A dual-output voltage reference circuit with two reference voltages of 281 mV (Vref1) and 320.5 mV (Vref2) is presented in this paper. With a novel and precise circuit structure, the proposed circuit, operating in the subthreshold region, integrates two different output voltages into a circuit to form a dual-output voltage reference, and cascode current mirrors are used to enhance the power supply rejection ratio (PSRR). The proposed circuit was designed in a standard 0.18-µm CMOS process and has a series of attractive features: low-temperature coefficient (TC), high-PSRR, low-Line sensitivity (LS), small-chip area and low-power consumption. Monte Carlo simulations for 2000 samples showed that the output voltages 281 mV and 320.5 mV had a variation coefficient of 1.73% and 1.44%, respectively. The minimum power consumption was 84.1 nW at 0.9 V supply, proving that the circuit is suitable for portable biomedical application. The active area of the proposed voltage reference was only 0.0086 mm².