Significance: North American and European countries built many large dams until 1975, after which both started to abandon a significant part of their installed hydropower because of the negative social and environmental impacts. However, there has been a recent trend of new large hydropower dams being built in developing countries, particularly in megabiodiversity river basins, such as the Amazon, the Congo, and the Mekong. The socioeconomic and environmental damages in these river systems are even greater than the early costs in North America and Europe. This paper discusses how the hydropower sector needs to not only focus on energy production but also, include the negative social and environmental externalities caused by dams and recognize the unsustainability of current common practices.

The ongoing and proposed construction of large-scale hydropower dams in the Mekong river basin is a subject of intense debate and growing international concern due to the unprecedented and potentially irreversible impacts these dams are likely to have on the hydrological, agricultural, and ecological systems across the basin. Studies have shown that some of the dams built in the tributaries and the main stem of the upper Mekong have already caused basin-wide impacts by altering the magnitude and seasonality of flows, blocking sediment transport, affecting fisheries and livelihoods of downstream inhabitants, and changing the flood pulse to the Tonle Sap Lake. There are hundreds of additional dams planned for the near future that would result in further changes, potentially causing permanent damage to the highly productive agricultural systems and fisheries, as well as the riverine and floodplain ecosystems. Several studies have examined the potential impacts of existing and planned dams but the integrated effects of the dams when combined with the adverse hydrologic consequences of climate change remain largely unknown. Here, we provide a detailed review of the existing literature on the changes in climate, land use, and dam construction and the resulting impacts on hydrological, agricultural, and ecological systems across the Mekong. The review provides a basis to better understand the effects of climate change and accelerating human water management activities on the coupled hydrological-agricultural-ecological systems, and identifies existing challenges to study the region’s Water, Energy, and Food (WEF) nexus with emphasis on the influence of future dams and projected climate change. In the last section, we synthesize the results and highlight the urgent need to develop integrated models to holistically study the coupled natural-human systems across the basin that account for the impacts of climate change and water infrastructure development. This review provides a framework for future research in the Mekong, including studies that integrate hydrological, agricultural, and ecological modeling systems.