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Polymer nanoparticles are a promising approach for cancer treatment and detection, due to their biocompatibility, biodegradability, targeting capabilities, capacity for drug loading and long blood circulation time. This study aims to evaluate the impact of poly (styrene–acrylic acid) latex particles on colorectal and cervical cancer cells for anti-tumor efficiency. Latex particles were synthesized by a surfactant-free radical emulsion polymerization process and the obtained polymer particles were characterized in terms of size, size distribution, morphology using scanning electron microscopy (SEM) and transmission electron microscopy (TEM), and electrokinetic property (i.e., zeta potential). Human colorectal and cervical cancer, and normal cell lines, were then treated with different concentrations of poly (styrene–acrylic acid) latex particles. The cell morphology changes were pointed out using an optical microscope and the nanoparticles’ (NPs) cell cytotoxicity was evaluated using MTT assay. The obtained results showed that poly (styrene–acrylic acid) latex particles are effective against colorectal and cervical cancer cells if treated with an appropriate particle concentration for 48 h. In addition, it showed that normal cells are the least affected by this treatment. This indicates that these NPs are safe as a drug delivery carrier when used at a low concentration.
Munther Alomari; Arwa Almahasheer; Balasamy Jermy; Amal Al-Dossary; Hiba Bahmdan; Vijaya Ravinayagam; Deena Ababneh; Mohamad Tarhini; Abdelhamid Elaissari. Impact of Poly (Styrene–Acrylic Acid) Latex Nanoparticles on Colorectal and Cervical Cancer Cells. Polymers 2021, 13, 2025 .
AMA StyleMunther Alomari, Arwa Almahasheer, Balasamy Jermy, Amal Al-Dossary, Hiba Bahmdan, Vijaya Ravinayagam, Deena Ababneh, Mohamad Tarhini, Abdelhamid Elaissari. Impact of Poly (Styrene–Acrylic Acid) Latex Nanoparticles on Colorectal and Cervical Cancer Cells. Polymers. 2021; 13 (13):2025.
Chicago/Turabian StyleMunther Alomari; Arwa Almahasheer; Balasamy Jermy; Amal Al-Dossary; Hiba Bahmdan; Vijaya Ravinayagam; Deena Ababneh; Mohamad Tarhini; Abdelhamid Elaissari. 2021. "Impact of Poly (Styrene–Acrylic Acid) Latex Nanoparticles on Colorectal and Cervical Cancer Cells." Polymers 13, no. 13: 2025.
Structural, magnetic, and optical properties along with N2 absorption-desorption features of Sm3+–Dy3+ ions co-substituted BaSr hexaferrite microspheres (HFMSs) engineered through a hydrothermal gel approach were investigated. The microstructural and morphological features were examined by powder X-ray diffraction (XRD), surface area and pore size distribution (BET), scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), high-resolution transmission electron microscopy (HR-TEM), and transmission electron microscopy (TEM) techniques. Rietveld analysis proved the purity of products. The BET revealed a slight variation in textural characteristics with increasing Sm3+–Dy3+ substitution. The surface area (11–16 m2/g) exhibits a pore volume of ~0.07 cm3/g and average pore size distributions of 26.6 nm. The 300 K and 10 K field-dependent hysteresis loops were registered. Remanent magnetizations (Mr) and coercive fields (HC) are in a range of 29.15–34.05 emu/g and 1420–5391 Oe at 300 K, respectively. The estimated saturation magnetizations (Ms) vary between 53.22 emu/g and 71.08 emu/g, and magneton numbers (nB) are in a range of 10.51–13.93 μB. At 10 K, the Mr = 35.18–46.83 emu/g, HC = 1487–4760 Oe, Ms = 81.82–99.17 emu/g, and nB = 14.83–19.44 μB, which are greatly higher compared to room temperature. All magnetic parameters exhibit strong ferrimagnetic features of pristine Sr0·5Ba0·5Fe12O19 and Dy3+ and Sm3+ co-doped HFMSs at both temperatures. Squareness ratios (SQRs), which are very close to 0.50 assign the single domain uniaxially symmetric structured HFMSs. δM type of remanence plots was applied to specify the intensity and type of interparticle interactions as a function of the externally magnetic field, H. The Schuster-Kubelka-Munk theory provides to estimate direct energy band gaps (Eg). Undoped or co-doped HFMSs have a very narrow magnitude of Eg data between 1.795 and 1.865 eV depending on the couple ion concentrations.
M.A. Almessiere; S. Güner; Y. Slimani; B. Rabindran Jermy; M. Sertkol; N. Taskhandi; A. Demir Korkmaz; A. Baykal. Sm–Dy co-substituted Sr hexaferrite microspheres: An investigation on their structural, magnetic, optical, and porosity characteristics. Ceramics International 2021, 1 .
AMA StyleM.A. Almessiere, S. Güner, Y. Slimani, B. Rabindran Jermy, M. Sertkol, N. Taskhandi, A. Demir Korkmaz, A. Baykal. Sm–Dy co-substituted Sr hexaferrite microspheres: An investigation on their structural, magnetic, optical, and porosity characteristics. Ceramics International. 2021; ():1.
