Background: The phenomenon of the increasing number of ageing people in the world is arguably the most significant economic, health and social challenge that we face today. Additionally, one of the major epidemiologic trends of current times is the increase in chronic and degenerative diseases. This paper tries to deliver a more up to date overview of chronic diseases and other limitations associated with old age and provide a more detailed outlook on the research that has gone into this field. Methods: First, challenges for seniors, including chronic diseases and other limitations associated with old age, are specified. Second, a review of seniors’ needs and concerns is performed. Finally, solutions that can improve seniors’ quality of life are discussed. Publications obtained from the following databases are used in this scoping review: Web of Science, PubMed, and Science Direct. Four independent reviewers screened the identified records and selected relevant publications published from 2010 to 2017. A total of 1916 publications were selected. In all, 52 papers were selected based on abstract content. For further processing, 21 full papers were screened.” Results: The results indicate disabilities as a major problem associated with seniors’ activities of daily living dependence. We founded seven categories of different conditions - psychological problems, difficulties in mobility, poor cognitive function, falls and incidents, wounds and injuries, undernutrition, and communication problems. In order to minimize ageing consequences, some areas require more attention, such as education and training; technological tools; government support and welfare systems; early diagnosis of undernutrition, cognitive impairment, and other diseases; communication solutions; mobility solutions; and social contributions. Conclusions: This scoping review supports the view on chronic diseases in old age as a complex issue. To prevent the consequences of chronic diseases and other limitations associated with old age related problems demands multicomponent interventions. Early recognition of problems leading to disability and activities of daily living (ADL) dependence should be one of essential components of such interventions.

The introduction of information technology into all aspects of our lives has brought forth qualitative and quantitative changes on such a large scale that this process has come to be known as the Fourth Industrial Revolution, or Industry 4.0. The aim of this paper is to fill in the gaps and provide an overview of studies dealing with Industry 4.0 from the business and economic perspectives. A scoping review is performed regarding business, microeconomic and macroeconomic economic problems. Four investigators performed a literature search of the Web of Science, Scopus, and Science Direct. The selected period spanned from 2014 to 2018, and the following keywords were used for the search: Industry 4.0, economics, economic development, production economics, and financial sector. A total of 2275 results were returned. In all, 67 full papers were screened. Results obtained from the relevant studies were, furthermore, divided into the following categories: work and skills development; economy growth and macroeconomic aspect; sustainability; intelligent manufacturing; policy; and change in business processes. Findings show that the aspects of work and skills development, smart technology adoption, intelligent manufacturing, and digitalization are very well described. The government and its policies usually play the role of a needed supportive element. Usually studies lack a coherent view of the topic in question and solve partial questions.

Today’s challenges to sustainability are explored through a complex combination of interdisciplinary topics that explore various interactions between economic, social, and environmental systems that further contribute to existing uncertainties. Solving complex/dynamic sustainability constraints does not demand exclusively technical and practical methods, as it is equally important to have a profound conceptual understanding of the origins of such challenges. The purpose of this study was to investigate the challenges to the sustainable development process from the perspective of the philosophy of grey systems theory (GST). GST considers inherent defects and shortcomings in human understanding/knowledge and identifies the roots of uncertainty. The study concentrates on the sustainable development process, highlighting the ways in which GST explains the causes and sources of uncertainty in this process. It is emphasized that sustainability cannot be achieved without intentional human intervention, and that international collaboration is vital in solving sustainability problems. Uncertainty and challenges to sustainable development stem from human grey understanding and knowledge. This problem makes it difficult for humans to understand and model dynamicity, to strike a balance between different spheres of science, and to have an objective view of reality due to the dependence of knowledge on thinking paradigms and values. These shortcomings ultimately bring about value conflicts, different understandings of risks, and impediments to international collaboration and agreement. Finally, the study explains that uncertainty arises from incomplete understanding and grey knowledge, and that uncertainty undermines the prediction of outcomes. Furthermore, delays inherent in interactions and the impacts of diverse systems on the world increase uncertainty and complicate decision- and policymaking in improvement projects. In their efforts to implement their decisions and policies, humans also encounter various limitations in terms of their capacities, resources, and facilities. The application of GST-based approaches to the operational area is also discussed.

