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Dr. Claudia Pratesi
University of New Mexico

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0 Celiac Disease
0 Health Equity
0 microplastic
0 Environment and Health
0 Quality Of life

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microplastic
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Short Biography

Claudia Pratesi, PhD in Health Sciences, MWR, MCRP is an adjunct professor at the University of New Mexico at the College of Population Health.

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Journal article
Published: 13 July 2021 in Brain Sciences
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Studies have shown that children and adolescents with autism and their relatives present a high level of stress and more family problems, impacting parents’ and caregivers’ quality of life (QoL). Despite studies on this subject, there is no specific questionnaire to evaluate QoL in parents or caregivers of children and adolescents with an autistic spectrum disorder (ASD) in Brazil. Therefore, this study’s primary purpose was to develop and validate a specific questionnaire to evaluate QoL in these individuals. The study was performed using the following steps: development of the ASD Parent/caregiver QoL questionnaire (autistic spectrum disorder parent/caregiver quality of life—ASDPC-QoL), subjective evaluation, validation of the questionnaire by the Delphi method, assessment of internal consistency, responsiveness, and reliability of the ASLPC-QoL, and administration of the questionnaire to 881 Brazilian ASD caregivers or parents. ASDPC-QoL comprises 28 questions divided into four domains (social, concerns, physical and mental health) with good psychometric properties (reproducibility, reliability, internal consistency, responsiveness, and validity). Our data showed that worries and physical health were the domains with the lowest scores in ASDPCA-QoL. ASDPCA-QoL did not differ among gender and age of child considering the total and all domains. Older participants (≥41 y/o) presented the best scores for social and worries domains but did not differ in other domains and the total. Parents or caregivers of ASD children diagnosed for more than three years have better mental and physical health domains than those recently diagnosed (up to 1 year) but did not differ in the total and other domains. Individuals with a partner and with the highest educational level present the best score for the social domain. Employed individuals showed better scores than unemployed ones for all domains and the total, except for worries, which did not differ. It also occurred comparing the individuals that do not use antidepressants and the ones that use them. Assessing and better understanding the QoL of caregivers is highly relevant. By understanding the social, worries, physical, and emotional health domains of caregivers, it is possible to track harmful aspects, prevent and treat pathologies, in addition to assisting in the implementation of effective public policies.

ACS Style

Claudia Pratesi; Alessandra Garcia; Riccardo Pratesi; Lenora Gandolfi; Mariana Hecht; Eduardo Nakano; Renata Zandonadi. Quality of Life in Caregivers of Children and Adolescents with Autistic Spectrum Disorder: Development and Validation of the Questionnaire. Brain Sciences 2021, 11, 924 .

AMA Style

Claudia Pratesi, Alessandra Garcia, Riccardo Pratesi, Lenora Gandolfi, Mariana Hecht, Eduardo Nakano, Renata Zandonadi. Quality of Life in Caregivers of Children and Adolescents with Autistic Spectrum Disorder: Development and Validation of the Questionnaire. Brain Sciences. 2021; 11 (7):924.

Chicago/Turabian Style

Claudia Pratesi; Alessandra Garcia; Riccardo Pratesi; Lenora Gandolfi; Mariana Hecht; Eduardo Nakano; Renata Zandonadi. 2021. "Quality of Life in Caregivers of Children and Adolescents with Autistic Spectrum Disorder: Development and Validation of the Questionnaire." Brain Sciences 11, no. 7: 924.

Communication
Published: 04 June 2021 in Sustainability
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Plastic pollution is a rapidly growing environmental and human health crisis, with no sign of improvement. From 2012 to 2020, the number of studies on plastic pollution increased, and macro to nano-sized plastics have been documented in the most remote biomes of the planet. Studies have shown contamination by microplastics (MPs) in various types of food consumed by humans, including seafood, honey, sugar, salt, tap and bottled water and beer. This study’s objective was to detect the possible contamination by MPs in drinking water samples collected from two main residential and commercial areas of Brasilia. A total of 32 samples (500 mL) of tap water were collected from residential and commercial areas. Samples were processed and transferred to a Sedgewick-Rafter counting cell chamber. The presence of MP particles was analyzed using a Nikon Eclipse fluorescence microscope. MPs were found in 100% of the samples. The mean microplastic particles per 500 mL found in the South Wing area was 97 ± 55, while the mean number of particles in the North Wing area was 219 ± 158, and the MPs found ranged in size from 6–50 microns. The study results reveal a disturbing amount of MP particles in Brasilia’s tap water. This surprising number of particles in residential and commercial tap water is especially considering that tap water is not the only source of MPs to which people are exposed.

