Since the 1970s, a great deal of attention has been paid to the development of semiconductor-based biosensors because of the numerous advantages they offer, including high sensitivity, faster response time, miniaturization, and low-cost manufacturing for quick biospecific analysis with reusable features. Commercial biosensors have become highly desirable in the fields of medicine, food, and environmental monitoring as well as military applications, whereas increasing concerns about food safety and health issues have resulted in the introduction of novel legislative standards for these sensors. Numerous devices have been developed for monitoring biological processes such as nucleic acid hybridization, protein–protein interaction, antigen–antibody bonds, and substrate–enzyme reactions, just to name a few. Since the 1980s, scientific interest moved to the development of semiconductor-based devices, which also include integrated front-end electronics, such as the extended-gate field-effect transistor (EGFET) biosensor, one of the first miniaturized chemical sensors. This work is intended to be a review of the state of the art focused on the development of biosensors and chemosensors based on extended-gate field-effect transistor within the field of bioanalytical applications, which will highlight the most recent research reported in the literature. Moreover, a comparison among the diverse EGFET devices will be presented, giving particular attention to the materials and technologies.

Wearable technologies have established novel strategies for continuous electrocardiogram (ECG) monitoring, exploiting recent developments in sensors and integrated circuit technology. Advances in dry electrodes fabrication improved the growth of wearable devices. Herein, we present an on-chip integrated ECG signal acquisition system along with dry electrodes for wearable and long-term monitoring. Custom electrodes are fabricated using multi-walled carbon nanotube (MWCNT) and Polydimethylsiloxane (PDMS) composite on a flexible substrate. A1.5 μW fully-differential operational transconductance amplifier (OTA) with a capacitive-resistive feedback network is designed in 130 nm CMOS process achieving a mid-band gain of 43.09 dB and an input-referred noise of 2.81 μVrms in the range from 0.175 Hz to 1.636 kHz. Reconfigurability of the lower cut-off frequency is achieved by controlling the bias voltage of the triple-well nMOS transistors acting as the feedback pseudoresistor. Electrodes with different surface area and MWCNT concentrations were investigated in a real-time ECG measurement scenario. The recorded signals achieve a high signal-to-noise ratio which spans from 35.7 dB to 38.6 dB with the increasing MWCNT concentration. Experimental results demonstrate that the proposed system allows for high performance and low-power ECG signal recording for the long-term and wearable applications.

Polyvinylidene fluoride (PVDF), a material with ferroelectric characteristics, is still extremely topical for the manufacturing of transducers, and different examples, some of which were actively commercialized since the ‘80s, are reported in literature. In this work we present a review focused on the PVDF technology for the manufacturing of in-air ultrasonic transducers, which found application in medical robotics, sonar systems and automation industry (e.g. proximity sensors, obstacle detection). The aim is to provide a comprehensive view on the development of such ultrasonic transducers, highlighting the constructive choices and the advantages/disadvantages in a thorough and concise way.