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Aim Onion is one of the commonly cultivated and consumed vegetables rich in nutrients and phytochemicals. Various nutraceuticals are found in the outer fleshy layers and dry peel of onion which usually is treated as a common biowaste. Diabetes mellitus is a leading non communicable disease causing hyperglycemia and increased production of free radicals that potentially disrupts antioxidant enzymatic activity. Considering global consumption of wheat, the present study was designed to evaluate the anti-hyperglycemic and antioxidant effects of wheat bread supplemented with onion peel extract (OPE) or onion powder (OP) on diabetic rats. Methods In this study, ethanolic extract of onion peel and onion bulb were prepared separately. Male Sprague Dawley rats were divided into 6 groups (n = 7). Different regimens of supplemented wheat bread (OPE (1% and 3%) and OP (5% and 7%)) were given to diabetic rats for eight weeks, plain bread was used as the control. Blood glucose level, body weight and activities of SOD, CAT, GPx, GR, GSH and MDA in the liver and kidney tissues were evaluated. Statistical analysis was performed using SPSS Version (25) and Dunnett’s multiple comparison test. Results Bread supplemented with 1% and 3% onion peel extract and 7% onion powder significantly reduced blood glucose levels and MDA in the treated rats compared with the control group diabetic rats. Body weight of diabetic rats was reduced for control group, while onion supplemented diet improved the body weight of treated rats. Onion supplementation also brought significant improvement in antioxidant enzyme activities among the treated diabetic rats. Conclusion These findings suggested that onion supplementation is effective in lowering blood glucose and could potentially aid in protecting organs from oxidative stress.
Sara Masood; Attiq Ur Rehman; Shahid Bashir; Mohamed El Shazly; Muhammad Imran; Palwasha Khalil; Faiza Ifthikar; Hafiza Madiha Jaffar; Tara Khursheed. Investigation of the anti-hyperglycemic and antioxidant effects of wheat bread supplemented with onion peel extract and onion powder in diabetic rats. Journal of Diabetes & Metabolic Disorders 2021, 20, 485 -495.
AMA StyleSara Masood, Attiq Ur Rehman, Shahid Bashir, Mohamed El Shazly, Muhammad Imran, Palwasha Khalil, Faiza Ifthikar, Hafiza Madiha Jaffar, Tara Khursheed. Investigation of the anti-hyperglycemic and antioxidant effects of wheat bread supplemented with onion peel extract and onion powder in diabetic rats. Journal of Diabetes & Metabolic Disorders. 2021; 20 (1):485-495.
Chicago/Turabian StyleSara Masood; Attiq Ur Rehman; Shahid Bashir; Mohamed El Shazly; Muhammad Imran; Palwasha Khalil; Faiza Ifthikar; Hafiza Madiha Jaffar; Tara Khursheed. 2021. "Investigation of the anti-hyperglycemic and antioxidant effects of wheat bread supplemented with onion peel extract and onion powder in diabetic rats." Journal of Diabetes & Metabolic Disorders 20, no. 1: 485-495.
: Medicinal plants and their derived compounds have drawn the attention of researchers due to their considerable impact on human health. Among medicinal plants, mint (Mentha species) exhibits multiple health beneficial properties, such as prevention from cancer development and anti-obesity, antimicrobial, anti-inflammatory, anti-diabetic, and cardioprotective effects, as a result of its antioxidant potential, combined with low toxicity and high efficacy. Mentha species are widely used in savory dishes, food, beverages, and confectionary products. Phytochemicals derived from mint also showed anticancer activity against different types of human cancers such as cervix, lung, breast and many others. Mint essential oils show a great cytotoxicity potential, by modulating MAPK and PI3k/Akt pathways; they also induce apoptosis, suppress invasion and migration potential of cancer cells lines along with cell cycle arrest, upregulation of Bax and p53 genes, modulation of TNF, IL-6, IFN-γ, IL-8, and induction of senescence phenotype. Essential oils from mint have also been found to exert antibacterial activities against Bacillus subtilis, Streptococcus aureus, Pseudomonas aeruginosa, and many others. The current review highlights the antimicrobial role of mint-derived compounds and essential oils with a special emphasis on anticancer activities, clinical data and adverse effects displayed by such versatile plants.
Majid Tafrihi; Muhammad Imran; Tabussam Tufail; Tanweer Aslam Gondal; Gianluca Caruso; Somesh Sharma; Ruchi Sharma; Maria Atanassova; Lyubomir Atanassov; Patrick Valere Tsouh Fokou; Raffaele Pezzani. The Wonderful Activities of the GenusMentha: Not Only Antioxidant Properties. Molecules 2021, 26, 1118 .
