Alzheimer’s is a chronic neurodegenerative disease that frequently occurs in many people today. It has a major effect on the routine activities of affected people. Previous advancement in smartphone sensors technology enables us to help people suffering from Alzheimer’s. For people in the Muslim community, where it is mandatory to offer prayers five times a day, it may mean that they are struggling in their daily life prayers due to Alzheimer’s or lack of concentration. To deal with such a problem, automated mobile sensor-based activity recognition applications can be supportive to design accurate and precise solutions with an objective to direct the Namazi (worshipper). In this paper, a Salah activities recognition model (SARM) using a mobile sensor is proposed with the aim to recognize specific activities, such as Al-Qayam (standing), Ruku (standing to bowing), and Sujud (standing to prostration). This model entails the collection of data, selection and placement of sensor, data preprocessing, segmentation, feature extraction, and classification. The proposed model will provide a stepping edge to develop an application for observing prayer. For these activities’ recognition, data sets were collected from ten subjects, and six different features sets were used to get improved results. Extensive experiments were performed to test and validate the model features to train random forest (RF), K-nearest neighbor (KNN), naive Bayes (NB), and decision tree (DT). The predicted average accuracy of RF, KNN, NB, and DT was 97%, 94%, 71.6%, and 95% respectively.

G protein-coupled receptors (GPCRs) belong to the largest family of protein targets comprising over 800 members in which at least 500 members are the therapeutic targets. Among the GPCRs, G protein-coupled estrogen receptor-1 (GPER-1) has shown to have the ability in estrogen signaling. As GPER-1 plays a critical role in several physiological responses, GPER-1 has been considered as a potential therapeutic target to treat estrogen-based cancers and other non-communicable diseases. However, the progress in the understanding of GPER-1 structure and function is relatively slow due to the availability of a only a few selective GPER-1 modulators. As with many GPCRs, the X-ray crystal structure of GPER-1 is yet to be resolved and thus has led the researchers to search for new GPER-1 modulators using homology models of GPER-1. In this review, we aim to summarize various approaches used in the generation of GPER-1 homology model and their applications that have resulted in new GPER-1 ligands. Highlights Features and role of homology modeling in structure. Approaches to model structure. Application of the homology model for the identification of new ligand. Communicated by Ramaswamy H. Sarma

Human activity recognition (HAR) has emerged as a prominent research field in recent years. Current HAR models are only able to model bilateral correlations between two sensing devices for feature extraction. However, for some activities, exploiting correlations among more than two sensing devices, which we call hyper-correlations in this paper, is essential for extracting discriminatory features. In this work, we propose a novel HyperHAR framework that automatically models both bilateral and hyper-correlations among sensing devices. The HyperHAR consists of three modules. The Intra-sensing Device Feature Extraction Module generates latent representation across the data of each sensing device, based on which the Inter-sensing Device Multi-order Correlations Learning Module simultaneously learns both bilateral correlations and hyper-correlations. Lastly, the Information Aggregation Module generates a representation for an individual sensing device by aggregating the bilateral correlations and hyper-correlations it involves in. It also generates the representation for a pair of sensing devices by aggregating the hyper-correlations between the pair and other different individual sensing devices. We also propose a computationally more efficient HyperHAR-Lite framework, a lightweight variant of the HyperHAR framework, at a small cost of accuracy. Both the HyperHAR and HyperHAR-Lite outperform SOTA models across three commonly used benchmark datasets with significant margins. We validate the efficiency and effectiveness of the proposed frameworks through an ablation study and quantitative and qualitative analysis.

Human activity recognition (HAR) is a prominent research direction in ubiquitous computing. Current state-of-the-art HAR models achieve great success by learning the correlations between the regions of the body parts by using the attached sensing devices for feature extraction. However, explicitly computing the correlations between whole body parts and whole sub-body parts, which is crucial for extracting discriminatory features for some activities, has not been investigated due to the lack of sensing devices that capture the movements of the whole (sub-)body parts. This study proposes an effective yet lightweight VirtualHAR framework, which automatically models correlations between the whole body parts, whole sub-body parts, and regions based on the concept of virtual sensing devices. The VirtualHAR framework mainly encompasses three modules. The backbone feature extraction (BEF) module extracts the features from a physical sensing device, based on which the Multipurpose Correlations Learning module constructs virtual sensing devices for body parts and sub-body parts and then exploits the explicit correlations between body parts, sub-body parts as well as in regions by using their attached physical sensing devices. Finally, the global aggregation (GA) module learns the GA representation for each physical sensing device by collecting the learned correlated representation from each virtual sensing device and physical sensing device. Comprehensive experiments on benchmark HAR datasets and a resource-constrained device confirm that VirtualHAR outperforms SOTA models in recognition performance and computational complexity. Through thorough quantitative and qualitative analysis, we validate the proposed VirtualHAR framework’s effectiveness and efficiency.