Chicago/Turabian StyleM.A. Almessiere; S. Güner; Y. Slimani; B. Rabindran Jermy; M. Sertkol; N. Taskhandi; A. Demir Korkmaz; A. Baykal. 2021. "Sm–Dy co-substituted Sr hexaferrite microspheres: An investigation on their structural, magnetic, optical, and porosity characteristics." Ceramics International , no. : 1.
This study proposes a bio-directed approach for the formation of titanium oxide and silver nanoparticles (TiO2 and Ag NPs), using a wild mushroom, Fomitopsis pinicola, identified by 18S ribosomal RNA gene sequencing (gene accession no. MK635350) and phenotypic examination.
Suriya Rehman; RabindraN Jermy; Sarah Mousa Asiri; Manzoor A. Shah; Romana Farooq; Vijaya Ravinayagam; Mohammad Azam Ansari; Zainab Alsalem; Reem Al Jindan; Zafar Reshi; Firdos Alam Khan. Using Fomitopsis pinicola for bioinspired synthesis of titanium dioxide and silver nanoparticles, targeting biomedical applications. RSC Advances 2020, 10, 32137 -32147.
AMA StyleSuriya Rehman, RabindraN Jermy, Sarah Mousa Asiri, Manzoor A. Shah, Romana Farooq, Vijaya Ravinayagam, Mohammad Azam Ansari, Zainab Alsalem, Reem Al Jindan, Zafar Reshi, Firdos Alam Khan. Using Fomitopsis pinicola for bioinspired synthesis of titanium dioxide and silver nanoparticles, targeting biomedical applications. RSC Advances. 2020; 10 (53):32137-32147.
Chicago/Turabian StyleSuriya Rehman; RabindraN Jermy; Sarah Mousa Asiri; Manzoor A. Shah; Romana Farooq; Vijaya Ravinayagam; Mohammad Azam Ansari; Zainab Alsalem; Reem Al Jindan; Zafar Reshi; Firdos Alam Khan. 2020. "Using Fomitopsis pinicola for bioinspired synthesis of titanium dioxide and silver nanoparticles, targeting biomedical applications." RSC Advances 10, no. 53: 32137-32147.
Tamoxifen (TAM) is a hormonal drug and is mainly used as an anti-estrogen in breast cancer patients. TAM binds to estrogen receptors (ERs), resulting in inhibition of estrogen signaling pathways and thus, a downregulation of cell proliferation. Cancer cells with negative or low ER expression will not uptake TAM and will show low response. Poly (methyl methacrylate) (PMMA) nanoparticles were prepared using surfactant-free emulsion polymerization, then were loaded with Nile red (NR), which resulted in PMMA-NR. To enhance TAM delivery to cervical cancer cells (HELA), which is considered ER-negative, we loaded TAM and polymethyl methacrylate nanoparticles-Nile-red into silica (PMMA-NR-Si-TAM). The uptake and intracellular distribution were visualized by confocal laser scanning microscopy, and the in vitro cytotoxic activity was evaluated by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) assay using HELA and non-tumorigenic cell line HFF-1. The sensitivity of HELA (LC50: 207.31 µg/mL) and HFF-1 (LC50: 234.08 µg/mL) to free TAM was very low. However, after the encapsulation of TAM with PMMA-NR, the sensitivity significantly increased HELA (LC50: 71.83 µg/mL) and HFF-1 (LC50: 37.36 µg/mL). This indicates that TAM can be used for the treatment of ER-negative cervical cancer once conjugated to PMMA-NR nanoparticles. In addition, the PMMA-NR formulation appears to be highly suitable for cancer imaging and drug delivery.
Munther AlOmari; Rabindran Jermy Balasamy; Dana Almohazey; Vijaya Ravinayagam; Mohammad Al Hamad; Deena Ababneh; Hiba Bahmdan; Abdul-Hakeem AlOmari; Zakaria Mokadem; Abdelhamid Elaissari. Nile Red-Poly(Methyl Methacrylate)/Silica Nanocomposite Particles Increase the Sensitivity of Cervical Cancer Cells to Tamoxifen. Polymers 2020, 12, 1516 .
AMA StyleMunther AlOmari, Rabindran Jermy Balasamy, Dana Almohazey, Vijaya Ravinayagam, Mohammad Al Hamad, Deena Ababneh, Hiba Bahmdan, Abdul-Hakeem AlOmari, Zakaria Mokadem, Abdelhamid Elaissari. Nile Red-Poly(Methyl Methacrylate)/Silica Nanocomposite Particles Increase the Sensitivity of Cervical Cancer Cells to Tamoxifen. Polymers. 2020; 12 (7):1516.
Chicago/Turabian StyleMunther AlOmari; Rabindran Jermy Balasamy; Dana Almohazey; Vijaya Ravinayagam; Mohammad Al Hamad; Deena Ababneh; Hiba Bahmdan; Abdul-Hakeem AlOmari; Zakaria Mokadem; Abdelhamid Elaissari. 2020. "Nile Red-Poly(Methyl Methacrylate)/Silica Nanocomposite Particles Increase the Sensitivity of Cervical Cancer Cells to Tamoxifen." Polymers 12, no. 7: 1516.
