Central venous catheter-related bloodstream infection is clinically important because of its high mortality rate. This prospective study shows by multivariate analysis that the use of maximal sterile barrier precautions (odds ratio, 5.205 [95% confidence interval, 0.015-1.136]; P= .023) and the use of antimicrobial-coated catheters (odds ratio, 5.269 [95% confidence interval, 0.073-0.814]; P = .022) are independent factors associated with a lowered risk of acquiring a central venous catheter-related bloodstream infection.

Acute kidney injury (AKI) after out-of-hospital cardiac arrest (OHCA) is a well-known predictor for mortality. However, the natural course of AKI including recovery rate after OHCA is uncertain. This study investigated the clinical course of AKI after OHCA and determined whether recovery from AKI impacted the outcomes of OHCA. This retrospective multicentre cohort study included adult OHCA patients treated with targeted temperature management (TTM) between January 2016 and December 2017. AKI was diagnosed using the Kidney Disease: Improving Global Outcomes criteria. The primary outcome was the recovery rate after AKI and its association with survival and good neurological outcome at discharge. A total of 3697 OHCA patients from six hospitals were screened and 275 were finally included. AKI developed in 175/275 (64%) patients and 69/175 (39%) patients recovered from AKI. In most cases, AKI developed within three days of return of spontaneous circulation [155/175 (89%), median time to AKI development 1 (1–2) day] and patients recovered within seven days of return of spontaneous circulation [59/69 (86%), median time to AKI recovery 3 (2–7) days]. Duration of AKI was significantly longer in the AKI non-recovery group than in the AKI recovery group [5 (2–9) vs. 1 (1–5) days; P < 0.001]. Most patients were diagnosed with AKI stage 1 initially [120/175 (69%)]. However, the number of stage 3 AKI patients increased from 30/175 (17%) to 77/175 (44%) after the initial diagnosis of AKI. The rate of survival discharge was significantly higher in the AKI recovery group than in the AKI non-recovery group [45/69 (65%) vs. 17/106 (16%); P < 0.001]. Recovery from AKI was a potent predictor of survival and good neurological outcome at discharge in the multivariate analysis (adjusted odds ratio, 8.308; 95% confidence interval, 3.120–22.123; P < 0.001 and adjusted odds ratio, 36.822; 95% confidence interval, 4.097–330.926; P = 0.001). In our cohort of adult OHCA patients treated with TTM (n = 275), the recovery rate from AKI after OHCA was 39%, and recovery from AKI was a potent predictor of survival and good neurological outcome at discharge.

Vital signs are essential for monitoring and prognostication in the emergency department (ED); however, they may not fully capture the complexity of frailty in older adults. In this multicenter retrospective study of 932 older patients who visited the EDs of three tertiary university hospitals between August 1 and October 31, 2023, we investigated the prognostic value of the Clinical Frailty Scale (CFS) in older patients in the ED and its potential to improve existing vital sign-based scoring systems. The primary outcomes were hospital admission, intensive care unit (ICU) admission, and in-hospital mortality. The AUROC was used to evaluate and compare the predictive performance of CFS, qSOFA, NEWS2, and REMS scores individually and in combination. Combining the CFS with these scores significantly improved predictive accuracy compared to individual scores alone. For hospital admission, the AUROCs were 0.715 (95% CI 0.685–0.744), 0.723 (95% CI 0.693–0.752), and 0.688 (95% CI 0.657–0.718) for CFS + qSOFA, CFS + NEWS2, and CFS + REMS, respectively. For ICU admission, the AUROCs were 0.730 (95% CI 0.701–0.759), 0.714 (95% CI 0.684–0.743), and 0.707 (95% CI 0.677–0.736), respectively. For in-hospital mortality, the AUROCs were 0.798 (95% CI: 0.771–0.823), 0.774 (95% CI: 0.746–0.801), and 0.819 (95% CI: 0.793–0.843), respectively, indicating excellent performance. Incorporating frailty assessment using the CFS enhances risk stratification in older patients in the ED by complementing vital sign-based scores. This provides a more comprehensive assessment, enabling better informed clinical decisions. This study supports employing routine frailty assessment in the ED and the development of enhanced risk stratification tools that incorporate frailty.

Occupational stress can have a harmful effect on the individual both physically and psychologically. In Korea, occupational stress of physician is rarely demonstrated. Although it is well reported that physicians tend to have a high incidence of minor psychiatric disorders, the magnitude of the problem remains unclear. Interns and residents are thought to be under substantial amount of stress, and tend to have psychiatric disorder. In this paper, we aimed to evaluate the relationship between the occupational stress and depression of residents. The participants of this study were surgical and medical residents in a tertiary hospital in Korea. For measurement of occupational stress, we used an occupational stress scale. In addition, to evaluate the prevalence of depression, we used the Beck Depression Inventory. Female doctors showed higher degree of occupational stress than the males. The interns and chief residents showed higher degree of occupational stress than the other residents. Interestingly, in this study, most of the participants experienced a depressive mood. Compared with the general population, job demand and culture of workplace were high. Occupational stress was the only significant predictor of a depressive mood. Hospital residents experience a high degree of occupational stress leading to a depressed mood due to various risk factors. Therefore, it is essential to recognize the occupational stress of residents early, to encourage positive competition and peer and social support, and to help improve the residents' ability to cope with stress.