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Seaweeds are industrially exploited for obtaining pigments, polysaccharides, or phenolic compounds with application in diverse fields. Nevertheless, their rich composition in fiber, minerals, and proteins, has pointed them as a useful source of these components. Seaweed proteins are nutritionally valuable and include several specific enzymes, glycoproteins, cell wall-attached proteins, phycobiliproteins, lectins, or peptides. Extraction of seaweed proteins requires the application of disruptive methods due to the heterogeneous cell wall composition of each macroalgae group. Hence, non-protein molecules like phenolics or polysaccharides may also be co-extracted, affecting the extraction yield. Therefore, depending on the macroalgae and target protein characteristics, the sample pretreatment, extraction and purification techniques must be carefully chosen. Traditional methods like solid–liquid or enzyme-assisted extraction (SLE or EAE) have proven successful. However, alternative techniques as ultrasound- or microwave-assisted extraction (UAE or MAE) can be more efficient. To obtain protein hydrolysates, these proteins are subjected to hydrolyzation reactions, whether with proteases or physical or chemical treatments that disrupt the proteins native folding. These hydrolysates and derived peptides are accounted for bioactive properties, like antioxidant, anti-inflammatory, antimicrobial, or antihypertensive activities, which can be applied to different sectors. In this work, current methods and challenges for protein extraction and purification from seaweeds are addressed, focusing on their potential industrial applications in the food, cosmetic, and pharmaceutical industries.
Javier Echave; Maria Fraga-Corral; Pascual Garcia-Perez; Jelena Popović-Djordjević; Edina H. Avdović; Milanka Radulović; Jianbo Xiao; Miguel A. Prieto; Jesus Simal-Gandara. Seaweed Protein Hydrolysates and Bioactive Peptides: Extraction, Purification and Applications. Marine Drugs 2021, 19, 500 .
AMA StyleJavier Echave, Maria Fraga-Corral, Pascual Garcia-Perez, Jelena Popović-Djordjević, Edina H. Avdović, Milanka Radulović, Jianbo Xiao, Miguel A. Prieto, Jesus Simal-Gandara. Seaweed Protein Hydrolysates and Bioactive Peptides: Extraction, Purification and Applications. Marine Drugs. 2021; 19 (9):500.
Chicago/Turabian StyleJavier Echave; Maria Fraga-Corral; Pascual Garcia-Perez; Jelena Popović-Djordjević; Edina H. Avdović; Milanka Radulović; Jianbo Xiao; Miguel A. Prieto; Jesus Simal-Gandara. 2021. "Seaweed Protein Hydrolysates and Bioactive Peptides: Extraction, Purification and Applications." Marine Drugs 19, no. 9: 500.
The increase in life expectancy has led to the appearance of chronic diseases and interest in healthy aging, in turn promoting a growing interest in bioactive compounds (BCs) and functional ingredients. There are certain foods or products rich in functional ingredients, and algae are one of them. Algae consumption has been nominal in Europe until now. However, in recent years, it has grown significantly, partly due to globalization and the adoption of new food trends. With the aim of obtaining BCs from foods, multiple methods have been proposed, ranging from conventional ones, such as maceration or Soxhlet extraction, to more innovative methods, e.g., ultrasound-assisted extraction (UAE). UAE constitutes a novel method, belonging to so-called green chemistry, that enables the extraction of BCs requiring lower amounts of solvent and energy costs, preserving the integrity of such molecules. In recent years, this method has been often used for the extraction of different BCs from a wide range of algae, especially polysaccharides, such as carrageenans and alginate; pigments, including fucoxanthin, chlorophylls, or β-carotene; and phenolic compounds, among others. In this way, the application of UAE to marine algae is an efficient and sustainable strategy to pursue their deep characterization as a new source of BCs, especially suitable for vegetarian and vegan diets.
Anxo Carreira-Casais; Paz Otero; Pascual Garcia-Perez; Paula Garcia-Oliveira; Antia G. Pereira; Maria Carpena; Anton Soria-Lopez; Jesus Simal-Gandara; Miguel A. Prieto. Benefits and Drawbacks of Ultrasound-Assisted Extraction for the Recovery of Bioactive Compounds from Marine Algae. International Journal of Environmental Research and Public Health 2021, 18, 9153 .
AMA StyleAnxo Carreira-Casais, Paz Otero, Pascual Garcia-Perez, Paula Garcia-Oliveira, Antia G. Pereira, Maria Carpena, Anton Soria-Lopez, Jesus Simal-Gandara, Miguel A. Prieto. Benefits and Drawbacks of Ultrasound-Assisted Extraction for the Recovery of Bioactive Compounds from Marine Algae. International Journal of Environmental Research and Public Health. 2021; 18 (17):9153.
Chicago/Turabian StyleAnxo Carreira-Casais; Paz Otero; Pascual Garcia-Perez; Paula Garcia-Oliveira; Antia G. Pereira; Maria Carpena; Anton Soria-Lopez; Jesus Simal-Gandara; Miguel A. Prieto. 2021. "Benefits and Drawbacks of Ultrasound-Assisted Extraction for the Recovery of Bioactive Compounds from Marine Algae." International Journal of Environmental Research and Public Health 18, no. 17: 9153.
Presently, biopreservation through protective bacterial cultures and their antimicrobial products or using antibacterial compounds derived from plants are proposed as feasible strategies to maintain the long shelf-life of products. Another emerging category of food biopreservatives are bacteriophages or their antibacterial enzymes called “phage lysins” or “enzybiotics”, which can be used directly as antibacterial agents due to their ability to act on the membranes of bacteria and destroy them. Bacteriophages are an alternative to antimicrobials in the fight against bacteria, mainly because they have a practically unique host range that gives them great specificity. In addition to their potential ability to specifically control strains of pathogenic bacteria, their use does not generate a negative environmental impact as in the case of antibiotics. Both phages and their enzymes can favor a reduction in antibiotic use, which is desirable given the alarming increase in resistance to antibiotics used not only in human medicine but also in veterinary medicine, agriculture, and in general all processes of manufacturing, preservation, and distribution of food. We present here an overview of the scientific background of phages and enzybiotics in the food industry, as well as food applications of these biopreservatives.