The present study offers an alternative method for green synthesis of the formation of two types of nanoparticles (NPs). These NPs, titanium oxide and silver NPs (TiO2 and Ag NPs, respectively), were obtained from the amalgamation of intracellular extract of a wild mushroom, Fomes fomentarius, with aqueous solutions of titanium isopropoxide and silver nitrate, respectively. F. fomentarius was identified phenotypically and by 18S ribosomal RNA gene sequencing (Gene accession no: MK635351). The biosynthesis of TiO2 and Ag NPs was studied and characterized by X-ray diffraction (XRD), diffuse reflectance UV-Visible spectroscopy (DR-UV), fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and transmission electron microscope (TEM). Success was achieved in obtaining NPs of differing sizes and shapes. The antibacterial and anticancer activity of the NPs was significant with morphological damage being caused by both, although Ag NPs (10–20 nm) were found to have profound effects on bacterial and cancer cells in comparison to TiO2 NPs (100–120 nm). These metal NPs, synthesized using wild mushrooms, hold a great potential in biomedicinedue to an effective enzyme combination, which permits them to modify different chemical compounds to less toxic forms, which is required for ecofriendly and safe biomaterials.
Suriya Rehman; Romana Farooq; RabindraN Jermy; Sarah Mousa Asiri; Vijaya Ravinayagam; Reem Al Jindan; Zainab AlSalem; Manzoor A. Shah; Zafar Reshi; Hussein Sabit; Firdos Alam Khan. A Wild Fomes fomentarius for Biomediation of One Pot Synthesis of Titanium Oxide and Silver Nanoparticles for Antibacterial and Anticancer Application. Biomolecules 2020, 10, 622 .
AMA StyleSuriya Rehman, Romana Farooq, RabindraN Jermy, Sarah Mousa Asiri, Vijaya Ravinayagam, Reem Al Jindan, Zainab AlSalem, Manzoor A. Shah, Zafar Reshi, Hussein Sabit, Firdos Alam Khan. A Wild Fomes fomentarius for Biomediation of One Pot Synthesis of Titanium Oxide and Silver Nanoparticles for Antibacterial and Anticancer Application. Biomolecules. 2020; 10 (4):622.
Chicago/Turabian StyleSuriya Rehman; Romana Farooq; RabindraN Jermy; Sarah Mousa Asiri; Vijaya Ravinayagam; Reem Al Jindan; Zainab AlSalem; Manzoor A. Shah; Zafar Reshi; Hussein Sabit; Firdos Alam Khan. 2020. "A Wild Fomes fomentarius for Biomediation of One Pot Synthesis of Titanium Oxide and Silver Nanoparticles for Antibacterial and Anticancer Application." Biomolecules 10, no. 4: 622.
30%MFe2O4/Silica/Chitosan (M = Ni, Cu, Co and Mn) was prepared by pre-wrapping chitosan (CS) over hydrophilic silica (HYPS) for cisplatin (cis-Pt) release. CS coating was optimized with 0.06 wt% and 0.6 wt % at different pH (5, 6 and 6.5). CS (0.6 wt%) coated over CuFe2O4/HYPS/cis-Pt by optimizing two ways of pH adjustments. In method I, cis-Pt (0.15 mmolg−1 of nanocarrier) was preloaded with CuFe2O4/HYPS, then immersed in CS of pH 6.0 (cis-Pt/CuFe2O4/HYPS/CS). In method II, CS was pre-wrapped over CuFe2O4/HYPS and then loaded with cis-Pt (CS/CuFe2O4/HYPS/cis-Pt). CoFe2O4/HYPS showed ferromagnetic behavior with high magnetization (14.15 emu/g), while MnFe2O4/HYPS showed a super paramagnetic behavior (1.49 emu/g). CuFe2O4/HYPS showed preferable paramagnetic effect (7.65 emu/g) with cis-Pt release of about 64% for 72 h cis-Pt/CuFe2O4/HYPS and cis-Pt/CuFe2O4/HYPS/CS (0.025–0.5 mg/ml) were studied in MCF-7 and HEK293. CuFe2O4/HYPS was not cytotoxic, while cis-Pt/CuFe2O4/HYPS/CS, prepared by method I showed a non-significant anti-cancer effect due to premediated cis-Pt release. Conversely, cis-Pt/CuFe2O4/HYPS and CS/CuFe2O4/HYPS/cis-Pt prepared by method II significantly reduced cell viability in dose dependent manner. MCF7 cells treated with CS/CuFe2O4/HYPS/cis-Pt (method II) at lowest concentration (0.025 mg/ml) resulted in 70.7% cell viability, whereas HEK293 cells had a 95% viability, thus making the nanocomposite an effective drug delivery system.
RabindraN Jermy; Vijaya Ravinayagam; Widyan AlAmoudi; Dana Almohazey; Silviya Elanthikkal; Hatim Dafalla; Suriya Rehman; Govindasamy Chandrasekar; Abdulhadi Baykal. Tuning pH sensitive chitosan and cisplatin over spinel ferrite/silica nanocomposite for anticancer activity in MCF-7 cell line. Journal of Drug Delivery Science and Technology 2020, 57, 101711 .
AMA StyleRabindraN Jermy, Vijaya Ravinayagam, Widyan AlAmoudi, Dana Almohazey, Silviya Elanthikkal, Hatim Dafalla, Suriya Rehman, Govindasamy Chandrasekar, Abdulhadi Baykal. Tuning pH sensitive chitosan and cisplatin over spinel ferrite/silica nanocomposite for anticancer activity in MCF-7 cell line. Journal of Drug Delivery Science and Technology. 2020; 57 ():101711.