ACS Style

Claudia Pratesi; Maria A. L. Santos Almeida; Geysa Cutrim Paz; Marcelo Ramos Teotonio; Lenora Gandolfi; Riccardo Pratesi; Mariana Hecht; Renata Zandonadi. Presence and Quantification of Microplastic in Urban Tap Water: A Pre-Screening in Brasilia, Brazil. Sustainability 2021, 13, 6404 .

AMA Style

Claudia Pratesi, Maria A. L. Santos Almeida, Geysa Cutrim Paz, Marcelo Ramos Teotonio, Lenora Gandolfi, Riccardo Pratesi, Mariana Hecht, Renata Zandonadi. Presence and Quantification of Microplastic in Urban Tap Water: A Pre-Screening in Brasilia, Brazil. Sustainability. 2021; 13 (11):6404.

Chicago/Turabian Style

Claudia Pratesi; Maria A. L. Santos Almeida; Geysa Cutrim Paz; Marcelo Ramos Teotonio; Lenora Gandolfi; Riccardo Pratesi; Mariana Hecht; Renata Zandonadi. 2021. "Presence and Quantification of Microplastic in Urban Tap Water: A Pre-Screening in Brasilia, Brazil." Sustainability 13, no. 11: 6404.

Journal article
Published: 09 May 2021 in Nutrients
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Since the end of 2019, the world has been facing an unpredicted COVID-19 pandemic with consequences for the economy, environment, society, and health. The COVID-19 pandemic has increased the risk of death, bringing unbearable psychological pressure upon people worldwide. For celiac patients, the pandemic may represent an additional burden concerning the inherent aspects of celiac disease (CD) that compromise these individuals’ quality of life (QoL). Therefore, the objective of this study was to evaluate Brazilian celiac patients’ QoL during the course of the COVID-19 pandemic caused by its outbreak and rapid spread and subsequent restrictive measures in addition to the dietary restrictions and other burdens caused by CD. This country-wide cross-sectional study was conducted using a self-administered instrument previously validated in Brazilian–Portuguese to investigate the QoL of individuals with CD. Data collected through the online self-administration of the Brazilian version of the celiac disease quality of life questionnaire (CDQ) comprised 674 CD individuals’ responses. Although pandemics have historically posed a challenge for Brazilian population, this period was not associated with a negative impact on Brazilian CD individuals’ QoL. During the pandemic, the QoL of Brazilian’s with CD was more affected by gastrointestinal aspects than emotions and social aspects and worries. Gender, age, marital status, having (or not) children, occupation, and a positive test for COVID-19 did not affect CD individuals’ QoL. However, the study revealed a larger burden and diminished QoL for individuals not following a gluten-free diet and those using antidepressants. Additional research is necessary to verify how the length of the pandemic will affect celiac individuals and then compare those outcomes compare to the COVID-19 period and after.

ACS Style

Ana Falcomer; Priscila Farage; Cláudia Pratesi; Riccardo Pratesi; Lenora Gandolfi; Eduardo Nakano; António Raposo; Renata Zandonadi. Health-Related Quality of Life and Experiences of Brazilian Celiac Individuals over the Course of the Sars-Cov-2 Pandemic. Nutrients 2021, 13, 1582 .

AMA Style

Ana Falcomer, Priscila Farage, Cláudia Pratesi, Riccardo Pratesi, Lenora Gandolfi, Eduardo Nakano, António Raposo, Renata Zandonadi. Health-Related Quality of Life and Experiences of Brazilian Celiac Individuals over the Course of the Sars-Cov-2 Pandemic. Nutrients. 2021; 13 (5):1582.

Chicago/Turabian Style

Ana Falcomer; Priscila Farage; Cláudia Pratesi; Riccardo Pratesi; Lenora Gandolfi; Eduardo Nakano; António Raposo; Renata Zandonadi. 2021. "Health-Related Quality of Life and Experiences of Brazilian Celiac Individuals over the Course of the Sars-Cov-2 Pandemic." Nutrients 13, no. 5: 1582.

