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The current coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome virus 2 (SARS-CoV-2), has resulted in a major global pandemic, causing extreme morbidity and mortality. Few studies appear to suggest a significant impact of gender in morbidity and mortality, where men are reported at a higher risk than women. The infectivity, transmissibility, and varying degree of disease manifestation (mild, modest, and severe) in population studies reinforce the importance of a number of genetic and epigenetic factors, in the context of immune response and gender. The present review dwells on several contributing factors such as a stronger innate immune response, estrogen, angiotensin-converting enzyme 2 gene, and microbiota, which impart greater resistance to the SARS-CoV-2 infection and disease progression in women. In addition, the underlying importance of associated microbiota and certain environmental factors in gender-based disparity pertaining to the mortality and morbidity due to COVID-19 in women has also been addressed.
Suriya Rehman; Vijaya Ravinayagam; Insha Nahvi; Hanan Aldossary; Maha Al-Shammari; Mai Saad Al Amiri; Uday Kishore; Ebtesam A. Al-Suhaimi. Immunity, Sex Hormones, and Environmental Factors as Determinants of COVID-19 Disparity in Women. Frontiers in Immunology 2021, 12, 1 .
AMA StyleSuriya Rehman, Vijaya Ravinayagam, Insha Nahvi, Hanan Aldossary, Maha Al-Shammari, Mai Saad Al Amiri, Uday Kishore, Ebtesam A. Al-Suhaimi. Immunity, Sex Hormones, and Environmental Factors as Determinants of COVID-19 Disparity in Women. Frontiers in Immunology. 2021; 12 ():1.
Chicago/Turabian StyleSuriya Rehman; Vijaya Ravinayagam; Insha Nahvi; Hanan Aldossary; Maha Al-Shammari; Mai Saad Al Amiri; Uday Kishore; Ebtesam A. Al-Suhaimi. 2021. "Immunity, Sex Hormones, and Environmental Factors as Determinants of COVID-19 Disparity in Women." Frontiers in Immunology 12, no. : 1.
Landfills are an example of an environment that contains highly complex communities of microorganisms. To evaluate the microbial community structure, four stainless steel pilot-scale bioreactor landfills with single- and double-layered geotextile fabric were used. Two reactors (R-1 and R-2) contained municipal solid waste (MSW) and sewage sludge, while the other two reactors (R-3 and R-4) contained only MSW. A single layer of geotextile fabric (R2GT3 and R3GT3) was inserted in the drainage layers of the two reactors (R-2 and R-3), while a double layer of geotextile fabric (R4GT2 and R4GT1) was inserted in one of the reactors (R-4). Scanning electron microscopy demonstrated that biomass developed on the geotextile fabrics after 540 days of bioreactor operation. The metagenomics analyses of the geotextile samples by 16S rRNA gene sequencing indicated that the geotextile bacterial communities were dominated by the phyla Firmicutes, Bacteroidetes, and Thermotogeae, while Proteobacteria were detected as the rarest bacterial phylum in all the geotextile samples. Treponema, Caldicoprobacter, and Clostridium were the most dominant anaerobic and fermentative bacterial genera associated with the geotextile fabric in the bioreactors. Euryarchaeota was the predominant archaean phylum detected in all the geotextile samples. In the archaeal communities, Methanosarcina, and Vadin CA11 were identified as the predominant genera. The diversity of microorganisms in landfill bioreactors is addressed to reveal opportunities for landfill process modifications and associated operational optimization. Thus, this study provides insights into the population dynamics of microorganisms in geotextile fabrics used in bioreactor landfills.
Cevat Yaman; Suriya Rehman; Tanveer Ahmad; Yusuf Kucukaga; Burcu Pala; Noor AlRushaid; Syed Riyaz Ul Hassan; Ayse Burcu Yaman. Community Structure of Bacteria and Archaea Associated with Geotextile Filters in Anaerobic Bioreactor Landfills. Processes 2021, 9, 1377 .
AMA StyleCevat Yaman, Suriya Rehman, Tanveer Ahmad, Yusuf Kucukaga, Burcu Pala, Noor AlRushaid, Syed Riyaz Ul Hassan, Ayse Burcu Yaman. Community Structure of Bacteria and Archaea Associated with Geotextile Filters in Anaerobic Bioreactor Landfills. Processes. 2021; 9 (8):1377.
Chicago/Turabian StyleCevat Yaman; Suriya Rehman; Tanveer Ahmad; Yusuf Kucukaga; Burcu Pala; Noor AlRushaid; Syed Riyaz Ul Hassan; Ayse Burcu Yaman. 2021. "Community Structure of Bacteria and Archaea Associated with Geotextile Filters in Anaerobic Bioreactor Landfills." Processes 9, no. 8: 1377.
The current study offers an efficient design of novel nanoparticle microspheres (MCs) using a hydrothermal approach. The Co0.5Ni0.5GaxFe2−xO4 (0.0 ≤ x ≤ 1.0) MCs were prepared by engineering the elements, such as cobalt (Co), nickel (Ni), iron (Fe), and gallium (Ga). There was a significant variation in MCs’ physical structure and surface morphology, which was evaluated using energy dispersive X-ray analysis (EDX), X-ray diffractometer (XRD), high-resolution transmission electron microscopy (HR-TEM), and scanning electron microscope (SEM). The anti-proliferative activity of MCs was examined by MTT assay and DAPI staining using human colorectal carcinoma cells (HCT-116), human cervical cancer cells (HeLa), and a non-cancerous cell line—human embryonic kidney cells (HEK-293). Post 72 h treatment, MCs caused a dose dependent inhibition of growth and proliferation of HCT-116 and HeLa cells. Conversely, no cytotoxic effect was observed on HEK-293 cells. The anti-fungal action was assessed by the colony forming units (CFU) technique and SEM, resulting in the survival rate of Candida albicans as 20%, with severe morphogenesis, on treatment with MCs x = 1.0. These findings suggest that newly engineered microspheres have the potential for pharmaceutical importance, in terms of infectious diseases and anti-cancer therapy.
