0), 10 min after infusion (T1), at delivery (T2), and at the end of the operation (T3). Umbilical vein and artery blood was collected. Apgar scores were evaluated at 1 and 5 min after delivery. SBP, DBP, and HR in the Dex group were decreased at T3 compared with T0 (116 ± 10.4 vs 111 ± 9.2 mmHg, 74 ± 6.7 vs 66 ± 7.9 mmHg, 91 ± 12.1 vs 71 ± 8.4 beats/min, respectively, P < 0.05). HR was lower at T1, T2, and T3 in the Dex group compared with the NS group (P < 0.05). There were no significant differences in blood gases and Apgar scores between the groups (P > 0.05). Dexmedetomidine during caesarean section under epidural anaesthesia is beneficial to parturients. The placental transfer rate is 0.68.

Purpose: To investigate the effects of the selective NLRP3 inflammasome inhibitor MCC950 on post-resuscitation myocardial function and survival in a rat model of cardiopulmonary resuscitation (CPR). Methods: Thirty-six Sprague Dawley rats were randomized into three groups: (1) MCC950, (2) control, and (3) sham. Each group consisted of a 6 h non-survival subgroup (n = 6) and a 48 h survival subgroup (n = 6). Ventricular fibrillation (VF) was induced and untreated for 6 min. CPR was initiated and continued for 8 min. Resuscitation was attempted with a 4 J defibrillation. MCC950 (10 mg/kg) or vehicle was administered via intraperitoneal injection immediately after the return of spontaneous circulation (ROSC). Myocardial function and sublingual microcirculation were measured after ROSC in the non-survival subgroups. Plasma levels of interleukin Iβ (IL-1β) and cardiac troponin I (cTnI) were measured at baseline and 6 h in the non-survival subgroups. Heart tissue was harvested to measure the NLRP3 inflammasome constituents, including NLRP3, apoptosis-associated speck-like protein (ASC), Caspase-1, and IL-1β. Survival duration and neurologic deficit score (NDS) were recorded and evaluated among survival groups. Results: Post-resuscitation myocardial function and sublingual microcirculation were improved in MCC950 compared with control (p < 0.05). IL-1β and cTnI were decreased in MCC950 compared to control (p < 0.01). The MCC950 treated groups showed significantly reduced ASC, caspase-1, and IL-1β compared with the control group (p < 0.05). Survival at 48 h after ROSC was greater in MCC950 (p < 0.05) with improved NDS (p < 0.05). Conclusion: Administration of MCC950 following ROSC mitigates post-resuscitation myocardial dysfunction and improves survival.

To solve the technical problem of supporting a water-dripping roadway below contiguous seams at the Tuanbai coal mine, the deformation law of surrounding rocks for the roadway was studied using Fast Lagrangian Analysis of Continua in Three Dimensions (FLAC3D) numerical simulation. Then, a mechanical model of water-dripping rock using a bolt support was established, and further, technical countermeasures to control the deformation of the roadway with a bolt and cable support are proposed. The results show that the erosion of the water dripping on the roadway was substantial and showed notable changes over time during roadway excavation and mining work. These effects caused the road to heave slightly, but it tended to be stable during roadway excavation. Moreover, the erosion of the roof and two ribs increased exponentially, and the floor heave increased with significant displacement oscillation during mining. The anchoring length of bolts and the rock weakening from water dripping had noticeable effects on the surrounding rocks of the roadway. The logical parameters of the bolt spacing and tightening force (the bolt line spacing was 0.7–0.9 m and the tightening force exceeded 40 kN) of the bolt supports were studied and optimized. Finally, a support scheme for water dripping on the roadway at the Tuanbai coal mine is proposed. The observation data regarding the deformation of the surrounding rocks, monitoring of bolt and cable stress, endoscopy results of roof failure, and roof bed separation monitoring were used to verify the reasonableness of the scheme and ensure the requirements for support were met. The study results can serve as a reference regarding the support for water dripping on a roadway under similar conditions.