Objectives: In this study, we evaluated the association between perceived stress and indicators of metabolic syndrome and how this association is mediated by sleep problems, unhealthy eating habits, and night eating syndrome, in addition to serum levels of ghrelin and cortisol in university students. Methods: We recruited 192 students from a public university in Mexico. Weight, height, waist circumference and blood pressure were taken in accordance with standard protocols. Validated questionnaires were used to assess perceived stress, sleep quality and eating habits. Fasting blood samples were taken to measure ghrelin, cortisol, triglycerides, glucose and HDL-C. Results: Path Analysis indicated direct positive effects of stress over PSQI (β = 0.341) and NES (β = 0.443); PSQI over NES (β = 0.233) and NES over glucose (β = 0.170), triglycerides over LDL-C (β = 0.215), waist circumference over SBP (β = 0.259). Likewise, standardized negative regression weights of PSQI over Diet Quality Index (β = -0.239) and ghrelin concentrations (β = -0.132), ghrelin over Diet Quality Index (β = -0.188) and waist circumference (β = -0.147). Diet Quality Index over triglycerides (β = -0.184); sleep duration over systolic blood pressure (β = -0.242); waist circumference over HDL-C (β = -0.256). Conclusion: Psychological stress leads to increased indicators of MetS via decreased sleep quality, inadequate eating habits and eating behavior in university students.

Type 2 diabetes mellitus (T2DM) and cancer are significant contributors to morbidity and mortality worldwide. Recent studies have increasingly highlighted the potential of phytochemicals found in plants and plant-based foods for preventing and treating these chronic diseases. Mexico’s agrobiodiversity provides a valuable resource for phytochemistry. This review presents an examination of essential phytochemicals found in plants and foods within Mexican agrobiodiversity that have shown promising anti-cancer and anti-diabetic properties, including their roles as antioxidants, insulin sensitizers, and enzyme inhibitors. Notable compounds identified include flavonoids (such as quercetin and catechins), phenolic acids (chlorogenic, gallic, and caffeic acids), methylxanthines (like theobromine), xanthones (such as mangiferin), capsaicinoids (capsaicin), organosulfur compounds (like alliin), and various lipids (avocatins). Although these phytochemicals have shown promise in laboratory and animal studies, there is a significant scarcity of clinical trial data involving humans, underscoring an important area for future research.

The α7-nicotinic acetylcholine receptor (α7-nAChR) is a recognized target for the treatment of dementia associated with aging and certain developmental disorders. This study evaluates memory improvement in a rat model by the effects of polyunsaturated fatty acids EPA and DHA mediated by α7-nAChR, as well as identifying the minimum dose of EPA/DHA required to generate an effect in the improvement of cognition through α7-nAChR in rats. The modified Y-maze and object recognition behavioral tests were performed in scopolamine-induced amnesic rats, in order to study the effects of long-term supplementation (10, 15, 30, and 60 mg/kg) of the two polyunsaturated fatty acids in improving cognitive impairment. Cognitive enhancement by EPA and DHA is mediated through α7-nAChRs, as evidenced by memory recovery after treatment with a selective α7-nAChR antagonist, methyllycaconitine (MLA). Tacrine, a centrally active acetylcholinesterase inhibitor, and PNU282987, an α7-nAChR agonist, are employed as reference standards. Our data demonstrate that 15 mg/kg EPA and DHA can affect cholinergic neurotransmission positively through memory and cognition and, thus, can exert a beneficial action on learning and memory deficits.

There is growing evidence of the relationship between Metabolic Syndrome (MetS) and cognitive decline; however, this has not been conclusively established yet. This systematic review and meta-analysis address the most crucial cognitive performance findings, including those on global cognitive function, memory, attention, and executive functions, in adult people with MetS. Two electronic databases were searched (April–May 2020) using the terms “metabolic syndrome” and “cognition,” including publications from 2010 to 2020. Thirty-six studies were found. Among these, 17 reported negative associations in cognition with MetS, mainly in terms of verbal memory and executive functions, particularly in the middle-aged population. A meta-analysis of global cognitive function revealed that the MetS group had a lower score than the control group (25.26 and 25.6, respectively, 95% CI, −0.60 to −0.12, p = 0.004). MetS is related to the enhanced presentation of cognitive impairment and its evolution into a Major Neurocognitive Disorder (MND). Further research involving longitudinal studies, including assessments with similar instruments, correctly separated by age group and education, is required.

The objective of this study is to assess the effect of alcohol consumption, anxiety, and food restriction before and after consuming alcohol and body image on the risk of anorexia and bulimia in college students from Tijuana, Baja California, through predictive statistical models. A quantitative, descriptive, and cross-sectional design and a non-probabilistic sample of 526 college students from Tijuana, Baja California, México were used. Application of the scales (with acceptable psychometric properties) was conducted in classrooms. Through path analyses, four models were found with adequate indicators of goodness of fit: (1) risk of anorexia in women [Chi Square (X²) = 5.34, p = 0.376, Adjusted Determination Coefficient (R²)= 0.250]; (2) anorexia risk for men (X² = 13.067, p = 0.192, R² = 0.058); (3) risk of bulimia in women (X² = 3.358, p = 0.645, R² = 0.202); and bulimia risk for men (X² = 14.256, p = 0.075, R² = 0.284). The findings provide empirical evidence for the food and alcohol disturbance model.