Suriya Rehman; Munirah Almessiere; Suhailah Al-Jameel; Uzma Ali; Yassine Slimani; Nedaa Tashkandi; Najat Al-Saleh; Ayyar Manikandan; Firdos Khan; Ebtesam Al-Suhaimi; Abdulhadi Baykal. Designing of Co0.5Ni0.5GaxFe2−xO4 (0.0 ≤ x ≤ 1.0) Microspheres via Hydrothermal Approach and Their Selective Inhibition on the Growth of Cancerous and Fungal Cells. Pharmaceutics 2021, 13, 962 .
AMA StyleSuriya Rehman, Munirah Almessiere, Suhailah Al-Jameel, Uzma Ali, Yassine Slimani, Nedaa Tashkandi, Najat Al-Saleh, Ayyar Manikandan, Firdos Khan, Ebtesam Al-Suhaimi, Abdulhadi Baykal. Designing of Co0.5Ni0.5GaxFe2−xO4 (0.0 ≤ x ≤ 1.0) Microspheres via Hydrothermal Approach and Their Selective Inhibition on the Growth of Cancerous and Fungal Cells. Pharmaceutics. 2021; 13 (7):962.
Chicago/Turabian StyleSuriya Rehman; Munirah Almessiere; Suhailah Al-Jameel; Uzma Ali; Yassine Slimani; Nedaa Tashkandi; Najat Al-Saleh; Ayyar Manikandan; Firdos Khan; Ebtesam Al-Suhaimi; Abdulhadi Baykal. 2021. "Designing of Co0.5Ni0.5GaxFe2−xO4 (0.0 ≤ x ≤ 1.0) Microspheres via Hydrothermal Approach and Their Selective Inhibition on the Growth of Cancerous and Fungal Cells." Pharmaceutics 13, no. 7: 962.
Sources of contamination in a subsurface environment are petrol, diesel fuel, gasoline at oil refineries, underground storage tanks, transmission pipelines, and different industries. The permeable reactive barrier (PRB) is a promising technology to remediate groundwater in-situ. In this study, synthetic groundwater samples containing toluene are treated in three reactor columns by biological processes. PRB-1 consisted of sand and gravel as reactor media, microbial inoculum (bioaugmentation—BA), and nutrients (biostimulation—BS); PRB-2 consisted of sand and gravel as reactor media, microbial inoculum, nutrients, and 12 layers of nonwoven geotextile fabrics; and PRB-3 consisted of only sand and gravel as reactor media (natural attenuation—NA). This study was conducted to assess the impact of geotextile fabric filter, bioaugmentation, and biostimulation on toluene degradation efficiency. After 167 days of treatment, toluene biodegradation efficiencies varied between 88.2% and 93.8% for PRB 1, between 98.0% and 99.3% for PRB 2, and between 14.2% and 68.6% for PRB 3. The effluent toluene concentrations for PRB-2 were less than the guideline value (0.7 mg/L) of the World Health Organization. Reaction rate data were fitted with a first-order kinetic reaction rate model. This study showed that the toluene removal efficiency in the geotextile layered PRB combined with BA and BS process was significantly higher compared to the other processes tested. This lab-scale study introduced a new PRB configuration suitable for the remediation of sites contaminated with toluene.
Cevat Yaman; Ismail Anil; Omar Alagha; Nawaf Blaisi; Ayse Yaman; Aleem Qureshi; Emre Cevik; Suriya Rehman; Seyda Gunday; Mohammad Barghouthi. Toluene Bioremediation by Using Geotextile-Layered Permeable Reactive Barriers (PRBs). Processes 2021, 9, 906 .
AMA StyleCevat Yaman, Ismail Anil, Omar Alagha, Nawaf Blaisi, Ayse Yaman, Aleem Qureshi, Emre Cevik, Suriya Rehman, Seyda Gunday, Mohammad Barghouthi. Toluene Bioremediation by Using Geotextile-Layered Permeable Reactive Barriers (PRBs). Processes. 2021; 9 (6):906.
Chicago/Turabian StyleCevat Yaman; Ismail Anil; Omar Alagha; Nawaf Blaisi; Ayse Yaman; Aleem Qureshi; Emre Cevik; Suriya Rehman; Seyda Gunday; Mohammad Barghouthi. 2021. "Toluene Bioremediation by Using Geotextile-Layered Permeable Reactive Barriers (PRBs)." Processes 9, no. 6: 906.
In the present study, biocompatible manganese nanoparticles have been linked with zinc and iron molecules to prepare different derivatives of Mn0.5Zn0.5ErxYxFe2−2xO4 NPs (x = 0.02, 0.04, 0.06, 0.08, 0.10), using an ultrasonication approach. The structure, surface morphology, and chemical compositions of Mn0.5Zn0.5ErxYxFe2−2xO4 NPs were elucidated by X-ray diffractometer (XRD), High-resolution transmission electron microscopy (HR-TEM), scanning electron microscope (SEM), and Energy Dispersive X-Ray Analysis (EDX) techniques. The bioactivity of Mn0.5Zn0.5ErxYxFe2−2xO4 NPs on normal (HEK-293) and (HCT-116) colon cancer cell line was evaluated. The Mn0.5Zn0.5ErxYxFe2−2xO4 NPs treatment post 48 h resulted in a significant reduction in cells (via MTT assay, having an IC50 value between 0.88 µg/mL and 2.40 µg/mL). The specificity of Mn0.5Zn0.5ErxYxFe2−2xO4 NPs were studied by treating them on normal cells line (HEK-293). The results showed that Mn0.5Zn0.5ErxYxFe2−2xO4 NPs did not incur any effect on HEK-293, which suggests that Mn0.5Zn0.5ErxYxFe2−2xO4 NPs selectively targeted the colon cancerous cells. Using Candida albicans, antifungal activity was also studied by evaluating minimum inhibitory/fungicidal concentration (MIC/MFC) and the effect of nanomaterial on the germ tube formation, which exhibited that NPs significantly inhibited the growth and germ tube formation. The obtained results hold the potential to design nanoparticles that lead to efficient bioactivity.