AMA StyleMajid Tafrihi, Muhammad Imran, Tabussam Tufail, Tanweer Aslam Gondal, Gianluca Caruso, Somesh Sharma, Ruchi Sharma, Maria Atanassova, Lyubomir Atanassov, Patrick Valere Tsouh Fokou, Raffaele Pezzani. The Wonderful Activities of the GenusMentha: Not Only Antioxidant Properties. Molecules. 2021; 26 (4):1118.
Chicago/Turabian StyleMajid Tafrihi; Muhammad Imran; Tabussam Tufail; Tanweer Aslam Gondal; Gianluca Caruso; Somesh Sharma; Ruchi Sharma; Maria Atanassova; Lyubomir Atanassov; Patrick Valere Tsouh Fokou; Raffaele Pezzani. 2021. "The Wonderful Activities of the GenusMentha: Not Only Antioxidant Properties." Molecules 26, no. 4: 1118.
Mint and ginger are rich sources of phenolic compounds, and thus the present study aimed to assess the impact of different extraction techniques on their polyphenolic yield and antioxidant activity, and to develop a ginger-mint drink. Conventional, ultrasonic and supercritical fluid extraction techniques were used, and ethanol, methanol and distilled water selected as extraction solvents for mint and ginger. Antioxidant activity was determined by β-carotene bleaching inhibition, DPPH and FRAP assays. Total phenolics (TPC) and flavonoids contents were also quantified, and physicochemical and sensory characteristics of the ginger-mint drink assessed. The results elucidated higher TPC, β-carotene bleaching inhibition, DPPH, FRAP and total flavonoids of mint and ginger in supercritical on 30 min as 2481.6 ± 245 and 2441 ± 240, 74 ± 7.1 and 69 ± 6.1, 79 ± 7.1 and 74 ± 6.1, 17.21 ± 1.3 and 16.4 ± 1.5, and 35 ± 2.8 and 34 ± 2.9, respectively, followed by ultrasonic assisted extraction. Likewise, the functional drink prepared from these extracts exhibited promising physicochemical, sensorial and antioxidant traits. In conclusion, supercritical fluid extraction was the best method for maximum and accurate extraction with ethanol revealing to be the best solvent for this process, with higher yields, when compared to methanol and distilled water.
Ali Imran; Cristina Quispe; Adeela Zeeshan; Muhammad Imran; Muhammad Nadeem; Syed Amir Gilani; Tanweer Aslam Gondal; Tabussam Tufail; Farhan Aslam; Célia F. Rodrigues; Bahare Salehi; Javad Sharifi-Rad; Miquel Martorell; Natália Cruz-Martins. Development and antioxidant characterization of Ginger-Mint drink prepared through different extraction techniques. Journal of Food Measurement and Characterization 2021, 15, 2576 -2590.
AMA StyleAli Imran, Cristina Quispe, Adeela Zeeshan, Muhammad Imran, Muhammad Nadeem, Syed Amir Gilani, Tanweer Aslam Gondal, Tabussam Tufail, Farhan Aslam, Célia F. Rodrigues, Bahare Salehi, Javad Sharifi-Rad, Miquel Martorell, Natália Cruz-Martins. Development and antioxidant characterization of Ginger-Mint drink prepared through different extraction techniques. Journal of Food Measurement and Characterization. 2021; 15 (3):2576-2590.
Chicago/Turabian StyleAli Imran; Cristina Quispe; Adeela Zeeshan; Muhammad Imran; Muhammad Nadeem; Syed Amir Gilani; Tanweer Aslam Gondal; Tabussam Tufail; Farhan Aslam; Célia F. Rodrigues; Bahare Salehi; Javad Sharifi-Rad; Miquel Martorell; Natália Cruz-Martins. 2021. "Development and antioxidant characterization of Ginger-Mint drink prepared through different extraction techniques." Journal of Food Measurement and Characterization 15, no. 3: 2576-2590.
The medicinal importance of honey has been known for many decades due to its antimicrobial properties against life-threatening bacteria. However, previous studies revealed that microorganisms are able to develop adaptations after continuous exposure to antimicrobial compounds. The present study was conducted to explore the impact of subinhibitory concentrations of branded honey (Marhaba) and unbranded honey (extracted from Ziziphus mauritiana plant) locally available in Pakistan on Escherichia coli ATCC 10536, Salmonella Typhi and Klebsiella pneumoniae by investigating the development of self- or cross-resistance to antibiotics (gentamicin, kanamycin and imipenem). Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of autoclaved honeys were determined. The bacterial cells of E. coli ATCC 10536, S. Typhi and K. pneumoniae were subjected to honey adaptation by exposing to ¼ × MIC (4 passages) and ½ × MIC (4 passages) of both honeys. Moreover, tolerance to low pH and high temperature was also studied in adapted and unadapted cells. The decreasing trend in growth pattern (OD600nm) of E. coli ATCC 10536, S. Typhi and K. pneumoniae was observed with increases in the concentration of honeys (6.25–50% v/v) respectively. Our results showed that continuous exposure of both honeys did not lead to the development of any self- or cross-resistance in tested bacteria. However, percent survival to low pH was found to be significantly higher in adapted cells as compared to unadapted cells. The results indicate that both branded honey (Marhaba) and unbranded honey (extracted from Ziziphus mauritiana plant) were effective in controlling the growth of tested pathogenic bacteria. However, the emergence of tolerance to adverse conditions (pH 2.5, temperature 60 °C) deserves further investigation before proposing honey as a better antibacterial agent in food fabrication/processing, where low pH and high temperatures are usually implemented.