José Ramos-Vivas; María Elexpuru-Zabaleta; María Luisa Samano; Alina Pascual Barrera; Tamara Y. Forbes-Hernández; Francesca Giampieri; Maurizio Battino. Phages and Enzybiotics in Food Biopreservation. Molecules 2021, 26, 5138 .
AMA StyleJosé Ramos-Vivas, María Elexpuru-Zabaleta, María Luisa Samano, Alina Pascual Barrera, Tamara Y. Forbes-Hernández, Francesca Giampieri, Maurizio Battino. Phages and Enzybiotics in Food Biopreservation. Molecules. 2021; 26 (17):5138.
Chicago/Turabian StyleJosé Ramos-Vivas; María Elexpuru-Zabaleta; María Luisa Samano; Alina Pascual Barrera; Tamara Y. Forbes-Hernández; Francesca Giampieri; Maurizio Battino. 2021. "Phages and Enzybiotics in Food Biopreservation." Molecules 26, no. 17: 5138.
Crocus L. is a genus of perennial plants in the family Iridaceae. Numerous research regarding healing effects of Crocus spp. on human diseases are being published worldwide. Crocus sativus L. is the most studied species of this taxa, however, other Crocus species are also being used traditionally in different countries. The most commonly used plant part of C. sativus is the stigma, known as saffron. Traditional practitioners were using saffron for treating depression, inflammations and gastrointestinal, liver, respiratory, urogenital, eye and skin diseases. In modern studies, saffron and its constituents have been used for treating cancer, liver fibrosis, fatty liver, metabolic diseases, retinal damage, asthma, depression, inflammation and neurodegeneration. Inflammation and oxidative damage are crucial factors in the pathogenesis of these diseases and Crocus spp. has been used for treating inflammatory diseases in both traditional and modern research. This may result from the presence of anthocyanins and flavonoids as anti-oxidant components and safranal (monoterpenoid), crocin and crocetin (carotenoid) as anti-inflammatory components. These compounds can be considered as potential drug candidates for treating different respiratory, retinal, metabolic and neural ailments. In this review, general information regarding botany, ethnobotany, chemical profile, and pharmacological effects of different Crocus species and their constituents have been summarized.
Leila Mohtashami; Mohammad Sadegh Amiri; Mahin Ramezani; Seyed Ahmad Emami; Jesus Simal-Gandara. The genus Crocus L.: A review of ethnobotanical uses, phytochemistry and pharmacology. Industrial Crops and Products 2021, 171, 113923 .
AMA StyleLeila Mohtashami, Mohammad Sadegh Amiri, Mahin Ramezani, Seyed Ahmad Emami, Jesus Simal-Gandara. The genus Crocus L.: A review of ethnobotanical uses, phytochemistry and pharmacology. Industrial Crops and Products. 2021; 171 ():113923.
Chicago/Turabian StyleLeila Mohtashami; Mohammad Sadegh Amiri; Mahin Ramezani; Seyed Ahmad Emami; Jesus Simal-Gandara. 2021. "The genus Crocus L.: A review of ethnobotanical uses, phytochemistry and pharmacology." Industrial Crops and Products 171, no. : 113923.
Algae are an underexploited source of natural bioactive compounds in Western countries, so an increasing interest in the valorization of these marine organisms has emerged in recent years. In this work, the effect of extracting solvent on the extraction yield, phenolic content, antioxidant capacity, and antimicrobial activity of nine brown macroalgae species (Ascophyllum nodosum, Himanthalia elongata, Undaria pinnatifida, Pelvetia canaliculata, Saccharina latissima, Bifurcaria bifurcata, Laminaria ochroleuca, Sargassum muticum, and Fucus spiralis) was assessed. Total phenolic content (TPC) and the antioxidant properties of extracts by different assays: radical scavenging activity (DPPH-RSA) and ferric reducing antioxidant power (FRAP) were performed. The antimicrobial activity of extracts was studied against six different foodborne microorganisms: Staphylococcus aureus, Staphylococcus epidermidis, Bacillus cereus, Escherichia coli, Salmonella enteritidis, and Pseudomonas aeruginosa. The highest extraction yield was achieved in ethanolic extracts. However, the highest TPC and FRAP values were obtained on the ethyl acetate extracts, especially from A. nodosum. Concerning algal species, the highest TPC and FRAP values were found in A. nodosum, while the highest DPPH-RSA values were achieved in the hexane extracts of B. bifurcata. The antimicrobial activity of algal extracts varied according to the solvent and alga selected, suggesting the species- and solvent-dependent behavior of this property, with B. bifurcata extracts showing the highest results for a wide range of bacteria. Our results provide insight on the characterization of widespread brown algae in the coasts of the North-Western region of the Iberian Peninsula, reflecting multiple health-enhancing properties which may lead to their exploitation in food, pharmacological, and cosmetic industries.
Aurora Silva; Carla Rodrigues; Paula Garcia-Oliveira; Catarina Lourenço-Lopes; Sofia A. Silva; Pascual Garcia-Perez; Ana P. Carvalho; Valentina F. Domingues; M. Fátima Barroso; Cristina Delerue-Matos; Jesus Simal-Gandara; Miguel A. Prieto. Screening of Bioactive Properties in Brown Algae from the Northwest Iberian Peninsula. Foods 2021, 10, 1915 .
AMA StyleAurora Silva, Carla Rodrigues, Paula Garcia-Oliveira, Catarina Lourenço-Lopes, Sofia A. Silva, Pascual Garcia-Perez, Ana P. Carvalho, Valentina F. Domingues, M. Fátima Barroso, Cristina Delerue-Matos, Jesus Simal-Gandara, Miguel A. Prieto. Screening of Bioactive Properties in Brown Algae from the Northwest Iberian Peninsula. Foods. 2021; 10 (8):1915.