Suriya Rehman; Munirah Almessiere; Ebtesam A. Al-Suhaimi; Mehwish Hussain; Maha Yousuf Bari; Syed Mehmood Ali; Suhailah Al-Jameel; Yassine Slimani; Firdos Khan; Abdulhadi Baykal. Ultrasonic Synthesis and Biomedical Application of Mn0.5Zn0.5ErxYxFe2−2xO4 Nanoparticles. Biomolecules 2021, 11, 703 .
AMA StyleSuriya Rehman, Munirah Almessiere, Ebtesam A. Al-Suhaimi, Mehwish Hussain, Maha Yousuf Bari, Syed Mehmood Ali, Suhailah Al-Jameel, Yassine Slimani, Firdos Khan, Abdulhadi Baykal. Ultrasonic Synthesis and Biomedical Application of Mn0.5Zn0.5ErxYxFe2−2xO4 Nanoparticles. Biomolecules. 2021; 11 (5):703.
Chicago/Turabian StyleSuriya Rehman; Munirah Almessiere; Ebtesam A. Al-Suhaimi; Mehwish Hussain; Maha Yousuf Bari; Syed Mehmood Ali; Suhailah Al-Jameel; Yassine Slimani; Firdos Khan; Abdulhadi Baykal. 2021. "Ultrasonic Synthesis and Biomedical Application of Mn0.5Zn0.5ErxYxFe2−2xO4 Nanoparticles." Biomolecules 11, no. 5: 703.
The human-to-human transmitted respiratory illness in COVID-19 affected by the pathogenic Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), which appeared in the last of December 2019 in Wuhan, China, and rapidly spread in many countries. Thereon, based on the urgent need for therapeutic molecules, we conducted in silico based docking and simulation molecular interaction studies on repurposing drugs, targeting SARS-CoV-2 spike protein. Further, the best binding energy of doxorubicin interacting with virus spike protein (PDB: 6VYB) was observed to be −6.38 kcal/mol and it was followed by exemestane and gatifloxacin. The molecular simulation dynamics analysis of doxorubicin, Reference Mean Square Deviation (RMSD), Root Mean Square fluctuation (RMSF), Radius of Gyration (Rg), and formation of hydrogen bonds plot interpretation suggested, a significant deviation and fluctuation of Doxorubicin-Spike RBD complex during the whole simulation period. The Rg analysis has stated that the Doxorubicin-Spike RBD complex was stable during 15,000–35,000 ps MDS. The results have suggested that doxorubicin could inhibit the virus spike protein and prevent the access of the SARS-CoV-2 to the host cell. Thus, in-vitro/in-vivo research on these drugs could be advantageous to evaluate significant molecules that control the COVID-19 disease.
Qazi Mohammad Sajid Jamal; Varish Ahmad; Ali H Alharbi; Mohammad Azam Ansari; Mohammad A Alzohairy; Ahmad Almatroudi; Saad Alghamdi; Mohammad N. Alomary; Sami AlYahya; Nashwa Talaat Shesha; Suriya Rehman. Therapeutic development by repurposing drugs targeting SARS-CoV-2 spike protein interactions by simulation studies. Saudi Journal of Biological Sciences 2021, 1 .
AMA StyleQazi Mohammad Sajid Jamal, Varish Ahmad, Ali H Alharbi, Mohammad Azam Ansari, Mohammad A Alzohairy, Ahmad Almatroudi, Saad Alghamdi, Mohammad N. Alomary, Sami AlYahya, Nashwa Talaat Shesha, Suriya Rehman. Therapeutic development by repurposing drugs targeting SARS-CoV-2 spike protein interactions by simulation studies. Saudi Journal of Biological Sciences. 2021; ():1.
Chicago/Turabian StyleQazi Mohammad Sajid Jamal; Varish Ahmad; Ali H Alharbi; Mohammad Azam Ansari; Mohammad A Alzohairy; Ahmad Almatroudi; Saad Alghamdi; Mohammad N. Alomary; Sami AlYahya; Nashwa Talaat Shesha; Suriya Rehman. 2021. "Therapeutic development by repurposing drugs targeting SARS-CoV-2 spike protein interactions by simulation studies." Saudi Journal of Biological Sciences , no. : 1.
Globally, breast cancer is the most common type of cancer in females and is one of the leading causes of cancer death in women. The advancement in the targeted therapies and the slight understanding of the molecular cascades of the disease have led to small improvement in the rate of survival of breast cancer patients. However, metastasis and resistance to the current drugs still remain as challenges in the management of breast cancer patients. Metastasis, potentially, leads to failure of the available treatment, and thereby, makes the research on metastatic suppressors a high priority. Tumor metastasis suppressors are several genes and their protein products that have the capability of arresting the metastatic process without affecting the tumor formation. The metastasis suppressors KAI1 (also known as CD82) has been found to inhibit tumor metastasis in various types of solid cancers, including breast cancer. KAI1 was identified as a metastasis suppressor that inhibits the process of metastasis by regulating several mechanisms, including cell motility and invasion, induction of cell senescence, cell–cell adhesion and apoptosis. KAI1 is a member of tetraspanin membrane protein family. It interacts with other tetraspanins, chemokines and integrins to control diverse signaling pathways, which are crucial for protein trafficking and intracellular communication. It follows that better understanding of the molecular events of such genes is needed to develop prognostic biomarkers, and to identify specific therapies for breast cancer patients. This review aims to discuss the role of KAI1/CD82 as a prognosticator in breast cancer.
Khulood M. Al-Khater; Sarah Almofty; Vijaya Ravinayagam; Noor Alrushaid; Suriya Rehman. Role of a metastatic suppressor gene KAI1/CD82 in the diagnosis and prognosis of breast cancer. Saudi Journal of Biological Sciences 2021, 28, 3391 -3398.
AMA StyleKhulood M. Al-Khater, Sarah Almofty, Vijaya Ravinayagam, Noor Alrushaid, Suriya Rehman. Role of a metastatic suppressor gene KAI1/CD82 in the diagnosis and prognosis of breast cancer. Saudi Journal of Biological Sciences. 2021; 28 (6):3391-3398.
