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Sarcoidosis is a multisystem disease that raises several diagnostic difficulties in routine clinical practice due to its multisystemic involvement and the presence of nonspecific clinical pictures, except in some isolated cases
Claudio Tana; Cosima Schiavone. The Chameleon Behavior of Sarcoidosis. Journal of Clinical Medicine 2021, 10, 2780 .
AMA StyleClaudio Tana, Cosima Schiavone. The Chameleon Behavior of Sarcoidosis. Journal of Clinical Medicine. 2021; 10 (13):2780.
Chicago/Turabian StyleClaudio Tana; Cosima Schiavone. 2021. "The Chameleon Behavior of Sarcoidosis." Journal of Clinical Medicine 10, no. 13: 2780.
Cardiac sarcoidosis (CS) is an unusual, but potentially harmful, manifestation of systemic sarcoidosis (SA), a chronic disease characterized by organ involvement from noncaseating and nonnecrotizing granulomas. Lungs and intrathoracic lymph nodes are usually the sites that are most frequently affected, but no organ is spared and CS can affect a variable portion of SA patients, up to 25% from post-mortem studies. The cardiovascular involvement is usually associated with a bad prognosis and is responsible for the major cause of death and complications, particularly in African American patients. Furthermore, the diagnosis is often complicated by the occurrence of non-specific clinical manifestations, which can mimic the effect of more common heart disorders, and imaging and biopsies are the most valid approach to avoid misdiagnosis. This narrative review summarizes the main clinical features of CS and imaging findings, particularly of CMR and 18-Fluorodeoxyglucose Positron Emission Tomography (18F-FDG PET) that can give the best cost/benefit ratio in terms of the diagnostic approach. Imaging can be very useful in replacing the endomyocardial biopsy in selected cases, to avoid unnecessary, and potentially dangerous, invasive maneuvers.
Claudio Tana; Cesare Mantini; Iginio Donatiello; Luciano Mucci; Marco Tana; Fabrizio Ricci; Francesco Cipollone; Maria Giamberardino. Clinical Features and Diagnosis of Cardiac Sarcoidosis. Journal of Clinical Medicine 2021, 10, 1941 .
AMA StyleClaudio Tana, Cesare Mantini, Iginio Donatiello, Luciano Mucci, Marco Tana, Fabrizio Ricci, Francesco Cipollone, Maria Giamberardino. Clinical Features and Diagnosis of Cardiac Sarcoidosis. Journal of Clinical Medicine. 2021; 10 (9):1941.
Chicago/Turabian StyleClaudio Tana; Cesare Mantini; Iginio Donatiello; Luciano Mucci; Marco Tana; Fabrizio Ricci; Francesco Cipollone; Maria Giamberardino. 2021. "Clinical Features and Diagnosis of Cardiac Sarcoidosis." Journal of Clinical Medicine 10, no. 9: 1941.
Sarcoidosis is a granulomatous disease which can involve every organ, and can manifest with nonspecific clinical pictures that can be misdiagnosed with those observed with other disorders
Claudio Tana. Sarcoidosis: An Old but Always Challenging Disease. Diagnostics 2021, 11, 696 .
AMA StyleClaudio Tana. Sarcoidosis: An Old but Always Challenging Disease. Diagnostics. 2021; 11 (4):696.
Chicago/Turabian StyleClaudio Tana. 2021. "Sarcoidosis: An Old but Always Challenging Disease." Diagnostics 11, no. 4: 696.
We read with interest the article by Sweiss et al1Sweiss N.J. Korsten P. Syed H.J. et al.When the game changes: guidance to adjust sarcoidosis management during the coronavirus disease 2019 pandemic.Chest. 2020; 158: 892-895Abstract Full Text Full Text PDF PubMed Scopus (11) Google Scholar in a previous issue of CHEST (September 2020) that provides guidance on how to adjust immunosuppressive therapy in patients with sarcoidosis during the coronavirus disease 2019 (COVID-19) pandemic. The authors point out the importance of reducing the dose of immunosuppressive drugs to decrease the risk of infections and poor outcome. These recommendations are based on the results of some systematic reviews and meta-analyses that were conducted in other rheumatic diseases and that found an increased risk for serious infections, mostly with systemic glucocorticoids and biologic agents.
Claudio Tana; Cosima Schiavone; Francesco Cipollone; Maria Adele Giamberardino. Management Issues of Sarcoidosis in the Time of Coronavirus Disease 2019. Chest 2021, 159, 1306 -1307.
AMA StyleClaudio Tana, Cosima Schiavone, Francesco Cipollone, Maria Adele Giamberardino. Management Issues of Sarcoidosis in the Time of Coronavirus Disease 2019. Chest. 2021; 159 (3):1306-1307.
Chicago/Turabian StyleClaudio Tana; Cosima Schiavone; Francesco Cipollone; Maria Adele Giamberardino. 2021. "Management Issues of Sarcoidosis in the Time of Coronavirus Disease 2019." Chest 159, no. 3: 1306-1307.