Rabia Ayub; Muhammad Umer; Abid Aslam Maan; Bilal Rasool; Muhammad Kashif Iqbal Khan; Muhammad Kashif Iqbal Khan Tahira Younis; Shabbar Abbas; Muhammad Sajjad; Imdad Kaleem; Muhammad Imran; Azmat Ullah; Muhammad Sohail Afzal; Zaheer Hussain Shah; Sheraz Ahmed; Farhan Aslam; Neelam Chaudhary; Muhammad Inam Afzal; Muhammad Afzal; Muhammad Afzal. Antibiotics, Acid and Heat Tolerance of Honey adapted Escherichia coli, Salmonella Typhi and Klebsiella pneumoniae. Foods 2020, 9, 311 .
AMA StyleRabia Ayub, Muhammad Umer, Abid Aslam Maan, Bilal Rasool, Muhammad Kashif Iqbal Khan, Muhammad Kashif Iqbal Khan Tahira Younis, Shabbar Abbas, Muhammad Sajjad, Imdad Kaleem, Muhammad Imran, Azmat Ullah, Muhammad Sohail Afzal, Zaheer Hussain Shah, Sheraz Ahmed, Farhan Aslam, Neelam Chaudhary, Muhammad Inam Afzal, Muhammad Afzal, Muhammad Afzal. Antibiotics, Acid and Heat Tolerance of Honey adapted Escherichia coli, Salmonella Typhi and Klebsiella pneumoniae. Foods. 2020; 9 (3):311.
Chicago/Turabian StyleRabia Ayub; Muhammad Umer; Abid Aslam Maan; Bilal Rasool; Muhammad Kashif Iqbal Khan; Muhammad Kashif Iqbal Khan Tahira Younis; Shabbar Abbas; Muhammad Sajjad; Imdad Kaleem; Muhammad Imran; Azmat Ullah; Muhammad Sohail Afzal; Zaheer Hussain Shah; Sheraz Ahmed; Farhan Aslam; Neelam Chaudhary; Muhammad Inam Afzal; Muhammad Afzal; Muhammad Afzal. 2020. "Antibiotics, Acid and Heat Tolerance of Honey adapted Escherichia coli, Salmonella Typhi and Klebsiella pneumoniae." Foods 9, no. 3: 311.
Epigallocatechin gallate (EGCG) is the main bioactive component of catechins predominantly present in various types of tea. EGCG is well known for a wide spectrum of biological activities as an anti-oxidative, anti-inflammatory, and anti-tumor agent. The effect of EGCG on cell death mechanisms via the induction of apoptosis, necrosis, and autophagy has been documented. Moreover, its anti-proliferative action has been demonstrated in many cancer cell lines. It was also involved in the modulation of cyclooxygenase-2, oxidative stress and inflammation of different cellular processes. EGCG has been reported as a promising agent target for plasma membrane proteins, such as epidermal growth factor receptor. In addition, it has been demonstrated a mechanism of action relying on the inhibition of ERK1/2, p38 MAPK, NF-κB, and vascular endothelial growth factor. Furthermore, EGCG and its derivatives were used in proteasome inhibition and they were involved in epigenetic mechanisms. In summary, EGCG is the most predominant and bioactive constituent of tea and may play a role in cancer prevention.
Mehdi Sharifi-Rad; Raffaele Pezzani; Marco Redaelli; Maira Zorzan; Muhammad Imran; Anees Ahmed Khalil; Bahare Salehi; Farukh Sharopov; William C. Cho; Javad Sharifi-Rad; Sharifi- Rad. Preclinical Activities of Epigallocatechin Gallate in Signaling Pathways in Cancer. Molecules 2020, 25, 467 .
AMA StyleMehdi Sharifi-Rad, Raffaele Pezzani, Marco Redaelli, Maira Zorzan, Muhammad Imran, Anees Ahmed Khalil, Bahare Salehi, Farukh Sharopov, William C. Cho, Javad Sharifi-Rad, Sharifi- Rad. Preclinical Activities of Epigallocatechin Gallate in Signaling Pathways in Cancer. Molecules. 2020; 25 (3):467.