Preprint content
Published: 03 December 2020
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Background: Plastic pollution is a rapidly growing environmental and human health crisis, with no sign of improvement. Since 2012 the number of studies on plastic pollution has quadrupled, and macro to nano-size plastics have been documented even in the planet's remote biomes. Studies have shown contamination by microplastics (MPs) in various types of food consumed by humans, including seafood, honey, sugar, salt, tap-water and bottled water and beer. The study's objective was to detect the possible contamination by MPs in drinking water samples collected from the two main residential and commercial areas of Brasília.Methods: A total of 32 samples of tap water were collected, 16 samples in the south zone, and 16 samples in the north zone of the city (respectively, South Wing and North Wing). Samples were processed and transferred to the Sedgewick-Rafter counting cell chamber. The presence of MPs particles was analyzed using a Nikon Eclipse fluorescence microscope.Results: MPs were found in 100% of the samples. The mean MPs per 500 ml found in the South Wing area was 97, while the mean number of particles in the North Wing area was 219.Conclusion: The study results reveal a disturbing amount of MP particles in Brasilia's tap-water. This surprising number of particles in tap-water is especially concerning considering that tap-water is not the only source of MPs to which people are exposed. The cumulative and toxicological effect of this chronic exposure is alarming.

ACS Style

Claudia B. Pratesi; Maria Aparecida A.L. Santos Almeida; Geysa S. Cutrim Paz; Marcelo H. Ramos Teotonio; Felipe Mendes Dos Santos Cardia; Lenora Gandolfi; Riccardo Pratesi; Mariana Hecht. Presence and Quantification of Microplastic in Urban Tap-Water. 2020, 1 .

AMA Style

Claudia B. Pratesi, Maria Aparecida A.L. Santos Almeida, Geysa S. Cutrim Paz, Marcelo H. Ramos Teotonio, Felipe Mendes Dos Santos Cardia, Lenora Gandolfi, Riccardo Pratesi, Mariana Hecht. Presence and Quantification of Microplastic in Urban Tap-Water. . 2020; ():1.

Chicago/Turabian Style

Claudia B. Pratesi; Maria Aparecida A.L. Santos Almeida; Geysa S. Cutrim Paz; Marcelo H. Ramos Teotonio; Felipe Mendes Dos Santos Cardia; Lenora Gandolfi; Riccardo Pratesi; Mariana Hecht. 2020. "Presence and Quantification of Microplastic in Urban Tap-Water." , no. : 1.

Journal article
Published: 18 November 2020 in International Journal of Environmental Research and Public Health
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The COVID-19 outbreak, caused by Sars-Cov-2, was officially declared a global pandemic in February 2020, after an unexpected increase in hospitalization and mortality. When faced with this new disease, social and physical distancing and quarantine emerged as solutions to reduce virus transmission. This article examines the quality of life (QoL) of the Brazilian population’s during this period of isolation, due to the COVID-19 pandemic by analyzing; physical, psychological, social, and economic aspects. An online survey was distributed from 27 May to 14 August of 2020. A total of 1859 surveys were completed. Our results indicate that Brazilians were more affected by economic and social aspects than psychological and physical. Unemployed participants and individuals who tested positive for COVID-19 presented the lowest QoL. Females showed worst QoL scores than males, but having children did not influence the score. Higher educational level was associated with a better perception of QoL. Not following social distancing guidelines presented better scores in the psychological domain than the ones following restrict or partial social distancing rules. This study is the first to evaluate adults’ QoL related to the Sars-Cov-2 pandemic in Brazil at a national level. Our data may help health authorities identify the main factors affecting the QoL of the Brazilian population, thereby orientating them to recover after the pandemic.

ACS Style

Isabella Teotônio; Mariana Hecht; Luiz Claudio Castro; Lenora Gandolfi; Riccardo Pratesi; Eduardo Y. Nakano; Renata Puppin Zandonadi; Claudia B. Pratesi. Repercussion of COVID-19 Pandemic on Brazilians’ Quality of Life: A Nationwide Cross-Sectional Study. International Journal of Environmental Research and Public Health 2020, 17, 8554 .

AMA Style

Isabella Teotônio, Mariana Hecht, Luiz Claudio Castro, Lenora Gandolfi, Riccardo Pratesi, Eduardo Y. Nakano, Renata Puppin Zandonadi, Claudia B. Pratesi. Repercussion of COVID-19 Pandemic on Brazilians’ Quality of Life: A Nationwide Cross-Sectional Study. International Journal of Environmental Research and Public Health. 2020; 17 (22):8554.

Chicago/Turabian Style

Isabella Teotônio; Mariana Hecht; Luiz Claudio Castro; Lenora Gandolfi; Riccardo Pratesi; Eduardo Y. Nakano; Renata Puppin Zandonadi; Claudia B. Pratesi. 2020. "Repercussion of COVID-19 Pandemic on Brazilians’ Quality of Life: A Nationwide Cross-Sectional Study." International Journal of Environmental Research and Public Health 17, no. 22: 8554.

