Fabian H. Leendertz

Fabian H. Leendertz


Research Focus & Metrics

Academic Career Length

21Years (2006-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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30 December 2014 in EMBO Molecular Medicine
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Journal Article
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ASAlmudena Marí Saéz
Almudena Marí Saéz
SWSabrina Weiss
Sabrina Weiss
KNKathrin Nowak
Kathrin Nowak
VLVincent Lapeyre
Vincent Lapeyre
FZFee Zimmermann
Fee Zimmermann
FLFabian H. Leendertz
Fabian H. Leendertz
The severe Ebola virus disease epidemic occurring in West Africa stems from a single zoonotic transmission event to a 2‐year‐old boy in Meliandou, Guinea. We investigated the zoonotic origins of the epidemic using wildlife surveys, interviews, and molecular analyses of bat and environmental samples. We found no evidence for a concurrent outbreak in larger wildlife. Exposure to fruit bats is common in the region, but the index case may have been infected by playing in a hollow tree housing a colony of insectivorous free‐tailed bats ( Mops condylurus ). Bats in this family have previously been discussed as potential sources for Ebola virus outbreaks, and experimental data have shown that this species can survive experimental infection. These analyses expand the range of possible Ebola virus sources to include insectivorous bats and reiterate the importance of broader sampling efforts for understanding Ebola virus ecology.

15 September 2021 in Nature
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Journal Article
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AKAlpha Keita
Alpha Keita
FKFara R Koundouno
Fara R Koundouno
MFMartin Faye
Martin Faye
ADAriane Düx
Ariane Düx
JHJulia Hinzmann
Julia Hinzmann
NMN' Faly Magassouba
N' Faly Magassouba

22 October 2021 in Science
Verified
Journal Article
Open access
EWEduan Wilkinson
Eduan Wilkinson
Marta GiovanettiMarta Giovanetti
Marta Giovanetti
HTHouriiyah Tegally
Houriiyah Tegally
JSJames Emmanuel San
James Emmanuel San
RLRichard Lessells
Richard Lessells
TOTulio De Oliveira
Tulio De Oliveira
SARS-CoV-2 across Africa: The impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has been hard to track in African countries, largely because of patchy data. Wilkinson et al . curated viral genomes collected in 2021 from several countries across the continent. Outbreaks during 2020 in each African country were initiated by imported cases, mostly from Europe. As the pandemic developed, case numbers in African countries were likely many times higher than reported, and subsequent waves of the pandemic appear to have been more severe. Consequently, high-transmission variants have emerged that have spread within the continent, and African countries must be included in global control efforts. —CA

8 January 2013 in Molecular Ecology
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SCSebastien Calvignac-Spencer
Sebastien Calvignac-Spencer
KMKevin Merkel
Kevin Merkel
NKNadine Kutzner
Nadine Kutzner
HKHjalmar Kühl
Hjalmar Kühl
CBChristophe Boesch
Christophe Boesch
FLFabian H. Leendertz
Fabian H. Leendertz

19 June 2020 in Science
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Journal Article
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ADAriane Düx
Ariane Düx
SLSebastian Lequime
Sebastian Lequime
LPLivia Victoria Patrono
Livia Victoria Patrono
BVBram Vrancken
Bram Vrancken
SBSengül Boral
Sengül Boral
SCSebastien Calvignac-Spencer
Sebastien Calvignac-Spencer
Older origins of measles virus: Animal domestication by humans is thought to have given many pathogens an opportunity to invade a new host, and measles is one example of this. However, there is controversy about when measles emerged in humans, because the historical descriptions of measles are relatively recent (late ninth century CE). The controversy has persisted in part because ancient RNA is thought to be a poor target for molecular clock techniques. Düx et al. have overcome the ancient RNA challenge by sequencing a measles virus genome obtained from a museum specimen of the lungs of child who died in 1912 (see the Perspective by Ho and Duchêne). The authors used these and other more recent sequencing data in a Bayesian molecular clock–modeling technique, which showed that measles virus diverged from rinderpest virus in the sixth century BCE, indicating an early origin for measles possibly associated with the beginnings of urbanization. Science , this issue p. 1367 ; see also p. 1310

27 April 2020 in Nature Microbiology
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Journal Article
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LPLivia V. Patrono
Livia V. Patrono
KPKamilla Pléh
Kamilla Pléh
LSLiran Samuni
Liran Samuni
MUMarkus Ulrich
Markus Ulrich
CRCaroline Röthemeier
Caroline Röthemeier
FLFabian H. Leendertz
Fabian H. Leendertz