Dr. Ana Brankovic
University of Criminal Investigation and Police Studies
+1
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Academic Career Length
14Years (2013-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 May 2019 in Cancer Letters
Journal Article
OMOlja Mijanović
Olja Mijanović
Ana BrankovicAPAlexander N. Panin
Alexander N. Panin
SSSolomiia Savchuk
Solomiia Savchuk
PTPeter Timashev
Peter Timashev
MLMaciej Lesniak
Maciej Lesniak +1
Journal Article
OMOlja Mijanovic
Olja MijanovicAPAnastasiia Petushkova
Anastasiia PetushkovaAna BrankovicBTBoris Turk
Boris TurkASAnna B Solovieva
Anna B Solovieva
Andrey A. Zamyatnin Jr. +4
Lysosomal proteases play a crucial role in maintaining cell homeostasis. Human cathepsin D manages protein turnover degrading misfolded and aggregated proteins and favors apoptosis in the case of proteostasis disruption. However, when cathepsin D regulation is affected, it can contribute to numerous disorders. The down-regulation of human cathepsin D is associated with neurodegenerative disorders, such as neuronal ceroid lipofuscinosis. On the other hand, its excessive levels outside lysosomes and the cell membrane lead to tumor growth, migration, invasion and angiogenesis. Therefore, targeting cathepsin D could provide significant diagnostic benefits and new avenues of therapy. Herein, we provide a brief overview of cathepsin D structure, regulation, function, and its role in the progression of many diseases and the therapeutic potentialities of natural and synthetic inhibitors and activators of this protease.
Journal Article
OMOlja Mijanovic
Olja MijanovicAJAleksandra Jakovleva
Aleksandra JakovlevaAna BrankovicKZKristina Zdravkova
Kristina ZdravkovaMPMilena Pualic
Milena PualicAndrey A. Zamyatnin Jr. +3
Cathepsin K (CatK) is a part of the family of cysteine proteases involved in many important processes, including the degradation activity of collagen 1 and elastin in bone resorption. Changes in levels of CatK are associated with various pathological conditions, primarily related to bone and cartilage degradation, such as pycnodysostosis (associated with CatK deficiency), osteoporosis, and osteoarthritis (associated with CatK overexpression). Recently, the increased secretion of CatK is being highly correlated to vascular inflammation, hypersensitivity pneumonitis, Wegener granulomatosis, berylliosis, tuberculosis, as well as with tumor progression. Due to the wide spectrum of diseases in which CatK is involved, the design and validation of active site-specific inhibitors has been a subject of keen interest in pharmaceutical companies in recent decades. In this review, we summarized the molecular background of CatK and its involvement in various diseases, as well as its clinical significance for diagnosis and therapy.
Journal Article
OMOlja Mijanovic
Olja MijanovicAna BrankovicABAnton V. Borovjagin
Anton V. BorovjaginDBDenis V. Butnaru
Denis V. ButnaruEBEvgeny A. Bezrukov
Evgeny A. BezrukovIUIlya Ulasov
Ilya Ulasov +3
Neurodegenerative diseases (NDDs) are most commonly found in adults and remain essentially incurable. Gene therapy using AAV vectors is a rapidly-growing field of experimental medicine that holds promise for the treatment of NDDs. To date, effective delivery of a therapeutic gene into target cells via AAV has been a major obstacle in the field. Ideally, transgenes should be delivered into the target cells specifically and efficiently, while promiscuous or off-target gene delivery should be minimized to avoid toxicity. In the pursuit of an ideal vehicle for NDD gene therapy, a broad variety of vector systems have been explored. Here we specifically outline the advantages of adeno-associated virus (AAV)-based vector systems for NDD therapy application. In contrast to many reviews on NDDs that can be found in the literature, this review is rather focused on AAV vector selection and their testing in experimental and preclinical NDD models. Preclinical and in vitro data reveal the strong potential of AAV for NDD-related diagnostics and therapeutic strategies.
2 September 2013 in International Journal of Experimental Pathology
Journal Article
Ana BrankovicGBGoran Brajušković
Goran BrajuškovićZNZorana Nikolic
Zorana Nikolic
VVVinka Vukotić
Vinka Vukotić
SCSnezana Cerovic
Snezana Cerovic
SRStanka Romac
Stanka Romac
+1
Journal Article
OMOlja Mijanovic
Olja MijanovicTPTimofey Pylaev
Timofey PylaevANAngelina Nikitkina
Angelina NikitkinaMAMargarita Artiukhova
Margarita ArtiukhovaAna BrankovicPTPeter S. Timashev
Peter S. Timashev +5
Nowadays, tissue engineering is one of the most promising approaches for the regeneration of various tissues and organs, including the cornea. However, the inability of biomaterial scaffolds to successfully integrate into the environment of surrounding tissues is one of the main challenges that sufficiently limits the restoration of damaged corneal tissues. Thus, the modulation of molecular and cellular mechanisms is important and necessary for successful graft integration and long-term survival. The dynamics of molecular interactions affecting the site of injury will determine the corneal transplantation efficacy and the post-surgery clinical outcome. The interactions between biomaterial surfaces, cells and their microenvironment can regulate cell behavior and alter their physiology and signaling pathways. Nanotechnology is an advantageous tool for the current understanding, coordination, and directed regulation of molecular cell–transplant interactions on behalf of the healing of corneal wounds. Therefore, the use of various nanotechnological strategies will provide new solutions to the problem of corneal allograft rejection, by modulating and regulating host–graft interaction dynamics towards proper integration and long-term functionality of the transplant.
About Me
Ana Brankovic graduated from the Faculty of Biology, University of Belgrade (study group Molecular Biology and Physiology), in 2007. She defended her graduate thesis entitled "Influence of Mutations on Resistance to Antiretroviral Therapy in HIV Patients" in July 2007, with a grade of 10. She enrolled in doctoral studies at the Faculty of Biology, University of Belgrade, Module Molecular Biology, Department of Molecular Biology of eukaryotes in 2008. During her studies, she volunteered at the Institute of Microbiology and Immunology of the Medical Faculty of the University of Belgrade, and after graduating from the Laboratory for Human Genetics and Prenatal Diagnostics of the Clinical Hospital Center "Zvezdara" in Belgrade. Since 2008, she has been employed at the Criminal Police Academy, Belgrade, as a teaching associate, and in 2009, she was elected an assistant. In January 2014, she defended her doctoral dissertation on "Study of the association of genetic variants in regions 7q36, 8q24 and 17q12 with the risk of developing and progressing prostate cancer" at the Faculty of Biology, University of Belgrade. In June 2014, she was elected assistant professor at the University of Criminal Investigation and Police Studies in the scientific field of Biological Engineering. At the same University, she was promoted to associate professor in May 2023.