Journal article
Published: 15 October 2020 in Scientific Reports
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There has been a significant increase in autism spectrum disorder (ASD) in the last decades that cannot be exclusively attributed to better diagnosis and an increase in the communication of new cases. Patients with ASD often show dysregulation of proteins associated with synaptic plasticity, notably brain-derived neurotrophic factor (BDNF). The objective of the present study was to analyze BDNF serum concentration levels in children with classic forms autism and a healthy control group to determine if there is a correlation between ASD and BDNF serum levels. Forty-nine children with severe classic form of autism, and 37 healthy children were enrolled in the study. Blood samples, from both patients and controls, were collected and BNDF levels from both groups were analyzed. The average BDNF serum concentration level was statistically higher for children with ASD (P < 0.000) compared to the control group. There is little doubt that BDNF plays a role in the pathophysiology of ASD development and evolution, but its brain levels may fluctuate depending on several known and unknown factors. The critical question is not if BDNF levels can be considered a prognostic or diagnostic marker of ASD, but to determine its role in the onset and progression of this disorder.

ACS Style

Alexandre Garcia Barbosa; Riccardo Pratesi; Geysa Stefanne Cutrim Paz; Maria Aparecida Alves Leite Dos Santos; Rosa Harumi Uenishi; Eduardo Y. Nakano; Lenora Gandolfi; Claudia B. Pratesi. Assessment of BDNF serum levels as a diagnostic marker in children with autism spectrum disorder. Scientific Reports 2020, 10, 1 -7.

AMA Style

Alexandre Garcia Barbosa, Riccardo Pratesi, Geysa Stefanne Cutrim Paz, Maria Aparecida Alves Leite Dos Santos, Rosa Harumi Uenishi, Eduardo Y. Nakano, Lenora Gandolfi, Claudia B. Pratesi. Assessment of BDNF serum levels as a diagnostic marker in children with autism spectrum disorder. Scientific Reports. 2020; 10 (1):1-7.

Chicago/Turabian Style

Alexandre Garcia Barbosa; Riccardo Pratesi; Geysa Stefanne Cutrim Paz; Maria Aparecida Alves Leite Dos Santos; Rosa Harumi Uenishi; Eduardo Y. Nakano; Lenora Gandolfi; Claudia B. Pratesi. 2020. "Assessment of BDNF serum levels as a diagnostic marker in children with autism spectrum disorder." Scientific Reports 10, no. 1: 1-7.

Journal article
Published: 26 September 2020 in International Journal of Environmental Research and Public Health
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This cross-sectional study aimed to translate, culturally adapt, validate, and apply a Celiac Disease Quality of Life (CD-QoL) questionnaire to a representative sample of Argentina’s celiac population. A previously developed and validated questionnaire (Celiac Disease Questionnaire: CDQ) was chosen as a tool for assessing the health-related quality of Life (HRQoL) of adult celiac patients in Argentina. Therefore, the study was performed in four stages: (a) translation and re-translation of the CDQ to Argentinian-Spanish language; (b) cultural adaptation and semantic evaluation; based on the Delphi method (c) validation of the CDQ by applying it to a representative sample of Argentinian celiac patients; (d) statistical analysis of the data. The result of stages (a) and (b) was a translated and culturally adapted an Argentinian-Spanish version of the CDQ, which was generated after reaching consensus between the corresponding four (phase a) and 10 (phase b) professionals involved in the different phases of this process. Among them, we can cite bilingual healthcare professionals with extensive experience in research and celiac disease, celiac patients, gastroenterologists, general practitioners, dieticians, and psychologists. The resulting CDQ proved to be an appropriate measuring tool to assess the HRQoL of Argentinian celiac patients confirmed by a good fit in the confirmatory factor validity analysis (RMSEA < 0.001 and χ2 = 267.325, df = 313, p = 0.971) and high values of internal consistency (Cronbach’s alpha > 0.7). A total of 191 participants accessed the questionnaire, and 171 individuals from 20 out of 23 Argentinian states completed the questionnaire. There was no correlation between higher educational level nor marital status with QoL. Individuals on a strict gluten-free diet (GFD) and those who do not take antidepressants showed higher QoL. Male gender also presented better HRQoL. There was no correlation between differences in HRQoL and age of the respondent, age at diagnosis, symptoms at diagnosis, or having other chronic diseases. However, a significantly higher score of HRQoL was reported among those individuals who disclosed having knowledge of CD related national regulations and benefits. This study highlights the importance of maintaining current public health regulations that support chronic disease patients, such as celiac patients.