The recent COVID-19 pandemic has dramatically changed the world in the last months, leading to a serious global emergency related to a novel coronavirus infection that affects both sexes of all ages ubiquitously. Advanced age, cardiovascular comorbidity, and viral load have been hypothesized as some of the risk factors for severity, but their role in patients affected with other diseases, in particular immune disorders, such as sarcoidosis, and the specific interaction between these two diseases remains unclear. The two conditions might share similar imaging findings but have distinctive features that are here described. The recent development of complex imaging softwares, called deep learning techniques, opens new scenarios for the diagnosis and management.
Claudio Tana; Cesare Mantini; Francesco Cipollone; Maria Giamberardino. Chest Imaging of Patients with Sarcoidosis and SARS-CoV-2 Infection. Current Evidence and Clinical Perspectives. Diagnostics 2021, 11, 183 .
AMA StyleClaudio Tana, Cesare Mantini, Francesco Cipollone, Maria Giamberardino. Chest Imaging of Patients with Sarcoidosis and SARS-CoV-2 Infection. Current Evidence and Clinical Perspectives. Diagnostics. 2021; 11 (2):183.
Chicago/Turabian StyleClaudio Tana; Cesare Mantini; Francesco Cipollone; Maria Giamberardino. 2021. "Chest Imaging of Patients with Sarcoidosis and SARS-CoV-2 Infection. Current Evidence and Clinical Perspectives." Diagnostics 11, no. 2: 183.
: Nonalcoholic fatty liver disease (NAFLD) embraces histopathological entities ranging from the relatively benign simple steatosis to the progressive form nonalcoholic steatohepatitis (NASH), which is associated with fibrosis and an increased risk of progression to cirrhosis and hepatocellular carcinoma. NAFLD is the most common liver disease and is associated with extrahepatic comorbidities including a major cardiovascular disease burden. : The non-invasive diagnosis of NAFLD and the identification of subjects at risk of progressive liver disease and cardio-metabolic complications are key in implementing personalized treatment schedules and follow-up strategies. : In this review, we highlight the potential role of ultrasound semiquantitative scores for detecting and assessing steatosis severity, progression of NAFLD, and cardio-metabolic risk. : Ultrasonographic scores of fatty liver severity act as sensors of cardio-metabolic health and may assist in selecting patients to submit to second-line non-invasive imaging techniques and/or liver biopsy.
Stefano Ballestri; Claudio Tana; Maria Di Girolamo; Maria Cristina Fontana; Mariano Capitelli; Amedeo Lonardo; Giorgio Cioni. Semi-Quantitative Ultrasonographic Evaluation of NAFLD. Current Pharmaceutical Design 2020, 26, 3915 -3927.
AMA StyleStefano Ballestri, Claudio Tana, Maria Di Girolamo, Maria Cristina Fontana, Mariano Capitelli, Amedeo Lonardo, Giorgio Cioni. Semi-Quantitative Ultrasonographic Evaluation of NAFLD. Current Pharmaceutical Design. 2020; 26 (32):3915-3927.
Chicago/Turabian StyleStefano Ballestri; Claudio Tana; Maria Di Girolamo; Maria Cristina Fontana; Mariano Capitelli; Amedeo Lonardo; Giorgio Cioni. 2020. "Semi-Quantitative Ultrasonographic Evaluation of NAFLD." Current Pharmaceutical Design 26, no. 32: 3915-3927.
Sarcoidosis is a granulomatous disorder of unknown etiology characterized by noncaseating granulomas virtually in every organ and tissue. This finding represents the most important diagnostic clue to reach a correct definition of sarcoidosis, although the biopsy is invasive and has several risk procedures. Several efforts are made to suspect the diagnosis of sarcoidosis by combining noninvasive elements, in particular from imaging, though these findings are often nonspecific and reflect the wide multifactorial pathogenesis. Every effort should be made to obtain a detailed radiological picture that, if associated with a suggestive clinical picture, could avoid the need of biopsy in some specific cases. In this narrative review, we aim to describe main computed tomography (CT) features of pulmonary and abdominal sarcoidosis, by reporting strengths and limits of this technique, in particular for the identification of extrapulmonary, isolated disease.
Claudio Tana; Iginio Donatiello; Maria Gabriella Coppola; Fabrizio Ricci; Marica Tina Maccarone; Tiziana Ciarambino; Francesco Cipollone; Maria Adele Giamberardino. CT Findings in Pulmonary and Abdominal Sarcoidosis. Implications for Diagnosis and Classification. Journal of Clinical Medicine 2020, 9, 3028 .
AMA StyleClaudio Tana, Iginio Donatiello, Maria Gabriella Coppola, Fabrizio Ricci, Marica Tina Maccarone, Tiziana Ciarambino, Francesco Cipollone, Maria Adele Giamberardino. CT Findings in Pulmonary and Abdominal Sarcoidosis. Implications for Diagnosis and Classification. Journal of Clinical Medicine. 2020; 9 (9):3028.
Chicago/Turabian StyleClaudio Tana; Iginio Donatiello; Maria Gabriella Coppola; Fabrizio Ricci; Marica Tina Maccarone; Tiziana Ciarambino; Francesco Cipollone; Maria Adele Giamberardino. 2020. "CT Findings in Pulmonary and Abdominal Sarcoidosis. Implications for Diagnosis and Classification." Journal of Clinical Medicine 9, no. 9: 3028.