Chicago/Turabian StyleMehdi Sharifi-Rad; Raffaele Pezzani; Marco Redaelli; Maira Zorzan; Muhammad Imran; Anees Ahmed Khalil; Bahare Salehi; Farukh Sharopov; William C. Cho; Javad Sharifi-Rad; Sharifi- Rad. 2020. "Preclinical Activities of Epigallocatechin Gallate in Signaling Pathways in Cancer." Molecules 25, no. 3: 467.
The aim of the current study was to evaluate the effect of apple peel polyphenol extract (APPE) on the physicochemical and microbiological properties of probiotic yoghurt. Five concentrations of APPE were added in probiotic yoghurt as: (1) CTL, control without APPE; (2) AE1, addition of 1% APPE; (3) AE2, addition of 2% APPE; (4) AE3, addition of 3% APPE; (5) AE4, addition of 4% APPE; and (6) AE5, addition of 5% APPE. The prepared probiotic yoghurt was stored at 4 °C for 21 days and analyzed for physicochemical and microbiological properties. The initial viable count of L. bulgaricus, S. thermophilus, B. lactis and L. acidophilus were similar in all yoghurt samples at day 1. The maximum viability loss of probiotics was observed in CTL (p < 0.05). The lowest viability loss of probiotics was observed in AE5 samples (p < 0.05). The acidity, water holding capacity and viscosity were increased with the addition of APPE. No significant effects were observed on milk fat and total solid contents of probiotic yoghurt with the addition of APPE. The total phenolic contents of probiotic yoghurt increased significantly as 0.59, 0.71, 0.97, 1.18, 1.35 in AE1, AE2, AE3, AE4 and AE5, samples respectively. It was observed that AE3 and AE4 samples had better taste, flavour and colour with good texture. The survival of probiotics and antioxidant activity of the yoghurts were enhanced with the addition of APPE. In conclusion, apple peels could be successfully used as prebiotic in yoghurt with increased viable counts of probiotics.
Ishtiaque Ahmad; Anjum Khalique; Muhammad Qamar Shahid; Abdul Ahid Rashid; Furukh Faiz; Muhammad Asim Ikram; Sheraz Ahmed; Muhammad Imran; Muhammad Asif Khan; Muhammad Nadeem; Muhammad Inam Afzal; Muhammad Umer; Imdad Kaleem; Muhammad Shahbaz; Bilal Rasool; Kaleem Imdad. Studying the Influence of Apple Peel Polyphenol Extract Fortification on the Characteristics of Probiotic Yoghurt. Plants 2020, 9, 77 .
AMA StyleIshtiaque Ahmad, Anjum Khalique, Muhammad Qamar Shahid, Abdul Ahid Rashid, Furukh Faiz, Muhammad Asim Ikram, Sheraz Ahmed, Muhammad Imran, Muhammad Asif Khan, Muhammad Nadeem, Muhammad Inam Afzal, Muhammad Umer, Imdad Kaleem, Muhammad Shahbaz, Bilal Rasool, Kaleem Imdad. Studying the Influence of Apple Peel Polyphenol Extract Fortification on the Characteristics of Probiotic Yoghurt. Plants. 2020; 9 (1):77.
Chicago/Turabian StyleIshtiaque Ahmad; Anjum Khalique; Muhammad Qamar Shahid; Abdul Ahid Rashid; Furukh Faiz; Muhammad Asim Ikram; Sheraz Ahmed; Muhammad Imran; Muhammad Asif Khan; Muhammad Nadeem; Muhammad Inam Afzal; Muhammad Umer; Imdad Kaleem; Muhammad Shahbaz; Bilal Rasool; Kaleem Imdad. 2020. "Studying the Influence of Apple Peel Polyphenol Extract Fortification on the Characteristics of Probiotic Yoghurt." Plants 9, no. 1: 77.
Poro cheese is a regional product originally from the area of Los Rios, Tabasco in Mexico. In the context of preserving the heritage of Poro cheese and protecting the specific characteristics that define its typicity through an origin designation, the present study was conducted to establish a general profile of Poro cheese by characterizing their physicochemical, textural, rheological, sensorial and microbiological characteristics. Differences in moisture, proteins, fats, NaCl, titrable acidity, pH, color texture and rheology amongst cheese factories were observed and ranges were established. Fifteen descriptors were generated to provide a descriptive analysis, eight of which were significantly different amongst the factories with no differences in the global acceptability of cheese. The favorite cheese had the highest scores for aroma attributes. Conventional and molecular methods were used to identify the main microorganisms, for which Lactobacillus plantarum, L. fermentum, L. farciminis and L. rhamnosus were the main microorganisms found in Porocheese. The obtained data constituted the parameters for characterizing Poro cheese, which will strongly help to support its origin appellation request process.