ACS Style

Nicole Selleski; Renata Puppin Zandonadi; Laura B. Milde; Lenora Gandolfi; Riccardo Pratesi; Winfred Häuser; Rosa Harumi Uenishi; Eduardo Yoshio Nakano; Claudia B. Pratesi. Evaluation of Quality of Life of Adult Patients with Celiac Disease in Argentina: From Questionnaire Validation to Assessment. International Journal of Environmental Research and Public Health 2020, 17, 7051 .

AMA Style

Nicole Selleski, Renata Puppin Zandonadi, Laura B. Milde, Lenora Gandolfi, Riccardo Pratesi, Winfred Häuser, Rosa Harumi Uenishi, Eduardo Yoshio Nakano, Claudia B. Pratesi. Evaluation of Quality of Life of Adult Patients with Celiac Disease in Argentina: From Questionnaire Validation to Assessment. International Journal of Environmental Research and Public Health. 2020; 17 (19):7051.

Chicago/Turabian Style

Nicole Selleski; Renata Puppin Zandonadi; Laura B. Milde; Lenora Gandolfi; Riccardo Pratesi; Winfred Häuser; Rosa Harumi Uenishi; Eduardo Yoshio Nakano; Claudia B. Pratesi. 2020. "Evaluation of Quality of Life of Adult Patients with Celiac Disease in Argentina: From Questionnaire Validation to Assessment." International Journal of Environmental Research and Public Health 17, no. 19: 7051.

Journal article
Published: 25 March 2020 in Medicina
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Background and objectives: The present study is the first known in Latin America to enroll a substantial number of Kawasaki disease (KD) patients with an extended follow-up. This study aimed to: (1) to expose the difficulties and delays in the diagnosis of KD in a developing country, (2) to describe and correlate the clinical features of this disorder with the children’s age at the time of disease onset, (3) to correlate the frequent lack of early diagnosis with a delayed application of appropriate treatment, and (4) to describe the outcome and eventual recurrences of KD in our region. Materials and Methods: Three hundred and one participants (183 males and 118 females) included in the study were diagnosed and, subsequently, clinically followed for ten years (January 2007 to December 2016) at the Pediatric Rheumatology Walk-in Clinic of the Children’s Hospital of Brasilia. Results: Episodes ranged from four months to two years. This rate of recurrence was well-above that disclosed by previous reports. Delay in diagnosis, in all age groups, caused an undesirable delay between the disease onset, the final diagnosis, and the administration of intravenous immunoglobulin (IVIG). KD recurred in 25 (8.3%) of the children during the first three years of follow-up. In seven patients, KD recurred twice, with an interval between episodes ranging from four months to two years. Conclusions: This rate of recurrence was well-above that disclosed by previous reports. In Latin America, aside from a handful of physicians and researchers, KD is being ignored. There is a pressing need to educate primary health care physicians and bring awareness to the fact that KD is not an exotic condition that affects only the Asian populations but a disorder that already exists among us and that frequently results in severe consequences.

ACS Style

Cristina Medeiros R. De Magalhães; Fernanda Coutinho De Almeida; Lenora Gandolfi; Riccardo Pratesi; Natália Ribeiro De M. Alves; Nicole Selleski; Renata Puppin Zandonadi; Eduardo Yoshio Nakano; Claudia B. Pratesi. Clinical Manifestations of Kawasaki Disease at Different Age Spectrum: A Ten-Year Study. Medicina 2020, 56, 145 .

AMA Style

Cristina Medeiros R. De Magalhães, Fernanda Coutinho De Almeida, Lenora Gandolfi, Riccardo Pratesi, Natália Ribeiro De M. Alves, Nicole Selleski, Renata Puppin Zandonadi, Eduardo Yoshio Nakano, Claudia B. Pratesi. Clinical Manifestations of Kawasaki Disease at Different Age Spectrum: A Ten-Year Study. Medicina. 2020; 56 (4):145.

Chicago/Turabian Style

Cristina Medeiros R. De Magalhães; Fernanda Coutinho De Almeida; Lenora Gandolfi; Riccardo Pratesi; Natália Ribeiro De M. Alves; Nicole Selleski; Renata Puppin Zandonadi; Eduardo Yoshio Nakano; Claudia B. Pratesi. 2020. "Clinical Manifestations of Kawasaki Disease at Different Age Spectrum: A Ten-Year Study." Medicina 56, no. 4: 145.