Diabetes mellitus is a metabolic disorder characterized by the development of vascular complications associated with high morbidity and mortality and the consequent relevant costs for the public health systems. Diabetic kidney disease is one of these complications that represent the main cause of end-stage renal disease in Western countries. Hyperglycemia, inflammation, and oxidative stress contribute to its physiopathology, and several investigations have been performed to evaluate the role of antioxidant supplementation as a complementary approach for the prevention and control of diabetes and associated disturbances. Vitamin E compounds, including different types of tocopherols and tocotrienols, have been considered as a treatment to tackle major cardiovascular outcomes in diabetic subjects, but often with conflicting or even negative results. However, their effects on diabetic nephropathy are even less clear, despite several intervention studies that showed the improvement of renal parameters after supplementation in patients with diabetic kidney disease. Then we performed a review of the literature about the role of vitamin E supplementation on diabetic nephropathy, also describing the underlying antioxidant, anti-inflammatory, and metabolic mechanisms to evaluate the possible use of tocopherols and tocotrienols in clinical practice.
Angelo Di Vincenzo; Claudio Tana; Hamza El Hadi; Claudio Pagano; Roberto Vettor; Marco Rossato. Antioxidant, Anti-Inflammatory, and Metabolic Properties of Tocopherols and Tocotrienols: Clinical Implications for Vitamin E Supplementation in Diabetic Kidney Disease. International Journal of Molecular Sciences 2019, 20, 5101 .
AMA StyleAngelo Di Vincenzo, Claudio Tana, Hamza El Hadi, Claudio Pagano, Roberto Vettor, Marco Rossato. Antioxidant, Anti-Inflammatory, and Metabolic Properties of Tocopherols and Tocotrienols: Clinical Implications for Vitamin E Supplementation in Diabetic Kidney Disease. International Journal of Molecular Sciences. 2019; 20 (20):5101.
Chicago/Turabian StyleAngelo Di Vincenzo; Claudio Tana; Hamza El Hadi; Claudio Pagano; Roberto Vettor; Marco Rossato. 2019. "Antioxidant, Anti-Inflammatory, and Metabolic Properties of Tocopherols and Tocotrienols: Clinical Implications for Vitamin E Supplementation in Diabetic Kidney Disease." International Journal of Molecular Sciences 20, no. 20: 5101.
Gut microbiota composition and functionality are involved in the pathophysiology of several intestinal and extraintestinal diseases, and are increasingly considered a modulator of local and systemic inflammation. However, the involvement of gut microbiota in diverticulosis and in diverticular disease is still poorly investigated. In this review, we critically analyze the existing evidence on the fecal and mucosa-associated microbiota composition and functionality across different stages of diverticular disease. We also explore the influence of risk factors for diverticulosis on gut microbiota composition, and speculate on the possible relevance of these associations for the pathogenesis of diverticula. We overview the current treatments of diverticular disease targeting the intestinal microbiome, highlighting the current areas of uncertainty and the need for future studies. Although no conclusive remarks on the relationship between microbiota and diverticular disease can be made, preliminary data suggest that abdominal symptoms are associated with reduced representation of taxa with a possible anti-inflammatory effect, such as Clostridium cluster IV, and overgrowth of Enterobacteriaceae, Bifidobacteria and Akkermansia. The role of the microbiota in the early stages of the disease is still very uncertain. Future studies should help to disentangle the role of the microbiome in the pathogenesis of diverticular disease and its progression towards more severe forms.
Andrea Ticinesi; Antonio Nouvenne; Vincenzo Corrente; Claudio Tana; Francesco Di Mario; Tiziana Meschi. Diverticular Disease: a Gut Microbiota Perspective. Journal of Gastrointestinal and Liver Diseases 2019, 28, 327 -337.
AMA StyleAndrea Ticinesi, Antonio Nouvenne, Vincenzo Corrente, Claudio Tana, Francesco Di Mario, Tiziana Meschi. Diverticular Disease: a Gut Microbiota Perspective. Journal of Gastrointestinal and Liver Diseases. 2019; 28 (3):327-337.
Chicago/Turabian StyleAndrea Ticinesi; Antonio Nouvenne; Vincenzo Corrente; Claudio Tana; Francesco Di Mario; Tiziana Meschi. 2019. "Diverticular Disease: a Gut Microbiota Perspective." Journal of Gastrointestinal and Liver Diseases 28, no. 3: 327-337.
New evidence suggests that non-alcoholic fatty liver disease (NAFLD) has a strong multifaceted relationship with diabetes and metabolic syndrome, and is associated with increased risk of cardiovascular events, regardless of traditional risk factors, such as hypertension, diabetes, dyslipidemia, and obesity. Given the pandemic-level rise of NAFLD—in parallel with the increasing prevalence of obesity and other components of the metabolic syndrome—and its association with poor cardiovascular outcomes, the question of how to manage NAFLD properly, in order to reduce the burden of associated incident cardiovascular events, is both timely and highly relevant. This review aims to summarize the current knowledge of the association between NAFLD and cardiovascular disease, and also to discuss possible clinical strategies for cardiovascular risk assessment, as well as the spectrum of available therapeutic strategies for the prevention and treatment of NAFLD and its downstream events.
