Aging is related to a number of functional and morphological changes leading to progressive decline of the biological functions of an organism. Reactive Oxygen Species (ROS), released by several endogenous and exogenous processes, may cause important oxidative damage to DNA, proteins, and lipids, leading to important cellular dysfunctions. The imbalance between ROS production and antioxidant defenses brings to oxidative stress conditions and, related to accumulation of ROS, aging-associated diseases. The purpose of this review is to provide an overview of the most relevant data reported in literature on the natural compounds, mainly phytochemicals, with antioxidant activity and their potential protective effects on age-related diseases such as metabolic syndrome, diabetes, cardiovascular disease, cancer, neurodegenerative disease, and chronic inflammation, and possibly lower side effects, when compared to other drugs.

In recent years, environmental-friendly measures have been developed for managing crop diseases as alternative to chemical pesticides, including the use of natural compounds such as chitosan. In this chapter, the common uses of this natural product in agriculture and its potential uses in plant disease control are reviewed. The last advanced researches as seed coating, plant resistance elicitation and soil amendment applications are also described. Chitosan is a deacetylated derivative of chitin that is naturally present in the fungal cell wall and in crustacean shells from which it can be easily extracted. Chitosan has been reported to possess antifungal and antibacterial activity and it showed to be effective against seedborne pathogens when applied as seed treatment. It can form physical barriers (film) around the seed surface, and it can vehicular other antimicrobial compounds that could be added to the seed treatments. Chitosan behaves as a resistance elicitor inducing both local and systemic plant defence responses even when applied to the seeds. The chitosan used as soil amendment was shown to give many benefits to different plant species by reducing the pathogen attack and infection. Concluding, the chitosan is an active molecule that finds many possibilities for application in agriculture, including plant disease control.

Environmental pollution is one of the most pressing global issues, and it requires priority attention. Environmental remediation techniques have been developed over the years and can be applied to polluted sites, but they can have limited effectiveness and high energy consumption and costs. Bioremediation techniques, on the other hand, represent a promising alternative. Among them, phytoremediation is attracting particular attention, a green methodology that relies on the use of plant species to remediate contaminated sites or prevent the dispersion of xenobiotics into the environment. In this review, after a brief introduction focused on pollution and phytoremediation, the use of plant biostimulants (PBs) in the improvement of the remediation effectiveness is proposed. PBs are substances widely used in agriculture to raise crop production and resistance to various types of stress. Recent studies have also documented their ability to counteract the deleterious effects of pollutants on plants, thus increasing the phytoremediation efficiency of some species. The works published to date, reviewed and discussed in the present work, reveal promising prospects in the remediation of polluted environments, especially for heavy metals, when PBs derived from humic substances, protein and amino acid hydrolysate, inorganic salts, microbes, seaweed, plant extracts, and fungi are employed.

Nutraceuticals are biologically active molecules present in foods; they can have beneficial effects on health, but they are not available in large enough quantities to perform this function. Plant metabolites, such as polyphenols, are widely diffused in the plant kingdom, where they play fundamental roles in plant development and interactions with the environment. Among these, flavonoids are of particular interest as they have significant effects on human health. In vitro and/or in vivo studies described flavonoids as essential nutrients for preventing several diseases. They display broad and promising bioactivities to fight cancer, inflammation, bacterial infections, as well as to reduce the severity of neurodegenerative and cardiovascular diseases or diabetes. Therefore, it is not surprising that interest in flavonoids has sharply increased in recent years. More than 23,000 scientific publications on flavonoids have described the potential anticancer activity of these natural molecules in the last decade. Studies, in vitro and in vivo, show that flavonoids exhibit anticancer properties, and many epidemiological studies confirm that dietary intake of flavonoids leads to a reduced risk of cancer. This review provides a glimpse of the mechanisms of action of flavonoids on cancer cells.