Chicago/Turabian StyleAurora Silva; Carla Rodrigues; Paula Garcia-Oliveira; Catarina Lourenço-Lopes; Sofia A. Silva; Pascual Garcia-Perez; Ana P. Carvalho; Valentina F. Domingues; M. Fátima Barroso; Cristina Delerue-Matos; Jesus Simal-Gandara; Miguel A. Prieto. 2021. "Screening of Bioactive Properties in Brown Algae from the Northwest Iberian Peninsula." Foods 10, no. 8: 1915.
Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly infectious zoonotic virus first reported into the human population in September 2012 on the Arabian Peninsula. The virus causes severe and often lethal respiratory illness in humans with an unusually high fatality rate. The N-terminal domain (NTD) of receptor-binding S1 subunit of coronavirus spike (S) proteins can recognize a variety of host protein and mediates entry into human host cells. Blocking the entry by targeting the S1-NTD of the virus can facilitate the development of effective antiviral drug candidates against the pathogen. Therefore, the study has been designed to identify effective antiviral drug candidates against the MERS-CoV by targeting S1-NTD. Initially, a structure-based pharmacophore model (SBPM) to the active site (AS) cavity of the S1-NTD has been generated, followed by pharmacophore-based virtual screening of 11,295 natural compounds. Hits generated through the pharmacophore-based virtual screening have re-ranked by molecular docking and further evaluated through the ADMET properties. The compounds with the best ADME and toxicity properties have been retrieved, and a quantum mechanical (QM) based density-functional theory (DFT) has been performed to optimize the geometry of the selected compounds. Three optimized natural compounds, namely Taiwanhomoflavone B (Amb23604132), 2,3-Dihydrohinokiflavone (Amb23604659), and Sophoricoside (Amb1153724), have exhibited substantial docking energy >−9.00 kcal/mol, where analysis of frontier molecular orbital (FMO) theory found the low chemical reactivity correspondence to the bioactivity of the compounds. Molecular dynamics (MD) simulation confirmed the stability of the selected natural compound to the binding site of the protein. Additionally, molecular mechanics generalized born surface area (MM/GBSA) predicted the good value of binding free energies (ΔG bind) of the compounds to the desired protein. Convincingly, all the results support the potentiality of the selected compounds as natural antiviral candidates against the MERS-CoV S1-NTD.
Thamer A. Bouback; Sushil Pokhrel; Abdulaziz Albeshri; Amal Mohammed Aljohani; Abdus Samad; Rahat Alam; Saddam Hossen; Khalid Al-Ghamdi; Enamul Kabir Talukder; Foysal Ahammad; Ishtiaq Qadri; Jesus Simal-Gandara. Pharmacophore-Based Virtual Screening, Quantum Mechanics Calculations, and Molecular Dynamics Simulation Approaches Identified Potential Natural Antiviral Drug Candidates against MERS-CoV S1-NTD. Molecules 2021, 26, 4961 .
AMA StyleThamer A. Bouback, Sushil Pokhrel, Abdulaziz Albeshri, Amal Mohammed Aljohani, Abdus Samad, Rahat Alam, Saddam Hossen, Khalid Al-Ghamdi, Enamul Kabir Talukder, Foysal Ahammad, Ishtiaq Qadri, Jesus Simal-Gandara. Pharmacophore-Based Virtual Screening, Quantum Mechanics Calculations, and Molecular Dynamics Simulation Approaches Identified Potential Natural Antiviral Drug Candidates against MERS-CoV S1-NTD. Molecules. 2021; 26 (16):4961.
Chicago/Turabian StyleThamer A. Bouback; Sushil Pokhrel; Abdulaziz Albeshri; Amal Mohammed Aljohani; Abdus Samad; Rahat Alam; Saddam Hossen; Khalid Al-Ghamdi; Enamul Kabir Talukder; Foysal Ahammad; Ishtiaq Qadri; Jesus Simal-Gandara. 2021. "Pharmacophore-Based Virtual Screening, Quantum Mechanics Calculations, and Molecular Dynamics Simulation Approaches Identified Potential Natural Antiviral Drug Candidates against MERS-CoV S1-NTD." Molecules 26, no. 16: 4961.
The rapid increase in pathogenic microorganisms with antimicrobial resistant profiles has become a significant public health problem globally. The management of this issue using conventional antimicrobial preparations frequently results in an increase in pathogen resistance and a shortage of effective antimicrobials for future use against the same pathogens. In this review, we discuss the emergence of AMR and argue for the importance of addressing this issue by discovering novel synthetic or naturally occurring antibacterial compounds and providing insights into the application of various drug delivery approaches, delivered through numerous routes, in comparison with conventional delivery systems. In addition, we discuss the effectiveness of these delivery systems in different types of infectious diseases associated with antimicrobial resistance. Finally, future considerations in the development of highly effective antimicrobial delivery systems to combat antimicrobial resistance are presented.
Firzan Nainu; Andi Dian Permana; Nana Juniarti Natsir Djide; Qonita Kurnia Anjani; Rifka Nurul Utami; Nur Rahma Rumata; Jianye Zhang; Talha Bin Emran; Jesus Simal-Gandara. Pharmaceutical Approaches on Antimicrobial Resistance: Prospects and Challenges. Antibiotics 2021, 10, 981 .
AMA StyleFirzan Nainu, Andi Dian Permana, Nana Juniarti Natsir Djide, Qonita Kurnia Anjani, Rifka Nurul Utami, Nur Rahma Rumata, Jianye Zhang, Talha Bin Emran, Jesus Simal-Gandara. Pharmaceutical Approaches on Antimicrobial Resistance: Prospects and Challenges. Antibiotics. 2021; 10 (8):981.
Chicago/Turabian StyleFirzan Nainu; Andi Dian Permana; Nana Juniarti Natsir Djide; Qonita Kurnia Anjani; Rifka Nurul Utami; Nur Rahma Rumata; Jianye Zhang; Talha Bin Emran; Jesus Simal-Gandara. 2021. "Pharmaceutical Approaches on Antimicrobial Resistance: Prospects and Challenges." Antibiotics 10, no. 8: 981.