Chicago/Turabian StyleRabindraN Jermy; Vijaya Ravinayagam; Widyan AlAmoudi; Dana Almohazey; Silviya Elanthikkal; Hatim Dafalla; Suriya Rehman; Govindasamy Chandrasekar; Abdulhadi Baykal. 2020. "Tuning pH sensitive chitosan and cisplatin over spinel ferrite/silica nanocomposite for anticancer activity in MCF-7 cell line." Journal of Drug Delivery Science and Technology 57, no. : 101711.
The role of nano ZIF-8 in a Fe/SBA-16/ZIF composite has been explored as a potential anticancer drug and drug delivery system.
Rabindran Jermy Balasamy; Vijaya Ravinayagam; Munther Alomari; Mohammad Azam Ansari; Sarah Ameen Almofty; Suriya Rehman; Hatim Dafalla; Palanivel Rubavathi Marimuthu; Sultan Akhtar; Mohammad Al Hamad. Cisplatin delivery, anticancer and antibacterial properties of Fe/SBA-16/ZIF-8 nanocomposite. RSC Advances 2019, 9, 42395 -42408.
AMA StyleRabindran Jermy Balasamy, Vijaya Ravinayagam, Munther Alomari, Mohammad Azam Ansari, Sarah Ameen Almofty, Suriya Rehman, Hatim Dafalla, Palanivel Rubavathi Marimuthu, Sultan Akhtar, Mohammad Al Hamad. Cisplatin delivery, anticancer and antibacterial properties of Fe/SBA-16/ZIF-8 nanocomposite. RSC Advances. 2019; 9 (72):42395-42408.
Chicago/Turabian StyleRabindran Jermy Balasamy; Vijaya Ravinayagam; Munther Alomari; Mohammad Azam Ansari; Sarah Ameen Almofty; Suriya Rehman; Hatim Dafalla; Palanivel Rubavathi Marimuthu; Sultan Akhtar; Mohammad Al Hamad. 2019. "Cisplatin delivery, anticancer and antibacterial properties of Fe/SBA-16/ZIF-8 nanocomposite." RSC Advances 9, no. 72: 42395-42408.
The combination of magnetic nanoparticles with a porous silica is a composite that has attracted significant attention for potential multifunctional theranostic applications. In this study, 30 wt % CuFe2O4 was impregnated into a matrix of monodispersed spherical hydrophilic silica (HYPS) nanoparticles through a simple dry impregnation technique. The chemotherapy drug cisplatin was loaded through electrostatic equilibrium adsorption over 24 h in normal saline solution. The presence of cubic spinel CuFe2O4 on HYPS was confirmed through powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR) and diffuse reflectance UV-vis spectroscopy (DR UV-vis) analysis. The HYPS particles showed a surface area of 170 m2/g, pore size of 8.3 nm and pore volume of 0.35 cm3/g. The cisplatin/CuFe2O4/HYPS nanoformulation showed the accumulation of copper ferrite nanoparticles on the surface and in the pores of HYPS with a surface area of 45 m2/g, pore size of 16 nm and pore volume of 0.18 cm3/g. Transmission electron microscopy (TEM) and energy dispersive X-ray (EDX) mapping analysis showed the presence of homogeneous silica particles with nanoclusters of copper ferrite distributed on the HYPS support. Vibrating sample magnetometry (VSM) analysis of CuFe2O4/HYPS showed paramagnetic behavior with a saturated magnetization value of 7.65 emu/g. DRS UV-vis analysis revealed the functionalization of cisplatin in tetrahedral and octahedral coordination in the CuFe2O4/HYPS composite. Compared to other supports such as mesocellular foam and silicalite, the release of cisplatin using the dialysis membrane technique was found to be superior when CuFe2O4/HYPS was applied as the support. An in vitro experiment was conducted to determine the potential of CuFe2O4/HYPS as an anticancer agent against the human breast cancer cell line MCF-7. The results show that the nanoparticle formulation can effectively target cancerous cells and could be an effective tumor imaging guide and drug delivery system.
B. Rabindran Jermy; Vijaya Ravinayagam; Widyan A. AlAmoudi; Dana Almohazey; Hatim Dafalla; Lina Hussain Allehaibi; Abdulhadi Baykal; Muhammet S. Toprak; Thirunavukkarasu Somanathan. Targeted therapeutic effect against the breast cancer cell line MCF-7 with a CuFe2O4/silica/cisplatin nanocomposite formulation. Beilstein Journal of Nanotechnology 2019, 10, 2217 -2228.
AMA StyleB. Rabindran Jermy, Vijaya Ravinayagam, Widyan A. AlAmoudi, Dana Almohazey, Hatim Dafalla, Lina Hussain Allehaibi, Abdulhadi Baykal, Muhammet S. Toprak, Thirunavukkarasu Somanathan. Targeted therapeutic effect against the breast cancer cell line MCF-7 with a CuFe2O4/silica/cisplatin nanocomposite formulation. Beilstein Journal of Nanotechnology. 2019; 10 (1):2217-2228.
