Jane Fletcher

Mrs. Jane Fletcher

orcid

Research Focus & Metrics

Academic Career Length

18Years (2009-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 February 2018 in Clinical Nutrition
Verified
Journal Article
Closed access
FGFilomena Gomes
Filomena Gomes
PSPhilipp Schuetz
Philipp Schuetz
LBLisa Bounoure
Lisa Bounoure
PAPeter Austin
Peter Austin
MBMaría D. Ballesteros-Pomar
María D. Ballesteros-Pomar
SBStephan C. Bischoff
Stephan C. Bischoff

7 May 2019 in Nutrients
Verified
Journal Article
Open access
PDF file
JFJane Fletcher
Jane Fletcher
SCSheldon C Cooper
Sheldon C Cooper
SGSubrata Ghosh
Subrata Ghosh
MHMartin Hewison
Martin Hewison
Vitamin D has been linked to human health benefits that extend far beyond its established actions on calcium homeostasis and bone metabolism. One of the most well studied facets of extra-skeletal vitamin D is its activity as an immuno-modulator, in particular its potent anti-inflammatory effects. As a consequence, vitamin D deficiency has been associated with inflammatory diseases including inflammatory bowel disease (IBD). Low serum levels of the major circulating form of vitamin D, 25-hydroxyvitamin D (25-OH-D) are significantly more prevalent in patients with IBD, particularly in the winter and spring months when UV-induced synthesis of vitamin D is lower. Dietary malabsorption of vitamin D may also contribute to low serum 25(OH)D in IBD. The benefits of supplementation with vitamin D for IBD patients are still unclear, and improved vitamin D status may help to prevent the onset of IBD as well as ameliorating disease severity. Beneficial effects of vitamin D in IBD are supported by pre-clinical studies, notably with mouse models, where the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25-(OH)2D) has been shown to regulate gastrointestinal microbiota function, and promote anti-inflammatory, tolerogenic immune responses. The current narrative review aims to summarise the different strands of data linking vitamin D and IBD, whilst also outlining the possible beneficial effects of vitamin D supplementation in managing IBD in humans.

8 July 2023 in Clinical Nutrition
Verified
Journal Article
Open access
CWCarla Wunderle
Carla Wunderle
FGFilomena Gomes
Filomena Gomes
PSPhilipp Schuetz
Philipp Schuetz
FSFranziska Stumpf
Franziska Stumpf
PAPeter Austin
Peter Austin
SBStephan C. Bischoff
Stephan C. Bischoff
Disease-related malnutrition in polymorbid medical inpatients is a highly prevalent syndrome associated with significantly increased morbidity, disability, short- and long-term mortality, impaired recovery from illness, and cost of care. As there are uncertainties in applying disease-specific guidelines to patients with multiple conditions, our aim was to provide evidence-based recommendations on nutritional support for the polymorbid patient population hospitalized in medical wards. This update adheres to the standard operating procedures for ESPEN guidelines. We did a systematic literature search for 15 clinical questions in three different databases (Medline, Embase and the Cochrane Library), as well as in secondary sources (e.g. published guidelines), until July 12th. Retrieved abstracts were screened to identify relevant studies that were used to develop recommendations (incl. SIGN grading), which was followed by submission to Delphi voting. From a total of 3527 retrieved abstracts, 60 new relevant studies were analyzed and used to generate a guideline draft that proposed 32 recommendations (7x A, 11x B, 10x O and 4x GPP), which encompass different aspects of nutritional support including indication, route of feeding, energy and protein requirements, micronutrient requirements, disease-specific nutrients, timing, monitoring and procedure of intervention. The results of the first online voting showed a strong consensus (agreement of >90%) on 100% of the recommendations. Therefore, no final consensus conference was needed. Recent high-quality trials have provided increasing evidence that nutritional support can reduce morbidity and other complications associated with malnutrition in polymorbid patients. The timely screening of patients for risk of malnutrition at hospital admission followed by individualized nutritional support interventions for at-risk patients should be part of routine clinical care and multimodal treatment in hospitals worldwide. Use of this updated guideline offers an evidence-based nutritional approach to the polymorbid medical inpatients and may improve their outcomes.

18 September 2019 in Journal of Clinical Medicine
Verified
Journal Article
Open access
PDF file
MVMaria Vasiloglou
Maria Vasiloglou
JFJane Fletcher
Jane Fletcher
Kalliopi-Anna PouliaKalliopi-Anna Poulia
Kalliopi-Anna Poulia
Nutritional counselling has been recognised as the first line approach in the management of numerous chronic diseases. Though usually carried out by dietitians, nutritional counselling may be used by nurses, or other healthcare professionals to improve nutritional status and meet healthcare goals. Healthcare professionals require training and education to facilitate a patient centred approach to effective counselling. Advances in digital technology have the potential to improve access to nutritional counselling for some patients such as those in primary care. However, caution is required to ensure that valuable interpersonal relationships are not lost, as these form the cornerstone of effective nutritional counselling. The aim of this narrative review is to explore aspects of effective nutritional counselling, including advances in e-counselling and areas where nursing input in nutritional counselling might enhance overall nutritional care.

25 January 2024 in Clinical Nutrition
Verified
Journal Article
Closed access
CWCarla Wunderle
Carla Wunderle
FGFilomena Gomes
Filomena Gomes
PSPhilipp Schuetz
Philipp Schuetz
FSFranziska Stumpf
Franziska Stumpf
PAPeter Austin
Peter Austin
SBStephan C. Bischoff
Stephan C. Bischoff

11 August 2016 in British Journal of Nursing
Verified
Journal Article
Closed access
JFJane Fletcher
Jane Fletcher
There are over 300 000 people in the UK affected by inflammatory bowel disease (IBD). Though vitamin D deficiency is common in patients with IBD, National Institute for Health and Care Excellence (NICE) guidance regarding vitamin D supplementation does not address the needs of patients with chronic inflammatory diseases. However, there is growing evidence that vitamin D plays an important role in the management of IBD. Nurses caring for patients with IBD should have an understanding of the causes and consequences of vitamin D deficiency in this patient group. This article looks at the role vitamin D plays in the body and the challenges of treating deficiency. Consideration is given to diet, sun exposure and supplementation as possible treatments and acknowledges the limitations of treatments for patients with IBD. With a lack of clear national guidance, it is hoped that raising awareness of these issues will inform nursing practice and ensure a holistic approach to care.