Chicago/Turabian StyleKhulood M. Al-Khater; Sarah Almofty; Vijaya Ravinayagam; Noor Alrushaid; Suriya Rehman. 2021. "Role of a metastatic suppressor gene KAI1/CD82 in the diagnosis and prognosis of breast cancer." Saudi Journal of Biological Sciences 28, no. 6: 3391-3398.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a global pandemic and is posing a serious challenge to mankind. As per the current scenario, there is an urgent need for antiviral that could act as a protective and therapeutic against SARS-CoV-2. Previous studies have shown that SARS-CoV-2 is much similar to the SARS-CoV bat that occurred in 2002-03. Since it is a zoonotic virus, the exact source is still unknown, but it is believed bats may be the primary reservoir of SARS-CoV-2 through which it has been transferred to humans. In this review, we have tried to summarize some of the approaches that could be effective against SARS-CoV-2. Firstly, plants or plant-based products have been effective against different viral diseases, and secondly, plants or plant-based natural products have the minimum adverse effect. We have also highlighted a few vitamins and minerals that could be beneficial against SARS-CoV-2.
Syed Ali; Mohammad Ansari; Mohammad Alzohairy; Ahmad Almatroudi; Mohammad Alomary; Saad Alghamdi; Suriya Rehman; Haris Khan. Natural Products and Nutrients against Different Viral Diseases: Prospects in Prevention and Treatment of SARS-CoV-2. Medicina 2021, 57, 169 .
AMA StyleSyed Ali, Mohammad Ansari, Mohammad Alzohairy, Ahmad Almatroudi, Mohammad Alomary, Saad Alghamdi, Suriya Rehman, Haris Khan. Natural Products and Nutrients against Different Viral Diseases: Prospects in Prevention and Treatment of SARS-CoV-2. Medicina. 2021; 57 (2):169.
Chicago/Turabian StyleSyed Ali; Mohammad Ansari; Mohammad Alzohairy; Ahmad Almatroudi; Mohammad Alomary; Saad Alghamdi; Suriya Rehman; Haris Khan. 2021. "Natural Products and Nutrients against Different Viral Diseases: Prospects in Prevention and Treatment of SARS-CoV-2." Medicina 57, no. 2: 169.
The overproduction of reactive oxygen species (ROS) causes oxidative stress, such as Hydrogen peroxide (H2O2). Acute oxidative stress is one of the main reasons for cell death. In this study, the antioxidant properties of vanillic acid- a polyphenolic compound was evaluated. Therefore, this study aims to check the effectiveness of vanillic acid in H2O2-induced oxidative stress in D. Mel-2 cell line. The efficacy was determined by biochemical tests to check the ROS production. The cytotoxicity of H2O2 and vanillic acid was checked by MTT assay. The DNA fragmentation was visualized by gel electrophoresis. Protein biomarkers of oxidative stress were analyzed by western blotting. The results depict a promising antioxidant effect of vanillic acid. The IC50 value of vanillic acid and H2O2 was found 250 μg/ml and 125 μg/ml, respectively. The catalase activity, SOF, GPx, and PC was seen less in H2O2 treated group compared with the control and vanillic acid treated group. However, the TBRAS activity was hight in H2O2 treated group. The effect of H2O2 on DNA fragmentation was high as compared with vanillic acid-treated cells. The protein expression of Hsp70, IL-6 and iNOS was seen significant in a vanillic acid-treated group as compared with H2O2 treated group. These results reinforce that at low concentration, vanillic acid could be used as an antioxidant agent in the food and pharmaceutical industries.
Shagufta Taqvi; Eijaz Ahmed Bhat; Nasreena Sajjad; Jamal S.M. Sabir; Aleem Qureshi; Irfan A. Rather; Suriya Rehman. Protective effect of vanillic acid in hydrogen peroxide-induced oxidative stress in D.Mel-2 cell line. Saudi Journal of Biological Sciences 2020, 28, 1795 -1800.
AMA StyleShagufta Taqvi, Eijaz Ahmed Bhat, Nasreena Sajjad, Jamal S.M. Sabir, Aleem Qureshi, Irfan A. Rather, Suriya Rehman. Protective effect of vanillic acid in hydrogen peroxide-induced oxidative stress in D.Mel-2 cell line. Saudi Journal of Biological Sciences. 2020; 28 (3):1795-1800.
Chicago/Turabian StyleShagufta Taqvi; Eijaz Ahmed Bhat; Nasreena Sajjad; Jamal S.M. Sabir; Aleem Qureshi; Irfan A. Rather; Suriya Rehman. 2020. "Protective effect of vanillic acid in hydrogen peroxide-induced oxidative stress in D.Mel-2 cell line." Saudi Journal of Biological Sciences 28, no. 3: 1795-1800.
The emergence of resistance on exposure to pharmaceuticals among microorganisms has raised serious concern in the therapeutic approach against infectious diseases. Effluents discharge from hospitals, industries, and urban settlements containing pharmaceuticals and other toxic compounds into the aquatic ecosystem selects bacterial population against them; thereby promotes acquisition and dissemination of resistant traits among the inhabitant microbiota. The present study was aimed to determine the prevalence and multidrug resistance pattern of Extended Spectrum β-lactamase (ESBL) producing and non-producing bacterial isolates from the heavily polluted Delhi stretch of river Yamuna, India. Additionally, the role of abiotic factors in the dissemination of conjugative plasmids harbouring resistance genes was also studied using E. coli J53 as recipient and resistant E. coli isolates as donor strains. Of the 227 non-duplicate bacterial isolates, 60% (136) were identified as ESBL+ and 40% (91) as ESBL. ESBL+ isolates were found highly resistant to β-lactam and non-β-lactam classes of antibiotics compared with the ESBL− isolates. 68% of ESBL+ and 24% of ESBL− isolates showed an MAR index of ≥0.5. Surprisingly, multidrug resistance (MDR), extensively drug resistance (XDR), and pandrug resistance (PDR) phenotype were observed for 78.6%, 16.9%, and 0.7% of ESBL+ and 90%, 3%, and none for PDR among ESBL− isolates. Conjugation under different conditions showed a higher mobilization rate at neutral pH (7–7.5) for ESBL+ isolates. Conjugation frequency was maximum at 40 °C for the isolate E. coli MRB6 (4.1 × 10−5) and E. coli MRE32 (4.89 × 10−4) and at 35 °C for E. coli MRA11 (4.89 × 10−5). The transconjugants obtained were found tolerating different concentrations of mercuric chloride (0.0002–0.2 mg/L). Increased biofilm formation for ESBL+ isolates was observed on supplementing media with HgCl2 (2 μg/mL) either singly or in combination with CTX (10 μg/mL). The present study demonstrates that anthropogenically influenced aquatic environments act as a reservoir of MDR, XDR, and even PDR strains; thereby posing a potent public health risk.