Chicago/Turabian StyleB. Rabindran Jermy; Vijaya Ravinayagam; Widyan A. AlAmoudi; Dana Almohazey; Hatim Dafalla; Lina Hussain Allehaibi; Abdulhadi Baykal; Muhammet S. Toprak; Thirunavukkarasu Somanathan. 2019. "Targeted therapeutic effect against the breast cancer cell line MCF-7 with a CuFe2O4/silica/cisplatin nanocomposite formulation." Beilstein Journal of Nanotechnology 10, no. 1: 2217-2228.
Multifunctional nanomaterials can be used for dual applications: drug delivery as well as in bioimaging. In current study, we investigated potential use of silica based supports; 3D cage type SiSBA-16 (S-16), monodispersed hydrophilic spherical silica (HYPS) and mesocellular foam (MSU-F) for cisplatin (Cp) delivery. To obtain magnetic resonance characteristics, 10 wt% iron oxide was loaded through enforced adsorption technique. For pH stimuli responsive release of Cp, 10 wt%SPIONs/S-16 was functionalized with 3-(Aminopropyl)triethoxysilane (A) and poly acrylic acid (PAA) termed as 10 wt%SPIONs/S-16-A-Cp and 10 wt%SPIONs/S-16-APAA-Cp. By TEM analysis, the average diameter of the SPIONs was found to range between 10–60 nm. VSM analysis showed saturation magnetization over S-16, HYPS and MSU-F were in the following order: 10 wt%SPIONs/HYPS (4.08 emug−1) > 10 wt%SPIONs /S-16 (2.39 emug−1) > 10 wt%SPIONs/MSU-F (0.23 emug−1). Cp release study using dialysis membrane in PBS solution over 10 wt%SPIONs/S-16 nanoformulations showed highest cumulative release (65%) than 10 wt%SPIONs/MSU-F-A-Cp (63%), 10 wt%SPIONs/HYPS-A-Cp (58%), and Cp-F127/S-16 (53%), respectively. 10 wt%SPIONs/S-16-A-Cp and 10 wt%SPIONs/S-16-APAA-Cp were evaluated for in vitro target anticancer efficiency in human cancer cell lines (colon cancer (HCT 116), cervical cancer (HeLa)) and normal cells (Human embryonic kidney cells (HEK293) using MTT and DAPI staining. 10 wt%SPIONs/S-16-A-Cp treated Hela and HCT116 cancerous cell lines showed significant control of cell growth, apoptotic activity and less cytotoxic effect as compared to Cp and 10 wt%SPIONs/S-16. Target specific Cp release in the cells shows that 10 wt%SPIONs/S-16-A-Cp can be easily upgraded for magnetic resonance imaging capability.
B. Rabindran Jermy; Munther Alomari; Vijaya Ravinayagam; Sarah Almofty; Sultan Akhtar; J. Francis Borgio; Sayed AbdulAzeez. SPIONs/3D SiSBA-16 based Multifunctional Nanoformulation for target specific cisplatin release in colon and cervical cancer cell lines. Scientific Reports 2019, 9, 1 -12.
AMA StyleB. Rabindran Jermy, Munther Alomari, Vijaya Ravinayagam, Sarah Almofty, Sultan Akhtar, J. Francis Borgio, Sayed AbdulAzeez. SPIONs/3D SiSBA-16 based Multifunctional Nanoformulation for target specific cisplatin release in colon and cervical cancer cell lines. Scientific Reports. 2019; 9 (1):1-12.
Chicago/Turabian StyleB. Rabindran Jermy; Munther Alomari; Vijaya Ravinayagam; Sarah Almofty; Sultan Akhtar; J. Francis Borgio; Sayed AbdulAzeez. 2019. "SPIONs/3D SiSBA-16 based Multifunctional Nanoformulation for target specific cisplatin release in colon and cervical cancer cell lines." Scientific Reports 9, no. 1: 1-12.
Neodymium (Nd)-substituted cobalt ferrite nanoparticles (NPs), i.e., CoNdxFe2−xO4 (0.0 ≤ x ≤ 0.2) NPs, were synthesized by the sonochemical method. The compositional characterization was done by scanning electron microscopy (SEM) equipped with energy-dispersive X-ray spectroscopy (EDX) and transmission electron microscopy (TEM). Antistaphylococcal activity was found to be enhanced, i.e., survival rate was 50%, 45%, 40%, and 30% with the increase in the ratio of Nd (0.0 ≤ x ≤ 0.2), whereas anticandidal activity was found efficient, i.e., 9%, 20%, 22%, and 40% survival rate at all the four ratios. The morphogenesis studies indicated that the synthesized metal–ligand, improves the antimicrobial capacity by binding them strongly to the microbial walls. To the best of our knowledge, this is the first report which demonstrates the series of CoNdxFe2−xO4 (0.0 ≤ x ≤ 0.2) NPs being active towards Staphylococcus aureus and Candida albicans and encourages its potential candidature for pharmaceutical and biomedical purposes.
Suriya Rehman; Mohammad Azam Ansari; Mohammad A. Alzohairy; Mohammad N. Alomary; B. Rabindran Jermy; Raheem Shahzad; Neda Tashkandi; Zainab Hassan AlSalem. Antibacterial and Antifungal Activity of Novel Synthesized Neodymium-Substituted Cobalt Ferrite Nanoparticles for Biomedical Application. Processes 2019, 7, 714 .
