The structure, time-dependent mechanical deformation, and strength characteristics of loess, which is loose and porous with well-developed vertical joints, are greatly affected by the dry-wet cycles, which are attributed to periodic artificial irrigation, rainfall, and water evaporation. To better understand the creep characteristics of loess under the effect of dry-wet cycles, Q₂ loess samples obtained from the South Jingyang County, China, were subjected to different dry-wet cycles (0, 5, 10, 15, 20) and sheared in triaxial creep tests. The experimental results revealed that: firstly, the maximum value of the deviatoric stress corresponding to creep failure gradually decreases with an increase in the dry-wet cycles. Secondly, the long-term strength of the loess after dry-wet cycles were obtained through the Isochronous Curve Method. It is found that the long-term strength and the number of dry-wet cycles showed an exponential decreasing relationship. In addition, the creep damage mechanism of loess due to dry-wet cycles is proposed. This study may provide the basis for understanding the mechanical behavior of the loess under the effect of dry-wet cycles, as well as guidelines for the prevention and prediction of loess landslide stability.