In recent years, there have been international movements advocating more sustainable societies, and as a result of such movements, a remarkably important sub-branch has been shaped in systems studies called sustainability. It would be vital to propose methods that could deal with inherent complexities and uncertainties in such systems. Grey systems theory (GST) represents a nascent method that could help to solve complexities in the face of multifaceted problems, uncertainty, and complexity in systems, and the theory could considerably contribute to sustainability studies. The present study sought to fill a gap and provide an updated review of the literature on the roles and impacts of GST-based methods in sustainability studies as one of the most significant areas of exploring economic, social and environmental systems. Primarily, the theoretical foundations of sustainability and GST were briefly reviewed. Next, by categorizing the studies conducted in the literature on sustainability studies, GST-based methods used in such studies were identified. Finally, the advantages, effects and functions of GST-based theories and their applications in sustainability studies were explicated. The papers found in this systematic review were searched on such databases as Scopus, Web of Science, and ScienceDirect, as published from 2010 up to the first three months of 2020, based on these keywords: grey relation or grey relational, grey model, grey system or grey systems, grey prediction, grey control, grey incidence, grey cluster, grey decision, grey input-output. The total number of publications found on all of the databases was 446, although (following a more meticulous investigation of the publications) 145 ones were used for the comprehensive analysis. The 10 different areas in which GST was used to explore sustainability in the publications were: sustainability assessment, industrial sustainability, urban sustainability, energy sustainability, sustainability development, businesses sustainability, agricultural sustainability, sustainable products, tourism sustainability, social sustainability. The results revealed that complexity, uncertainty, and inaccessibility of a large set of data and initial statistical distributions led researchers to rely on GST in sustainability studies, and that the applied areas of GST in terms of sustainability issues had some features in common, including linguistic variables, long-term projects, technological demands, conflicting goals, and uncertainty. Moreover, compared to other methods used to deal with uncertainty, GST did not require the formation of an extensive databank of classified rules and was more practical and efficient in sustainability calculations (as complex systems) with fewer numerical calculations. Ignoring systematic approaches, causal relations, cause-effect loops, and dynamic feedback was the missing link in the application of GST in sustainability studies as complex economic, social and environmental systems.

The present study seeks to provide an overview of studies dealing with the grey systems theory from the perspective of socio-economic systems. A scoping review is conducted to explore the studies focusing grey systems theory and its applications in socio-economic systems. The publications selected for analysis were collected through searching the databases of the Web of Science, Scopus, and Science Direct. The publications were selected from 2010 to 2019, and the following keywords were used to detect them: grey systems, grey relational, grey model, grey prediction, grey control, grey incidence, grey cluster, grey decision, and grey input-output plus social, economic, and socioeconomic. Out of the 2375 records found, 147 full papers were screened. Results obtained from the studies were separated into the following categories: social network, healthcare, financial issues, sustainability, tourism, social and cultural, public sectors, urbanization, development, business, economics, demographics, innovation, and entrepreneurship. Findings showed that complexity, uncertainty, and a lack of access to a large collection of data directed researchers to rely on grey systems theory-based socio-economic systems. Furthermore, theory-based grey systems were more effective than other approaches of decision-making and analysis. Drawing on the grey systems theory-based holistic approaches and systems thinking methods helped to obtain better results in analyzing socio-economic systems.

The medical devices, biotechnology, and healthcare industries are closely tied to innovation, with companies relying on research and development and new product introduction. However, innovation activities like research and development can be costly, and commercializing new products faces complexities. Having effective business models (BMs) aligned with such innovation activities is crucial. This study delves into the intricacies of BMs in these innovator companies, emphasizing the pivotal role of effective BMs in navigating uncertainties and fostering innovation. This study conducted a systematic literature review to synthesize knowledge on BMs in innovator health-tech companies and compare models on dimensions like infrastructure, offering, customers, and finances. The review of 34 recent papers revealed 9 key BMs - open innovation, sustainable, dynamic, dual, spin-off, frugal, high-tech entrepreneurial content marketing, back-end, and product-service systems BMs. The analysis found open innovation, sustainability, and dynamicity as foundational models that can serve as a basis when combined with others. The paper unveils a tailored Dynamic Sustainable Business Model (DSBM) for Health-Tech, designed to integrate adaptability and sustainability, providing a framework for companies to leverage emerging technologies effectively. Additionally, a conceptual framework outlining 28 groups of uncertainty factors in BMs was developed to aid risk management in health-tech. The findings offer crucial insights for companies in health-tech industries, aiding them in managing innovation and value creation amidst a rapidly evolving landscape.