Mudsser Azam; Vijay Kumar; Kehkashan Siddiqui; Arif Tasleem Jan; Jamal S.M. Sabir; Irfan A. Rather; Suriya Rehman; Qazi Mohd Rizwanul Haq. Pharmaceutical disposal facilitates the mobilization of resistance determinants among microbiota of polluted environment. Saudi Pharmaceutical Journal 2020, 28, 1626 -1634.
AMA StyleMudsser Azam, Vijay Kumar, Kehkashan Siddiqui, Arif Tasleem Jan, Jamal S.M. Sabir, Irfan A. Rather, Suriya Rehman, Qazi Mohd Rizwanul Haq. Pharmaceutical disposal facilitates the mobilization of resistance determinants among microbiota of polluted environment. Saudi Pharmaceutical Journal. 2020; 28 (12):1626-1634.
Chicago/Turabian StyleMudsser Azam; Vijay Kumar; Kehkashan Siddiqui; Arif Tasleem Jan; Jamal S.M. Sabir; Irfan A. Rather; Suriya Rehman; Qazi Mohd Rizwanul Haq. 2020. "Pharmaceutical disposal facilitates the mobilization of resistance determinants among microbiota of polluted environment." Saudi Pharmaceutical Journal 28, no. 12: 1626-1634.
This study proposes a bio-directed approach for the formation of titanium oxide and silver nanoparticles (TiO2 and Ag NPs), using a wild mushroom, Fomitopsis pinicola, identified by 18S ribosomal RNA gene sequencing (gene accession no. MK635350) and phenotypic examination.
Suriya Rehman; RabindraN Jermy; Sarah Mousa Asiri; Manzoor A. Shah; Romana Farooq; Vijaya Ravinayagam; Mohammad Azam Ansari; Zainab Alsalem; Reem Al Jindan; Zafar Reshi; Firdos Alam Khan. Using Fomitopsis pinicola for bioinspired synthesis of titanium dioxide and silver nanoparticles, targeting biomedical applications. RSC Advances 2020, 10, 32137 -32147.
AMA StyleSuriya Rehman, RabindraN Jermy, Sarah Mousa Asiri, Manzoor A. Shah, Romana Farooq, Vijaya Ravinayagam, Mohammad Azam Ansari, Zainab Alsalem, Reem Al Jindan, Zafar Reshi, Firdos Alam Khan. Using Fomitopsis pinicola for bioinspired synthesis of titanium dioxide and silver nanoparticles, targeting biomedical applications. RSC Advances. 2020; 10 (53):32137-32147.
Chicago/Turabian StyleSuriya Rehman; RabindraN Jermy; Sarah Mousa Asiri; Manzoor A. Shah; Romana Farooq; Vijaya Ravinayagam; Mohammad Azam Ansari; Zainab Alsalem; Reem Al Jindan; Zafar Reshi; Firdos Alam Khan. 2020. "Using Fomitopsis pinicola for bioinspired synthesis of titanium dioxide and silver nanoparticles, targeting biomedical applications." RSC Advances 10, no. 53: 32137-32147.
Breast cancer is a group of diseases in which cells divide out of controlled, typically resulting in a mass. Erlotinib is targeted cancer drug which functions as an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. It is used mainly to treat of non-small cell lung cancer patients and has an action against pancreatic cancer. Vorinostat (aka suberanilohydroxamic acid) is an inhibitor of histone deacetylases (HDAC), which has an epigenetic modulation activity. It is used to treat cutaneous T cell lymphoma. In the present study, the erlotinib (ERL) and vorinostat (SAHA) loaded TiO2 nanoparticles (NPs) were used for the treatment of the breast cancer cells (MDA-MB-231 and MCF-7) and human cancerous amniotic cells (WISH). Cell count and viability were negatively affected in all treatments compared to normal cells and bare TiO2 NPs. Apoptosis results indicated a significant increase in the total apoptosis in all treatments compared with control cells. ERL- and SAHA-loaded TiO2 NPs treatments arrested breast cancer cells at G2/M phase, which indicate the cytotoxic effect of these treatment. Partner and localizer of BRCA2 (PALB2) gene expression was assessed using qPCR. The results indicate that PLAB2 was upregulated in ERL- and SAHA-loaded TiO2 NPs compared with control cells and can be used as nanocarrier for chemotherapy drugs. However, this conclusion necessitates further confirmative investigation.
Shaimaa Abdel-Ghany; Sara Raslan; Huseyin Tombuloglu; Aly Shamseddin; Emre Cevik; Osama A. Said; Engy F. Madyan; Mehmet Senel; Ayhan Bozkurt; Suriya Rehman; Hussein Sabit. Vorinostat-loaded titanium oxide nanoparticles (anatase) induce G2/M cell cycle arrest in breast cancer cells via PALB2 upregulation. 3 Biotech 2020, 10, 1 -14.
AMA StyleShaimaa Abdel-Ghany, Sara Raslan, Huseyin Tombuloglu, Aly Shamseddin, Emre Cevik, Osama A. Said, Engy F. Madyan, Mehmet Senel, Ayhan Bozkurt, Suriya Rehman, Hussein Sabit. Vorinostat-loaded titanium oxide nanoparticles (anatase) induce G2/M cell cycle arrest in breast cancer cells via PALB2 upregulation. 3 Biotech. 2020; 10 (9):1-14.