Claudio Tana; Stefano Ballestri; Fabrizio Ricci; Angelo Di Vincenzo; Andrea Ticinesi; Sabina Gallina; Maria Adele Giamberardino; Francesco Cipollone; Richard Sutton; Roberto Vettor; Artur Fedorowski; Tiziana Meschi. Cardiovascular Risk in Non-Alcoholic Fatty Liver Disease: Mechanisms and Therapeutic Implications. International Journal of Environmental Research and Public Health 2019, 16, 3104 .
AMA StyleClaudio Tana, Stefano Ballestri, Fabrizio Ricci, Angelo Di Vincenzo, Andrea Ticinesi, Sabina Gallina, Maria Adele Giamberardino, Francesco Cipollone, Richard Sutton, Roberto Vettor, Artur Fedorowski, Tiziana Meschi. Cardiovascular Risk in Non-Alcoholic Fatty Liver Disease: Mechanisms and Therapeutic Implications. International Journal of Environmental Research and Public Health. 2019; 16 (17):3104.
Chicago/Turabian StyleClaudio Tana; Stefano Ballestri; Fabrizio Ricci; Angelo Di Vincenzo; Andrea Ticinesi; Sabina Gallina; Maria Adele Giamberardino; Francesco Cipollone; Richard Sutton; Roberto Vettor; Artur Fedorowski; Tiziana Meschi. 2019. "Cardiovascular Risk in Non-Alcoholic Fatty Liver Disease: Mechanisms and Therapeutic Implications." International Journal of Environmental Research and Public Health 16, no. 17: 3104.
Human gut microbiota is able to influence the host physiology by regulating multiple processes, including nutrient absorption, inflammation, oxidative stress, immune function, and anabolic balance. Aging is associated with reduced microbiota biodiversity, increased inter-individual variability, and over-representation of pathobionts, and these phenomena may have great relevance for skeletal muscle mass and function. For this reason, the presence of a gut-muscle axis regulating the onset and progression of age-related physical frailty and sarcopenia has been recently hypothesized. In this narrative review, we summarize the studies supporting a possible association between gut microbiota-related parameters with measures of muscle mass, muscle function, and physical performance in animal models and humans. Reduced muscle mass has been associated with distinct microbiota composition and reduced fermentative capacity in mice, and the administration of probiotics or butyrate to mouse models of muscle wasting has been associated with improved muscle mass. However, no studies have targeted the human microbiome associated with sarcopenia. Limited evidence from human studies shows an association between microbiota composition, involving key taxa such as Faecalibacterium and Bifidobacterium, and grip strength. Similarly, few studies conducted on patients with parkinsonism showed a trend towards a different microbiota composition in those with reduced gait speed. No studies have assessed the association of fecal microbiota with other measures of physical performance. However, several studies, mainly with a cross-sectional design, suggest an association between microbiota composition and frailty, mostly assessed according to the deficit accumulation model. Namely, frailty was associated with reduced microbiota biodiversity, and lower representation of butyrate-producing bacteria. Therefore, we conclude that the causal link between microbiota and physical fitness is still uncertain due to the lack of targeted studies and the influence of a large number of covariates, including diet, exercise, multimorbidity, and polypharmacy, on both microbiota composition and physical function in older age. However, the relationship between gut microbiota and physical function remains a very promising area of research for the future.
Andrea Ticinesi; Antonio Nouvenne; Nicoletta Cerundolo; Pamela Catania; Beatrice Prati; Claudio Tana; Tiziana Meschi. Gut Microbiota, Muscle Mass and Function in Aging: A Focus on Physical Frailty and Sarcopenia. Nutrients 2019, 11, 1633 .
AMA StyleAndrea Ticinesi, Antonio Nouvenne, Nicoletta Cerundolo, Pamela Catania, Beatrice Prati, Claudio Tana, Tiziana Meschi. Gut Microbiota, Muscle Mass and Function in Aging: A Focus on Physical Frailty and Sarcopenia. Nutrients. 2019; 11 (7):1633.
Chicago/Turabian StyleAndrea Ticinesi; Antonio Nouvenne; Nicoletta Cerundolo; Pamela Catania; Beatrice Prati; Claudio Tana; Tiziana Meschi. 2019. "Gut Microbiota, Muscle Mass and Function in Aging: A Focus on Physical Frailty and Sarcopenia." Nutrients 11, no. 7: 1633.
Since it has been recognized that sarcoidosis (SA) is not an exclusive disorder of the lungs but can also affect other organs such as the liver and spleen, efforts have been made to define specific imaging criteria for the diagnosis of the single organ involvement, and the concept has been reinforced that the exclusion of alternative causes is important to achieve the correct diagnosis. Ultrasound (US) is a useful tool to evaluate patients with suspected abdominal SA, such as of the liver, spleen, kidney, pancreas and other organs, showing findings such as organomegaly, focal lesions and lymphadenopathy. While the diagnosis of abdominal SA is more predictable in the case of involvement of other organs (e.g., lungs), the problem is more complex in the case of isolated abdominal SA. The recent use of contrast-enhanced ultrasound and endoscopic ultrasound elastography has provided additional information about the enhancement patterns and tissue rigidity in abdominal SA. Here we critically review the role of US in abdominal SA, reporting typical findings and limitations of current evidence and by discussing future perspectives of study.