Colorectal cancer remains a challenging health burden worldwide. This study aimed to assess the potentiality of Strawberry tree honey (STH), a polyphenol-enriched food, to increase the effectiveness of 5-Fluorouracil (5-FU) in adenocarcinoma (HCT-116) and metastatic (LoVo) colon cancer cell lines. The combined treatment reduced cell viability and caused oxidative stress, by increasing oxidative biomarkers and decreasing antioxidant defence, in a more potent way compared to 5-FU alone. The expression of endoplasmic reticulum (ATF-6, XBP-1) and MAPK (p-p38 MAPK, p-ERK1/2) markers were also elevated after the combined treatment, enhancing the cell cycle arrest through the modulation of regulatory genes (i.e., cyclins and CDKs). Apoptotic gene (i.e., caspases) expressions were also increased after the combined treatment, while those of proliferation (i.e., EGFR), cell migration, invasion (i.e., matrix metallopeptidase) and epithelial–mesenchymal transition (N-cadherin, β-catenin) were suppressed. Finally, the combined treatment led cell metabolism towards a quiescent stage, by reducing mitochondrial respiration and glycolysis. In conclusion, this work represents an initial step to highlight the possibility to use STH in combination with 5-FU in the treatment of colon cancer, even if further in vitro an in vivo studies are strongly needed to confirm the possible chemo-sensitizing effects of STH.
Sadia Afrin; Francesca Giampieri; Danila Cianciosi; José M. Alvarez-Suarez; Beatriz Bullon; Adolfo Amici; Josè L. Quiles; Tamara Y. Forbes-Hernández; Maurizio Battino. Strawberry tree honey in combination with 5-fluorouracil enhances chemosensitivity in human colon adenocarcinoma cells. Food and Chemical Toxicology 2021, 156, 112484 .
AMA StyleSadia Afrin, Francesca Giampieri, Danila Cianciosi, José M. Alvarez-Suarez, Beatriz Bullon, Adolfo Amici, Josè L. Quiles, Tamara Y. Forbes-Hernández, Maurizio Battino. Strawberry tree honey in combination with 5-fluorouracil enhances chemosensitivity in human colon adenocarcinoma cells. Food and Chemical Toxicology. 2021; 156 ():112484.
Chicago/Turabian StyleSadia Afrin; Francesca Giampieri; Danila Cianciosi; José M. Alvarez-Suarez; Beatriz Bullon; Adolfo Amici; Josè L. Quiles; Tamara Y. Forbes-Hernández; Maurizio Battino. 2021. "Strawberry tree honey in combination with 5-fluorouracil enhances chemosensitivity in human colon adenocarcinoma cells." Food and Chemical Toxicology 156, no. : 112484.
The search for waste minimization and the valorization of by-products are key to good management and improved sustainability in the food industry. The great production of almonds, based on their high nutritional value as food, especially almond kernels, generates tons of waste yearly. The remaining parts (skin, shell, hulls, etc.) are still little explored, even though they have been used as fuel by burning or as livestock feed. The interest in these by-products has been increasing, as they possess beneficial properties, caused by the presence of different bioactive compounds, and can be used as promising sources of new ingredients for the food, cosmetic and pharmaceutical industry. Additionally, the use of almond by-products is being increasingly applied for the fortification of already-existing food products, but there are some limitations, including the presence of allergens and mycotoxins that harden their applicability. This review focuses on the extraction technologies applied to the valorization of almond by-products for the development of new value-added products that would contribute to the reduction of environmental impact and an improvement in the sustainability and competitiveness of the almond industry.
Pascual Garcia-Perez; Jianbo Xiao; Paulo Munekata; Jose Lorenzo; Francisco Barba; Muhammad Rajoka; Lillian Barros; Rafael Mascoloti Sprea; Joana Amaral; Miguel Prieto; Jesus Simal-Gandara. Revalorization of Almond By-Products for the Design of Novel Functional Foods: An Updated Review. Foods 2021, 10, 1823 .
AMA StylePascual Garcia-Perez, Jianbo Xiao, Paulo Munekata, Jose Lorenzo, Francisco Barba, Muhammad Rajoka, Lillian Barros, Rafael Mascoloti Sprea, Joana Amaral, Miguel Prieto, Jesus Simal-Gandara. Revalorization of Almond By-Products for the Design of Novel Functional Foods: An Updated Review. Foods. 2021; 10 (8):1823.
Chicago/Turabian StylePascual Garcia-Perez; Jianbo Xiao; Paulo Munekata; Jose Lorenzo; Francisco Barba; Muhammad Rajoka; Lillian Barros; Rafael Mascoloti Sprea; Joana Amaral; Miguel Prieto; Jesus Simal-Gandara. 2021. "Revalorization of Almond By-Products for the Design of Novel Functional Foods: An Updated Review." Foods 10, no. 8: 1823.
The search for waste minimization and the valorization of by-products are key practices for good management and improved sustainability in the food industry. The production of almonds generates a large amount of waste, most of which is not used. Until now, almonds have been used for their high nutritional value as food, especially almond meat. The other remaining parts (skin, shell, hulls, etc.) are still little explored, even though they have been used as fuel by burning or as livestock feed. However, interest in these by-products has been increasing as they possess beneficial properties (caused mainly by polyphenols and unsaturated fatty acids) and can be used as new ingredients for the food, cosmetic, and pharmaceutical industries. Therefore, it is important to explore almond’s valorization of by-products for the development of new added-value products that would contribute to the reduction of environmental impact and an improvement in the sustainability and competitiveness of the almond industry.
Marta Barral-Martinez; Maria Fraga-Corral; Pascual Garcia-Perez; Jesus Simal-Gandara; Miguel Prieto. Almond By-Products: Valorization for Sustainability and Competitiveness of the Industry. Foods 2021, 10, 1793 .
AMA StyleMarta Barral-Martinez, Maria Fraga-Corral, Pascual Garcia-Perez, Jesus Simal-Gandara, Miguel Prieto. Almond By-Products: Valorization for Sustainability and Competitiveness of the Industry. Foods. 2021; 10 (8):1793.
