Poly(glycerol sebacate) (PGS) is an aliphatic polyester which attracted significant scientific attention in recent years due to its vast potential in biomedical applications regarding to tissue engineering. It has been presented in the literature in the form of 2D films, porous scaffolds or nonwovens, to name just a few. Moreover, various applications have been proposed as a component of composite materials or polymer blends. Its physicochemical properties can be significantly adjusted by means of synthesis and post-synthetic modifications, including cross-linking or chemical modification such as copolymerization. Many of scientists have discussed PGS as a new-generation polymer for biomedical applications. Its regenerative potential has been confirmed, in particular, in tissue engineering of soft tissues (including nerve, cartilage and cardiac tissues). Therefore, we must anticipate growing importance of PGS in contemporary biomedical applications. This brief review aims to familiarize the readers with this relatively new polymeric material for tissue engineering applications.