Validation study
Published: 27 September 2019 in Nutrients
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Celiac disease (CD) is an autoimmune disorder triggered by the ingestion of gluten and affects approximately 1% of the global population. Currently, the only treatment available is lifelong strict adherence to a gluten-free diet (GFD). Chronic diseases such as CD affect patients and their family members’ quality of life (QoL); particularly parents and caregivers who play an essential role in the child’s care and treatment. A higher level of psychological distress has been found in the parents of children with chronic ailments due to limited control over the child’s daily activities and the child’s illness. In this context, the validation of a specific questionnaire of QoL is a valuable tool to evaluate the difficulties faced by parents or caregivers of children with this chronic illness. A specific questionnaire for this population can elucidate the reasons for stress in their daily lives as well as the physical, mental, emotional, and social impact caused by CD. Therefore, this study aimed to develop and validate a specific questionnaire to evaluate the QoL of parents and caregivers of children and adolescents with CD. Overall results showed that a higher family income resulted in a higher score of the worries domain. In addition, having another illness besides CD decreased the QoL (except in the worries domain). The other variables studied did not present a statistically significant impact on the QoL, which was shown to be low in all aspects. Knowledge of the QoL is important to help implement effective strategies to improve celiac patients’ quality of life and reduce their physical, emotional, and social burden.

ACS Style

Liliane Maria Abreu Paiva; Lenora Gandolfi; Riccardo Pratesi; Rosa Harumi Uenishi; Renata Puppin Zandonadi; Eduardo Yoshio Nakano; Claudia B. Pratesi. Measuring Quality of Life in Parents or Caregivers of Children and Adolescents with Celiac Disease: Development and Content Validation of the Questionnaire. Nutrients 2019, 11, 2302 .

AMA Style

Liliane Maria Abreu Paiva, Lenora Gandolfi, Riccardo Pratesi, Rosa Harumi Uenishi, Renata Puppin Zandonadi, Eduardo Yoshio Nakano, Claudia B. Pratesi. Measuring Quality of Life in Parents or Caregivers of Children and Adolescents with Celiac Disease: Development and Content Validation of the Questionnaire. Nutrients. 2019; 11 (10):2302.

Chicago/Turabian Style

Liliane Maria Abreu Paiva; Lenora Gandolfi; Riccardo Pratesi; Rosa Harumi Uenishi; Renata Puppin Zandonadi; Eduardo Yoshio Nakano; Claudia B. Pratesi. 2019. "Measuring Quality of Life in Parents or Caregivers of Children and Adolescents with Celiac Disease: Development and Content Validation of the Questionnaire." Nutrients 11, no. 10: 2302.

Validation study
Published: 04 April 2019 in Nutrients
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This study aimed to translate, culturally adapt, validate, and apply a questionnaire to the Brazilian non-celiac gluten sensitive (NCGS) population. We also aimed to estimate the prevalence of symptoms which affect Brazilian NCGS. The Brazilian Portuguese version of the NCGS questionnaire was developed according to revised international guidelines. Five-hundred-and-fourty-three participants responded the NCGS questionnaire. We evaluated the reproducibility and validity of the questionnaire which presents valid measures of reproducibility. This is the first specific self-reported validated questionnaire for NCGS patients in Brazilian Portuguese, and the first nationwide characterization of self-reported NCGS in Brazilian adults. Most respondents were female (92.3%), and the main intestinal symptoms reported were bloating and abdominal pain. The most frequent extraintestinal symptoms were lack of wellbeing, tiredness, and depression. We expect that the present study will provide a picture of Brazilian individuals with suspected NCGS, which could help health professionals and governmental institutions in developing effective strategies to improve the treatment and diagnosis of Brazilian NCGS.

ACS Style

Yanna A. Gadelha De Mattos; Renata Puppin Zandonadi; Lenora Gandolfi; Riccardo Pratesi; Eduardo Yoshio Nakano; Claudia B. Pratesi. Self-Reported Non-Celiac Gluten Sensitivity in Brazil: Translation, Cultural Adaptation, and Validation of Italian Questionnaire. Nutrients 2019, 11, 781 .