Chicago/Turabian StyleShaimaa Abdel-Ghany; Sara Raslan; Huseyin Tombuloglu; Aly Shamseddin; Emre Cevik; Osama A. Said; Engy F. Madyan; Mehmet Senel; Ayhan Bozkurt; Suriya Rehman; Hussein Sabit. 2020. "Vorinostat-loaded titanium oxide nanoparticles (anatase) induce G2/M cell cycle arrest in breast cancer cells via PALB2 upregulation." 3 Biotech 10, no. 9: 1-14.
Suriya Rehman; Tariq Majeed; Mohammad Azam Ansari; Ebtesam A. Al-Suhaimi. Syndrome resembling Kawasaki disease in COVID-19 asymptomatic children. 2020, 1 .
AMA StyleSuriya Rehman, Tariq Majeed, Mohammad Azam Ansari, Ebtesam A. Al-Suhaimi. Syndrome resembling Kawasaki disease in COVID-19 asymptomatic children. . 2020; ():1.
Chicago/Turabian StyleSuriya Rehman; Tariq Majeed; Mohammad Azam Ansari; Ebtesam A. Al-Suhaimi. 2020. "Syndrome resembling Kawasaki disease in COVID-19 asymptomatic children." , no. : 1.
The current knowledge about the COVID-19 (Coronavirus Disease-2019) pandemic is still limited and is unravelling with the passing days, especially clinical data, and research in pediatric age group. Recently, there is a new and crucial development reported recently among the COVID-19 asymptomatic children, a novel syndrome affecting asymptomatic COVID-19 children, presenting as a hyperinflammatory syndrome which is like Kawasaki disease shock syndrome. The purpose of this correspondence is to discuss some important findings of the syndrome for the better understanding of the disease.
Suriya Rehman; Tariq Majeed; Mohammad Azam Ansari; Ebtesam A. Al-Suhaimi. Syndrome resembling Kawasaki disease in COVID-19 asymptomatic children. Journal of Infection and Public Health 2020, 13, 1830 -1832.
AMA StyleSuriya Rehman, Tariq Majeed, Mohammad Azam Ansari, Ebtesam A. Al-Suhaimi. Syndrome resembling Kawasaki disease in COVID-19 asymptomatic children. Journal of Infection and Public Health. 2020; 13 (12):1830-1832.
Chicago/Turabian StyleSuriya Rehman; Tariq Majeed; Mohammad Azam Ansari; Ebtesam A. Al-Suhaimi. 2020. "Syndrome resembling Kawasaki disease in COVID-19 asymptomatic children." Journal of Infection and Public Health 13, no. 12: 1830-1832.
In the current study, we present the correlation between the capability of laser-induced breakdown spectroscopy (LIBS) to monitor the elemental compositions of plants and their biological effects. The selected plant, Moringa oleifera, is known to harbor various minerals and vitamins useful for human health and is a potential source for pharmaceutical interventions. From this standpoint, we assessed the antibacterial and in vitro cytotoxicity of the bioactive components present in Moringa oleifera seed (MOS) extract. Detailed elemental analyses of pellets of MOSs were performed via LIBS. Furthermore, the LIBS outcome was validated using gas chromatography–mass spectrometry (GC-MS). The LIBS signal was recorded, and the presence of the essential elements (Na, Ca, Se, K, Mg, Zn, P, S, Fe and Mn) in the MOSs were examined. The bactericidal efficacy of the alcoholic MOS extract was examined against Escherichia coli (E. coli) and Staphylococcus aureus(S. aureus) by agar well diffusion (AWD) assays and scanning electron microscopy (SEM), which depicted greater inhibition against Gram-positive bacteria. The validity and DNA nuclear morphology of human colorectal carcinoma cells (HCT-116) cells were evaluated via an MTT assay and DAPI staining. The MTT assay results manifested a profoundly inhibitory action of MOS extract on HCT116 cell growth. Additionally, MOS extracts produced inhibitory action in colon cancer cells (HCT-116), whereas no inhibitory action was seen using the same concentrations of MOS extract on HEK-293 cells (non-cancerous cells), suggesting that MOS extracts could be non-cytotoxic to normal cells. The antibacterial and anticancer potency of these MOS extracts could be due to the presence of various bioactive chemical complexes, such as ethyl ester and D-allose and hexadecenoic, oleic and palmitic acids, making them an ideal candidate for pharmaceutical research and applications.
Reem K. Aldakheel; Suriya Rehman; Munirah A. Almessiere; Firdos A. Khan; Mohammed A. Gondal; Ahmed Mostafa; Abdulhadi Baykal. Bactericidal and In Vitro Cytotoxicity of Moringa oleifera Seed Extract and Its Elemental Analysis Using Laser-Induced Breakdown Spectroscopy. Pharmaceuticals 2020, 13, 193 .
AMA StyleReem K. Aldakheel, Suriya Rehman, Munirah A. Almessiere, Firdos A. Khan, Mohammed A. Gondal, Ahmed Mostafa, Abdulhadi Baykal. Bactericidal and In Vitro Cytotoxicity of Moringa oleifera Seed Extract and Its Elemental Analysis Using Laser-Induced Breakdown Spectroscopy. Pharmaceuticals. 2020; 13 (8):193.
Chicago/Turabian StyleReem K. Aldakheel; Suriya Rehman; Munirah A. Almessiere; Firdos A. Khan; Mohammed A. Gondal; Ahmed Mostafa; Abdulhadi Baykal. 2020. "Bactericidal and In Vitro Cytotoxicity of Moringa oleifera Seed Extract and Its Elemental Analysis Using Laser-Induced Breakdown Spectroscopy." Pharmaceuticals 13, no. 8: 193.