Chicago/Turabian StyleMarta Barral-Martinez; Maria Fraga-Corral; Pascual Garcia-Perez; Jesus Simal-Gandara; Miguel Prieto. 2021. "Almond By-Products: Valorization for Sustainability and Competitiveness of the Industry." Foods 10, no. 8: 1793.
Litchi is recognized as a famous functional food for the management of various ailments. This study provides a comprehensive review of its phytochemistry, medicinal properties, and product development.
Pei-Fen Yao; Yan Gao; Jesus Simal-Gandara; Mohamed A. Farag; Weijie Chen; Dongning Yao; Dominique Delmas; Zhejie Chen; Kunmeng Liu; Hao Hu; Jianbo Xiao; Xianglu Rong; Shengpeng Wang; Yuanjia Hu; Yitao Wang. Litchi (Litchi chinensis Sonn.): a comprehensive review of phytochemistry, medicinal properties, and product development. Food & Function 2021, 1 .
AMA StylePei-Fen Yao, Yan Gao, Jesus Simal-Gandara, Mohamed A. Farag, Weijie Chen, Dongning Yao, Dominique Delmas, Zhejie Chen, Kunmeng Liu, Hao Hu, Jianbo Xiao, Xianglu Rong, Shengpeng Wang, Yuanjia Hu, Yitao Wang. Litchi (Litchi chinensis Sonn.): a comprehensive review of phytochemistry, medicinal properties, and product development. Food & Function. 2021; ():1.
Chicago/Turabian StylePei-Fen Yao; Yan Gao; Jesus Simal-Gandara; Mohamed A. Farag; Weijie Chen; Dongning Yao; Dominique Delmas; Zhejie Chen; Kunmeng Liu; Hao Hu; Jianbo Xiao; Xianglu Rong; Shengpeng Wang; Yuanjia Hu; Yitao Wang. 2021. "Litchi (Litchi chinensis Sonn.): a comprehensive review of phytochemistry, medicinal properties, and product development." Food & Function , no. : 1.
The present study was designed to investigate the redox quenching and anti-inflammatory potentials of ethanolic leaf extract of Terminalia myriocarpa Van Heurck & Müller (ETM), inspired by the reported antioxidant potential of the plant bark and the anti-edema effect of the same genus. HPLC-DAD dereplication study was conducted to detect various secondary metabolites. In-vitro DPPH free radical scavenging assay, nitric oxide scavenging assay, Fe2+ ion chelating ability assay and reducing power assay were conducted to evaluate the redox quenching capacity. The molecular mechanism of anti-inflammation was investigated via assessing the NO and NF-ĸB expressions in different cell lines. In-vivo carrageenan and histamine-induced edema tests were conducted using established animal models. Pro-inflammatory receptors iNOS and NF-κB were docked against isolated compounds in the in-silico study. HPLC analysis revealed the presence of considerable amount of ellagic acid, where methyl-(S)-flavogallonate was previously found in ETM. Significant antioxidant activity was found in every redox assay. NO was reduced in RAW 264.7 cells, showing 83.67 ± 4.18% inhibitory activity. TNF-α induced NF-κB was also observed to be reduced in 293/NF-кB-luc cells with an inhibitory activity of 66.23 ± 0.81%. In-vivo carrageenan-induced edema test demonstrated significant anti-inflammatory activity (p < 0.05; p < 0.01) at both doses of 250 and 500 mg/kg with 60.10% highest reduction in rat paw volume. Using same doses, histamine-induced edema test exhibited mentionable anti-inflammatory potential (p < 0.05; p < 0.01) with 67.91% highest reduction in rat paw volume. Ellagic acid and methyl-(S)-flavogallonate showed satisfactory binding affinity with iNOS (−8.5 and −8.7 Kcal/moL, respectively) and NF-κB (−7.3 and −7.3 Kcal/moL, respectively). Mentionable basis was found on behalf of the anti-inflammatory and antioxidant potentials of ETM which might be correlated with its NF-ĸB inhibiting properties.
Afjalus Siraj; Sariful Islam Howlader; Arman Islam; Tanzira Irin; Jesus Simal-Gandara. Regulation of the redox signaling and inflammation by Terminalia myriocarpa leaves and the predictive interactions of it's major metabolites with iNOS and NF-ĸB. Journal of Ethnopharmacology 2021, 280, 114459 .
AMA StyleAfjalus Siraj, Sariful Islam Howlader, Arman Islam, Tanzira Irin, Jesus Simal-Gandara. Regulation of the redox signaling and inflammation by Terminalia myriocarpa leaves and the predictive interactions of it's major metabolites with iNOS and NF-ĸB. Journal of Ethnopharmacology. 2021; 280 ():114459.
Chicago/Turabian StyleAfjalus Siraj; Sariful Islam Howlader; Arman Islam; Tanzira Irin; Jesus Simal-Gandara. 2021. "Regulation of the redox signaling and inflammation by Terminalia myriocarpa leaves and the predictive interactions of it's major metabolites with iNOS and NF-ĸB." Journal of Ethnopharmacology 280, no. : 114459.
Foods are natural sources of antioxidant compounds, that are known for their role in preventing many human diseases. Although several methods to assess the antioxidant activity/capacity of foods and their bioactive components have been developed, a simple universal method has not been proposed. Since both in vitro and in vivo assays have limitations, cell-based assays are gaining plenty of attention as a more suitable middle ground between in vitro chemical assays and in vivo studies. This review highlights the need for a transition to more biologically relevant cellular assays, and explores the latest developments and applications in the field. Lastly, critical insights, new emerging perspectives and future directions are presented. The most employed cell-based assay is the Cellular Antioxidant Activity (CAA). To date, Caco-2 cells represent the most suitable model to perform CAA as well as for bioavailability studies, which in turn plays a pivotal role in determining the biological activity of food antioxidants. In this review, the most recent applications of the Caco-2 cell line in the evaluation of both CAA and bioavailability are reported. Notwithstanding, CAA and cell cultures in general, also present critical aspects that cannot be under-appreciated. In order to overcome these limitations, new cell-based approaches are emerging and further efforts will be necessary in the coming years to obtain new, robust and reliable screening tools for an ever-better prediction of the antioxidant activity/capacity of foods in vivo.