AMA Style

Yanna A. Gadelha De Mattos, Renata Puppin Zandonadi, Lenora Gandolfi, Riccardo Pratesi, Eduardo Yoshio Nakano, Claudia B. Pratesi. Self-Reported Non-Celiac Gluten Sensitivity in Brazil: Translation, Cultural Adaptation, and Validation of Italian Questionnaire. Nutrients. 2019; 11 (4):781.

Chicago/Turabian Style

Yanna A. Gadelha De Mattos; Renata Puppin Zandonadi; Lenora Gandolfi; Riccardo Pratesi; Eduardo Yoshio Nakano; Claudia B. Pratesi. 2019. "Self-Reported Non-Celiac Gluten Sensitivity in Brazil: Translation, Cultural Adaptation, and Validation of Italian Questionnaire." Nutrients 11, no. 4: 781.

Journal article
Published: 31 July 2018 in Case Reports in Perinatal Medicine
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Kawasaki disease (KD) is one of the most common causes of childhood systemic vasculitis, with the potential to cause significant cardiovascular complications, especially if undiagnosed. An investigation of coronary artery abnormalities with the application of appropriate therapeutic measures can improve the prognosis in these infants, decreasing the risk of coronary artery aneurysms. Neonatal KD is a rare event, often characterized only by few of the clinical features observed in older children. In this case report, we describe a newborn male who presented an incomplete clinical presentation of KD, where symptoms of the disease erupted immediately after birth. The objective of this report is to draw the attention of pediatricians and neonatologists to the possible presence of KD in an asymptomatic newborn during the immediate postnatal period, even in the absence of the classic features of KD, such as fever.

ACS Style

Cristina Medeiros Ribeiro De Magalhães; Riccardo Pratesi; Lenora Gandolfi; Rosa Harume Uenishi; Claudia B. Pratesi. Onset of Kawasaki disease immediately after birth. Case Reports in Perinatal Medicine 2018, 7, 1 .

AMA Style

Cristina Medeiros Ribeiro De Magalhães, Riccardo Pratesi, Lenora Gandolfi, Rosa Harume Uenishi, Claudia B. Pratesi. Onset of Kawasaki disease immediately after birth. Case Reports in Perinatal Medicine. 2018; 7 (2):1.

Chicago/Turabian Style

Cristina Medeiros Ribeiro De Magalhães; Riccardo Pratesi; Lenora Gandolfi; Rosa Harume Uenishi; Claudia B. Pratesi. 2018. "Onset of Kawasaki disease immediately after birth." Case Reports in Perinatal Medicine 7, no. 2: 1.

Research article
Published: 11 June 2018 in BMC Complementary and Alternative Medicine
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Anacardium occidentale L phenolic lipid (LDT11) is used in traditional medicine as anti-inflammatory, astringent, antidiarrheal, anti-asthmatic and depurative. Phenolic derivatives, such as anacardic acid, extracted from cashew nut shell liquid (CNSL) have demonstrated biological and pharmacological properties, and its profile makes it a candidate for the development of new anti-inflammatory agents. The objective of the present study was to evaluate the anti-inflammatory profile of a derivative, synthesized from LDT11, on an in vitro cellular model. Organic synthesis of the phenolic derivative of CNSL that results in the hemi-synthetic compound LDT11. The cytotoxicity of the planned compound, LDT11, was analyzed in murine macrophages cell line, RAW264.7. The cells were previously treated with LDT11, and then, the inflammation was stimulated with lipopolysaccharide (LPS), in intervals of 6 h and 24 h. The analysis of the gene expression of inflammatory markers (TNFα, iNOS, COX-2, NF-κB, IL-1β and IL-6), nitric oxide (NO) dosage, and cytokine IL-6 were realized. The results showed that the phenolic derivative, LDT11, influenced the modulatory gene expression. The relative gene transcripts quantification demonstrated that the LDT11 disclosed an immunoprotective effect against inflammation by decreasing genes expression when compared with cells stimulated with LPS in the control group. The NO and IL-6 dosages confirmed the results found in gene expression. The present study evaluated the immunoprotective effect of LDT11. In addition to a significant reduction in the expression of inflammatory genes, LDT11 also had a faster and superior anti-inflammatory action than the commercial products, and its response was already evident in the test carried out six hours after the treatment of the cells. This study demonstrated LDT11 is potentially valuable as a rapid immunoprotective anti-inflammatory agent. Treatment with LDT11 decreased the gene expression of inflammatory markers, and the NO, and IL-6 production. When compared to commercial drugs, LDT11 showed a superior anti-inflammatory action.

