Magnetic resonance (MR) image reconstruction from undersampled k-space data can be formulated as a minimization problem involving data consistency and image prior. Existing deep learning (DL)-based methods for MR reconstruction employ deep networks to exploit the prior information and integrate the prior knowledge into the reconstruction under the explicit constraint of data consistency, without considering the real distribution of the noise. In this work, we propose a new DL-based approach termed Learned DC that implicitly learns the data consistency with deep networks, corresponding to the actual probability distribution of system noise. The data consistency term and the prior knowledge are both embedded in the weights of the networks, which provides an utterly implicit manner of learning reconstruction model. We evaluated the proposed approach with highly undersampled dynamic data, including the dynamic cardiac cine data with up to 24-fold acceleration and dynamic rectum data with the acceleration factor equal to the number of phases. Experimental results demonstrate the superior performance of the Learned DC both quantitatively and qualitatively than the state-of-the-art.

Due to the capability of fast multiparametric quantitative imaging, magnetic resonance fingerprinting (MRF) is becoming a promising quantitative magnetic resonance imaging approach. However, the artifacts caused by the highly undersampled data acquisition lead to inaccurate estimation of the tissue parameter maps. Based on the assumption that the 3-D MRF data can be modeled as a piecewise smooth signal, with the discontinuities localized to the zero sets of a bandlimited function, we exploit the low-rank property of the structured Toeplitz matrix constructed from the Fourier measurements. In addition, we adopt the subspace projection scheme to improve the accuracy of parameter estimation. In order to efficiently solve the regularized problem, we propose an iterative two-stage algorithm, which alternately updates the ${k}$ -space data and projects the space-time matrix into the dictionary space. Numerical experiments demonstrate that the proposed algorithm shows significant improvement in MRF time-series images reconstruction and can provide more accurate parameter maps over the state-of-the-art algorithms.

Accurate detection and segmentation of brain tumors is critical for medical diagnosis. However, current supervised learning methods require extensively annotated images and the state-of-the-art generative models used in unsupervised methods often have limitations in covering the whole data distribution. In this paper, we propose a novel framework T wo- S tage G enerative M odel (TSGM) that combines Cycle Generative Adversarial Network (CycleGAN) and V ariance E xploding stochastic differential equation using j oint p robability (VE-JP) to improve brain tumor detection and segmentation. The CycleGAN is trained on unpaired data to generate abnormal images from healthy images as data prior. Then VE-JP is implemented to reconstruct healthy images using synthetic paired abnormal images as a guide, which alters only pathological regions but not regions of healthy. Notably, our method directly learned the joint probability distribution for conditional generation. The residual between input and reconstructed images suggests the abnormalities and a thresholding method is subsequently applied to obtain segmentation results. Furthermore, the multimodal results are weighted with different weights to improve the segmentation accuracy further. We validated our method on three datasets, and compared with other unsupervised methods for anomaly detection and segmentation. The DSC score of 0.8590 in BraTs2020 dataset, 0.6226 in ITCS dataset and 0.7403 in In-house dataset show that our method achieves better segmentation performance and has better generalization.