Citlalli Celeste González Ariceaga; Muhammad Inam Afzal; Muhammad Umer; Shabbar Abbas; Haroon Ahmad; Muhammad Sajjad; Fahed Parvaiz; Kaleem Imdad; Muhammad Imran; Abid Aslam Maan; Muhammad Kashif Iqbal Khan; Azmat Ullah; Arturo Hernández-Montes; Eleazar Aguirre-Mandujano; Abraham Villegas De Gante; Muriel Jacquot; Catherine Cailliez-Grimal. Physicochemical, Sensorial and Microbiological Characterization of PoroCheese, an Artisanal Mexican Cheese Made from Raw Milk. Foods 2019, 8, 509 .
AMA StyleCitlalli Celeste González Ariceaga, Muhammad Inam Afzal, Muhammad Umer, Shabbar Abbas, Haroon Ahmad, Muhammad Sajjad, Fahed Parvaiz, Kaleem Imdad, Muhammad Imran, Abid Aslam Maan, Muhammad Kashif Iqbal Khan, Azmat Ullah, Arturo Hernández-Montes, Eleazar Aguirre-Mandujano, Abraham Villegas De Gante, Muriel Jacquot, Catherine Cailliez-Grimal. Physicochemical, Sensorial and Microbiological Characterization of PoroCheese, an Artisanal Mexican Cheese Made from Raw Milk. Foods. 2019; 8 (10):509.
Chicago/Turabian StyleCitlalli Celeste González Ariceaga; Muhammad Inam Afzal; Muhammad Umer; Shabbar Abbas; Haroon Ahmad; Muhammad Sajjad; Fahed Parvaiz; Kaleem Imdad; Muhammad Imran; Abid Aslam Maan; Muhammad Kashif Iqbal Khan; Azmat Ullah; Arturo Hernández-Montes; Eleazar Aguirre-Mandujano; Abraham Villegas De Gante; Muriel Jacquot; Catherine Cailliez-Grimal. 2019. "Physicochemical, Sensorial and Microbiological Characterization of PoroCheese, an Artisanal Mexican Cheese Made from Raw Milk." Foods 8, no. 10: 509.
The manifestation of aflatoxins in feed and food is a major issue in the world as its presence leads to some health problems. This study investigates the incidence of aflatoxin M1 (AFM1) contamination in raw milk samples which were collected from Punjab, Pakistan. The Cluster Random Sampling technique was used to collect 960 milk samples from five different regions, and samples were collected every month. The AFM1 level in raw milk was analyzed by the ELISA technique. The findings demonstrate that 70% of samples exceeded the United States permissible maximum residue limits (MRL 0.50 µg/L), with an overall AFM1 level that ranged from 0.3 to 1.0 µg/L. AFM1 contamination varied with the season: The highest average contamination was detected in winter (0.875 µg/L), followed by autumn (0.751 µg/L), spring (0.654 µg/L), and summer (0.455 µg/L). The Eastern region exhibited the highest average AFM1 contamination (0.705 µg/L). Milk samples from the Northern region were found to be widely contaminated, as 86.9% samples exceeded the US MRL, followed by the Eastern region, with 72.3% samples being contaminated with >0.5 µg/L AFM1. The study indicated that the raw milk supply chain was heavily contaminated. Recommendations and remedial measures need to be developed by regulatory authorities to improve the raw milk quality.
Naveed Akbar; Muhammad Nasir; Naureen Naeem; Mansur-Ud-Din Ahmad; Sanaullah Iqbal; Anjum Rashid; Muhammad Imran; Tanweer Aslam Gondal; Muhammad Atif; Bahare Salehi; Javad Sharifi-Rad; Miquel Martorell; William C. Cho. Occurrence and Seasonal Variations of Aflatoxin M1 in Milk from Punjab, Pakistan. Toxins 2019, 11, 574 .
AMA StyleNaveed Akbar, Muhammad Nasir, Naureen Naeem, Mansur-Ud-Din Ahmad, Sanaullah Iqbal, Anjum Rashid, Muhammad Imran, Tanweer Aslam Gondal, Muhammad Atif, Bahare Salehi, Javad Sharifi-Rad, Miquel Martorell, William C. Cho. Occurrence and Seasonal Variations of Aflatoxin M1 in Milk from Punjab, Pakistan. Toxins. 2019; 11 (10):574.
Chicago/Turabian StyleNaveed Akbar; Muhammad Nasir; Naureen Naeem; Mansur-Ud-Din Ahmad; Sanaullah Iqbal; Anjum Rashid; Muhammad Imran; Tanweer Aslam Gondal; Muhammad Atif; Bahare Salehi; Javad Sharifi-Rad; Miquel Martorell; William C. Cho. 2019. "Occurrence and Seasonal Variations of Aflatoxin M1 in Milk from Punjab, Pakistan." Toxins 11, no. 10: 574.
