Cancer is the second most common cause of death in the world. Several natural products have been studied for anticancer activity and for prevention or repair of oxidative injury. Curcumin is one of the natural products of high medicinal interest. This study was performed to investigate effects of curcumin on lipid peroxidation and antioxidant enzymes in tissues of mice bearing Ehrlich solid tumor. Forty mice were distributed to four groups as healthy control and treatments that received 1 × 10⁶ Ehrlich ascites tumor (EAT) cells and EAT cells plus 25 mg/kg/day or 50 mg/kg/day curcumin subcutaneously. The liver, kidney, brain and testis tissues were collected for the malondialdehyde, superoxide dismutase and catalase analyses. Tumor development increased MDA levels in liver (p = 0.001), kidney (p < 0.001) and testis (p < 0.01) and curcumin reduced liver Mathew decreased liver and kidney SOD activities were increased by both levels of curcumin (p = 0.001) but 50 mg/kg/day curcumin increased brain SOD activity (p < 0.001). The kidney CAT activity was increased by 50 mg/kg/day curcumin (p < 0.001). This study showed that curcumin suppresses tumor progression, and alleviates the lipid peroxidation and improves antioxidant status in the tissues of solid tumor-bearing mice.

The Apiaceae (previously known as the Umbelliferae) is one of the largest plant families in the world. This family comprises approximately 450 genera and 3700 species worldwide. The members of this family are well known as vegetables, culinary and medicinal plants. Members of Apiaceae possess various compounds with many biological activities. Some of the main properties are ability to induce apoptosis, antibacterial, hepatoprotective, vaso-relaxant, cyclooxygenase inhibitory and antitumor activities. In this study, 70% methanol extract prepared from the aerial parts of Eryngium billardieri, which belongs to Apiaceae family, and ethyl acetate, n-butanol fractions obtained from this extract were investigated by MTT method for cytotoxic effect on MCF7 (human breast cancer cell line) cell line. In result, the methanol extract was found more cytotoxic than fractions with 99.50 µg/mL IC₅₀ value on MCF7 cell line.

Achillea millefolium L. an herbaceous perennial plant from Asteraceae family which has antitumor, anti-inflammatory and antioxidant activity. Breast cancer is the most common cancer in woman. Therefore, in this study we aimed to investigate the effects of the different extracts of A. millefolium on breast cancer with in vitro cytotoxicity assay. Within the scope of this study, the compositions of extracts prepared with water, 30% ethanol, 60% ethanol, 90% ethanol and absolute ethanol obtained from the above-ground parts of A. millefolium, was investigated by Folin-Ciocalteu method for total phenolics, AlCl₃ colorimetric method for total flavonoid content. Cytotoxic effects on MCF7 (human breast cancer cell line) cell line were studied with MTT assay. It has been elucidated that 60% ethanol extract is rich in total phenolics content and 90% ethanol extract is rich in total flavonoid content. Water extract was found to be most cytotoxic extract with 30.67 ± 2.27 µg/mL IC₅₀ value on MCF7 cell line.

Snake venoms are extremely important for alternative medicine applications and discovery of new bioactive molecules. Especially in the recent years, there are promising studies in the literature on the development of new therapies for targeting the cancer with the use of snake venom peptides. In the present study, PLA2 and SVMPs venom peptide fractions of M. bulgardaghica were investigated for their apoptotic effects on human cervix adenocarcinoma cell line, HeLa and human lung adenocarcinoma cell line, A549. The cytotoxicity of crude venom was assessed by MTT assay with IC50 values of 4.34 ± 0.19 and 2.60 ± 0.18 µg/mL against HeLa and A549 cells, respectively. Following treatment, the cells with fractions for 48 h, the percentage of apoptotic cells was quantified by Annexin V/PI double staining assay and analyzed with flow cytometry. Our results show that, M. bulgardaghica venom fractions weren’t significantly triggered apoptotic effect on cells but affected the cell cycle in PI staining experiments. As a result, snake venom peptides might have potential use in the treatment of cancer with new drug targeting techniques.

Herbal medicine has been used historically for anticancer effect and potent antiproliferative effects on different cancer cell lines. Prostate cancer has become the most common malignancy and the second highest cause of cancer death Western world. The antioxidant, antidepressant and antimicrobial effect of Viscum album, Inula viscosa, Hypericum perforatum, Lysimachia nummularia, Oleocanthal, Pinus pinaster and Rubus caeisus on cancer cell lines. In this study, we investigated whether these seven plants show any anticancer properties on prostat cancer cell line. Du145 cancer cells and human adipose tissue derived mesenchymal stem cell were assessed for seven medical plants in culture with different doses. Firstly, the cytotoxicity rate (IC50) determined by MTT and then immunocytochemical procedure were done for oxidative stress (eNOS), angiogenesis (VEGF) and TUNEL method for apoptosis. The stainings were evaluated by H-score. According to the results, Inula viscosa and Rubus caeisus have a higher improvement effect than the other medicinal plants. And these plants were not toxic for adipose tissue derived mesenchymal stem cells. These plants caused the inhibition of cell proliferation and apoptosis in prostat cancer cells. Our results indicated that these plants may be potential agents in prostat cancer treatment.

A novel Hall magnetometer using dynamic offset cancellation principle is presented. It consists from a single triangular silicon plate with three contacts and interface electronics. The proposed dynamic offset-cancelling measurement cycle includes three states. During each state, an external circuit is switched to the plate contacts in a certain way. This way, the direction of current flow through the Hall plate is changed from phase to phase. At the same time, the output voltage is measured. After averaging the obtained three voltages per a measurement cycle, the offset voltage cancelled and this way the offset-free Hall voltage is obtained. The obtained offset reduction factor is very promising, reaching 120–130. The Hall device sensitivity is about 25 V/AT.