Giulio Benincasa

Dr. Giulio Benincasa

Pineta Grande Hospital, Via Domitiana, km 30/00, 81030 Castel Volturno CE, Italy
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Academic Career Length

29Years (1998-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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11 December 2003 in Cancer
Verified
Journal Article
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PZPio Zeppa
Pio Zeppa
GMGilda Marino
Gilda Marino
GTGiancarlo Troncone
Giancarlo Troncone
Franco FulcinitiFranco Fulciniti
Franco Fulciniti
ARAmalia De Renzo
Amalia De Renzo
LPLucio Palombini
Lucio Palombini
1 April 2011 in Gynecologic Oncology
Verified
Journal Article
Closed access
Maria Lina TorneselloMaria Lina Tornesello
Maria Lina Tornesello
SLS. Losito
S. Losito
GBGiulio Benincasa
Giulio Benincasa
Franco FulcinitiFranco Fulciniti
Franco Fulciniti
GGerardo Botti
Gerardo Botti
FBF.M. Buonaguro
F.M. Buonaguro
1 March 2002 in American Journal of Physiology-Heart and Circulatory Physiology
Verified
Journal Article
Open access
PDF file
EPEmiliano A. Palmieri
Emiliano A. Palmieri
GBGiulio Benincasa
Giulio Benincasa
FRFrancesca Di Rella
Francesca Di Rella
CCCosma Casaburi
Cosma Casaburi
MMMaria G. Monti
Maria G. Monti
Antonio CittadiniAntonio Cittadini
Antonio Cittadini
An isovolumic normal rat heart Langendorff model was used to examine the effects of moderate (15 mmHg) and severe (35 mmHg) mechanical stretch on the time course (from 0 to 60 min) of myocardial expression of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and insulin-like growth factor (IGF)-1 and their cognate receptors. After 10 min of moderate stretch, TNF-α was de novo expressed, whereas constitutive IL-6 and IGF-1 levels were slightly upregulated; no further changes occurred up to 60 min. In comparison, severe stretch resulted in a higher and progressive increase in TNF-α, IL-6, and IGF-1 expression up to 20 min. After 20 min, whereas TNF-α expression further increased, IL-6 and IGF-1 levels progressively reduced to values lower than those observed under moderate stretch and in unstretched (5 mmHg) control myocardium (IL-6). Mechanical stretch did not significantly alter the expression of the cognate receptors. Indeed, the TNF-α receptor (p55) tended to be progressively upregulated under severe stretch over time. The current data provide the first demonstration that TNF-α, IL-6, and IGF-1 ligand-receptor systems are differentially expressed within the normal rat myocardium in response to graded mechanical stretch. Such findings may have potential implications with regard to compensatory hypertrophy and failure.
1 May 2021 in Pharmacogenomics and Personalized Medicine
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Journal Article
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CCConcetta Cafiero
Concetta Cafiero
FRFelice Rosapepe
Felice Rosapepe
Raffaele PalmirottaRaffaele Palmirotta
Raffaele Palmirotta
ARAgnese Re
Agnese Re
MOMaria Pia Ottaiano
Maria Pia Ottaiano
SPSalvatore Pisconti
Salvatore Pisconti
Introduction: The renin–angiotensin–aldosterone system (RAAS), a metabolic cascade regulating pressure and circulating blood volume, has been considered the main system involved in the pathogenesis of severe lung injury and organs decline in COVID-19 patients. The angiotensin I-converting enzyme (ACE1), angiotensin-converting enzyme 2 (ACE2), angiotensinogen (AGT) and receptors angiotensin II receptor type 1 (AGTR1) are key factors for SARS-CoV-2 entering in the cells, sodium and water retention with an increase blood pressure, promotion of fibrotic and inflammatory phenomena resulting in a cytokine storm. Methods: In this pilot study, the frequencies of six polymorphisms in the ACE1, ACE2, AGT and AGTR1 genes were analysed in symptomatic patients affected by COVID-19 and compared with the results obtained from asymptomatic subjects. Results: Thus, we have identified that rs2074192 (ACE2), rs1799752 (ACE1) and rs699 (AGT) SNPs could potentially be a valuable tool for predicting the clinical outcome of SARS-CoV-2 infected patients. A genetic predisposition may be prospected for severe internal organ damages and poor prognosis in patients with COVID-19 disease, as observed in symptomatic vs asymptomatic. Conclusion: This study provides evidence that analysis of RAAS polymorphisms could be considered the key point in understanding and predicting the SARS-CoV-2 course infection.
9 February 2018 in Frontiers in Aging Neuroscience
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Journal Article
Open access
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MCMarco Cascella
Marco Cascella
Sabrina BimonteSabrina Bimonte
Sabrina Bimonte
ABAntonio Barbieri
Antonio Barbieri
VVVitale Del Vecchio
Vitale Del Vecchio
MMMaria Rosaria Muzio
Maria Rosaria Muzio
ACArturo Cuomo
Arturo Cuomo
Several nutraceuticals have been investigated for preventing or retarding the progression of different neurodegenerative diseases, including Alzheimer's disease (AD). Because Nigella sativa (NS) and its isolated compound thymoquinone (TQ) have significant anti-oxidant and anti-inflammatory proprieties, they could represent effective neuroprotective agents. The purpose of this manuscript is to analyze and to recapitulate the results of in vitro and in vivo studies on the potential role of NS/TQ in AD's prevention and treatment. The level of evidence for each included animal study has been assessed by using a modified CAMARADES (Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies) 10-item checklist. We used MEDLINE and EMBASE databases to screen relevant articles published up to July 2017. A manual search was also performed. The database search yielded 38 studies, of which 18 were included in this manuscript. Results from these approaches suggest that NS or TQ could represent an effective strategy against AD due to the balancing of oxidative processes and the binding to specific intracellular targets. The overall effects mainly regard the prevention of hippocampal pyramidal cell loss and the increased cognitive functions.
20 March 2021 in Medicina
Verified
Journal Article
Open access
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BBBarbara Brogna
Barbara Brogna
CBCarlo Brogna
Carlo Brogna
MPMauro Petrillo
Mauro Petrillo
ACAdriana Modestina Conte
Adriana Modestina Conte
GBGiulio Benincasa
Giulio Benincasa
Marina PiscopoMarina Piscopo
Marina Piscopo
Reverse transcriptase polymerase chain reaction (RT-PCR) negative results in the upper respiratory tract represent a major concern for the clinical management of coronavirus disease 2019 (COVID-19) patients. Herein, we report the case of a 43-years-old man with a strong clinical suspicion of COVID-19, who resulted in being negative to multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RT-PCR tests performed on different oropharyngeal and nasopharyngeal swabs, despite serology having confirmed the presence of SARS-CoV-2 IgM. The patient underwent a chest computed tomography (CT) that showed typical imaging findings of COVID-19 pneumonia. The presence of viral SARS-CoV-2 was confirmed only by performing a SARS-CoV-2 RT-PCR test on stool. Performing of SARS-CoV-2 RT-PCR test on fecal samples can be a rapid and useful approach to confirm COVID-19 diagnosis in cases where there is an apparent discrepancy between COVID-19 clinical symptoms coupled with chest CT and SARS-CoV-2 RT-PCR tests’ results on samples from the upper respiratory tract.