Naturally occurring food-derived active ingredients have received huge attention for their chemopreventive and chemotherapy capabilities in several diseases. Rosmarinic acid (RA) is a caffeic acid ester and a naturally-occurring phenolic compound in a number of plants belonging to the Lamiaceae family, such as Rosmarinus officinalis (rosemary) from which it was formerly isolated. RA intervenes in carcinogenesis through different ways, including in tumor cell proliferation, apoptosis, metastasis, and inflammation. On the other hand, it also exerts powerful antimicrobial, anti-inflammatory, antioxidant and even antidepressant, anti-aging effects. The present review aims to provide an overview on anticancer activities of RA and to deliberate its therapeutic potential against a wide variety of diseases. Given the current evidence, RA may be considered as part of the daily diet in the treatment of several diseases, with pre-determined doses avoiding cytotoxicity.
Muhammad Nadeem; Muhammad Imran; Tanweer Aslam Gondal; Ali Imran; Muhammad Shahbaz; Rai Muhammad Amir; Muhammad Wasim Sajid; Tahira Batool Qaisrani; Muhammad Atif; Ghulam Hussain; Bahare Salehi; Elise Adrian Ostrander; Miquel Martorell; Javad Sharifi-Rad; William C. Cho; Natália Martins. Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review. Applied Sciences 2019, 9, 3139 .
AMA StyleMuhammad Nadeem, Muhammad Imran, Tanweer Aslam Gondal, Ali Imran, Muhammad Shahbaz, Rai Muhammad Amir, Muhammad Wasim Sajid, Tahira Batool Qaisrani, Muhammad Atif, Ghulam Hussain, Bahare Salehi, Elise Adrian Ostrander, Miquel Martorell, Javad Sharifi-Rad, William C. Cho, Natália Martins. Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review. Applied Sciences. 2019; 9 (15):3139.
Chicago/Turabian StyleMuhammad Nadeem; Muhammad Imran; Tanweer Aslam Gondal; Ali Imran; Muhammad Shahbaz; Rai Muhammad Amir; Muhammad Wasim Sajid; Tahira Batool Qaisrani; Muhammad Atif; Ghulam Hussain; Bahare Salehi; Elise Adrian Ostrander; Miquel Martorell; Javad Sharifi-Rad; William C. Cho; Natália Martins. 2019. "Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review." Applied Sciences 9, no. 15: 3139.
A marked decrease in human cancers, including breast cancer, bone cancer, and cervical cancer, has been linked to the consumption of vegetable and fruit, and the corresponding chemoprotective effect has been associated with the presence of several active molecules, such as kaempferol. Kaempferol is a major flavonoid aglycone found in many natural products, such as beans, bee pollen, broccoli, cabbage, capers, cauliflower, chia seeds, chives, cumin, moringa leaves, endive, fennel, and garlic. Kaempferol displays several pharmacological properties, among them antimicrobial, anti-inflammatory, antioxidant, antitumor, cardioprotective, neuroprotective, and antidiabetic activities, and is being applied in cancer chemotherapy. Specifically, kaempferol-rich food has been linked to a decrease in the risk of developing some types of cancers, including skin, liver, and colon. The mechanisms of action include apoptosis, cell cycle arrest at the G2/M phase, downregulation of epithelial-mesenchymal transition (EMT)-related markers, and phosphoinositide 3-kinase/protein kinase B signaling pathways. In this sense, this article reviews data from experimental studies that investigated the links between kaempferol and kaempferol-rich food intake and cancer prevention. Even though growing evidence supports the use of kaempferol for cancer prevention, further preclinical and clinical investigations using kaempferol or kaempferol-rich foods are of pivotal importance before any public health recommendation or formulation using kaempferol.
Muhammad Imran; Bahare Salehi; Javad Sharifi-Rad; Tanweer Aslam Gondal; Farhan Saeed; Ali Imran; Muhammad Shahbaz; Patrick Valere Tsouh Fokou; Muhammad Umair Arshad; Haroon Khan; Susana Gomes Guerreiro; Natália Martins; Leticia M. Estevinho. Kaempferol: A Key Emphasis to Its Anticancer Potential. Molecules 2019, 24, 2277 .
AMA StyleMuhammad Imran, Bahare Salehi, Javad Sharifi-Rad, Tanweer Aslam Gondal, Farhan Saeed, Ali Imran, Muhammad Shahbaz, Patrick Valere Tsouh Fokou, Muhammad Umair Arshad, Haroon Khan, Susana Gomes Guerreiro, Natália Martins, Leticia M. Estevinho. Kaempferol: A Key Emphasis to Its Anticancer Potential. Molecules. 2019; 24 (12):2277.
