Drug–target interaction (DTI) prediction can identify novel ligands for specific protein targets, and facilitate the rapid screening of effective new drug candidates to speed up the drug discovery process. However, the current methods are not sensitive enough to complex topological structures, and complicated relations between multiple node types are not fully captured yet. To address the above challenges, we construct a metapath-based heterogeneous bioinformatics network, and then propose a DTI prediction method with metapath-based hierarchical transformer and attention network for drug–target interaction prediction (MHTAN-DTI), applying metapath instance-level transformer, single-semantic attention and multi-semantic attention to generate low-dimensional vector representations of drugs and proteins. Metapath instance-level transformer performs internal aggregation on the metapath instances, and models global context information to capture long-range dependencies. Single-semantic attention learns the semantics of a certain metapath type, introduces the central node weight and assigns different weights to different metapath instances to obtain the semantic-specific node embedding. Multi-semantic attention captures the importance of different metapath types and performs weighted fusion to attain the final node embedding. The hierarchical transformer and attention network weakens the influence of noise data on the DTI prediction results, and enhances the robustness and generalization ability of MHTAN-DTI. Compared with the state-of-the-art DTI prediction methods, MHTAN-DTI achieves significant performance improvements. In addition, we also conduct sufficient ablation studies and visualize the experimental results. All the results demonstrate that MHTAN-DTI can offer a powerful and interpretable tool for integrating heterogeneous information to predict DTIs and provide new insights into drug discovery.

Single Image Super-resolution (SISR) produces high-resolution images with fine spatial resolutions from a remotely sensed image with low spatial resolution. Recently, deep learning and generative adversarial networks (GANs) have made breakthroughs for the challenging task of single image super-resolution (SISR) . However, the generated image still suffers from undesirable artifacts such as the absence of texture-feature representation and high-frequency information. We propose a frequency domain-based spatio-temporal remote sensing single image super-resolution technique to reconstruct the HR image combined with generative adversarial networks (GANs) on various frequency bands (TWIST-GAN). We have introduced a new method incorporating Wavelet Transform (WT) characteristics and transferred generative adversarial network. The LR image has been split into various frequency bands by using the WT, whereas the transfer generative adversarial network predicts high-frequency components via a proposed architecture. Finally, the inverse transfer of wavelets produces a reconstructed image with super-resolution. The model is first trained on an external DIV2 K dataset and validated with the UC Merced Landsat remote sensing dataset and Set14 with each image size of 256 × 256. Following that, transferred GANs are used to process spatio-temporal remote sensing images in order to minimize computation cost differences and improve texture information. The findings are compared qualitatively and qualitatively with the current state-of-art approaches. In addition, we saved about 43% of the GPU memory during training and accelerated the execution of our simplified version by eliminating batch normalization layers.

Semantic segmentation of remote sensing (RS) images is vital in various practical applications, including urban construction planning, natural disaster monitoring, and land resources investigation. However, RS images are captured by airplanes or satellites at high altitudes and long distances, resulting in ground objects of the same category being scattered in various corners of the image. Moreover, objects of different sizes appear simultaneously in RS images. For example, some objects occupy a large area in urban scenes, while others only have small regions. Technically, the above two universal situations pose significant challenges to the segmentation with a high quality for RS images. Based on these observations, this paper proposes a Mask2Former with an improved query (IQ2Former) for this task. The fundamental motivation behind the IQ2Former is to enhance the capability of the query of Mask2Former by exploiting the characteristics of RS images well. First, we propose the Query Scenario Module (QSM), which aims to learn and group the queries from feature maps, allowing the selection of distinct scenarios such as the urban and rural areas, building clusters, and parking lots. Second, we design the query position module (QPM), which is developed to assign the image position information to each query without increasing the number of parameters, thereby enhancing the model’s sensitivity to small targets in complex scenarios. Finally, we propose the query attention module (QAM), which is constructed to leverage the characteristics of query attention to extract valuable features from the preceding queries. Being positioned between the duplicated transformer decoder layers, QAM ensures the comprehensive utilization of the supervisory information and the exploitation of those fine-grained details. Architecturally, the QSM, QPM, and QAM as well as an end-to-end model are assembled to achieve high-quality semantic segmentation. In comparison to the classical or state-of-the-art models (FCN, PSPNet, DeepLabV3+, OCRNet, UPerNet, MaskFormer, Mask2Former), IQ2Former has demonstrated exceptional performance across three publicly challenging remote-sensing image datasets, 83.59 mIoU on the Vaihingen dataset, 87.89 mIoU on Potsdam dataset, and 56.31 mIoU on LoveDA dataset. Additionally, overall accuracy, ablation experiment, and visualization segmentation results all indicate IQ2Former validity.

