Skeletal muscle mishaps are the most well-known incidents in society, especially among athletes and the military population. From the various urgency, this accident needs to be cured more quickly. However, the current treatment still has some shortcomings and is less effective. In this case, Paired box 3 and Paired box 7 (Pax3/Pax7) proteins that induce stem cells could potentially be an alternative treatment for skeletal muscle injuries. This paper aimed to analyse the potential treatment of Pax3/Pax7 proteins inducing the stem cell for skeletal muscle injuries. We did a narrative review by gathering several scientific journals from several leading platforms like PubMed and Scopus. As common accidents, skeletal muscle disease could be due to workplace and non-workplace causes. The highest risk occurs in the athlete and military environment. The treatment of current skeletal muscle injuries is protection, rest, ice, compression, and elevation (PRICE), non-steroidal anti-inflammatory drugs (NSAIDs), and mechanical stimulation. However, it is considered less effective, especially in NSAIDs, inhibiting myogenic cell proliferation. The current finding indicates that the stem cells have markers known as Pax3/Pax7. The role of both markers in muscle injury, Pax3/Pax7, as transcription factors will induce cell division by H3K4 methylation mechanisms and chromatin modifications that stimulate gene activation. Regulation by Pax3/Pax7 factors that affect stem cells and stem cell proliferation is one of the alternative treatments. This regulation can accelerate the healing of injury victims, especially injuries to the skeletal muscles. Finally, after being compared, Pax3/Pax7 induces stem cells to have the potential to be one of the skeletal muscle injury treatments. Pax3 and Pax7, Pax3/Pax7, Skeletal muscle, Athlete, Stem cells, Cell proliferation, Injuries.

Alzheimer’s disease (AD) is a neurodegenerative condition characterized by considerable cognitive decline and functional impairment, primarily due to the progressive alteration of neurons, microglia, and astrocytes. Pathological manifestations of AD include the loss of synaptic plasticity, reduction in synaptic strength by amyloid-beta, aggregation, and neurotoxicity from tau protein post-translational modifications, all contributing to the disruption of neural networks. Despite its current pharmacological treatment for AD, different approaches to treat such disease are being developed, from a microbiome perspective. The microbiome encompasses a diverse microorganism, including beneficial bacteria that create a positive impact to diminish AD pathogenesis. Growing evidence suggests that probiotic, prebiotic, synbiotic, and postbiotics can positively modulate the gut–brain axis, reducing systemic inflammation, restoring neurotransmitter balance, and improving gut health, thereby possibly mitigating AD pathogenesis. Moreover, there is paraprobiotics as the most recently developed biotherapeutic with beneficial effects. This review explores the correlation between AD and gut–brain axis as a novel biotherapeutic target. The underlying mechanism of the microbiota–gut–brain axis in AD is examined. Novel insights into the current applications as potential treatment and its limitations are highlighted.

Bloodstream infections (BSIs) are some of the most devastating preventable complications in critical care units. Of the bacterial causes of BSIs, Escherichia coli is the most common among Enterobacteriaceae. Bacteria resistant to therapeutic antibiotics represent a significant global health challenge. In this study, we present whole genome sequence data of 22 E. coli isolates that were obtained from bloodstream infection patients admitted to Cipto Mangunkusumo National Hospital, Jakarta, Indonesia. These data will be useful for analysing the serotypes, virulence genes, and antimicrobial resistance genes of E. coli. DNA sequences of E. coli were obtained using the Illumina MiSeq platform. The FASTQ raw files of these sequences are available under BioProject accession number PRJNA596854 and Sequence Read Archive accession numbers SRR10761126-SRR10761147.

ABSTRAK   Integrasi program pengabdian masyarakat ini dengan kegiatan pengajaran dilakukan dalam bentuk pemberian tugas kuliah pada mata kuliah Mikrobiologi Farmasi di tingkat dua semester genap tahun ajaran 2021/2022. Topik yang diangkat adalah penggunaan antibiotika yang tepat dan benar. Penyuluhan Mikrobiologi #2 diharapkan dapat meningkatkan pengetahuan dan memperbaiki perilaku masyarakat dalam penggunaan antibiotik. Hal ini tentu saja akan membangun kewaspadaan masyarakat terhadap kejadian resistensi. Penyuluhan dilaksanakan secara virtual menggunakan perangkat lunak Zoom Meeting dan disiarkan secara terbuka melalui live streaming pada kanal youtube Fakultas Farmasi Militer Universitas Pertahanan Oficial pada hari Sabtu, 4 Juni 2022 pukul 09.00-11.30 WIB. Jumlah peserta sebanyak 74 peserta masyarakat umum dari berbagai daerah di Indonesia. Kegiatan penyuluhan dilakukan oleh narasumber Dr. apt. Bantari Wisynu Kusuma Wardhani, M.Biomed, apt. Nurul Latifah, M.Clin.Pharm, dan Dr. Anggi Gayatri, SpFK. Berdasarkan hasil evaluasi kegiatan 74% peserta penyuluhan menyatakan sangat berminat terhadap kegiatan serupa dan 89% menyatakan sangat puas dengan pelaksanaan kegiatan. Materi dalam kegiatan ini juga dibutuhkan dan dapat diaplikasian dalam penggunaan antibiotika di kehidupan sehari-hari oleh sebagian besar peserta (>75%).   Kata Kunci: Edukasi, Daring, Antibiotika, Infeksi Bakteri   ABSTRACT     This community service program integrated with teaching activities by giving assignments in the Pharmaceutical Microbiology course at the second even semester level of the 2021/2022 academic year. The topic raised is the proper and correct use of antibiotics. Microbiology Counseling #2 is aimed to increase knowledge and improve community behavior in the use of antibiotics. This of course will generate public awareness in the incidence of resistance. The counseling was carried out virtually using the Zoom Meeting software and broadcast openly via live streaming on the Youtube channel of the Faculty of Military Pharmacy, Oficial Defense University on Saturday, June 4, 2022, 09.00-11.30 WIB. The number of participants were 74 participants from the society from various regions in Indonesia. Counseling activities were carried out by resource persons, Dr. apt. Bantari Wisynu Kusuma Wardhani, M. Biomed, apt. Nurul Latifah, M.Clin.Pharm, and Dr. Anggi Gayatri, SpFK. Based on the results of the evaluation of activities, 74% of the extension participants stated that they were very interested in similar activities and 89% said they were very satisfied with the implementation of the activities. The material in this activity is also needed and can be applied in the use of antibiotics in daily life by most of the participants (>75%).   Keywords: Education, Online Meeting, Antibiotics, Bacterial Infection