AMA StyleSuriya Rehman, Mohammad Azam Ansari, Mohammad A. Alzohairy, Mohammad N. Alomary, B. Rabindran Jermy, Raheem Shahzad, Neda Tashkandi, Zainab Hassan AlSalem. Antibacterial and Antifungal Activity of Novel Synthesized Neodymium-Substituted Cobalt Ferrite Nanoparticles for Biomedical Application. Processes. 2019; 7 (10):714.
Chicago/Turabian StyleSuriya Rehman; Mohammad Azam Ansari; Mohammad A. Alzohairy; Mohammad N. Alomary; B. Rabindran Jermy; Raheem Shahzad; Neda Tashkandi; Zainab Hassan AlSalem. 2019. "Antibacterial and Antifungal Activity of Novel Synthesized Neodymium-Substituted Cobalt Ferrite Nanoparticles for Biomedical Application." Processes 7, no. 10: 714.
The study investigates curcumin/SPIONs hybridized mesocellular foam type silica for potential dual purpose of drug delivery (curcumin) and magnetic resonance imaging. Magnetization capability and curcumin release was assessed for different structured silica such as spherical silica (Q-10), Si-MCM-41, Si-SBA-16, mesocellular foam (MSU-Foam), Si-KIT-6, ULPFDU-12, and silicalite. The phase, textural, and morphological variation was systematically scrutinized using various physico-chemical techniques. Ten weight percent SPIONs loading was found to generate magnetically active SPIONs in the following order: Q-10 (1.44 emu/g) > SBA-16 (0.80 emu/g) > MSU-Foam (0.24 emu/g) > Si-MCM-41 (0.07 emu/g) > Si-KIT-6 (0.07 emu/g) > silicalite (0.08 emu/g), respectively. The iron oxide dispersion, specific surface area, and porosity play a major role in various structured silicas. MSU-Foam with wormhole structure showed highest specific surface area occupation of SPIONs (73%). The presence of interconnected porosity of foam tends to generate external agglomeration of SPIONs (7–18 nm) at the pore surface contributing to expansion of pore sizes from 16.4 to 40.2 nm. The SPIONs over spherical micron-sized silica Q-10 showed the formation of large nanoclusters (10–25 nm). Thirty to 390 μg/ml of curcumin was loaded over silica and SPIONs/silica structured hybrid, and drug release was studied at pH 5.6 for 72 h. SPIONs/MSU-Foam with less magnetization showed the highest cumulative curcumin release (53.2%), while Q-10 spherical silica with high magnetization property showed less cumulative release of curcumin (12%).
B. Rabindran Jermy; V. Ravinayagam; S. Akhtar; W. A. AlAmoudi; Nada A. Alhamed; A. Baykal. Magnetic Mesocellular Foam Functionalized by Curcumin for Potential Multifunctional Therapeutics. Journal of Superconductivity and Novel Magnetism 2018, 32, 2077 -2090.
AMA StyleB. Rabindran Jermy, V. Ravinayagam, S. Akhtar, W. A. AlAmoudi, Nada A. Alhamed, A. Baykal. Magnetic Mesocellular Foam Functionalized by Curcumin for Potential Multifunctional Therapeutics. Journal of Superconductivity and Novel Magnetism. 2018; 32 (7):2077-2090.
Chicago/Turabian StyleB. Rabindran Jermy; V. Ravinayagam; S. Akhtar; W. A. AlAmoudi; Nada A. Alhamed; A. Baykal. 2018. "Magnetic Mesocellular Foam Functionalized by Curcumin for Potential Multifunctional Therapeutics." Journal of Superconductivity and Novel Magnetism 32, no. 7: 2077-2090.
The study investigates the hydrophobic antioxidant Coenzyme Q10 (CoQ10) adsorption over industrially relevant hierarchical ZSM-5 for potential therapeutic applications. The designing of hierarchical nanocomposites was optimized with two different NaOH/CTAB ratios (0.18 and 0.62) over ZSM-5 (SiO2/Al2O3 = 22-27) of different crystal sizes (0.5 µm, 2.0 µm and 3.0 µm) and different SiO2/Al2O3 ratios (23, 80, 280 and 1500) through top-down approach. Hydrothermal stability of samples was studied using 100% water steam at 700 °C and 750 °C for 2 h, respectively. Reassembling nano ZSM-5 into hierarchical composite was found to be exhibit ordered/disordered hexagonal mesophase depending on alkaline treated ZSM-5 crystal sizes and silica to alumina ratios. The phase changes was analyzed using different textural characterizations such as X-ray diffraction, BET surface area, ammonia desorption technique, 27Al MAS NMR, thermogravimetric analysis and transmission electron microscope. 21 different nanoformulations were screened for CoQ10 adsorption and subsequently selected samples was applied for curcumin and ascorbic acid adsorption. Hierarchical ZSM-5 with SiO2/Al2O3 ratio 80 (ZSM-5-80 (0.62)) was found to be steam stable and optimum with highest Q10 adsorption (55%). The adsorption influence over different crystal size and silica to alumina ratios, clearly showed the dependency over synergistic action of textural characteristics such as external surface area, pore volume, and weak acidity. The structured nanosupports with pore sizes between 3-4.0 nm was found to exhibit highest CoQ10 adsorption.