The occurrence of human fungal infections, particularly from drug resistance-acquiring pathogenic yeast, has increased considerably and poses a major problem towards the implementation of successful fungal therapies. Efficient therapeutics is hampered by the emergence of drug resistance in fungi. Understanding the molecular pathways specific to yeast is essential for the development of strategies to combat multidrug resistance (MDR). Many signaling cascades in yeasts are yet to be exploited for therapeutic purposes. One such promising signaling pathway is the retrograde (RTG) signaling pathway. The mitochondrion is an essential organelle which performs many crucial functions in eukaryotic cells. Apart from energy production, the mitochondrion is also the site of various catabolic and anabolic reactions which contribute to intracellular signaling, aging, and formation of reactive oxygen species. In the present chapter, we have summarized the current knowledge on the retrograde signaling, activated by mitochondrial dysfunction. We also report on the connections between the RTG signaling pathway and other signaling pathways in yeast, such as the TOR signaling pathway.
Zeeshan Fatima; Bablu Kumar; Suriya Rehman; Saif Hameed. Retrograde signaling: A novel antifungal drug target. New and Future Developments in Microbial Biotechnology and Bioengineering 2020, 219 -226.
AMA StyleZeeshan Fatima, Bablu Kumar, Suriya Rehman, Saif Hameed. Retrograde signaling: A novel antifungal drug target. New and Future Developments in Microbial Biotechnology and Bioengineering. 2020; ():219-226.
Chicago/Turabian StyleZeeshan Fatima; Bablu Kumar; Suriya Rehman; Saif Hameed. 2020. "Retrograde signaling: A novel antifungal drug target." New and Future Developments in Microbial Biotechnology and Bioengineering , no. : 219-226.
COVID-19 pandemic caused by SARS-CoV-2, continues to manifest with severe acute respiratory syndrome among the adults, however, it offers a convincing indication of less severity and fatality in pediatric age group (0–18 years). The current trend suggests that children may get infected but are less symptomatic with less fatality, which is concordant to earlier epidemic outbreaks of SARS-CoV and MERS-CoV, in 2002 and 2012, respectively. According to the available data, children appear to be at lower risk for COVID-19, as adults constitute for maximum number of the confirmed cases (308,592) and deaths (13,069) as on 22nd March (https://www.worldometers.info/coronavirus). However, rapid publications and information of the adult patients with COVID-19 is in progress and published, on the contrary, almost no comprehensive data or discussion about the COVID-19 in children is available. Therefore, in this review, we outline the epidemiology, clinical symptoms, diagnosis, treatment, prevention, possible immune response and role of thymus in children to combat the COVID-19 outbreak.
Suriya Rehman; Tariq Majeed; Mohammad Azam Ansari; Uzma Ali; Hussein Sabit; Ebtesam A. Al-Suhaimi. Current scenario of COVID-19 in pediatric age group and physiology of immune and thymus response. Saudi Journal of Biological Sciences 2020, 27, 2567 -2573.
AMA StyleSuriya Rehman, Tariq Majeed, Mohammad Azam Ansari, Uzma Ali, Hussein Sabit, Ebtesam A. Al-Suhaimi. Current scenario of COVID-19 in pediatric age group and physiology of immune and thymus response. Saudi Journal of Biological Sciences. 2020; 27 (10):2567-2573.
Chicago/Turabian StyleSuriya Rehman; Tariq Majeed; Mohammad Azam Ansari; Uzma Ali; Hussein Sabit; Ebtesam A. Al-Suhaimi. 2020. "Current scenario of COVID-19 in pediatric age group and physiology of immune and thymus response." Saudi Journal of Biological Sciences 27, no. 10: 2567-2573.
Here we report the electrospinning synthesis of Cd-substituted Ni-Co ferrite Ni0.5Co0.5-xCdxFe1.78Nd0.02O4(x ≤ 0.25) nanofiber (NFs) with a very low concentration of Nd as a dopant. The structure and surface morphology of the Ni0.5Co0.5-xCdxFe1.78Nd0.02O4 (x ≤ 0.25) NFs were analyzed by X-ray powder pattern (XRD), transmission and scanning electron microscopes (TEM) along with Energy-dispersive X-ray (EDX). We have examined the biological applications of the Ni0.5Co0.5-xCdxFe1.78Nd0.02O4 (x ≤ 0.25) NFs on both cancerous cells and bacterial cells. We have found that Ni0.5Co0.5-xCdxFe1.78Nd0.02O4 (x ≤ 0.25) NFs produced inhibitory action on the human colorectal carcinoma cells (HEK-293) and also showed inhibitory action on the bacterial strains (S. aureus and E. coli) respectively. Finally, this is the first report on the synthesis of Cd- substituted Co–Ni ferrite nanofibers using electrospinning technique exhibiting anti-cancer and anti-bacterial activities.
Fatimah Alahmari; Suriya Rehman; M. Almessiere; F. A Khan; Yassine Slimani; A. Baykal. Synthesis of Ni0.5Co0.5-xCdxFe1.78Nd0.02O4 (x ≤ 0.25) nanofibers by using electrospinning technique induce anti-cancer and anti-bacterial activities. Journal of Biomolecular Structure and Dynamics 2020, 1 -8.
AMA StyleFatimah Alahmari, Suriya Rehman, M. Almessiere, F. A Khan, Yassine Slimani, A. Baykal. Synthesis of Ni0.5Co0.5-xCdxFe1.78Nd0.02O4 (x ≤ 0.25) nanofibers by using electrospinning technique induce anti-cancer and anti-bacterial activities. Journal of Biomolecular Structure and Dynamics. 2020; ():1-8.
Chicago/Turabian StyleFatimah Alahmari; Suriya Rehman; M. Almessiere; F. A Khan; Yassine Slimani; A. Baykal. 2020. "Synthesis of Ni0.5Co0.5-xCdxFe1.78Nd0.02O4 (x ≤ 0.25) nanofibers by using electrospinning technique induce anti-cancer and anti-bacterial activities." Journal of Biomolecular Structure and Dynamics , no. : 1-8.