Chicago/Turabian StyleMuhammad Imran; Bahare Salehi; Javad Sharifi-Rad; Tanweer Aslam Gondal; Farhan Saeed; Ali Imran; Muhammad Shahbaz; Patrick Valere Tsouh Fokou; Muhammad Umair Arshad; Haroon Khan; Susana Gomes Guerreiro; Natália Martins; Leticia M. Estevinho. 2019. "Kaempferol: A Key Emphasis to Its Anticancer Potential." Molecules 24, no. 12: 2277.
(1) Background: Multiple attempts have been conducted to correlate milk keeping quality with chemical, physical or bacteriological parameters. These methods only measure the chemical changes in milk produced by bacteria. Headspace solid-phase micro-extraction (HS-SPME) is an economic and recent method used to measure both volatile compounds and microbial load in milk, also allowing to keep the quality of the milk product. (2) Methods: The present study was conducted to identify and measure the off-flavoring volatile compounds through gas chromatography coupled with flame ionization detector (GC-FID) and the microbial load of pasteurized fluid milk stored at different temperatures, as a possible indicator of its keeping quality. (3) Results: The highest results were obtained to acetone, followed by butanone, pentanal and ethanol. These mean values were significantly enhanced from the 0 to 19th day of storage, at 10 °C. At day 19th, the minimum score for aroma, flavor and overall acceptability were also recorded as 4.33 ± 0.17, 4.02 ± 0.06, 4.00 ± 0.04, respectively. Likewise, maximum values for standard plate count (Log10 CFU 15.54 ± 0.40 mL−1) and total psychotroph count (Log10 CFU 11.67 ± 0.30mL−1) were reported at 10 °C and 4 °C. (4) Conclusion: HS-SPME/GC-FID methodology revealed to be very sensitive and capable to be applied in volatile compounds quantification in pasteurized milk produced during the storage period at different temperatures.
Anjum Rashid; Imran Javed; Barbara Rasco; Shyam Sablani; Muhammad Ayaz; Muhammad A. Ali; Muhammad Abdullah; Muhammad Imran; Tanweer Aslam Gondal; Muhammad Inam Afzal; Muhammad Atif; Bahare Salehi; Célia F. Rodrigues; Javad Sharifi-Rad; Natália Martins. Measurement of Off-Flavoring Volatile Compounds and Microbial Load as a Probable Marker for Keeping Quality of Pasteurized Milk. Applied Sciences 2019, 9, 959 .
AMA StyleAnjum Rashid, Imran Javed, Barbara Rasco, Shyam Sablani, Muhammad Ayaz, Muhammad A. Ali, Muhammad Abdullah, Muhammad Imran, Tanweer Aslam Gondal, Muhammad Inam Afzal, Muhammad Atif, Bahare Salehi, Célia F. Rodrigues, Javad Sharifi-Rad, Natália Martins. Measurement of Off-Flavoring Volatile Compounds and Microbial Load as a Probable Marker for Keeping Quality of Pasteurized Milk. Applied Sciences. 2019; 9 (5):959.
Chicago/Turabian StyleAnjum Rashid; Imran Javed; Barbara Rasco; Shyam Sablani; Muhammad Ayaz; Muhammad A. Ali; Muhammad Abdullah; Muhammad Imran; Tanweer Aslam Gondal; Muhammad Inam Afzal; Muhammad Atif; Bahare Salehi; Célia F. Rodrigues; Javad Sharifi-Rad; Natália Martins. 2019. "Measurement of Off-Flavoring Volatile Compounds and Microbial Load as a Probable Marker for Keeping Quality of Pasteurized Milk." Applied Sciences 9, no. 5: 959.