Vijaya Ravinayagam; B. Rabindran Jermy. Fabricating hierarchical ZSM-5 to induct long chain antioxidant coenzyme Q10 for biomedical application. Journal of Saudi Chemical Society 2018, 23, 461 -476.
AMA StyleVijaya Ravinayagam, B. Rabindran Jermy. Fabricating hierarchical ZSM-5 to induct long chain antioxidant coenzyme Q10 for biomedical application. Journal of Saudi Chemical Society. 2018; 23 (4):461-476.
Chicago/Turabian StyleVijaya Ravinayagam; B. Rabindran Jermy. 2018. "Fabricating hierarchical ZSM-5 to induct long chain antioxidant coenzyme Q10 for biomedical application." Journal of Saudi Chemical Society 23, no. 4: 461-476.
Hierarchically structured zeolitic ZSM-5 and meso MCM-41 interlinked domain had an impeccable use as catalysis in many applications. The aim of the study was to develop a new drug delivery nanoformulation, specifically, cisplatin/mesosilicalite using top–down approach for cancer therapy. Hierarchical mesosilicalite with variable porosity was synthesized using alkaline molar solution (0.2 and 0.7 M NaOH) and was loaded with cisplatin through equilibrium adsorption technique. Physico-chemical properties of the nanoformulation (IAUM-56—Imam Abdulrahman Bin Faisal University Mesosilicalite-56) were characterized using X-ray diffraction, surface area analysis (BET), Fourier transformed infrared spectroscopy (FT-IR), diffuse reflectance UV–Vis spectroscopy, and transmission electron microscopy. Drug release study and anticancer activity were assayed on HeLa and MCF7 cancer cells using MTT assay. X-ray diffraction pattern showed interrelated meso- and microphases, while BET analysis revealed considerable mesoporosity formation with a remodulation of isotherm hysteresis indicating the presence of hierarchical pores. FT-IR showed the presence of nanozeolitic subunits into mesostructure with a band at about 550 cm−1. IAUM-56 demonstrated high cytotoxic activity against HeLa cancer cells with an LC50 of 0.02 mg/ml, MCF7 cancer cells with an LC50 of 0.05 mg/ml, and less toxic to normal fibroblast cells with an LC50 of approximately ten times higher at 0.5 mg/ml. Overall, IAUM-56 showed a high rate of sustained release of cisplatin imparting target specific cytotoxic effect against tumor cells with at least tenfold lower toxicity on normal fibroblast cells. Our nanoformulation has the potential use in cancer therapy as a targeted drug delivery system.
B. Rabindran Jermy; Sadananda Acharya; Vijaya Ravinayagam; Hajer Saleh Alghamdi; Sultan Akhtar; Rehab S. Basuwaidan. Hierarchical mesosilicalite nanoformulation integrated with cisplatin exhibits target-specific efficient anticancer activity. Applied Nanoscience 2018, 8, 1205 -1220.
AMA StyleB. Rabindran Jermy, Sadananda Acharya, Vijaya Ravinayagam, Hajer Saleh Alghamdi, Sultan Akhtar, Rehab S. Basuwaidan. Hierarchical mesosilicalite nanoformulation integrated with cisplatin exhibits target-specific efficient anticancer activity. Applied Nanoscience. 2018; 8 (5):1205-1220.
Chicago/Turabian StyleB. Rabindran Jermy; Sadananda Acharya; Vijaya Ravinayagam; Hajer Saleh Alghamdi; Sultan Akhtar; Rehab S. Basuwaidan. 2018. "Hierarchical mesosilicalite nanoformulation integrated with cisplatin exhibits target-specific efficient anticancer activity." Applied Nanoscience 8, no. 5: 1205-1220.
The study investigates the suitable nanosilica carriers to transport acidic type cargo molecules for potential targeted drug delivery application. Using phenolic acidic type antioxidant gallic acid (GA) as model compound, the present study investigates the loading effect of GA (0.3–15.9 mmol GA g−1 support) on textural characteristics of amorphous silica nanoparticles such as Q10 silica (1D), structured two-dimensional Si-MCM-41 (2D), and three-dimensional Si-SBA-16 (3D). The variation in the nature of textures after GA loading was analyzed using X-ray diffraction, N2 adsorption, FT-IR, scanning electron microscopy with energy dispersive X-ray spectroscopy, and high-resolution transmission electron microscopy. Among the nanocarriers, high adsorption of GA was found in the following order: Si-SBA-16 (3D)∼Si-KIT-6 (3D) > Si-MCM-41 (2D) > ultralarge pore FDU-12 (ULPFDU-12; 3D) > Q10 (1D)∼mesostructured cellular silica foam (MSU-F). 3D-type silicas Si-SBA-16 and KIT-6 were shown to maintain structural integrity at acidic condition (pH ∼3) and accommodate GA in non-crystalline form. In the case of ULPFDU-12 and MSU-F cellular foam, only crystalline deposition of GA occurs with a significant variation in the surface area and pore volume.
Vijaya Ravinayagam; B. Rabindran Jermy. Studying the loading effect of acidic type antioxidant on amorphous silica nanoparticle carriers. Journal of Nanoparticle Research 2017, 19, 190 .
