A new CdTe@SiO ₂ @CdSe nanohybrid was demonstrated for the ratiometric fluorescence detection of Cd ²⁺ via the turn-on model and “ion-imprinting” technique.

Two novel Pt(II) complexes, [Pt(B-TFA)Cl]Cl (Pt1) and [Pt(J-TFA)Cl]Cl (Pt2) with jatrorrhizine and berberine derivatives (B-TFA and J-TFA) were first prepared as desirable luminescent agents for cellular applications and potent telomerase inhibitors, which can induce bladder T-24 tumor cell apoptosis by targeting telomerase, together with induction of mitochondrial dysfunction, telomere DNA damage and cell-cycle arrest. Importantly, T-24 tumor inhibition rate (TIR) was 50.4% for Pt2, which was higher than that of Pt1 (26.4%) and cisplatin (37.1%). Taken together, all the results indicated that jatrorrhizine and berberine derivatives Pt1 and Pt2 show low toxicity and could be novel Pt-based anti-cancer drug candidates.

Functionalized mesoporous silica nanoparticles (MSNs) have been widely investigated in the fields of nanotechnology and material science, owing to their high surface area, diverse structure, controllable cavity, high biocompatibility, and ease of surface modification. In the past few years, great efforts have been devoted to preparing functionalized MSNs for biosensing applications with satisfactory performance. The functional structure and composition in the synthesis of MSNs play important roles in high biosensing performance. With the development of material science, diverse functional units have been rationally incorporated into mesoporous structures, which endow MSNs with design flexibility and multifunctionality. Here, an overview of the recent developments of MSNs as nanocarriers is provided, including the methodologies for the preparation of MSNs and the nanostructures and physicochemical properties of MSNs, as well as the latest trends of MSNs and their use in biosensing. Finally, the prospects and challenges of MSNs are presented.