Claudio Tana; Cosima Schiavone; Andrea Ticinesi; Fabrizio Ricci; Maria Adele Giamberardino; Francesco Cipollone; Mauro Silingardi; Tiziana Meschi; Christoph F Dietrich. Ultrasound imaging of abdominal sarcoidosis: State of the art. World Journal of Clinical Cases 2019, 7, 809 -818.
AMA StyleClaudio Tana, Cosima Schiavone, Andrea Ticinesi, Fabrizio Ricci, Maria Adele Giamberardino, Francesco Cipollone, Mauro Silingardi, Tiziana Meschi, Christoph F Dietrich. Ultrasound imaging of abdominal sarcoidosis: State of the art. World Journal of Clinical Cases. 2019; 7 (7):809-818.
Chicago/Turabian StyleClaudio Tana; Cosima Schiavone; Andrea Ticinesi; Fabrizio Ricci; Maria Adele Giamberardino; Francesco Cipollone; Mauro Silingardi; Tiziana Meschi; Christoph F Dietrich. 2019. "Ultrasound imaging of abdominal sarcoidosis: State of the art." World Journal of Clinical Cases 7, no. 7: 809-818.
The assistance to older community-dwellers provided by family caregivers is crucial for the maintenance of an acceptable quality of life, especially when dementia is present. The caregiver burden may be extremely high, but few data are available on what patient domains mainly affect the caregiver. The aim of this cross-sectional study, performed in older outpatients, was to examine the impact of cognitive, physical and nutritional status of elderly community-dwellers on the caregiver burden, as evaluated by the Caregiver Burden Inventory (CBI). A group of 406 elderly outpatients (161 M, 245 F, mean age of 83.20 ± 6.40) was enrolled. A significant correlation was observed between Mini Nutritional Assessment Instrument-Short Form (MNA-SF) and CBI (r = −0.34; p < 0.001), suggesting that a poor nutritional status is significantly associated with the caregiver burden. There was also a significant correlation between CBI and Short Physical Performance Battery score (r = −0.29; p < 0.001), hand grip strength (r = −0.25; p < 0.001), Mini-Mental State Examination score (r = −0.39; p < 0.001), Geriatric Depression Scale (r = 0.23; p < 0.001), Body Mass Index (BMI) (r = 0.01; p = 0.03), Activities of Daily Living and Instrumental Activities of Daily Living (ADL/IADL) (r = −0.61 and −0.62, respectively; p < 0.001), and with the 4-m walking speed (r = −0.42; p < 0.001). In the multivariate analysis, only the relationships of the CBI (in particular the physical subcomponent) with ADL, IADL and MNA-SF remained statistically significant (β ± SE −0.89 ± 0.20, p < 0.001; −0.58 ± 0.15, p < 0.001 and −0.25 ± 0.11, p = 0.02, respectively). The relationship between CBI and BMI remained statistically significant only for the physical subcomponent (β ± SE 0.14 ± 0.05; p = 0.006). Thus, in this study, we confirmed that the impairment in the activities of daily living is associated with a significant impact on the caregiver burden, and we found also that a poor nutritional status of the older outpatient is independently more associated with the caregiver burden than cognitive and physical disability. The combined evaluation of both patients and caregivers can improve the knowledge and assistance to the elderly subjects.
Claudio Tana; Fulvio Lauretani; Andrea Ticinesi; Luciano Gionti; Antonio Nouvenne; Beatrice Prati; Tiziana Meschi; Marcello Maggio. Impact of Nutritional Status on Caregiver Burden of Elderly Outpatients. A Cross-Sectional Study. Nutrients 2019, 11, 281 .
AMA StyleClaudio Tana, Fulvio Lauretani, Andrea Ticinesi, Luciano Gionti, Antonio Nouvenne, Beatrice Prati, Tiziana Meschi, Marcello Maggio. Impact of Nutritional Status on Caregiver Burden of Elderly Outpatients. A Cross-Sectional Study. Nutrients. 2019; 11 (2):281.
Chicago/Turabian StyleClaudio Tana; Fulvio Lauretani; Andrea Ticinesi; Luciano Gionti; Antonio Nouvenne; Beatrice Prati; Tiziana Meschi; Marcello Maggio. 2019. "Impact of Nutritional Status on Caregiver Burden of Elderly Outpatients. A Cross-Sectional Study." Nutrients 11, no. 2: 281.
Carlo De Innocentiis; Fabrizio Ricci; Mohammed Y. Khanji; Nay Aung; Claudio Tana; Elvira Verrengia; Steffen E. Petersen; Sabina Gallina. Authors’ Reply to Kindermann et al.’s Comment on: “Athlete’s Heart: Diagnostic Challenges and Future Perspectives”. Sports Medicine 2019, 49, 495 -496.