AMA StyleVijaya Ravinayagam, B. Rabindran Jermy. Studying the loading effect of acidic type antioxidant on amorphous silica nanoparticle carriers. Journal of Nanoparticle Research. 2017; 19 (6):190.
Chicago/Turabian StyleVijaya Ravinayagam; B. Rabindran Jermy. 2017. "Studying the loading effect of acidic type antioxidant on amorphous silica nanoparticle carriers." Journal of Nanoparticle Research 19, no. 6: 190.
Influence of calcination on the binary-metal oxide 30 wt% Bi-20 wt% Ni–O/gamma-Al 2 O 3 catalyst was studied for n -butane oxidative dehydrogenation to 1,3-butadiene. Influence of calcination on the binary-metal oxide 30 wt% Bi-20 wt% Ni–O/gamma-Al 2 O 3 catalyst was studied for n -butane oxidative dehydrogenation to 1,3-butadiene. The importance of the calcination was confirmed with the facts that (1) the two step calcination of more than 2 h at the 2nd step resulted in higher activity and selectivity to butadiene and (2) the second step calcination temperatures showed clear effects on the activity and the selectivity. The activity showed a volcano shaped trend, with the top at 590 °C and at a lower reaction temperature, 400 °C, and a downward slope at 450 °C. As for the reaction selectivity, either the total dehydrogenation or the specific butadiene selectivity showed a volcano shape with the calcination temperature. The top along the calcination temperature existed at 590 °C in both cases of 400 °C and 450 °C reaction temperatures. Conversely, the selectivity of oxygenate formation (partially followed by cracking) or partial oxidation to CO/H 2 showed a valley shape with the bottom at 590 °C or 650 °C along the calcination temperature, respectively. The butadiene selectivity was more strongly influenced competitively by both the oxygenate formation and the partial oxidation. From the catalyst characterization, it was observed that the redox and acid/base system (active and selective to the reaction) of the combined oxides with porous structure are formed as a cohabitation consisting of ‘hierarchical nanoparticles’ (NiO, alpha-/beta-Bi 2 O 3 and gamma-Al 2 O 3 ), resulting from catalyst calcination in preferable conditions.
B. Rabindran Jermy; S. Asaoka; S. Al-Khattaf. Influence of calcination on performance of Bi–Ni–O/gamma-alumina catalyst for n-butane oxidative dehydrogenation to butadiene. Catalysis Science & Technology 2015, 5, 4622 -4635.
AMA StyleB. Rabindran Jermy, S. Asaoka, S. Al-Khattaf. Influence of calcination on performance of Bi–Ni–O/gamma-alumina catalyst for n-butane oxidative dehydrogenation to butadiene. Catalysis Science & Technology. 2015; 5 (9):4622-4635.
Chicago/Turabian StyleB. Rabindran Jermy; S. Asaoka; S. Al-Khattaf. 2015. "Influence of calcination on performance of Bi–Ni–O/gamma-alumina catalyst for n-butane oxidative dehydrogenation to butadiene." Catalysis Science & Technology 5, no. 9: 4622-4635.
Highly ordered three-dimensional V-SBA-16 materials were prepared at mild acidic condition by tuning the key parameters for metal substitution such as molar ratio of silica to 1-butanol (TEOS/BuOH), water to hydrochloric acid (H2O/HCl ratio) and hydrothermal aging time in the initial gel containing 0.0035 F127/0.01 V/0.91–2.00 TEOS/2.08–0.76 BuOH/0.70–1.16 HCl/118.6–120.1 H2O. The extent of mesopore structural ordering was confirmed by small-angle X-ray scattering and nitrogen adsorption isotherms. The presence of incorporated vanadium in a highly dispersed tetrahedral state was confirmed by electron spin resonance (ESR) and Drs-UV spectroscopy. The NH3-TPD profile showed that the materials tend to posses medium-acidic V–OH sites; strong-acidic sites increased with decreasing Si/V ratios. TEM analysis shows that the cubic phase was stable up to 3.6 wt.% vanadium loading. The activity of V-SBA-16 was tested for the selective oxidation of ethylbenzene to acetophenone by studying the effect of temperatures, time on stream, and the mole ratio of ethylbenzene to TBHP.
B. Rabindran Jermy; S.Y. Kim; D.K. Kim; D.W. Park. Optimization of key parameters for effective vanadium substitution into cubic SBA-16 in the presence of co-surfactant at low acidity: Application in the selective oxidation of ethylbenzene. Journal of Industrial and Engineering Chemistry 2011, 17, 130 -137.
AMA StyleB. Rabindran Jermy, S.Y. Kim, D.K. Kim, D.W. Park. Optimization of key parameters for effective vanadium substitution into cubic SBA-16 in the presence of co-surfactant at low acidity: Application in the selective oxidation of ethylbenzene. Journal of Industrial and Engineering Chemistry. 2011; 17 (1):130-137.
Chicago/Turabian StyleB. Rabindran Jermy; S.Y. Kim; D.K. Kim; D.W. Park. 2011. "Optimization of key parameters for effective vanadium substitution into cubic SBA-16 in the presence of co-surfactant at low acidity: Application in the selective oxidation of ethylbenzene." Journal of Industrial and Engineering Chemistry 17, no. 1: 130-137.