Latin America and the Caribbean (LAC) is the world’s largest net exporter of agricultural products and a region marked by persistent rural poverty, inequality, and climate vulnerability, making its agrifood systems central to global food security. Sustainability functions as a structural, cross-cutting determinant of food security, shaping availability, access, utilization, and stability through the environmental, economic, and social conditions under which agrifood systems operate. Drawing on three coordinated scoping reviews covering 226 peer-reviewed and grey literature studies across 15 countries, Avanzar2030 examines how public policy, livestock technology, and climate-related institutional mechanisms interact to shape outcomes for productivity, equity, and sustainability — the mechanisms through which food security is determined in the region. The evidence identifies three recurring constraints on transformation: fragmented governance and policy coherence, weak delivery and implementation capacity, and structural inequalities in producers’ access to resources, services, and markets. Interventions that address these constraints together —bundling economic, environmental, and social objectives, embedding programs in coherent institutional arrangements, and centering inclusion— consistently outperform siloed efforts. As a global testing ground for agrifood innovation, LAC's experience offers lessons for advancing food security in other regions confronting similar structural trade-offs between short-term economic gains and long-term resilience. For policymakers and donors, durable food security outcomes depend on treating sustainability as integral to, rather than in tension with, agrifood transformation, and on building the governance, delivery, and equity foundations needed to sustain it at scale in the region.