Recently oxidative stress induced maladies have amplified owing to sedentary lifestyle and monotonous diet. Introduction of plant based biomolecules may be a suitable strategy to cope with the lipid peroxidation. In this context, black tea polyphenols (theaflavin & thearubigins) are in fame among the scientific community as cost effective therapeutic agents owing to their safety, economics, structural diversity and ability to modulate various lipid peroxidation responses by halting the expression of different metabolic targets. The mandate of present investigation was to first time check the synergism among the isolated theaflavins & thearubigins against lipid peroxidative indicators both in vitro and in vivo. Purposely, theaflavins and thearubigins were isolated from black tea through solvent partition methods by using different solvents (Aqueous ethanol, Aqueous methanol & Water) and time intervals (30, 60 & 90 min) and subjected to in vitro characterization through different antioxidant indices to access the in vitro lipid peroxidation shooting effect of these bioactive moieties. Moreover, individual theaflavins contents also estimate through HPLC. For evaluation of in vivo antioxidant effect, renal malfunction was induced through arginine and forty rats were divided in four groups (10 each after power analysis) and 04 types of diets were given i.e. T0 (control diet without supplementation), T1 (Basic experimental Diet+ theaflavins supplementation @ 1 g), T2 (Basic experimental Diet+ Thearubigins supplementation @ 1 g) & T3 (Basic experimental Diet+ Supplementation of theaflavins+ thearubigins @ 0.5 + 0.5 g, respectively) for the period of 56 days. Alongside, a control study was also carried out for comparison by involving normal rats fed on arginine free diet. The body weight, lipid profile, glycemic responses, Renal function test, liver function test, antioxidant indices and hematological parameters were estimated at the termination of study. The results indicated that theaflavins and thearubigins isolation was significantly affected by time of extraction and solvent. In this context, aqueous ethanol at 60 min extraction interval caused maximum extraction. Likewise, theaflavins isolate exhibited more antioxidant activity as compared to thearubigins. Moreover, the theaflavins and thearubigins based experimental diets imparted significant reduction in Lipid profile, glucose content, renal function tests and TBARS with enhancement in insulin, HDL and hematological parameters. In this context, theaflavin based diet caused maximum reduction in lipid profile and TBARS better as compared to thearubigins and theaflavins + thearubigins based. However, theaflavin+ thearubigins based diet caused highest glucose, urea & creatinine decline and maximum insulin increase & antioxidant indices as compared to other nutraceuticals. It was deduced that theaflavins & thearubigins have strong antioxidative potential both in in vitro as well as in vivo to tackle the menace associated with lipid peroxidation.
Ali Imran; Muhammad Umair Arshad; Muhammad Imran; Farhan Saeed; Muhammad Sohaib. Lipid peroxidation diminishing perspective of isolated theaflavins and thearubigins from black tea in arginine induced renal malfunctional rats. Lipids in Health and Disease 2018, 17, 157 .
AMA StyleAli Imran, Muhammad Umair Arshad, Muhammad Imran, Farhan Saeed, Muhammad Sohaib. Lipid peroxidation diminishing perspective of isolated theaflavins and thearubigins from black tea in arginine induced renal malfunctional rats. Lipids in Health and Disease. 2018; 17 (1):157.
Chicago/Turabian StyleAli Imran; Muhammad Umair Arshad; Muhammad Imran; Farhan Saeed; Muhammad Sohaib. 2018. "Lipid peroxidation diminishing perspective of isolated theaflavins and thearubigins from black tea in arginine induced renal malfunctional rats." Lipids in Health and Disease 17, no. 1: 157.
The current review article is an attempt to explain the therapeutic potential of mangiferin, a bioactive compound of the mango, against lifestyle-related disorders. Mangiferin (2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one) can be isolated from higher plants as well as the mango fruit and their byproducts (i.e. peel, seed, and kernel). It possesses several health endorsing properties such as antioxidant, antimicrobial, antidiabetic, antiallergic, anticancer, hypocholesterolemic, and immunomodulatory. It suppresses the activation of peroxisome proliferator activated receptor isoforms by changing the transcription process. Mangiferin protects against different human cancers, including lung, colon, breast, and neuronal cancers, through the suppression of tumor necrosis factor α expression, inducible nitric oxide synthase potential, and proliferation and induction of apoptosis. It also protects against neural and breast cancers by suppressing the expression of matrix metalloproteinase (MMP)-9 and MMP-7 and inhibiting enzymatic activity, metastatic potential, and activation of the β-catenin pathway. It has the capacity to block lipid peroxidation, in order to provide a shielding effect against physiological threats. Additionally, mangiferin enhances the capacity of the monocyte-macrophage system and possesses antibacterial activity against gram-positive and gram-negative bacteria. This review summarizes the literature pertaining to mangiferin and its associated health claims.
Muhammad Imran; Muhammad Sajid Arshad; Masood Sadiq Butt; Joong-Ho Kwon; Muhammad Tauseef Sultan. Mangiferin: a natural miracle bioactive compound against lifestyle related disorders. Lipids in Health and Disease 2017, 16, 1 -17.
AMA StyleMuhammad Imran, Muhammad Sajid Arshad, Masood Sadiq Butt, Joong-Ho Kwon, Muhammad Tauseef Sultan. Mangiferin: a natural miracle bioactive compound against lifestyle related disorders. Lipids in Health and Disease. 2017; 16 (1):1-17.
Chicago/Turabian StyleMuhammad Imran; Muhammad Sajid Arshad; Masood Sadiq Butt; Joong-Ho Kwon; Muhammad Tauseef Sultan. 2017. "Mangiferin: a natural miracle bioactive compound against lifestyle related disorders." Lipids in Health and Disease 16, no. 1: 1-17.