The guided mode resonance (GMR) effect is widely used in biosensing due to its advantages of narrow linewidth and high efficiency. However, the optimization of a figure of merit (FOM) has not been considered for most GMR sensors. Aimed at obtaining a higher FOM of GMR sensors, we proposed an effective design method for the optimization of FOM. Combining the analytical model and numerical simulations, the FOM of “grating–waveguide” GMR sensors for the wavelength and angular shift detection schemes were investigated systematically. In contrast with previously reported values, higher FOM values were obtained using this method. For the “waveguide–grating” GMR sensors, a linear relationship between the grating period and groove depth was obtained, which leads to excellent FOM values for both the angular and wavelength resonance. Such higher performance GMR sensors will pave the way to lower detection limits in biosensing.

The detection of small molecules has increasingly attracted the attention of researchers because of its important physiological function. In this manuscript, we propose a novel optical sensor which uses an optofluidic microbubble resonator (OFMBR) for the highly sensitive detection of small molecules. This paper demonstrates the binding of the small molecule biotin to surface-immobilized streptavidin with a detection limit reduced to 0.41 pM. Furthermore, binding specificity of four additional small molecules to surface-immobilized streptavidin is shown. A label-free OFMBR-based optical sensor has great potential in small molecule detection and drug screening because of its high sensitivity, low detection limit, and minimal sample consumption.

The distributed feedback (DFB) laser is widely used in sensing because of its portable size, simple fabrication and high sensitivity. Most theoretical design models are based on passive Bragg gratings. However, passive grating models cannot be used to predict sensor performance using the important indicator of figure of merit (FOM) through theoretical calculations. To solve this problem, we replaced the passive grating with an active grating by using the imaginary part of the coupling constant that represents the value of the gain. As a comparison, the influence of the full width at half maximum (FWHM) and sensitivity were analyzed for different grating duty cycles and depths in the passive grating sensors. To obtain a higher FOM in the active grating sensors, we systematically investigated the effects of duty cycle and gain value through numerical simulations. We found that the redshift caused by a duty cycle increase can improve the sensitivity of biomolecule detection by 1.7 times.