The object identification within an image captured during rough weather conditions (such as haze, fog) poses difficulty due to the reduction of an image. The rough weather conditions lead not only to the variation of the image's visual effect but also to the disadvantage of post‐processing of an image. Furthermore, it causes inconvenience of all types of instruments that rely on optical imaging, such as satellite remote‐sensing systems, aerial photo systems, outdoor monitoring systems, and object identification systems, respectively. Hence, the improvement and restorement of the visual effects and enhanced post‐processing are needed. This research introduces a new image enhancement approach for image dehazing based on dark channel prior and piecewise linear transformation; also, the histogram equalisation technique, i.e. contrast limited adaptive histogram equalisation is applied. A dark channel prior is well known for its simplicity and productivity. In this work, the dark channel prior to a new angle is analysed in the first step, where average patch sizes are estimated for the computation of haze densities. Furthermore, the sky is approximated up to 5–10% of the hazy images, which has a good effect in removing the haze from the image. Using the dark channel, the proposed algorithm significantly boosted the effects of the dark images as well as reduced the influence of haze and noise. Eventually, for colour correction, the piecewise linear transformation technique is applied, which enhances the colour close to the original image. Experimental results demonstrate that the proposed method significantly improves the visibility of the algorithm on dark remote‐sensing images as well as on hazy natural images.

Semantic segmentation in high-resolution remote-sensing (RS) images is a fundamental task for RS-based urban understanding and planning. However, various types of artificial objects in urban areas make this task quite challenging. Recently, the use of Deep Convolutional Neural Networks (DCNNs) with multiscale information fusion has demonstrated great potential in enhancing performance. Technically, however, existing fusions are usually implemented by summing or concatenating feature maps in a straightforward way. Seldom do works consider the spatial importance for global-to-local context-information aggregation. This paper proposes a Learnable-Gated CNN (L-GCNN) to address this issue. Methodologically, the Taylor expression of the information-entropy function is first parameterized to design the gate function, which is employed to generate pixelwise weights for coarse-to-fine refinement in the L-GCNN. Accordingly, a Parameterized Gate Module (PGM) was designed to achieve this goal. Then, the single PGM and its densely connected extension were embedded into different levels of the encoder in the L-GCNN to help identify the discriminative feature maps at different scales. With the above designs, the L-GCNN is finally organized as a self-cascaded end-to-end architecture that is able to sequentially aggregate context information for fine segmentation. The proposed model was evaluated on two public challenging benchmarks, the ISPRS 2Dsemantic segmentation challenge Potsdam dataset and the Massachusetts building dataset. The experiment results demonstrate that the proposed method exhibited significant improvement compared with several related segmentation networks, including the FCN, SegNet, RefineNet, PSPNet, DeepLab and GSN.For example, on the Potsdam dataset, our method achieved a 93.65% $F_1$ score and 88.06% $IoU$ score for the segmentation of tiny cars in high-resolution RS images. As a conclusion, the proposed model showed potential for object segmentation from the RS images of buildings, impervious surfaces, low vegetation, trees and cars in urban settings, which largely varies in size and have confusing appearances.

Cloud recognition is a basic task in ground meteorological observation. It is of great significance to accurately identify cloud types from long-time-series satellite cloud images for improving the reliability and accuracy of weather forecasting. However, different from ground-based cloud images with a small observation range and easy operation, satellite cloud images have a wider cloud coverage area and contain more surface features. Hence, it is difficult to effectively extract the structural shape, area size, contour shape, hue, shadow and texture of clouds through traditional deep learning methods. In order to analyze the regional cloud type characteristics effectively, we construct a China region meteorological satellite cloud image dataset named CRMSCD, which consists of nine cloud types and the clear sky (cloudless). In this paper, we propose a novel neural network model, UATNet, which can realize the pixel-level classification of meteorological satellite cloud images. Our model efficiently integrates the spatial and multi-channel information of clouds. Specifically, several transformer blocks with modified self-attention computation (swin transformer blocks) and patch merging operations are used to build a hierarchical transformer, and spatial displacement is introduced to construct long-distance cross-window connections. In addition, we introduce a Channel Cross fusion with Transformer (CCT) to guide the multi-scale channel fusion, and design an Attention-based Squeeze and Excitation (ASE) to effectively connect the fused multi-scale channel information to the decoder features. The experimental results demonstrate that the proposed model achieved 82.33% PA, 67.79% MPA, 54.51% MIoU and 70.96% FWIoU on CRMSCD. Compared with the existing models, our method produces more precise segmentation performance, which demonstrates its superiority on meteorological satellite cloud recognition tasks.