Roberto Fernandez-Lafuente earned his PhD at ICP-CSIC, Spain (1992) and carried out a 46-month postdoc stay at UCL, United Kingdom, first as the beneficiary of a CSIC fellowship and later on a Marie Curie contract. In 2000, he won a staff research position at ICP-CSIC. Since 2008, he has been a research professor. All his research has been focused on biocatalysis, and the most intense area of research has been in enzyme immobilization. He tries to understand and control the interaction between solids and biomacromolecules. Strategies to integrate site-directed mutagenesis, chemical modification, and immobilization have also been intensively investigated. Currently, his research interest is focused on the development of protocols for enzyme immobilization that can shortcut some of the problems of standard immobilization. He has participated in many research contracts with companies, as the main vocation of his research is in the application of biocatalysts on process development. As a result of his work, he has been included in the Web of Science HighlyCited Researchers (HCR) 2019 and 2020 lists.