In this study, the maple wood surface was coated with nanostructured zinc oxide, grown on the surface by using a hydrothermal process, and furtherly treated with shellac varnish. Samples obtained both after ZnO treatment and after the final varnish application were characterized by different techniques, i.e., X-ray diffraction (XRD), scanning electron microscopy combined with energy-dispersive X-ray spectroscopy (SEM-EDS), micro-FTIR with attenuated total reflectance (μ-ATR-FTIR), chromatic variation measurements, and contact angle determinations. Analytical results showed that the wood surface was covered by quite a homogeneous array of inorganic nanoparticles and that the natural resin forms a regular film over the ZnO nanostructures. An accelerated aging test was used to evaluate the protecting effectiveness of the treatments towards UV-induced decay of wood material. After the test, wood treated with ZnO and with the shellac/ZnO combination underwent a considerably lower chromatic change if compared to the untreated wood, suggesting an enhanced resistance of the treated maple to the decay due to light exposition. The presence of nanostructured ZnO protects from decay not only the wood substrate but also the shellac film. A microbiology test showed that growth of fungal species, e.g., common mold, is prevented on the wood surface treated with ZnO or with shellac/ZnO, indicating that the nanostructured zinc oxide also provides an effective protection from biodeterioration. The coating obtained by consecutive application of nanosized ZnO particles and shellac varnish combines the excellent aesthetical features and water repellence of the traditional finish with the protecting effectiveness of the nanostructured inorganic component.