Erika Martinelli; Daniel Granato; Luciana Azevedo; José Eduardo Gonçalves; José M. Lorenzo; Paulo E.S. Munekata; Jesus Simal-Gandara; Francisco J. Barba; Celia Carrillo; Muhammad Shahid Riaz Rajoka; Luigi Lucini. Current perspectives in cell-based approaches towards the definition of the antioxidant activity in food. Trends in Food Science & Technology 2021, 116, 232 -243.
AMA StyleErika Martinelli, Daniel Granato, Luciana Azevedo, José Eduardo Gonçalves, José M. Lorenzo, Paulo E.S. Munekata, Jesus Simal-Gandara, Francisco J. Barba, Celia Carrillo, Muhammad Shahid Riaz Rajoka, Luigi Lucini. Current perspectives in cell-based approaches towards the definition of the antioxidant activity in food. Trends in Food Science & Technology. 2021; 116 ():232-243.
Chicago/Turabian StyleErika Martinelli; Daniel Granato; Luciana Azevedo; José Eduardo Gonçalves; José M. Lorenzo; Paulo E.S. Munekata; Jesus Simal-Gandara; Francisco J. Barba; Celia Carrillo; Muhammad Shahid Riaz Rajoka; Luigi Lucini. 2021. "Current perspectives in cell-based approaches towards the definition of the antioxidant activity in food." Trends in Food Science & Technology 116, no. : 232-243.
The outbreak of coronavirus disease (COVID-19) caused by a novel RNA virus emerged at the end of 2019. Most of the patient's symptoms are mild to moderate, and influenza, acute respiratory distress syndrome (ARDS) and multi-organ failure are common. The disease is mild to moderate in most patients and is reported in many cases such as pneumonia, ARDS and multi-organ dysfunction. This study's objective is to evaluate 25 natural compounds from Citrus limon (CL) used by comprehensive molecular docking, density functional theory (DFT) and molecular dynamics analysis against SARS-CoV-2 main protease (Mpro). Among all the experimental compounds, diosmetin has shown the best docking values against the Mpro of SARS-CoV-2 compared to the standard antiviral drug. In DFT calculations, the order associated with biochemical reactivity is as follows: eriodictoyl > quercetin > spinacetin > diosmetin > luteolin > apigenin, whereas the regions of oxygen and hydrogen atoms from the selected isolated compounds are appropriate for electrophilic and nucleophilic attacks, respectively. Also, HOMO-LUMO and global descriptors values indicated a promising result of these compounds. Moreover, a molecular dynamics simulation study revealed the stable conformation and binding pattern in a stimulating environment of natural compounds CL. Considering molecular docking, simulation, and DFT analysis of the selected compounds, notably eriodictoyl, quercetin, and diosmetin showed good potential against SARS-CoV-2 Mpro. Our in silico study revealed promising antiviral activity, which may be considered a potential key factor or a therapeutic target for COVID-19.Communicated by Ramaswamy H. Sarma.
Jishan Khan; Shahenur Alam Sakib; Shafi Mahmud; Zidan Khan; Mohammad Nazmul Islam; Mahfuz Ahmed Sakib; Talha Bin Emran; Jesus Simal-Gandara. Identification of potential phytochemicals from Citrus Limon against main protease of SARS-CoV-2: molecular docking, molecular dynamic simulations and quantum computations. Journal of Biomolecular Structure and Dynamics 2021, 1 -12.
AMA StyleJishan Khan, Shahenur Alam Sakib, Shafi Mahmud, Zidan Khan, Mohammad Nazmul Islam, Mahfuz Ahmed Sakib, Talha Bin Emran, Jesus Simal-Gandara. Identification of potential phytochemicals from Citrus Limon against main protease of SARS-CoV-2: molecular docking, molecular dynamic simulations and quantum computations. Journal of Biomolecular Structure and Dynamics. 2021; ():1-12.
Chicago/Turabian StyleJishan Khan; Shahenur Alam Sakib; Shafi Mahmud; Zidan Khan; Mohammad Nazmul Islam; Mahfuz Ahmed Sakib; Talha Bin Emran; Jesus Simal-Gandara. 2021. "Identification of potential phytochemicals from Citrus Limon against main protease of SARS-CoV-2: molecular docking, molecular dynamic simulations and quantum computations." Journal of Biomolecular Structure and Dynamics , no. : 1-12.
The desire to extend the wisdom of traditional health systems has motivated the trade of many phytomedicine on a global scale for centuries, especially some dietary herbs, making a great overlap exits between western and eastern phytomedicine. Despite the communication since ancient times, a key disconnect still exists in the dialog among western and eastern herbal researchers. There is very little systematic effort to tap into the friction and fusion of eastern and western wisdom in utilizing phytomedicine. In this review, we analyzed the similarities and differences of three representative phytomedicine, namely Rhodiola, seabuckthorn, and fenugreek, aiming to open up new horizons in developing novel health products by integrating the wisdom of the east and the west.
Xiuzhu Li; Weijie Chen; Jesus Simal-Gandara; Milen I. Georgiev; Hongyi Li; Hao Hu; Xu Wu; Thomas Efferth; Shengpeng Wang. West meets east: open up a dialogue on phytomedicine. Chinese Medicine 2021, 16, 1 -18.
AMA StyleXiuzhu Li, Weijie Chen, Jesus Simal-Gandara, Milen I. Georgiev, Hongyi Li, Hao Hu, Xu Wu, Thomas Efferth, Shengpeng Wang. West meets east: open up a dialogue on phytomedicine. Chinese Medicine. 2021; 16 (1):1-18.
Chicago/Turabian StyleXiuzhu Li; Weijie Chen; Jesus Simal-Gandara; Milen I. Georgiev; Hongyi Li; Hao Hu; Xu Wu; Thomas Efferth; Shengpeng Wang. 2021. "West meets east: open up a dialogue on phytomedicine." Chinese Medicine 16, no. 1: 1-18.