The present study offers an alternative method for green synthesis of the formation of two types of nanoparticles (NPs). These NPs, titanium oxide and silver NPs (TiO2 and Ag NPs, respectively), were obtained from the amalgamation of intracellular extract of a wild mushroom, Fomes fomentarius, with aqueous solutions of titanium isopropoxide and silver nitrate, respectively. F. fomentarius was identified phenotypically and by 18S ribosomal RNA gene sequencing (Gene accession no: MK635351). The biosynthesis of TiO2 and Ag NPs was studied and characterized by X-ray diffraction (XRD), diffuse reflectance UV-Visible spectroscopy (DR-UV), fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and transmission electron microscope (TEM). Success was achieved in obtaining NPs of differing sizes and shapes. The antibacterial and anticancer activity of the NPs was significant with morphological damage being caused by both, although Ag NPs (10–20 nm) were found to have profound effects on bacterial and cancer cells in comparison to TiO2 NPs (100–120 nm). These metal NPs, synthesized using wild mushrooms, hold a great potential in biomedicinedue to an effective enzyme combination, which permits them to modify different chemical compounds to less toxic forms, which is required for ecofriendly and safe biomaterials.
Suriya Rehman; Romana Farooq; RabindraN Jermy; Sarah Mousa Asiri; Vijaya Ravinayagam; Reem Al Jindan; Zainab AlSalem; Manzoor A. Shah; Zafar Reshi; Hussein Sabit; Firdos Alam Khan. A Wild Fomes fomentarius for Biomediation of One Pot Synthesis of Titanium Oxide and Silver Nanoparticles for Antibacterial and Anticancer Application. Biomolecules 2020, 10, 622 .
AMA StyleSuriya Rehman, Romana Farooq, RabindraN Jermy, Sarah Mousa Asiri, Vijaya Ravinayagam, Reem Al Jindan, Zainab AlSalem, Manzoor A. Shah, Zafar Reshi, Hussein Sabit, Firdos Alam Khan. A Wild Fomes fomentarius for Biomediation of One Pot Synthesis of Titanium Oxide and Silver Nanoparticles for Antibacterial and Anticancer Application. Biomolecules. 2020; 10 (4):622.
Chicago/Turabian StyleSuriya Rehman; Romana Farooq; RabindraN Jermy; Sarah Mousa Asiri; Vijaya Ravinayagam; Reem Al Jindan; Zainab AlSalem; Manzoor A. Shah; Zafar Reshi; Hussein Sabit; Firdos Alam Khan. 2020. "A Wild Fomes fomentarius for Biomediation of One Pot Synthesis of Titanium Oxide and Silver Nanoparticles for Antibacterial and Anticancer Application." Biomolecules 10, no. 4: 622.
30%MFe2O4/Silica/Chitosan (M = Ni, Cu, Co and Mn) was prepared by pre-wrapping chitosan (CS) over hydrophilic silica (HYPS) for cisplatin (cis-Pt) release. CS coating was optimized with 0.06 wt% and 0.6 wt % at different pH (5, 6 and 6.5). CS (0.6 wt%) coated over CuFe2O4/HYPS/cis-Pt by optimizing two ways of pH adjustments. In method I, cis-Pt (0.15 mmolg−1 of nanocarrier) was preloaded with CuFe2O4/HYPS, then immersed in CS of pH 6.0 (cis-Pt/CuFe2O4/HYPS/CS). In method II, CS was pre-wrapped over CuFe2O4/HYPS and then loaded with cis-Pt (CS/CuFe2O4/HYPS/cis-Pt). CoFe2O4/HYPS showed ferromagnetic behavior with high magnetization (14.15 emu/g), while MnFe2O4/HYPS showed a super paramagnetic behavior (1.49 emu/g). CuFe2O4/HYPS showed preferable paramagnetic effect (7.65 emu/g) with cis-Pt release of about 64% for 72 h cis-Pt/CuFe2O4/HYPS and cis-Pt/CuFe2O4/HYPS/CS (0.025–0.5 mg/ml) were studied in MCF-7 and HEK293. CuFe2O4/HYPS was not cytotoxic, while cis-Pt/CuFe2O4/HYPS/CS, prepared by method I showed a non-significant anti-cancer effect due to premediated cis-Pt release. Conversely, cis-Pt/CuFe2O4/HYPS and CS/CuFe2O4/HYPS/cis-Pt prepared by method II significantly reduced cell viability in dose dependent manner. MCF7 cells treated with CS/CuFe2O4/HYPS/cis-Pt (method II) at lowest concentration (0.025 mg/ml) resulted in 70.7% cell viability, whereas HEK293 cells had a 95% viability, thus making the nanocomposite an effective drug delivery system.
RabindraN Jermy; Vijaya Ravinayagam; Widyan AlAmoudi; Dana Almohazey; Silviya Elanthikkal; Hatim Dafalla; Suriya Rehman; Govindasamy Chandrasekar; Abdulhadi Baykal. Tuning pH sensitive chitosan and cisplatin over spinel ferrite/silica nanocomposite for anticancer activity in MCF-7 cell line. Journal of Drug Delivery Science and Technology 2020, 57, 101711 .
AMA StyleRabindraN Jermy, Vijaya Ravinayagam, Widyan AlAmoudi, Dana Almohazey, Silviya Elanthikkal, Hatim Dafalla, Suriya Rehman, Govindasamy Chandrasekar, Abdulhadi Baykal. Tuning pH sensitive chitosan and cisplatin over spinel ferrite/silica nanocomposite for anticancer activity in MCF-7 cell line. Journal of Drug Delivery Science and Technology. 2020; 57 ():101711.
Chicago/Turabian StyleRabindraN Jermy; Vijaya Ravinayagam; Widyan AlAmoudi; Dana Almohazey; Silviya Elanthikkal; Hatim Dafalla; Suriya Rehman; Govindasamy Chandrasekar; Abdulhadi Baykal. 2020. "Tuning pH sensitive chitosan and cisplatin over spinel ferrite/silica nanocomposite for anticancer activity in MCF-7 cell line." Journal of Drug Delivery Science and Technology 57, no. : 101711.