ACS Style

Marilen Queiroz de Souza; Isabella Márcia Soares Nogueira Teotônio; Fernanda Coutinho de Almeida; Gabriella Simões Heyn; Priscilla Souza Alves; Luiz Antônio Soares Romeiro; Riccardo Pratesi; Yanna Karla De Medeiros Nóbrega; Claudia B. Pratesi. Molecular evaluation of anti-inflammatory activity of phenolic lipid extracted from cashew nut shell liquid (CNSL). BMC Complementary and Alternative Medicine 2018, 18, 181 .

AMA Style

Marilen Queiroz de Souza, Isabella Márcia Soares Nogueira Teotônio, Fernanda Coutinho de Almeida, Gabriella Simões Heyn, Priscilla Souza Alves, Luiz Antônio Soares Romeiro, Riccardo Pratesi, Yanna Karla De Medeiros Nóbrega, Claudia B. Pratesi. Molecular evaluation of anti-inflammatory activity of phenolic lipid extracted from cashew nut shell liquid (CNSL). BMC Complementary and Alternative Medicine. 2018; 18 (1):181.

Chicago/Turabian Style

Marilen Queiroz de Souza; Isabella Márcia Soares Nogueira Teotônio; Fernanda Coutinho de Almeida; Gabriella Simões Heyn; Priscilla Souza Alves; Luiz Antônio Soares Romeiro; Riccardo Pratesi; Yanna Karla De Medeiros Nóbrega; Claudia B. Pratesi. 2018. "Molecular evaluation of anti-inflammatory activity of phenolic lipid extracted from cashew nut shell liquid (CNSL)." BMC Complementary and Alternative Medicine 18, no. 1: 181.

Gastroenterology and hepatology
Published: 13 February 2018 in BMJ Open
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BackgroundKawasaki disease (KD) is a self-limited acute systemic vasculitis of unknown aetiology that predominantly affects infants and young children eventually associated with immunological abnormalities. Coeliac disease (CD) is an inflammatory autoimmune disease characterised by a permanent gluten intolerance, which affects genetically susceptible individuals of any age group, and can cause intestinal and systemic symptoms. Association of CD with KD has been previously described in a single study that disclosed a surprisingly high prevalence of CD in children with a history of KD.ObjectiveTo confirm the existence of a higher prevalence of CD among individuals with a history of KD, which would turn the screening for CD in patients with history of KD highly advisable.SettingChildren with history of KD, diagnosed and followed at the Rheumatology Clinic of the Children’s Hospital of Brasilia (Brasilia, Brazil).ParticipantsThis study included 110 children with history of KD and a control group composed of 110 presumably healthy children.InterventionsParticipants underwent anti-transglutaminase and anti-endomysial antibodies tests and genetic typing for the presence of CD predisposing alleles (HLA-DQ2 and DQ8). Jejunal biopsy was performed when necessary, according the European Society of Paediatric Gastroenterology, Hepatology and Nutrition guidelines.ResultsDiagnosis of CD was confirmed in one (0.91%) patient with KD by positive serological tests, presence of predisposing alleles and CD typical lesions on duodenal biopsy. All serological tests were negative among the controls. The prevalence of CD predisposing alleles among patients with KD was 29.09%, similar to the prevalence found among controls, 33.64%.ConclusionThe detected CD prevalence (0.91%) does not confirm the existence of an association between KD and CD since this prevalence is similar to that found in the general population (≃1%).

ACS Style

Alessandra Dos Santos Domingues; Nicole Selleski; Rosa Harumi Uenishi; Cristina Medeiros Ribeiro De Magalhães; Lenora Gandolfi; Claudia B Pratesi. The possible link between coeliac and Kawasaki diseases in Brazil: a cross-sectional study. BMJ Open 2018, 8, e018803 .

AMA Style

Alessandra Dos Santos Domingues, Nicole Selleski, Rosa Harumi Uenishi, Cristina Medeiros Ribeiro De Magalhães, Lenora Gandolfi, Claudia B Pratesi. The possible link between coeliac and Kawasaki diseases in Brazil: a cross-sectional study. BMJ Open. 2018; 8 (2):e018803.

Chicago/Turabian Style

Alessandra Dos Santos Domingues; Nicole Selleski; Rosa Harumi Uenishi; Cristina Medeiros Ribeiro De Magalhães; Lenora Gandolfi; Claudia B Pratesi. 2018. "The possible link between coeliac and Kawasaki diseases in Brazil: a cross-sectional study." BMJ Open 8, no. 2: e018803.