Indole alkaloids are very promising for potential therapeutic purposes and appear to be particularly effective against respiratory diseases. Several experimental studies have been performed, both in vivo and in vitro, to evaluate the effectiveness of indole alkaloids for the management of respiratory disorders, including asthma, emphysema, tuberculosis, cancer, and pulmonary fibrosis. The fundamental objective of this review was to summarize the in-depth therapeutic potential of indole alkaloids against various respiratory disorders. In addition to describing the therapeutic potential, this review also evaluates the toxicity of these alkaloids, which have been utilized for therapeutic benefits but have demonstrated toxic consequences. Some indole alkaloids, including scholaricine, 19-epischolaricine, vallesamine, and picrinine, which are derived from the plant Alstonia scholaris, have shown toxic effects in non-rodent models. This review also discusses clinical studies exploring the therapeutic efficacy of indole alkaloids, which have confirmed the promising benefits observed in vivo and in vitro. The indole alkaloidal compounds have shown efficacy in subjects with respiratory diseases. The available data established both preclinical and clinical studies confirm the potential of indole alkaloids to treat the respiratory disorders.
Saikat Mitra; Shajuthi Rahman Prova; Sifat Ara Sultana; Rajib Das; Firzan Nainu; Talha Bin Emran; Abu Montakim Tareq; Sahab Uddin; Ali M. Alqahtani; Kuldeep Dhama; Jesus Simal-Gandara. Therapeutic potential of indole alkaloids in respiratory diseases: A comprehensive review. Phytomedicine 2021, 90, 153649 .
AMA StyleSaikat Mitra, Shajuthi Rahman Prova, Sifat Ara Sultana, Rajib Das, Firzan Nainu, Talha Bin Emran, Abu Montakim Tareq, Sahab Uddin, Ali M. Alqahtani, Kuldeep Dhama, Jesus Simal-Gandara. Therapeutic potential of indole alkaloids in respiratory diseases: A comprehensive review. Phytomedicine. 2021; 90 ():153649.
Chicago/Turabian StyleSaikat Mitra; Shajuthi Rahman Prova; Sifat Ara Sultana; Rajib Das; Firzan Nainu; Talha Bin Emran; Abu Montakim Tareq; Sahab Uddin; Ali M. Alqahtani; Kuldeep Dhama; Jesus Simal-Gandara. 2021. "Therapeutic potential of indole alkaloids in respiratory diseases: A comprehensive review." Phytomedicine 90, no. : 153649.
Neurodegenerative disorders, particularly in the elderly population, represent one of the most pressing social and health-care problems in the world. Besides the well-established role of both oxidative stress and inflammation, alterations of the immune response have been found to be closely linked to the development of neurodegenerative diseases. Interestingly, various scientific evidence reported that an altered gut microbiota composition may contribute to the development of neuroinflammatory disorders. This leads to the proposal of the concept of the gut-brain-immune axis. In this scenario, polyphenols play a pivotal role due to their ability to exert neuroprotective, immunomodulatory and microbiota-remodeling activities. In the present review, we summarized the available literature to provide a scientific evidence regarding this neuroprotective and immunomodulatory effects and the interaction with gut microbiota of polyphenols and, the main signaling pathways involved that can explain their potential therapeutic application in neurodegenerative diseases.
Giuseppe Annunziata; Antoni Sureda; Ilkay Erdogan Orhan; Maurizio Battino; Angela Arnone; Manuel Jiménez-García; Xavier Capó; Joan Cabot; Nima Sanadgol; Francesca Giampieri; Gian Carlo Tenore; Hamid Reza Khayat Kashani; Ana Sanches Silva; Solomon Habtemariam; Seyed Fazel Nabavi. The neuroprotective effects of polyphenols, their role in innate immunity and the interplay with the microbiota. Neuroscience & Biobehavioral Reviews 2021, 128, 437 -453.
AMA StyleGiuseppe Annunziata, Antoni Sureda, Ilkay Erdogan Orhan, Maurizio Battino, Angela Arnone, Manuel Jiménez-García, Xavier Capó, Joan Cabot, Nima Sanadgol, Francesca Giampieri, Gian Carlo Tenore, Hamid Reza Khayat Kashani, Ana Sanches Silva, Solomon Habtemariam, Seyed Fazel Nabavi. The neuroprotective effects of polyphenols, their role in innate immunity and the interplay with the microbiota. Neuroscience & Biobehavioral Reviews. 2021; 128 ():437-453.
Chicago/Turabian StyleGiuseppe Annunziata; Antoni Sureda; Ilkay Erdogan Orhan; Maurizio Battino; Angela Arnone; Manuel Jiménez-García; Xavier Capó; Joan Cabot; Nima Sanadgol; Francesca Giampieri; Gian Carlo Tenore; Hamid Reza Khayat Kashani; Ana Sanches Silva; Solomon Habtemariam; Seyed Fazel Nabavi. 2021. "The neuroprotective effects of polyphenols, their role in innate immunity and the interplay with the microbiota." Neuroscience & Biobehavioral Reviews 128, no. : 437-453.
Bee products have long been used in traditional healing practices to treat many types of disorders, including cancer and microbial-related diseases. Indeed, several chemical compounds found in bee products have been demonstrated to display anticancer, antibacterial, antiviral, and antiparasitic properties. With the improvement of research tools and in view of recent advances related to bee products, this review aims to provide broad yet detailed insight into the pharmaceutical prospects of bee products such as honey, propolis, bee pollen, royal jelly, bee bread, beeswax, and bee venom, in the domain of cancer and infectious disease management. Available literature confirms the efficacy of these bee products in the alleviation of cancer progression, inhibition of bacterial and viral proliferation, and mitigation of parasitic-related symptoms. With such potentials, bioactive components isolated from the bee products can be used as an alternative approach in the long-run effort to improve humans’ health at a personal and community level.