AMA StyleCarlo De Innocentiis, Fabrizio Ricci, Mohammed Y. Khanji, Nay Aung, Claudio Tana, Elvira Verrengia, Steffen E. Petersen, Sabina Gallina. Authors’ Reply to Kindermann et al.’s Comment on: “Athlete’s Heart: Diagnostic Challenges and Future Perspectives”. Sports Medicine. 2019; 49 (3):495-496.
Chicago/Turabian StyleCarlo De Innocentiis; Fabrizio Ricci; Mohammed Y. Khanji; Nay Aung; Claudio Tana; Elvira Verrengia; Steffen E. Petersen; Sabina Gallina. 2019. "Authors’ Reply to Kindermann et al.’s Comment on: “Athlete’s Heart: Diagnostic Challenges and Future Perspectives”." Sports Medicine 49, no. 3: 495-496.
This article summarizes the advances of research on the role of the intestinal microbiota in influencing sarcopenia, frailty, and cognitive dysfunction in older individuals, and thus its relevance for healthy active ageing. Age-related alterations of intestinal microbiota composition may negatively influence muscle protein synthesis and function by promoting chronic systemic inflammation, insulin resistance, oxidative stress, and reducing nutrient bioavailability. However, this ‘gut-muscle axis’ hypothesis is not supported by human data to date. Some observational studies have instead demonstrated that, in older individuals, frailty and Alzheimer-type dementia are associated with fecal microbiota dysbiosis, that is, reduced biodiversity and overexpression of pathobionts. The main possible mechanisms of the ‘gut-brain axis’ in cognitive function modulation include effects on neurotransmission, neuroinflammation, and amyloid deposition. Conversely, longevity in good health may be associated with the maintenance of a fecal microbiota composition similar to that of healthy young adults. However, the role of gut microbiota as an independent modulator of frailty and cognition still remains uncertain, being influenced by several physiological factors, including diet and exercise. The intestinal microbiome composition represents a possible determinant of functional performance in older people, and a promising target for antiaging therapeutic interventions.
Andrea Ticinesi; Claudio Tana; Antonio Nouvenne. The intestinal microbiome and its relevance for functionality in older persons. Current Opinion in Clinical Nutrition & Metabolic Care 2019, 22, 4 -12.
AMA StyleAndrea Ticinesi, Claudio Tana, Antonio Nouvenne. The intestinal microbiome and its relevance for functionality in older persons. Current Opinion in Clinical Nutrition & Metabolic Care. 2019; 22 (1):4-12.
Chicago/Turabian StyleAndrea Ticinesi; Claudio Tana; Antonio Nouvenne. 2019. "The intestinal microbiome and its relevance for functionality in older persons." Current Opinion in Clinical Nutrition & Metabolic Care 22, no. 1: 4-12.
Background: Sarcoidosis is a multisystem granulomatous disease with a neglected but high prevalence of life-threatening cardiac involvement. Discussion: The clinical presentation of Cardiac Sarcoidosis (CS) depends upon the location and extent of the granulomatous inflammation, with left ventricular free wall the most common location followed by interventricular septum. The lack of a diagnostic gold standard and the unpredictable risk of sudden cardiac death pose serious challenges for the validation of accurate and effective screening test and the management of the disease. In the last few years advanced cardiac imaging modalities such as Cardiac Magnetic Resonance (CMR) and Positron Emission Tomography (PET) have significantly improved our knowledge and understanding of CS, and have also contributed in risk stratification, assessment of inflammatory activity and therapeutic monitoring of the disease. Conclusion: In this review, we will discuss the state of the art in the diagnosis of CS focusing on the role and importance of multi-modality cardiac imaging.
Fabrizio Ricci; Cesare Mantini; Chrysanthos Grigoratos; Francesco Bianco; Valentina Bucciarelli; Claudio Tana; Domenico Mastrodicasa; Massimo Caulo; Giovanni Donato Aquaro; Antonio Raffaele Cotroneo; Sabina Gallina. The Multi-modality Cardiac Imaging Approach to Cardiac Sarcoidosis. Current Medical Imaging Formerly Current Medical Imaging Reviews 2018, 15, 10 -20.
AMA StyleFabrizio Ricci, Cesare Mantini, Chrysanthos Grigoratos, Francesco Bianco, Valentina Bucciarelli, Claudio Tana, Domenico Mastrodicasa, Massimo Caulo, Giovanni Donato Aquaro, Antonio Raffaele Cotroneo, Sabina Gallina. The Multi-modality Cardiac Imaging Approach to Cardiac Sarcoidosis. Current Medical Imaging Formerly Current Medical Imaging Reviews. 2018; 15 (1):10-20.
Chicago/Turabian StyleFabrizio Ricci; Cesare Mantini; Chrysanthos Grigoratos; Francesco Bianco; Valentina Bucciarelli; Claudio Tana; Domenico Mastrodicasa; Massimo Caulo; Giovanni Donato Aquaro; Antonio Raffaele Cotroneo; Sabina Gallina. 2018. "The Multi-modality Cardiac Imaging Approach to Cardiac Sarcoidosis." Current Medical Imaging Formerly Current Medical Imaging Reviews 15, no. 1: 10-20.
