In this paper, we first describe the basics of the field of cancer diagnosis, which includes steps of cancer diagnosis followed by the typical classification methods used by doctors, providing a historical idea of cancer classification techniques to the readers. These methods include Asymmetry, Border, Color and Diameter (ABCD) method, seven-point detection method, Menzies method, and pattern analysis. They are used regularly by doctors for cancer diagnosis, although they are not considered very efficient for obtaining better performance. Moreover, considering all types of audience, the basic evaluation criteria are also discussed. The criteria include the receiver operating characteristic curve (ROC curve), Area under the ROC curve (AUC), F1 score, accuracy, specificity, sensitivity, precision, dice-coefficient, average accuracy, and Jaccard index. Previously used methods are considered inefficient, asking for better and smarter methods for cancer diagnosis. Artificial intelligence and cancer diagnosis are gaining attention as a way to define better diagnostic tools. In particular, deep neural networks can be successfully used for intelligent image analysis. The basic framework of how this machine learning works on medical imaging is provided in this study, i.e., pre-processing, image segmentation and post-processing. The second part of this manuscript describes the different deep learning techniques, such as convolutional neural networks (CNNs), generative adversarial models (GANs), deep autoencoders (DANs), restricted Boltzmann’s machine (RBM), stacked autoencoders (SAE), convolutional autoencoders (CAE), recurrent neural networks (RNNs), long short-term memory (LTSM), multi-scale convolutional neural network (M-CNN), multi-instance learning convolutional neural network (MIL-CNN). For each technique, we provide Python codes, to allow interested readers to experiment with the cited algorithms on their own diagnostic problems. The third part of this manuscript compiles the successfully applied deep learning models for different types of cancers. Considering the length of the manuscript, we restrict ourselves to the discussion of breast cancer, lung cancer, brain cancer, and skin cancer. The purpose of this bibliographic review is to provide researchers opting to work in implementing deep learning and artificial neural networks for cancer diagnosis a knowledge from scratch of the state-of-the-art achievements.

Machine learning (ML) is an interdisciplinary sector in the subset of artificial intelligence (AI) that creates systems to set up logical connections using algorithms, and thus offers predictions for complex data analysis. In the present review, an up-to-date summary of the current state of the art regarding ML and AI implementation for thyroid nodule ultrasound characterization and cancer is provided, highlighting controversies over AI application as well as possible benefits of ML, such as, for example, training purposes. There is evidence that AI increases diagnostic accuracy and significantly limits inter-observer variability by using standardized mathematical algorithms. It could also be of aid in practice settings with limited sub-specialty expertise, offering a second opinion by means of radiomics and computer-assisted diagnosis. The introduction of AI represents a revolutionary event in thyroid nodule evaluation, but key issues for further implementation include integration with radiologist expertise, impact on workflow and efficiency, and performance monitoring.

Medical images play an important role in medical diagnosis and treatment. Oncologists analyze images to determine the different characteristics of deadly diseases, plan the therapy, and observe the evolution of the disease. The objective of this paper is to propose a method for the detection of brain tumors. Brain tumors are identified from Magnetic Resonance (MR) images by performing suitable segmentation procedures. The latest technical literature concerning radiographic images of the brain shows that deep learning methods can be implemented to extract specific features of brain tumors, aiding clinical diagnosis. For this reason, most data scientists and AI researchers work on Machine Learning methods for designing automatic screening procedures. Indeed, an automated method would result in quicker segmentation findings, providing a robust output with respect to possible differences in data sources, mostly due to different procedures in data recording and storing, resulting in a more consistent identification of brain tumors. To improve the performance of the segmentation procedure, new architectures are proposed and tested in this paper. We propose deep neural networks for the detection of brain tumors, trained on the MRI scans of patients’ brains. The proposed architectures are based on convolutional neural networks and inception modules for brain tumor segmentation. A comparison of these proposed architectures with the baseline reference ones shows very interesting results. MI-Unet showed a performance increase in comparison to baseline Unet architecture by $7.5\%$ in dice score, $23.91\%$ insensitivity, and $7.09\%$ in specificity. Depth-wise separable MI-Unet showed a performance increase by $10.83\%$ in dice score, $2.97\%$ in sensitivity, and $12.72\%$ in specificity as compared to the baseline Unet architecture. Hybrid Unet architecture achieved performance improvement of $9.71\%$ in dice score, $3.56\%$ in sensitivity, and $12.6\%$ in specificity. Whereas the depth-wise separable hybrid Unet architecture outperformed the baseline architecture by $15.45\%$ in dice score, $20.56\%$ in sensitivity, and $12.22\%$ in specificity.