Firzan Nainu; Ayu Masyita; Muh. Bahar; Muhammad Raihan; Shajuthi Prova; Saikat Mitra; Talha Emran; Jesus Simal-Gandara. Pharmaceutical Prospects of Bee Products: Special Focus on Anticancer, Antibacterial, Antiviral, and Antiparasitic Properties. Antibiotics 2021, 10, 822 .
AMA StyleFirzan Nainu, Ayu Masyita, Muh. Bahar, Muhammad Raihan, Shajuthi Prova, Saikat Mitra, Talha Emran, Jesus Simal-Gandara. Pharmaceutical Prospects of Bee Products: Special Focus on Anticancer, Antibacterial, Antiviral, and Antiparasitic Properties. Antibiotics. 2021; 10 (7):822.
Chicago/Turabian StyleFirzan Nainu; Ayu Masyita; Muh. Bahar; Muhammad Raihan; Shajuthi Prova; Saikat Mitra; Talha Emran; Jesus Simal-Gandara. 2021. "Pharmaceutical Prospects of Bee Products: Special Focus on Anticancer, Antibacterial, Antiviral, and Antiparasitic Properties." Antibiotics 10, no. 7: 822.
Though the instability of polyphenols in cell culture experiment has been investigated previously, the underlying mechanism is not completely clear yet. Therefore, in this study, the stability of epigallocatechin gallate (EGCG) in cell culture medium DMEM was investigated at 4 °C and 37 °C via UPLC-MS-MS analysis followed by determination of the antioxidant capacity of EGCG. EGCG was instable in DMEM and formed various degradation products derived from its dimer with increasing incubation time with many isomers being formed at both temperatures. The dimer products were more stable at 4 °C than at 37 °C. The structure and formation mechanism of five products were analyzed with four unidentified. Ascorbic acid significantly improved the stability of EGCG by protecting EGCG from auto-oxidation in DMEM, particularly at 4 °C. The antioxidative activity of EGCG in DMEM was determined by DPPH, ABTS and FRAP assay. The antioxidative properties of EGCG continuously decreased over 8 h in DMEM, which was consistent with its course of degradation.
Minglong Wang; Haolin Zhang; Lunzhao Yi; Petra Högger; Randolph Arroo; Vivek K. Bajpai; Miguel-Angel Prieto; Jesus Simal-Gandara; Shengpeng Wang; Hui Cao. Stability and antioxidant capacity of epigallocatechin gallate in Dulbecco's modified eagle medium. Food Chemistry 2021, 366, 130521 .
AMA StyleMinglong Wang, Haolin Zhang, Lunzhao Yi, Petra Högger, Randolph Arroo, Vivek K. Bajpai, Miguel-Angel Prieto, Jesus Simal-Gandara, Shengpeng Wang, Hui Cao. Stability and antioxidant capacity of epigallocatechin gallate in Dulbecco's modified eagle medium. Food Chemistry. 2021; 366 ():130521.
Chicago/Turabian StyleMinglong Wang; Haolin Zhang; Lunzhao Yi; Petra Högger; Randolph Arroo; Vivek K. Bajpai; Miguel-Angel Prieto; Jesus Simal-Gandara; Shengpeng Wang; Hui Cao. 2021. "Stability and antioxidant capacity of epigallocatechin gallate in Dulbecco's modified eagle medium." Food Chemistry 366, no. : 130521.
Currently, a worldwide pandemic has been declared in response to the spread of coronavirus disease 2019 (COVID-19), a fatal and fast-spreading viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The low availability of efficient vaccines and treatment options has resulted in a high mortality rate, bringing the world economy to its knees. Thus, mechanistic investigations of drugs capable of counteracting this disease are in high demand. The main protease (Mpro) expressed by SARS-CoV-2 has been targeted for the development of potential drug candidates due to the crucial role played by Mpro in viral replication and transcription. We generated a phytochemical library containing 1672 phytochemicals derived from 56 plants, which have been reported as having antiviral, antibacterial, and antifungal activity. A molecular docking program was used to screen the top three candidate compounds: epicatechin-3-O-gallate, psi-taraxasterol, and catechin gallate, which had respective binding affinities of −8.4, −8.5, and −8.8 kcal/mol. Several active sites in the targeted protein, including Cys145, His41, Met49, Glu66, and Met165, were found to interact with the top three candidate compounds. The multiple simulation profile, root-mean-square deviation, root-mean-square fluctuation, radius of gyration, and solvent-accessible surface area values supported the inflexible nature of the docked protein–compound complexes. The toxicity and carcinogenicity profiles were assessed, which showed that epicatechin-3-O-gallate, psi-taraxasterol, and catechin gallate had favorable pharmacological properties with no adverse effects. These findings suggest that these compounds could be developed as part of an effective drug development pathway to treat COVID-19.
Shafi Mahmud; Suvro Biswas; Gobindo Paul; Mohasana Mita; Maria Promi; Shamima Afrose; Robiul Hasan; Shahriar Zaman; Salah Uddin; Kuldeep Dhama; Talha Emran; Abu Saleh; Jesus Simal-Gandara. Plant-Based Phytochemical Screening by Targeting Main Protease of SARS-CoV-2 to Design Effective Potent Inhibitors. Biology 2021, 10, 589 .
AMA StyleShafi Mahmud, Suvro Biswas, Gobindo Paul, Mohasana Mita, Maria Promi, Shamima Afrose, Robiul Hasan, Shahriar Zaman, Salah Uddin, Kuldeep Dhama, Talha Emran, Abu Saleh, Jesus Simal-Gandara. Plant-Based Phytochemical Screening by Targeting Main Protease of SARS-CoV-2 to Design Effective Potent Inhibitors. Biology. 2021; 10 (7):589.
Chicago/Turabian StyleShafi Mahmud; Suvro Biswas; Gobindo Paul; Mohasana Mita; Maria Promi; Shamima Afrose; Robiul Hasan; Shahriar Zaman; Salah Uddin; Kuldeep Dhama; Talha Emran; Abu Saleh; Jesus Simal-Gandara. 2021. "Plant-Based Phytochemical Screening by Targeting Main Protease of SARS-CoV-2 to Design Effective Potent Inhibitors." Biology 10, no. 7: 589.