Oleg M. Demchuk

Prof. Oleg M. Demchuk

Pharmaceutical Research Institute, Lublin, Lublin District, Poland
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orcid

Research Focus & Metrics

Academic Career Length

29Years (1998-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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30 October 2019 in Frontiers in Chemistry
Verified
Journal Article
Open access
PDF file
GGGrzegorz Grynkiewicz
Grzegorz Grynkiewicz
Oleg M. DemchukOleg M. Demchuk
Oleg M. Demchuk
Fisetin is a flavonol that shares distinct antioxidant properties with a plethora of other plant polyphenols. Additionally, it exhibits a specific biological activity of considerable interest as regards the protection of functional macromolecules against stress which results in the sustenance of normal cells cytoprotection. Moreover, it shows potential as an anti-inflammatory, chemopreventive, chemotherapeutic and recently also senotherapeutic agent. In view of its prospective applications in healthcare and likely demand for fisetin, methods for its preparation and their suitability for pharmaceutical use are discussed herein.

1 May 2018 in Ultrasonics Sonochemistry
Verified
Journal Article
Open access
Ali MalekiAli Maleki
Ali Maleki
JRJamal Rahimi
Jamal Rahimi
Oleg M. DemchukOleg M. Demchuk
Oleg M. Demchuk
Agnieszka WilczewskaAgnieszka Wilczewska
Agnieszka Wilczewska
Radomir JasinskiRadomir Jasinski
Radomir Jasinski
A green approach for the one-pot four-component sonochemical synthesis of 5-methyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylic esters from the reaction of 2-cyano-guanidine, sodium azide, various aromatic aldehydes and methyl or ethyl acetoacetate in the presence of a catalytic amount of Fe2O3@SiO2-(CH2)3NHC(O)(CH2)2PPh2 as a new hybrid organic-inorganic core-shell nanomagnetic catalyst is described. This is the first design, preparation, characterization and application of the present nanomaterial and also the first ultrasound irradiated synthesis of the biologically and pharmaceutically important heterocyclic compounds in water as a green solvent. This novel sonocatalysis/nanocatalysis protocol offers several advantages such as high yields, short reaction times, environmentally-friendly reaction media, easily isolation of the products, simple preparation, full characterization and recoverability of the nanocatalyst by an external magnet and reusing several times without significant loss of activity.

1 November 2016 in European Journal of Medicinal Chemistry
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Journal Article
Closed access
MJMonika Janeczko
Monika Janeczko
Oleg M. DemchukOleg M. Demchuk
Oleg M. Demchuk
DSDorota Strzelecka
Dorota Strzelecka
KKKonrad Kubiński
Konrad Kubiński
MMMaciej Masłyk
Maciej Masłyk

7 August 2003 in Organic Letters
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Journal Article
Closed access
Oleg M. DemchukOleg M. Demchuk
Oleg M. Demchuk
KPK. Michał Pietrusiewicz
K. Michał Pietrusiewicz
AMAnna Michrowska
Anna Michrowska
KGKarol Grela
Karol Grela

30 August 2004 in European Journal of Organic Chemistry
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Journal Article
Closed access
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ZPZbigniew Pakulski
Zbigniew Pakulski
Oleg M. DemchukOleg M. Demchuk
Oleg M. Demchuk
JFJadwiga Frelek
Jadwiga Frelek
RLRoman Luboradzki
Roman Luboradzki
KPK. Michał Pietrusiewicz
K. Michał Pietrusiewicz

5 May 2006 in Advanced Synthesis & Catalysis
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Journal Article
Closed access
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NVNikolai Vinokurov
Nikolai Vinokurov
AMAnna Michrowska
Anna Michrowska
ASAnna Szmigielska
Anna Szmigielska
ZDZbigniew Drzazga
Zbigniew Drzazga
GWGrzegorz Wójciuk
Grzegorz Wójciuk
PBProf. Dr. Holger Butenschön
Prof. Dr. Holger Butenschön