It is worldwide known that the most common type of cancer among women is breast cancer. Traditional procedures involve surgery, chemotherapy and radiation therapy; however, these treatments are invasive and have serious side effects. For this reason, minimally invasive thermal treatments like microwave ablation are being considered. In this study, thermal behavior of three types of slot-coaxial antennas for breast cancer microwave ablation is presented. By using finite element method (FEM), all antennas were modeled to estimate the heat transfer in breast tumor tissue surrounded by healthy breast tissue. Experimentation was carried out by using the antennas inserted inside sphere-shaped-tumor phantoms with two different diameters, 1.0 and 1.5 cm. A microwave radiation system was used to apply microwave energy to each designed antenna, which were located into the phantom. A non-interfering thermometry system was used to measure the temperature increase during the experimentation. Temperature increases, recorded by the thermal sensors placed inside the tumor phantom surrounded by healthy breast phantom, were used to validate the FEM models. The results conclude that, in all the cases, after 240 s, the three types of coaxial slot antenna reached the temperature needed produce hyperthermia of the tumor volume considered in this paper.

According to statistics of the American Cancer Society, the number of young people diagnosed with bone tumors is growing. Surgery and radiotherapy are the common treatments, however they have several side effects which affect the patient’s life. Therefore, a cheaper and less side-effect therapy called thermal ablation has been explored. The goal of this paper is to measure the therapeutic temperatures and the viability of a double slot antenna designed to treat bone tissue by microwave ablation. The antenna (at an operating frequency of 2.45 GHz) was designed, modeled, constructed, and experimentally evaluated. The finite element method was used to predict the antenna performance by means of 2D axisymmetric models. The modeling parameters were used to build the antenna. The experimental evaluation shows that the antenna behavior is repeatable and the standing wave ratio (SWR) was around 1.5–1.8. Temperatures around 60–100 °C were achieved over the bone tissue. The antenna insertion modifies the antenna performance. An insertion lower than 3.5 cm is not recommended because the convection effects modified the tissue temperature. The thermal patterns showed a heat focus near to the slots, which makes it possible for use in the treatment of small tumors.

Microwave ablation (MWA) by using coaxial antennas is a promising alternative for breast cancer treatment. A double short distance slot coaxial antenna as a newly optimized applicator for minimally invasive treatment of breast cancer is proposed. To validate and to analyze the feasibility of using this method in clinical treatment, a computational model, phantom, and breast swine in vivo experimentation were carried out, by using four microwave powers (50 W, 30 W, 20 W, and 10 W). The finite element method (FEM) was used to develop the computational model. Phantom experimentation was carried out in breast phantom. The in vivo experimentation was carried out in a 90 kg swine sow. Tissue damage was estimated by comparing control and treated micrographs of the porcine mammary gland samples. The coaxial slot antenna was inserted in swine breast glands by using image-guided ultrasound. In all cases, modeling, in vivo and phantom experimentation, and ablation temperatures (above 60°C) were reached. The in vivo experiments suggest that this new MWA applicator could be successfully used to eliminate precise and small areas of tissue (around 20–30 mm²). By modulating the power and time applied, it may be possible to increase/decrease the ablation area.

According to the American Cancer Society the number of patients with bone tumors is growing up. The extremities of the long bones are the most affected by this disease. The common treatments are surgery (amputation), radio and chemotherapy. However, their high cost and side-effects show the necessity of new treatments. These should not only eradicate the tumor but also offer a major control over the treated area. In this sense, the microwave ablation plays an important role. A micro-coaxial slot antenna to generated thermal ablation in bone tumors is proposed. The antenna was modeled, constructed and evaluated in pig tissue. A parametric study to evaluate the effect of the blood perfusion in the thermal distributions was done. Values of bone blood perfusion among 30-1171 ml/min/kg were included in this study. Subsequently, temperature profiles and thermal distributions generated in pig bones were obtained and compared with those obtained in the model. This evaluation shows a high level of concordance; in the best cases, a difference between simulation and measurement of 0.13°C-3.83°C and 0.08°C-0.41°C was found. This study corroborates the efficiency of the models to predict the antenna behavior and the efficiency of the proposed antenna to generated thermal ablation in bone tissue.

Bone cancer is rare in adults, the most affected persons by this disease are young people and children. The common treatments for bone cancer are surgery, chemotherapy, and targeted therapies; however, all of them have side-effects that decrease the patient’s quality of life. Thermotherapy is one of the most promising treatments for bone cancer; its main goal is to increase the tumor temperature to kill cancerous cells. Although some micro-coaxial antennas have been used to treat bone tumors, most of them are designed to treat soft tissue. Therefore, the purpose of this work is to analyze the thermal behavior of four micro-coaxial antennas specifically designed to generate thermal ablation in bone tissue to treat bone tumors, at 2.45 GHz. The proposed antennas were the metal-tip monopole (MTM), the choked metal-tip monopole (CMTM), the double slot (DS) and the choked double slot (CDS). The design and optimization of the antennas by using the Finite Element Method (FEM) allow to predict the optimal antenna dimensions and their performance when they are in contact with the affected biological tissues (bone, muscle, and fat). In the FEM model, a maximum power transmission was selected as the main parameter to choose the optimum antenna design, i.e., a Standing Wave Ratio (SWR) value around 1.2–1.5. The four optimized antennas were constructed and experimentally evaluated. The evaluation was carried out in multilayer phantoms (fat, muscle, cortical, and cancellous bone) and ex vivo porcine tissue at different insertion depths of the antennas. To fully evaluate the antennas performance, the standing wave ratio (SWR), power loss, temperature profiles, and thermal distributions were analyzed. In the experimentation, the four antennas were able to reach ablation temperatures (>60 °C) and the highest reached SWR was 1.7; the MTM (power loss around 16%) and the CDS (power loss around 6.4%) antennas presented the lowest SWR values depending on the antenna insertion depth, either in multilayer tissue phantom or in ex vivo tissue. These proposed antennas allow to obtain ablation temperatures with an input power of 5 W after 5 min of treatment; these values are lower than the ones reported in the literature.