Lung lesions often appear in patients with sarcoidosis; however, miliary opacities are rare. We present the case of a 55-year-old Indian man who presented with dyspnea and low-grade fever. Miliary Tuberculosis (TB) was initially suspected, despite the direct microscopic examination from bronchoalveolar lavage was negative for acid-fast bacilli because imaging showed miliary opacities, and transbronchial lung biopsy revealed the presence of typical caseating granulomas. Antitubercular treatment with the classic four-drug regimen was initiated. However, the patient did not improve and cultures were negative for Mycobacterium growth. The diagnosis of sarcoidosis was made only after a negative culture and clinical and histopathological re-evaluation of the case. Although miliary sarcoidosis is rare, physicians should consider sarcoidosis in the differential diagnosis with conditions like tuberculosis, malignancy, and pneumoconiosis when patients present with miliary opacities who do not respond to the traditional treatment.
Omar Arar; Fabrizio Boni; Tiziana Meschi; Claudio Tana. Pulmonary Sarcoidosis Presenting with Miliary Opacities. Current Medical Imaging Formerly Current Medical Imaging Reviews 2018, 15, 81 -83.
AMA StyleOmar Arar, Fabrizio Boni, Tiziana Meschi, Claudio Tana. Pulmonary Sarcoidosis Presenting with Miliary Opacities. Current Medical Imaging Formerly Current Medical Imaging Reviews. 2018; 15 (1):81-83.
Chicago/Turabian StyleOmar Arar; Fabrizio Boni; Tiziana Meschi; Claudio Tana. 2018. "Pulmonary Sarcoidosis Presenting with Miliary Opacities." Current Medical Imaging Formerly Current Medical Imaging Reviews 15, no. 1: 81-83.
The capacity of Short-Physical Performance Battery (SPPB) test to discriminate between fallers and non-fallers is controversial, and has never been compared with fall risk assessment-specific tools, such as Performance-Oriented Mobility Assessment (POMA). To verify the association of SPPB and POMA scores with falls in older outpatients. 451 older subjects (150 males, mean age 82.1 ± 6.8) evaluated in a geriatric outpatient clinic for suspected frailty were enrolled in this cross-sectional study. Self-reported history of falls and medication history were carefully assessed. Each participant underwent comprehensive geriatric assessment, including SPPB, POMA, Geriatric Depression Scale (GDS), mini-mental state examination (MMSE) and mini-nutritional assessment-short form (MNA-SF). Multivariate logistic regression and receiver-operating characteristic (ROC) analyses were performed to determine the factors associated with the status of faller. 245 (54.3%) subjects were identified as fallers. They were older and had lower SPPB and POMA test scores than non-fallers. At ROC analysis, SPPB (AUC 0.676, 95% CI 0.627–0.728, p < 0.001) and POMA (AUC 0.677, 95% CI 0.627–0.726, p < 0.001) scores were both associated with falls. At multivariate logistic regression models, SPPB total score (OR 0.83, 95% CI 0.76–0.92, p < 0.001), POMA total score (OR 0.94, 95% CI 0.91–0.98, p = 0.002) and SPPB balance score alteration (OR 2.88, 95% CI 1.42–5.85, p = 0.004), but not POMA balance subscale score alteration, were independently associated with recorded falls, as also GDS, MMSE and MNA-SF scores. SPPB total score was independently associated with reported falls in older outpatients, resulting non-inferior to POMA scale. The use of SPPB for fall risk assessment should be implemented.
Fulvio Lauretani; Andrea Ticinesi; Luciano Gionti; Beatrice Prati; Antonio Nouvenne; Claudio Tana; Tiziana Meschi; Marcello Maggio. Short-Physical Performance Battery (SPPB) score is associated with falls in older outpatients. Aging Clinical and Experimental Research 2018, 31, 1435 -1442.
AMA StyleFulvio Lauretani, Andrea Ticinesi, Luciano Gionti, Beatrice Prati, Antonio Nouvenne, Claudio Tana, Tiziana Meschi, Marcello Maggio. Short-Physical Performance Battery (SPPB) score is associated with falls in older outpatients. Aging Clinical and Experimental Research. 2018; 31 (10):1435-1442.
Chicago/Turabian StyleFulvio Lauretani; Andrea Ticinesi; Luciano Gionti; Beatrice Prati; Antonio Nouvenne; Claudio Tana; Tiziana Meschi; Marcello Maggio. 2018. "Short-Physical Performance Battery (SPPB) score is associated with falls in older outpatients." Aging Clinical and Experimental Research 31, no. 10: 1435-1442.
In migraine patients with cervical myofascial trigger points whose target areas coincide with migraine sites (M + cTrPs), TrP anesthetic injection reduces migraine symptoms, but the procedure often causes discomfort. This study evaluated if a topical TrP treatment with 3% nimesulide gel has similar efficacy as the injection but produces lesser discomfort with higher acceptability by the patients. Retrospective analysis of medical charts of M + cTrPs patients in the period January 2012-December 2016 at a single Headache Center. Three groups of 25 patients each were included, all receiving migraine prophylaxis (flunarizine 5 mg/day) for 3 months and symptomatic treatment on demand. Group 1 received no TrP treatment, group 2 received TrP injections (bupivacaine 5 mg/ml at basis, 3rd, 10th, 30th and 60th day), group 3 received daily TrP topical treatment with 1.5 g of 3% nimesulide gel for 15 consecutive days, 15 days interruption and again 15 consecutive days. The following were evaluated: monthly number of migraine attacks and rescue medications, migraine intensity; pain thresholds to skin electrical stimulation (EPTs) and muscle pressure stimulation (PPTs) in TrP and target (basis, 30th, 60th and 180th days); discomfort from, acceptability of and willingness to repeat treatment (end of study). ANOVA for repeated measures and 1-way ANOVA were used to assess temporal trends in each group and comparisons among groups, respectively. Significance level was set at p < 0.05. Migraine improved over time in all groups, but significantly more and earlier in those receiving TrP treatment vs no TrP treatment (0.02 < p < 0.0001, 30-180 days for intensity and rescue medication, 60-180 days for number). All thresholds in the non-TrP-treated group did not change over time, while significantly improving in both the injection and nimesulide gel groups (0.01 < p < 0.0001, 30-180 days). Improvement of migraine and thresholds did not differ in the two TrP-treated groups. Discomfort was significantly lower, acceptability and willingness to repeat treatment significantly higher (0.05 < p < 0.0001) with gel than injection. In migraine patients, topical treatment of cervical TrPs with 5% nimesulide gel proves equally effective as TrP injection with local anesthetics but more acceptable by the patients. This treatment could be effectively associated to standard migraine prophylaxis to improve therapeutic outcomes.
Giannapia Affaitati; Raffaele Costantini; Claudio Tana; Domenico Lapenna; Cosima Schiavone; Francesco Cipollone; Maria Adele Giamberardino. Effects of topical vs injection treatment of cervical myofascial trigger points on headache symptoms in migraine patients: a retrospective analysis. The Journal of Headache and Pain 2018, 19, 104 -10.
AMA StyleGiannapia Affaitati, Raffaele Costantini, Claudio Tana, Domenico Lapenna, Cosima Schiavone, Francesco Cipollone, Maria Adele Giamberardino. Effects of topical vs injection treatment of cervical myofascial trigger points on headache symptoms in migraine patients: a retrospective analysis. The Journal of Headache and Pain. 2018; 19 (1):104-10.
Chicago/Turabian StyleGiannapia Affaitati; Raffaele Costantini; Claudio Tana; Domenico Lapenna; Cosima Schiavone; Francesco Cipollone; Maria Adele Giamberardino. 2018. "Effects of topical vs injection treatment of cervical myofascial trigger points on headache symptoms in migraine patients: a retrospective analysis." The Journal of Headache and Pain 19, no. 1: 104-10.
Distinguishing between adaptive and maladaptive cardiovascular response to exercise is crucial to prevent the unnecessary termination of an athlete’s career and to minimize the risk of sudden death. This is a challenging task essentially due to the substantial phenotypic overlap between electrical and structural changes seen in the physiological athletic heart remodeling and pathological changes seen in inherited or acquired cardiomyopathies. Stress testing is an ideal tool to discriminate normal from abnormal cardiovascular response by unmasking subtle pathologic responses otherwise undetectable at rest. Treadmill or bicycle electrocardiography, transthoracic echocardiography, and cardiopulmonary exercise testing are common clinical investigations used in sports cardiology, specifically among participants presenting with resting electrocardiographic abnormalities, frequent premature ventricular beats, or non-sustained ventricular arrhythmias. In this setting, as well as in cases of left ventricular hypertrophy or asymptomatic left ventricular dysfunction, stress imaging and myocardial tissue characterization by cardiovascular magnetic resonance show promise. In this review, we aimed to reappraise current diagnostic schemes, screening strategies and novel approaches that may be used to distinguish adaptive remodeling patterns to physical exercise from early phenotypes of inherited or acquired pathological conditions commanding prompt intervention.
Carlo De Innocentiis; Fabrizio Ricci; Mohammed Y. Khanji; Nay Aung; Claudio Tana; Elvira Verrengia; Steffen E. Petersen; Sabina Gallina. Athlete’s Heart: Diagnostic Challenges and Future Perspectives. Sports Medicine 2018, 48, 2463 -2477.
AMA StyleCarlo De Innocentiis, Fabrizio Ricci, Mohammed Y. Khanji, Nay Aung, Claudio Tana, Elvira Verrengia, Steffen E. Petersen, Sabina Gallina. Athlete’s Heart: Diagnostic Challenges and Future Perspectives. Sports Medicine. 2018; 48 (11):2463-2477.
Chicago/Turabian StyleCarlo De Innocentiis; Fabrizio Ricci; Mohammed Y. Khanji; Nay Aung; Claudio Tana; Elvira Verrengia; Steffen E. Petersen; Sabina Gallina. 2018. "Athlete’s Heart: Diagnostic Challenges and Future Perspectives." Sports Medicine 48, no. 11: 2463-2477.